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    Far-field P-wave sensing in near real-time for timing delivery of pacing therapy in a cardiac medical device and medical device system
    111.
    发明授权
    Far-field P-wave sensing in near real-time for timing delivery of pacing therapy in a cardiac medical device and medical device system 有权

    公开(公告)号：US10342981B2

    公开(公告)日：2019-07-09

    申请号：US15858017

    申请日：2017-12-29

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Kushagr Gupta

    IPC: A61N1/00 ,  A61N1/365 ,  A61N1/368 ,  A61N1/37 ,  A61N1/372 ,  A61N1/39

    Abstract: A medical device system for controlling ventricular pacing therapy during cardiac resynchronization therapy that includes a sensing device to sense a cardiac signal and emit a trigger signal in response to the sensed cardiac signal, a therapy delivery device to deliver the ventricular pacing in response to the emitted trigger signal, and a processor configured to identify a fiducial point of the cardiac signal sensed in real-time, set a window comprising a start point positioned a first distance prior to the fiducial point and an endpoint positioned a second distance less than the first distance subsequent to the fiducial point, determine a signal characteristic of the cardiac signal within the window, determine whether a P-wave is detected in response to the signal characteristic, determine whether an atrio-ventricular interval timer has expired, and emit a trigger signal to deliver the ventricular pacing timed off of the local maximum in response to the P-wave being detected and not timed off of the local maximum in response to the timer being expired.

    GENERATING ACTIVATION TIMES
    114.
    发明申请
    GENERATING ACTIVATION TIMES 审中-公开

    公开(公告)号：US20190030332A1

    公开(公告)日：2019-01-31

    申请号：US16047625

    申请日：2018-07-27

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Karen J. Kleckner

    IPC: A61N1/36 ,  A61N1/362 ,  A61B5/053 ,  A61N1/04

    Abstract: Systems and methods are described herein for generating surrogate cardiac electrical activation times from electrical activity monitored by a plurality of external electrodes. Surrogate cardiac electrical activation times that should be corrected may be identified, or determined, according to one or more metrics, and then such surrogate cardiac electrical activation times may be corrected according to various criterion.

    CONFIRMING SENSED ATRIAL EVENTS FOR PACING DURING RESYNCHRONIZATION THERAPY IN A CARDIAC MEDICAL DEVICE AND MEDICAL DEVICE SYSTEM
    115.
    发明申请
    CONFIRMING SENSED ATRIAL EVENTS FOR PACING DURING RESYNCHRONIZATION THERAPY IN A CARDIAC MEDICAL DEVICE AND MEDICAL DEVICE SYSTEM 审中-公开

    公开(公告)号：US20180289964A1

    公开(公告)日：2018-10-11

    申请号：US16005943

    申请日：2018-06-12

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Juan Du ,  Saul E. Greenhut ,  Michael T. Hemming

    IPC: A61N1/368 ,  A61B5/00 ,  A61B5/0452 ,  A61B5/042

    Abstract: A medical device and medical device system for controlling delivery of therapeutic stimulation pulses that includes a sensing device to sense a cardiac signal and emit a trigger signal in response to the sensed cardiac signal, a therapy delivery device to receive the trigger signal and deliver therapy to the patient in response to the emitted trigger signal, and a processor positioned within the sensing device, the processor configured to determine whether the sensed cardiac signal exceeds a possible P-wave threshold, compare a portion of the sensed cardiac signal to a P-wave template having a sensing window having a length less than a width of the P-wave, confirm an occurrence of a P-wave signal in response to the comparing, emit the trigger signal in response to the occurrence of a P-wave signal being confirmed, and inhibit delivery of the emitting signal in response to the occurrence of a P-wave signal not being confirmed.

    ASSESSING INTRA-CARDIAC ACTIVATION PATTERNS AND ELECTRICAL DYSSYNCHRONY
    120.
    发明申请
    ASSESSING INTRA-CARDIAC ACTIVATION PATTERNS AND ELECTRICAL DYSSYNCHRONY 有权
    评估心脏内皮细胞活化模式和电学性质

    公开(公告)号：US20170049347A1

    公开(公告)日：2017-02-23

    申请号：US15345225

    申请日：2016-11-07

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Jeffrey M. Gillberg ,  Robert W. Stadler

    IPC: A61B5/04 ,  A61B5/0452 ,  A61N1/368 ,  A61B5/044

    CPC classification number: A61B5/04012 ,  A61B5/02 ,  A61B5/0402 ,  A61B5/04085 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/05 ,  A61B5/742 ,  A61N1/0476 ,  A61N1/0484 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    Abstract: Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.

    Abstract translation: 描述了评估心脏电气不同步的技术。 在一些示例中，为多个躯干表面电位信号中的每一个确定激活时间。 可以分析或呈现这些激活时间的分散或序列以提供患者心脏的电不同步的各种指征。 在一些示例中，电极组的电极的位置以及因此感测躯干表面电位信号的位置可以投影在包括模型心脏的模型躯干的表面上。 可以基于从患者感测到的躯干表面电位信号来解决心电图的逆问题，以确定模型心脏区域的电激活时间。

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