-
公开(公告)号:US20100190760A1
公开(公告)日:2010-07-29
申请号:US12665019
申请日:2008-06-17
申请人: Graham Ruecroft , James Robinson , Dipesh Parikh
发明人: Graham Ruecroft , James Robinson , Dipesh Parikh
CPC分类号: B01J2/06 , A61K9/0073 , A61K9/14 , B01D9/0009 , B01D9/0018 , B01D9/005 , B01D9/0054 , B01D9/0059 , B01D9/0081 , B01J2/18
摘要: A process for preparing an emulsion or a dispersion comprising crystalline particles of at least one active principal that comprises contacting a solution of at least one solute in a solvent or mixture of solvents in a first flowing stream with a non-solvent in a second flowing stream wherein the non-solvent and solvent are not miscible with each other, so as to form an emulsion or a dispersion. Super saturation is brought about by suitable means, and the emulsion or dispersion is subjected to ultrasonic irradiation to mediate crystal nucleation.
摘要翻译: 一种制备包含至少一种活性主体的结晶颗粒的乳液或分散体的方法,包括使第一流动中的溶剂或溶剂混合物中的至少一种溶质的溶液与第二流动流中的非溶剂接触 其中所述非溶剂和溶剂彼此不混溶,以形成乳液或分散体。 通过合适的方法产生超饱和,并且对乳液或分散体进行超声波照射以介导晶体成核。
-
公开(公告)号:US07276612B2
公开(公告)日:2007-10-02
申请号:US10818755
申请日:2004-04-06
IPC分类号: C07D307/78 , A61K31/34
CPC分类号: A61K31/343 , A61K31/18 , A61K31/33 , A61K31/34 , A61K31/4015 , A61K31/4415 , A61K41/00 , A61K45/06 , A61N5/10 , C07C259/10 , C07C2601/02 , C07D207/12 , C07D207/327 , C07D207/34 , C07D209/08 , C07D209/18 , C07D209/42 , C07D209/44 , C07D211/46 , C07D213/56 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/08 , C07D215/18 , C07D215/48 , C07D215/54 , C07D217/04 , C07D217/06 , C07D217/26 , C07D231/56 , C07D235/06 , C07D235/24 , C07D241/52 , C07D249/18 , C07D261/18 , C07D263/58 , C07D277/30 , C07D277/42 , C07D277/56 , C07D277/68 , C07D307/54 , C07D307/68 , C07D307/79 , C07D307/81 , C07D307/85 , C07D307/86 , C07D317/60 , C07D333/16 , C07D333/24 , C07D333/28 , C07D333/38 , C07D333/70 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/04 , C07D417/12 , A61K2300/00
摘要: The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.
摘要翻译: 本发明涉及可用于治疗丙型肝炎的某些异羟肟酸衍生物。这些化合物也是组蛋白脱乙酰酶的抑制剂,因此可用于治疗与组蛋白脱乙酰酶活性相关的疾病。 还公开了制备这些化合物的药物组合物和方法。
-
公开(公告)号:US20070036903A1
公开(公告)日:2007-02-15
申请号:US11463446
申请日:2006-08-09
申请人: Peter Mayr , Paul Cooke , Trevor Fielding , Ronald Goodwin , Gregory Paulson , James Robinson , Anthony Violleau
发明人: Peter Mayr , Paul Cooke , Trevor Fielding , Ronald Goodwin , Gregory Paulson , James Robinson , Anthony Violleau
IPC分类号: B05D1/36
CPC分类号: B05D7/5483 , B05D7/14 , B05D7/53 , B05D7/542 , B65D25/14 , C08L61/00 , C09D5/106 , C09D167/00 , Y10T428/256 , Y10T428/31511 , Y10T428/31794 , Y10T428/31797 , C08L2666/16
摘要: Disclosed are Bisphenol A (BPA), Bisphenol F, Bisphenol A diglycidyl ether (BADGE), and Bisphenol F diglycidyl ether (BFDGE)-free coating compositions for metal substrates including an under-coat composition containing a polyester (co)polymer, and an under-coat cross-linker; and an over-coat composition containing a poly(vinyl chloride) (co)polymer dispersed in a substantially nonaqueous carrier liquid, an over-coat cross-linker, and a functional (meth)acrylic (co)polymer. Also provided is a method of coating a metal substrate using the BPA, BPF, BADGE and BFDGE-free coating system to produce a hardened protective coating useful in fabricating metal storage containers. The coated substrate is particularly useful in fabricating multi-part foodstuffs storage containers with “easy-open” end closures.
摘要翻译: 公开了包含含有聚酯(共)聚合物的底涂层组合物的金属基材的双酚A(BPA),双酚F,双酚A二缩水甘油醚(BADGE)和双酚F二缩水甘油醚(BFDGE)的涂料组合物, 底涂层交联剂; 以及包含分散在基本上非水性载体液体中的聚(氯乙烯)(共)聚合物,外涂层交联剂和官能(甲基)丙烯酸(共))聚合物的外涂层组合物。 还提供了使用BPA,BPF,BADGE和无BFDGE的涂层系统涂覆金属基材以产生用于制造金属储存容器的硬化保护涂层的方法。 涂覆的基材特别适用于制造具有“易开”端盖的多部件食品储存容器。
-
公开(公告)号:US20070015125A1
公开(公告)日:2007-01-18
申请号:US11268256
申请日:2005-11-07
申请人: Tommie Mobbs , Juan Benavidez , James Robinson , Bruce Richardson
发明人: Tommie Mobbs , Juan Benavidez , James Robinson , Bruce Richardson
IPC分类号: G09B19/00
CPC分类号: G09B7/00 , G06Q10/1053
摘要: The results of a performance appraisal are correlated with data collected from a job assessment process. Questions from the assessment that relate to high employee performance, and low employee performance are desirably identified. Questions that have no relation to performance are also desirably identified, as well as any additional questions such as those that show gender, age, or racial bias, for example. For those questions that are shown to predict high or low performance, the relative weights of those questions in the job assessment can be adjusted upwards so that they will have a greater bearing on whether an employee is hired. Those questions that show little or no relation to employee performance can be weighted downward, or removed entirely, resulting in a more streamlined and efficient job assessment process.
摘要翻译: 绩效评估的结果与从工作评估过程收集的数据相关联。 理想地确定评估中与员工绩效高,员工绩效低的问题。 与性能无关的问题也被期望地识别,以及任何其他问题,例如显示性别,年龄或种族偏见的问题。 对于那些可以预测高绩效或低绩效的问题,工作评估中的这些问题的相对权重可以向上调整,以便对员工是否被雇用有更大的影响。 那些与员工绩效几乎没有关系的问题可以向下权衡,或者完全被删除,从而导致更加精简和有效的工作评估过程。
-
公开(公告)号:US20070015124A1
公开(公告)日:2007-01-18
申请号:US11204800
申请日:2005-08-16
申请人: Tommie Mobbs , Juan Benavidez , James Robinson , Bruce Richardson
发明人: Tommie Mobbs , Juan Benavidez , James Robinson , Bruce Richardson
IPC分类号: G09B19/00
CPC分类号: G09B7/00
摘要: A job analysis is created for a particular job based on a database of job related skills and abilities. Using the job analysis, a job requisition process, an assessment process, and a performance appraisal process are generated. One or more employees are hired through the requisition and assessment processes. After some period of time, one or more of the employees are assessed through the assessment process. During the assessment process administrators may identify skills or abilities not recognized in the job analysis. A database of job related skills may be searched for the previously unidentified skills or abilities. If found, the skills or abilities are incorporated into the existing job analysis. If the identified skills or abilities are not found, the database is updated to incorporate the newly identified skills or abilities. A new job requisition process, assessment process, and performance appraisal process are then generated using the updated job analysis.
摘要翻译: 基于与工作有关的技能和能力的数据库为特定工作创建工作分析。 使用作业分析,生成工作申请过程,评估过程和绩效考核流程。 通过申请和评估过程聘请一名或多名员工。 经过一段时间,一名或多名员工通过评估过程进行评估。 在评估过程中,管理员可以确定工作分析中未识别的技能或能力。 可能搜索与工作有关的技能数据库,以了解以前不明的技能或能力。 如果发现,技能或能力被纳入现有的工作分析。 如果找不到确定的技能或能力,则更新数据库以包含新确定的技能或能力。 然后使用更新的作业分析生成新的工作申请过程,评估过程和绩效评估过程。
-
公开(公告)号:US20060043143A1
公开(公告)日:2006-03-02
申请号:US10945412
申请日:2004-09-20
IPC分类号: B25C1/04
摘要: A combustion tool having a gas actuated magazine advance includes a combustion chamber defined in part by a cylinder, a valve sleeve axially reciprocating relative to the cylinder and an upper surface of a piston, a pneumatically actuated magazine fastener mechanism, and an exhaust driven actuation feed tube having a first end configured for insertion into an opening in the cylinder in fluid communication with the combustion chamber and a second end connected to the magazine fastener advance mechanism.
-
公开(公告)号:US20060024575A1
公开(公告)日:2006-02-02
申请号:US10903693
申请日:2004-07-30
申请人: Andre Robinson , Due Huynh , James Robinson
发明人: Andre Robinson , Due Huynh , James Robinson
CPC分类号: H01M2/1094 , B29C45/14467 , B29C45/14639 , B29L2031/7146 , H01M2/1061 , H01M10/425 , H01M10/46 , H01M2200/00 , Y10T29/4911
摘要: A sealed battery pack is provided that prevents liquid, dust and gas from compromising the reliability of the rechargeable cell and circuitry disposed within the pack. A rechargeable cell and printed circuit board are coupled together and are placed into a five sided housing. In one embodiment, one of the sides is longer that the others to accommodate electrical contacts for coupling to a host device. Once the cell/board assembly is positioned in the housing, plastic is drawn through the housing using an insert molding process to seal and encapsulate the cell and board within the housing. The seal provided by the insert molding process ensures that liquid, gas and dust do not penetrate the pack.
摘要翻译: 提供密封的电池组,其防止液体,灰尘和气体损害可充电电池和设置在包装内的电路的可靠性。 可再充电电池和印刷电路板耦合在一起,并被放置在五面体中。 在一个实施例中,其中一个侧面比另一个更长,以容纳用于耦合到主机设备的电触点。 一旦电池/电路板组件定位在壳体中,则通过插入成型工艺将塑料拉过外壳,以将电池和电路板封装在外壳内。 由插入成型工艺提供的密封确保液体,气体和灰尘不会穿透包装。
-
公开(公告)号:US20050285309A1
公开(公告)日:2005-12-29
申请号:US11215651
申请日:2005-08-30
申请人: Richard Ernst , George Dewey , George Dowse , James Robinson
发明人: Richard Ernst , George Dewey , George Dowse , James Robinson
IPC分类号: E04B1/48 , F16B13/00 , F16B25/00 , F16B25/04 , F16B25/06 , F16B25/10 , F16B35/04 , F16B37/12 , B29C39/02
CPC分类号: F16B13/002 , F16B37/127 , Y10T29/49833 , Y10T29/49947 , Y10T29/49963 , Y10T29/49964 , Y10T29/49966
摘要: A method of making a self drilling anchor for use in a friable material mounted on a member comprising an elongated body having an axis, an axial bore adapted to receive an elongated fastener, a flared end having torque transmitting surfaces therein, a proximal portion, an intermediate portion, a distal portion, and a drilling tip generally opposite the flared end, wherein the proximal portion has a threaded exterior having a root, a crest diameter, and a thread height, the intermediate portion has a threaded exterior having a root, a crest diameter substantially smaller than the crest diameter of the proximal portion, and a thread height substantially smaller than the thread height of the proximal portion, and the distal portion has a threaded exterior with a root that tapers toward the drilling tip, a crest diameter substantially smaller than the crest diameter of the proximal portion, and a thread height substantially smaller than the thread height of the proximal portion.
摘要翻译: 一种制造用于安装在构件上的脆性材料中的自钻锚固件的方法,该构件包括具有轴线的细长主体,适于容纳细长紧固件的轴向孔,其中具有扭矩传递表面的扩口端,近端部分, 中间部分,远端部分和大致与扩口端相对的钻尖,其中近端部分具有带根部,螺纹直径和螺纹高度的螺纹外部,中间部分具有螺纹外部,具有根部, 脊部直径基本上小于近端部分的顶部直径,并且螺纹高度基本上小于近端部分的螺纹高度,并且远端部分具有螺纹外部,根部朝向钻头尖端逐渐变细,顶部直径基本上 小于近端部分的波峰直径,并且线高度基本上小于近端部分的螺纹高度。
-
公开(公告)号:US20050187261A1
公开(公告)日:2005-08-25
申请号:US10818755
申请日:2004-04-06
申请人: Erik Verner , Martin Sendzik , Chitra Baskaran , Joseph Buggy , James Robinson
发明人: Erik Verner , Martin Sendzik , Chitra Baskaran , Joseph Buggy , James Robinson
IPC分类号: A61K31/18 , A61K31/33 , A61K31/34 , A61K31/4015 , A61K31/4415 , A61K41/00 , A61K45/06 , C07C259/10 , C07D207/12 , C07D207/32 , C07D207/327 , C07D207/34 , C07D209/08 , C07D209/18 , C07D209/42 , C07D209/44 , C07D211/46 , C07D213/56 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/08 , C07D215/18 , C07D215/48 , C07D215/54 , C07D217/04 , C07D217/06 , C07D217/26 , C07D231/56 , C07D235/06 , C07D235/24 , C07D241/52 , C07D249/18 , C07D261/18 , C07D263/58 , C07D277/30 , C07D277/42 , C07D277/56 , C07D277/68 , C07D307/54 , C07D307/68 , C07D307/79 , C07D307/81 , C07D307/85 , C07D307/86 , C07D317/60 , C07D333/16 , C07D333/24 , C07D333/28 , C07D333/38 , C07D333/70 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D213/78
CPC分类号: A61K31/343 , A61K31/18 , A61K31/33 , A61K31/34 , A61K31/4015 , A61K31/4415 , A61K41/00 , A61K45/06 , A61N5/10 , C07C259/10 , C07C2601/02 , C07D207/12 , C07D207/327 , C07D207/34 , C07D209/08 , C07D209/18 , C07D209/42 , C07D209/44 , C07D211/46 , C07D213/56 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/08 , C07D215/18 , C07D215/48 , C07D215/54 , C07D217/04 , C07D217/06 , C07D217/26 , C07D231/56 , C07D235/06 , C07D235/24 , C07D241/52 , C07D249/18 , C07D261/18 , C07D263/58 , C07D277/30 , C07D277/42 , C07D277/56 , C07D277/68 , C07D307/54 , C07D307/68 , C07D307/79 , C07D307/81 , C07D307/85 , C07D307/86 , C07D317/60 , C07D333/16 , C07D333/24 , C07D333/28 , C07D333/38 , C07D333/70 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/04 , C07D417/12 , A61K2300/00
摘要: The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.
摘要翻译: 本发明涉及可用于治疗丙型肝炎的某些异羟肟酸衍生物。这些化合物也是组蛋白脱乙酰酶的抑制剂,因此可用于治疗与组蛋白脱乙酰酶活性相关的疾病。 还公开了制备这些化合物的药物组合物和方法。
-
公开(公告)号:US20050079027A1
公开(公告)日:2005-04-14
申请号:US10844706
申请日:2004-05-12
申请人: Richard Ernst , George Dewey , George Dowse , James Robinson
发明人: Richard Ernst , George Dewey , George Dowse , James Robinson
IPC分类号: E04B1/48 , F16B13/00 , F16B25/00 , F16B25/04 , F16B25/06 , F16B25/10 , F16B35/04 , F16B37/12 , F16B13/06
CPC分类号: F16B13/002 , F16B37/127 , Y10T29/49833 , Y10T29/49947 , Y10T29/49963 , Y10T29/49964 , Y10T29/49966
摘要: A self drilling anchor for use in a friable material mounted on a member comprises an elongated body having an axis, an axial bore adapted to receive an elongated fastener, a flared end having torque transmitting surfaces therein, a proximal portion, an intermediate portion, a distal portion, and a drilling tip generally opposite the flared end, wherein the proximal portion has a threaded exterior having a root, a crest diameter, and a thread height, the intermediate portion has a threaded exterior having a root, a crest diameter substantially smaller than the crest diameter of the proximal portion, and a thread height substantially smaller than the thread height of the proximal portion, and the distal portion has a threaded exterior with a root that tapers toward the drilling tip, a crest diameter substantially smaller than the crest diameter of the proximal portion, and a thread height substantially smaller than the thread height of the proximal portion.
摘要翻译: 用于安装在构件上的脆性材料中的自钻锚固件包括具有轴线的细长主体,适于接收细长紧固件的轴向孔,其中具有扭矩传递表面的扩口端,近端部分,中间部分, 远端部分和大致与扩口端相对的钻尖,其中近端部分具有带根部,螺纹直径和螺纹高度的螺纹外部,中间部分具有带根部的螺纹外部,顶部直径基本上较小 比近端部分的波峰直径大,而且螺纹高度远小于近端部分的螺纹高度,而远侧部分具有螺纹外部,根部朝向钻头尖端逐渐变细,波峰直径基本上小于顶部 近端部分的直径以及基本上小于近端部分的螺纹高度的螺纹高度。
-
-
-
-
-
-
-
-
-