公开(公告)号：US20050250890A1

公开(公告)日：2005-11-10

申请号：US11122722

申请日：2005-05-05

申请人： Yan Chen ,  John Myles ,  Ramesh Rengarajan ,  Bill Sparhawk

发明人： Yan Chen ,  John Myles ,  Ramesh Rengarajan ,  Bill Sparhawk

IPC分类号： C08J3/22 ,  C08K3/04 ,  C08K3/26 ,  C08K3/34

CPC分类号： C08J3/226 ,  C08J2323/00 ,  C08J2423/00 ,  C08K3/04 ,  C08K3/26 ,  C08K3/34

摘要： The present invention relates to a filler masterbatch composition comprised of a polymer selected from an impact polypropylene, a high density polyethylene, and a polyolefin elastomer and a mineral filler and a filled thermoplastic composition produced by combining such a filer masterbatch composition with a polymer. The inventive filler masterbatch allows for a higher compounding rate, better dispersion, and elimination of a typical compounding step in the production of filled thermoplastic compositions.

摘要翻译： 本发明涉及由选自抗冲聚丙烯，高密度聚乙烯和聚烯烃弹性体的聚合物和矿物填料组成的填料母料组合物，以及通过将这种滤料母料组合物与聚合物组合而制备的填充的热塑性组合物。 本发明的填充母料允许在生产填充的热塑性组合物中具有更高的配混速率，更好的分散和消除典型的配混步骤。

公开(公告)号：US20050203167A1

公开(公告)日：2005-09-15

申请号：US11077391

申请日：2005-03-10

申请人： Mathai Mammen ,  Yu-Hua Ji ,  Yan Chen ,  Craig Husfeld

发明人： Mathai Mammen ,  Yu-Hua Ji ,  Yan Chen ,  Craig Husfeld

IPC分类号： A61K31/4025 ,  C07D207/08 ,  C07D207/30 ,  C07D409/06 ,  C07D49/02

CPC分类号： C07D207/08 ,  C07D409/06

摘要： This invention provides compounds of formula I: wherein a, b, c, e, m, n, Ar1, R1, R2, R3, R4a, R4b, R5 and R6 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

摘要翻译： 本发明提供式I化合物：其中a，b，c，e，m，n，Ar 1，R 1，R 2， R 3，R 4a，R 4b，R 5和R 6， 如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US06935116B2

公开(公告)日：2005-08-30

申请号：US10424350

申请日：2003-04-28

申请人： Peter J. Stuttaford ,  Stephen Jennings ,  Andrew Green ,  Ryan McMahon ,  Yan Chen ,  Hany Rizkalla ,  John Carella ,  Vamsi Duraibabu ,  Martin Spalding

发明人： Peter J. Stuttaford ,  Stephen Jennings ,  Andrew Green ,  Ryan McMahon ,  Yan Chen ,  Hany Rizkalla ,  John Carella ,  Vamsi Duraibabu ,  Martin Spalding

IPC分类号： F23R3/14 ,  F23R3/28 ,  F23R3/34 ,  F02C3/00 ,  F02C7/22 ,  F23R3/54

CPC分类号： F23R3/34 ,  F23R3/14 ,  F23R3/286

摘要： A gas turbine combustion system having reduced emissions and improved flame stability at multiple load conditions is disclosed. The improved combustion system accomplishes this through complete premixing, a plurality of fuel injector locations, combustor geometry, and precise three dimensional staging between fuel injectors. Axial, radial, and circumferential fuel staging is utilized including fuel injection proximate air swirlers. Furthermore, strong recirculation zones are established proximate the introduction of fuel and air premixture from different stages to the combustion zone. The combination of the strong recirculation zones, efficient premixing, and staged fuel flow thereby provide the opportunity to produce low emissions combustion at various load conditions.

摘要翻译： 公开了一种在多个负载条件下具有减少的排放和改进的火焰稳定性的燃气轮机燃烧系统。 改进的燃烧系统通过完全预混合，多个燃料喷射器位置，燃烧器几何形状和燃料喷射器之间的精确三维分级来实现。 使用轴向，径向和周向燃料分级，包括靠近空气旋流器的燃料喷射。 此外，在从不同阶段到燃烧区的燃料和空气预混物的引入附近建立强的再循环区域。 强再循环区域的组合，有效的预混合和分级燃料流量因此提供在各种负载条件下产生低排放燃烧的机会。

公开(公告)号：US20050135577A1

公开(公告)日：2005-06-23

申请号：US11002228

申请日：2004-12-03

申请人： ShuGuang Jin ,  Yan Chen ,  PeiLiang Xu

发明人： ShuGuang Jin ,  Yan Chen ,  PeiLiang Xu

IPC分类号： H04M15/00 ,  H04Q3/00 ,  H04M17/00

CPC分类号： H04M15/74 ,  H04M15/00 ,  H04M15/41 ,  H04M15/43 ,  H04M15/44 ,  H04M15/49 ,  H04M15/50 ,  H04M15/51 ,  H04M15/54 ,  H04M15/55 ,  H04M15/58 ,  H04M2215/0104 ,  H04M2215/0164 ,  H04M2215/0188 ,  H04M2215/2046 ,  H04M2215/44 ,  H04M2215/46 ,  H04M2215/52 ,  H04M2215/54 ,  H04M2215/709 ,  H04Q3/0025

摘要： A method and apparatus for division of revenue of communication among different proprietors is provided in this invention, where the division of revenue among the different proprietors is performed by a gateway office, wherein the gateway office will set a source parameter and a destination parameter respectively from the source and the destination when a call goes through the gateway office; Judge the two parameters to get a revenue zone index; Judge the value of the revenue zone index, and modulate the revenue zone index to get a revenue class index; The gateway office generates contents related to the revenue class index; A central memory receives all these contents, adds an increment of each counter of the revenue class memory related to the revenue class index to a corresponding counter and carries out multiple safety mechanisms; Output the information in the revenue class memory to a storage medium for storing, then output it to a billing center for revenue sorting. The billing mode present in this invention is based on group pairs, so it is more adaptive for the gateway office to divide revenue.

摘要翻译： 本发明提供了一种用于在不同所有者之间分配通信收入的方法和装置，其中不同所有者之间的收入分配由网关办公室执行，其中，网关办公室将分别设置源参数和目的地参数 呼叫通过网关办公室时的来源和目的地; 判断两个参数以获得收益区指数; 判断收益区指数的价值，并调整收益区指数以获得收入类指数; 网关办公室生成与收入类别指数相关的内容; 中央记忆体接收所有这些内容，将与收入类别指数相关的收入类记忆的每个计数器的增量增加到相应的计数器，并执行多个安全机制; 将收入类别存储器中的信息输出到用于存储的存储介质，然后将其输出到计费中心进行收益分类。 本发明中的计费模式是基于组对，因此它更适应于网关办公室分配收入。

公开(公告)号：US06849608B2

公开(公告)日：2005-02-01

申请号：US10454354

申请日：2003-06-03

申请人： Wei-Guo Su ,  Yan Chen

发明人： Wei-Guo Su ,  Yan Chen

IPC分类号： A61K31/7048 ,  A61P31/04 ,  A61P33/02 ,  A61P43/00 ,  C07H17/00 ,  C07H17/08 ,  A61K31/70

CPC分类号： C07H17/08 ,  C07H17/00

摘要： A macrolide antibiotic of the formula wherein the variables are defined as described herein.

摘要翻译： 变量中的大环内酯类抗生素的定义如本文所述。

公开(公告)号：US06585864B1

公开(公告)日：2003-07-01

申请号：US09589196

申请日：2000-06-08

申请人： Gary Anthony Fisher ,  Robert Prescott ,  Yan Chen ,  Hang Zheng ,  Chinnia Subramanian ,  Andrew George Wysiekierski

发明人： Gary Anthony Fisher ,  Robert Prescott ,  Yan Chen ,  Hang Zheng ,  Chinnia Subramanian ,  Andrew George Wysiekierski

IPC分类号： C23C1435

CPC分类号： C23C28/3215 ,  C23C26/00 ,  C23C28/322 ,  C23C28/325 ,  C23C28/345

摘要： A method for protecting high temperature stainless steel from coking and corrosion at elevated temperatures in corrosive environments, such as during ethylene production, by coating the stainless steel with an overlay coating of MCrAlX in which M is nickel, cobalt, iron or a mixture thereof and X is yttrium, hafnium, zirconium, lanthanum or combination thereof. The overlay coating and stainless steel substrate are heat-treated to metallurgically bond the overlay coating to the substrate and to form a multiphased microstructure. The overlay coating preferably is aluminized by depositing a layer of aluminum thereon and subjecting the resulting coating to oxidation to form an alumina surface layer. An intermediary aluminum-containing diffusion coating may be deposited directly onto the stainless steel substrate prior to deposition of the overlay coating to form a protective interlayer between the stainless steel substrate and overlay coating.

摘要翻译： 一种在腐蚀性环境例如乙烯生产过程中，在高温下保护高温不锈钢的方法，用不锈钢涂覆MCrAlX，其中M是镍，钴，铁或其混合物， X是钇，铪，锆，镧或其组合。 将覆盖层和不锈钢衬底进行热处理，将覆盖层冶金结合到衬底上并形成多相微结构。 覆盖涂层优选通过在其上沉积铝层而进行镀铝，并对所得到的涂层进行氧化以形成氧化铝表面层。 中间含铝扩散涂层可以在沉积覆盖层之前直接沉积到不锈钢衬底上，以在不锈钢衬底和覆盖涂层之间形成保护性中间层。

公开(公告)号：US5880204A

公开(公告)日：1999-03-09

申请号：US717446

申请日：1996-09-20

申请人： Thomas F. McCarthy ,  Yan Chen ,  Peter Petersen

发明人： Thomas F. McCarthy ,  Yan Chen ,  Peter Petersen

IPC分类号： C08F214/24 ,  C08F259/08 ,  C09D127/12 ,  C09D151/00 ,  C09G1/16 ,  C09J127/12

CPC分类号： C09D151/003 ,  C08F214/245 ,  C08F259/08 ,  C09D127/12 ,  C09G1/16

摘要： This invention relates to novel room temperature coalescable aqueous fluoropolymer dispersions and a process for their manufacture. These dispersions may be used in a variety of applications including high temperature thermoplastic coatings, polishes, room temperature formable paints and coatings, extrudable or injection moldable resins, and adhesives.

公开(公告)号：US5683879A

公开(公告)日：1997-11-04

申请号：US475236

申请日：1995-06-07

申请人： Maureen Laney ,  Yan Chen ,  Edwin F. Ullman ,  Karen M. Hahnenberger

发明人： Maureen Laney ,  Yan Chen ,  Edwin F. Ullman ,  Karen M. Hahnenberger

IPC分类号： C12N15/09 ,  C07H21/04 ,  C12Q1/68 ,  G01N33/50 ,  C07H21/02 ,  C12P19/34

CPC分类号： C12Q1/6853 ,  C12Q1/6844 ,  C12Q1/686

摘要： A method is disclosed for extending a primer to produce a single stranded polydeoxynucleotide that has two or more defined sequences. A combination is provided which comprises a template polynucleotide, a blocker polynucleotide, a primer polynucleotide and a polynucleotide Q. The template polynucleotide has three sequences T1, T2 and T3 wherein T1 is non-contiguous and 3' of T3 and wherein the 5' end of T3 is 5' of the 5' end of T2. The primer polynucleotide has a second defined sequence at its 3' end that is hybridizable with T1. The blocker polynucleotide has sequence B1 that is hybridizable with T3. Polynucleotide Q has sequences S1 and S2 wherein S1 is 3' of S2 and homologous with T2 and S2 is complementary to a first defined sequence that is to be introduced at the 3' end of the polynucleotide primer, when it is extended during the method of the invention. Polynucleotide Q is either attached to the 5' end of the blocker polynucleotide or present as a separate reagent. The primer is extended along the template polynucleotide and along at least a portion of sequence T2 and thereafter along the polynucleotide Q to give a single stranded polynucleotide having two or more defined sequences.

摘要翻译： 公开了一种扩展引物以产生具有两个或多个限定序列的单链多脱氧核苷酸的方法。 提供了包含模板多核苷酸，阻断多聚核苷酸，引物多核苷酸和多核苷酸Q的组合。模板多核苷酸具有三个序列T1，T2和T3，其中T1不连续且T3的3'，其中5'末端 T3的T3的5'端是5'。 引物多核苷酸在其3'端具有与T1杂交的第二定义序列。 阻断剂多核苷酸具有可与T3杂交的序列B1。 多核苷酸Q具有序列S1和S2，其中S1是S2的3'，与T2同源，S2与在多核苷酸引物的3'端引入的第一定义序列互补，当其在 本发明。 多核苷酸Q连接于阻断多核苷酸的5'末端或作为单独的试剂存在。 引物沿着模板多核苷酸并沿着序列T2的至少一部分延伸，然后沿着多核苷酸Q延伸，得到具有两个或多个限定序列的单链多核苷酸。

公开(公告)号：US10710983B2

公开(公告)日：2020-07-14

申请号：US15633258

申请日：2017-06-26

申请人： Yan Chen ,  Rose Yen ,  Jiaxin Yu ,  Vanessa Taylor ,  Rajinder Singh

发明人： Yan Chen ,  Rose Yen ,  Jiaxin Yu ,  Vanessa Taylor ,  Rajinder Singh

IPC分类号： C07D401/14 ,  C07D403/12 ,  C07D239/48 ,  C07D405/14

摘要： Compounds within the scope of the present invention have a Formula 1 or a salt or prodrug thereof, where ring A is selected from cycloaliphatic; ring B is aryl; R1 is selected from (C1-C10)alkyl, (C3-C10)cycloalkyl, halo, aryl, and heteroaryl; and R2 and R3 are independently selected from hydrogen and (C1-C6)alkyl. Disclosed compounds may have an IRAK4 IC50 of from 0.003 μM to 3.7 μM; a TAK1 IC50 of from 0.008 μM to 132 μM; and/or an IRAK4/TAK1 selectivity of from 1 to 450. Particular compounds may have an IRAK4/TAK1 selectivity of from 100 to 500. Disclosed compositions may be formulated as pharmaceutical compositions. A method for using the compounds and/or compositions also are disclosed. The method may comprise administering to a subject an effective amount of a compound within the scope of the present invention, particularly to selectively inhibit IRAK 1 and/or IRAK4 over TAK1.

公开(公告)号：US20180111923A1

公开(公告)日：2018-04-26

申请号：US15793770

申请日：2017-10-25

申请人： Hui Li ,  Thilo Heckrodt ,  Yan Chen ,  Ryan Kelley ,  Darren McMurtrie ,  Kin Tso ,  Vanessa Taylor ,  Rajinder Singh ,  Rose Yen ,  Jack Maung

发明人： Hui Li ,  Thilo Heckrodt ,  Yan Chen ,  Ryan Kelley ,  Darren McMurtrie ,  Kin Tso ,  Vanessa Taylor ,  Rajinder Singh ,  Rose Yen ,  Jack Maung

IPC分类号： C07D413/14

CPC分类号： C07D413/14 ,  A61P29/00

摘要： Disclosed embodiments concern interleukin receptor associated kinases (IRAK) inhibitors, such as oxazole compounds, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.