公开(公告)号：US5250135A

公开(公告)日：1993-10-05

申请号：US536086

申请日：1990-06-11

Applicant: Rodney H. Moss ,  Donald C. Bradley ,  Marc M. Faktor ,  Dario M. Frigo

Inventor： Rodney H. Moss ,  Donald C. Bradley ,  Marc M. Faktor ,  Dario M. Frigo

IPC: B01J4/00 ,  B01J4/04 ,  C30B25/14 ,  C30B25/16

CPC classification number: C23C16/45561 ,  B01J4/00 ,  B01J4/04 ,  C30B25/14

Abstract: A method of providing a reagent into a chemical process said provision being in the vapor phase and at a controlled mass flow rate wherein the method comprises:(a) providing a gas stream which contains a gaseous phase complexing agent for the reagent said complexing agent being provided at a controlled partial vapor pressure in said gas stream;(b) providing a primary source of the reagent in a reservoir which is connected to the gas stream via a diffusion path;(c) causing the gaseous phase complexing agent to diffuse into the reservoir at a mass flow rate controlled by its partial pressure in the gas stream;(d) causing the gaseous phase complexing agent in the reservoir to react with the primary source to generate a gaseous phase complex of the reagent and the gaseous phase complexing agent, said generation being, in the steady state, at a rate equivalent to the rate of inflow of said complexing agent;(e) causing the gaseous phase complex to diffuse out of the reservoir into the gas stream at a rate, in the steady state, which is equivalent to its rate of generation in stage (d);whereby the mass flow of reagent occurs at a rate defined and controlled by the vapor pressure of the vapor phase complexing agent in the gas stream.

Abstract translation: 一种将试剂提供到化学过程中的方法，所述提供处于气相和受控的质量流量，其中所述方法包括：（a）提供气流，所述气流含有所述试剂的气相络合剂，所述络合剂为 在所述气流中以受控的部分蒸气压提供; （b）在经由扩散路径连接到气流的储存器中提供试剂的主要来源; （c）使气相络合剂以其气流中其分压控制的质量流量扩散到储存器中; （d）使储存器中的气相络合剂与初级源反应以产生试剂和气相络合剂的气相络合物，所述生成处于稳定状态，速率等于速率 所述络合剂的流入; （e）使气相配合物以稳定的速度使其从储层中扩散到气流中，其速率等于其在阶段（d）中的产生速率; 由此试剂的质量流量以气流中气相络合剂的蒸气压限定和控制的速率发生。

公开(公告)号：US4965128A

公开(公告)日：1990-10-23

申请号：US168631

申请日：1988-02-26

Applicant: Pieter J. Greidanus ,  Jan Feijen ,  Marinus J. D. Eenink ,  Johannes C. Rieke ,  Jan Olijslager ,  Jan H. M. Albers

Inventor： Pieter J. Greidanus ,  Jan Feijen ,  Marinus J. D. Eenink ,  Johannes C. Rieke ,  Jan Olijslager ,  Jan H. M. Albers

IPC: A01N25/10 ,  A61K9/00 ,  A61K9/22 ,  B01J4/04 ,  C07K14/575 ,  C07K17/04 ,  C07K19/00 ,  C08L101/16 ,  C12N11/04 ,  D01F4/00 ,  D01F6/62

CPC classification number: A61K9/0092 ,  Y10T428/2927 ,  Y10T428/2935 ,  Y10T428/2975

Abstract: Biodegradable hollow fibres with an asymmetric wall, the cavity of which containing an active substance like a drug, hormone etc. or a dilute form of the latter and both ends of the hollow fibre being closed for the controlled release of the active substance as well as a process for the manufacturing of such hollow fibres.

Abstract translation: 具有不对称壁的可生物降解的中空纤维，其空腔含有药物，激素等活性物质，或后者的稀释形式，中空纤维的两端封闭以控制活性物质的释放，以及 这种中空纤维的制造方法。

公开(公告)号：US4952139A

公开(公告)日：1990-08-28

申请号：US463016

申请日：1990-01-09

Applicant: Emmanuel Goldenberg

Inventor： Emmanuel Goldenberg

IPC: B01J10/00 ,  B01F3/02 ,  B01F5/00 ,  B01F5/04 ,  B01J4/00 ,  B01J4/04 ,  B01J12/00 ,  B01J19/24 ,  C01B3/36

CPC classification number: B01F5/0453 ,  B01J12/005 ,  B01J4/04 ,  C01B3/36

Abstract: A device is provided for conveying separately at least two gases as far as a mixing zone, said device including several tubes, and means for supplying these tubes with one of the gases, the invention also relating to a reactor having at least one cell equipped with said conveying device, said device further including means for holding the tubes in position with respect to each other, the tubes being held together jointingly by said means and defining empty spaces or intertube gaps, some at least of said tubes having narrowed zones placed substantially at the same level so as to form a network for distributing the other gas to some at least of the intertube gaps.

Abstract translation: 提供了一种装置，用于分别输送至少两种气体至混合区域，所述装置包括多个管子，以及用于向这些管道供应气体的装置，本发明还涉及具有至少一个装有 所述输送装置还包括用于将管子相对于彼此保持在适当位置的装置，所述管由所述装置共同保持在一起，并且限定空的空间或管间隙，一些至少所述管具有基本位于 以形成用于将其它气体分配到至少一些管间隙的网络。

公开(公告)号：US4938931A

公开(公告)日：1990-07-03

申请号：US54351

申请日：1987-05-26

Applicant: Edward L. Cussler

Inventor： Edward L. Cussler

IPC: B01D53/86 ,  B01D63/02 ,  B01J4/04 ,  B01J8/00 ,  B01J8/02 ,  B01J19/24 ,  C01B17/775 ,  C01B17/80

CPC classification number: C01B17/803 ,  B01J19/2475 ,  B01J8/009 ,  B01J8/0278 ,  C01B17/775 ,  B01J2208/00548

Abstract: Trickle bed reactors are prone to channelling, flooding, and similar flow problems. It has been found that these problems can be avoided by the use of a microporous membrane to separate a reactant fluid phase from a catalysis fluid phase surrounding a catalyst bed. An advantage of such a reactor is that the fluid flows can be separately controlled. An apparatus useful as a trickle bed reactor can include a plurality of microporous hollow fibers arranged in a shell-and-tube configuration within a housing. Such an apparatus is operated with a reactant fluid phase flowing through the fibers and with a catalyst bed on the shell-side of the arrangement.

公开(公告)号：US4921633A

公开(公告)日：1990-05-01

申请号：US902010

申请日：1986-08-28

Applicant: Tadashi Funada ,  Jiro Hirano ,  Shiro Ishida ,  Kensuke Morioka ,  Sachiko Murakami

Inventor： Tadashi Funada ,  Jiro Hirano ,  Shiro Ishida ,  Kensuke Morioka ,  Sachiko Murakami

IPC: B01J13/00 ,  B01J4/04 ,  B01J14/00 ,  B01J19/26 ,  C12M1/40

CPC classification number: B01J4/04 ,  B01J14/00 ,  Y10S516/06

Abstract: A method of heterogeneous reaction is described, comprising reacting a water-soluble component and an oil-soluble component dispersed in the water-soluble component or an aqueous medium containing the same. This dispersion is attained by passing the oil-soluble component through the micropores of a hydrophilic material as it is introduced into the aqueous medium. This hydrophilic material can be shaped into a desired form such as a membrane and a fabric. The flow rate, reaction rate and conversion are easy to control in the present method since the particle size of the oil-soluble component can be appropriately controlled. Furthermore, the present method does not need any stirring power nor an emulsification operation, and thus is advantageous from an economic standpoint.

Abstract translation: 描述了一种非均相反应的方法，包括使水溶性组分和分散在水溶性组分中的油溶性组分或含有它的水溶性组分反应。 该分散体是通过使油溶性组分在引入水性介质时通过亲水材料的微孔而达到的。 该亲水材料可以成形为所需形状，例如膜和织物。 由于可以适当地控制油溶性成分的粒径，因此本方法容易控制流量，反应速度和转化率。 此外，本方法不需要任何搅拌力和乳化操作，因此从经济角度来看是有利的。

公开(公告)号：US4752586A

公开(公告)日：1988-06-21

申请号：US933008

申请日：1986-11-20

Applicant: Claude Ropars ,  Yves Nicolau ,  Maurice Chassaigne

Inventor： Claude Ropars ,  Yves Nicolau ,  Maurice Chassaigne

IPC: A61J3/07 ,  A61K9/48 ,  A61K9/50 ,  A61K31/66 ,  A61K31/70 ,  A61K35/14 ,  A61K35/18 ,  A61K38/16 ,  A61K38/21 ,  A61K38/28 ,  A61M1/16 ,  A61M1/36 ,  B01J4/04 ,  C12M1/12 ,  C12M1/00

CPC classification number: B01D61/28 ,  A61K35/18 ,  A61K9/5068 ,  A61M1/36 ,  A61M1/16 ,  B01D2311/04 ,  B01D2313/243

Abstract: This invention relates to a process for the encapsulation in human or animal erythrocytes of at least one substance having a biological activity, characterized in that the primary compartment of at least one dialysis element is continuously supplied with an aqueous suspension of erythrocytes, the secondary compartment of the dialysis element contains an aqueous solution which is hypotonic with respect to the erythrocyte suspension in order to lyse the erythrocytes, the erythrocyte lysate is in contact with said substance having a biological activity and, in order to reseal the membrane of the erythrocytes, the osmotic and/or oncotic pressure of the erythrocyte lysate is increased after it has been brought into contact with said substance having a biological activity.

Abstract translation: 本发明涉及一种用于在人或动物红细胞中包封具有生物活性的至少一种物质的方法，其特征在于至少一种透析元件的初级隔室连续地供应红细胞的水性悬浮液，第二隔室 透析元件含有相对于红细胞悬液低渗的水溶液，以溶解红细胞，红细胞裂解物与具有生物活性的所述物质接触，为了重新密封红细胞膜，渗透 在与所述具有生物活性的物质接触后，红细胞溶解产物的和/或肿瘤的压力增加。

公开(公告)号：US4681755A

公开(公告)日：1987-07-21

申请号：US757601

申请日：1985-07-22

Applicant: Paolo Colombo ,  Ubaldo Conte ,  Alberto Reiner

Inventor： Paolo Colombo ,  Ubaldo Conte ,  Alberto Reiner

IPC: A01N25/00 ,  A61K9/00 ,  A61K9/24 ,  B01J4/04 ,  A61K9/22 ,  A61K9/32

CPC classification number: A61K9/209 ,  Y10S514/965

Abstract: A delivery device for zero-order release of an active principle into a dissolution fluid includes a reservoir consisting of a solid matrix of a homogeneous mixture of a polymer material, at least a portion of the active principle and an additive soluble in the dissolution fluid with negative heat of solution, a coating on the solid matrix-type reservoir of a first, release rate-controlling insoluble membrane which modulates the active principle release according to the desired kinetics; and a second, protective membrane on the release rate-controlling membrane of a soluble polymer material.

Abstract translation: 用于将有效原理零次释放到溶解流体中的输送装置包括由聚合物材料的均匀混合物的固体基质，活性成分的至少一部分和溶解流体中可溶解的添加剂 溶液的负热，固体基质型储层上的涂层，其是根据期望的动力学调节活性原子释放的第一释放速率控制不溶性膜; 以及可溶性聚合物材料的释放速率控制膜上的第二个保护膜。

公开(公告)号：US4564373A

公开(公告)日：1986-01-14

申请号：US357560

申请日：1982-03-12

Applicant: Franz J. Schmitz ,  Rudi Wollbeck ,  Wolfgang Klein

Inventor： Franz J. Schmitz ,  Rudi Wollbeck ,  Wolfgang Klein

IPC: B01J10/00 ,  A61M1/16 ,  B01F1/00 ,  B01F3/04 ,  B01J4/00 ,  B01J4/04 ,  C02F1/00 ,  C02F3/20 ,  C12M1/04 ,  C12M1/12 ,  C12M3/06 ,  B01D53/22

CPC classification number: C12M29/04 ,  B01F3/04439 ,  B01J4/04 ,  C02F3/208 ,  C12M23/24 ,  C12M29/06 ,  Y02W10/15

Abstract: A method for the bubble-free feed of gaseous reactants of a chemical and/or biological reaction into a liquid reaction medium, characterized by filling the pores of a porous polymer membrane with the reaction medium, providing one side of the porous polymer membrane with the gaseous reactants, and immersing the other side of the porous polymer membrane into the liquid reaction medium. The pressure of the gaseous reactants should lie below the bubble pressure determined for the reaction medium, but be at least so great that the liquid reaction medium does not pass through the porous polymer membrane to the gas side. Preferred parameters include relative pore volume between 50 and 90%; maximal pore diameter between 0.2 and 3 .mu.m; and disposing the porous polymer membrane in the form of a flat membrane, tube or hollow filaments.

Abstract translation: 一种用于将化学和/或生物反应的气态反应物无气泡地进料到液体反应介质中的方法，其特征在于用反应介质填充多孔聚合物膜的孔，提供多孔聚合物膜的一侧与 气态反应物，并将多孔聚合物膜的另一侧浸入液体反应介质中。 气态反应物的压力应低于为反应介质确定的气泡压力，但至少要使液体反应介质不能通过多孔聚合物膜到气体侧。 优选的参数包括50-90％的相对孔体积; 0.2〜3μm的最大孔径; 并且将多孔聚合物膜设置为平膜，管或中空丝的形式。

公开(公告)号：US4547273A

公开(公告)日：1985-10-15

申请号：US618014

申请日：1984-06-07

Applicant: William Ayers

Inventor： William Ayers

IPC: B01J4/04 ,  B01J19/08 ,  B01J19/24 ,  C01B3/50 ,  C01B6/00 ,  C01B15/029 ,  C01B21/16 ,  C01C1/04 ,  C07C29/15 ,  C07C45/00 ,  C07C45/49 ,  C07C51/00 ,  C25B1/00 ,  C25B3/00 ,  C25B3/04 ,  C25B9/00 ,  C25B9/08 ,  C25B11/00 ,  C01B15/01

CPC classification number: C25B3/04 ,  B01J19/2475 ,  B01J4/04 ,  C01B15/0295 ,  C01B21/16 ,  C01B3/50 ,  C01B6/00 ,  C01C1/04 ,  C07C255/00 ,  C07C29/15 ,  C07C45/00 ,  C07C45/49 ,  C07C51/00 ,  C25B1/00 ,  B01J2219/00177 ,  B01J2219/00186 ,  C01B2203/0465

Abstract: Disclosed is a method of carrying out a mobile atom insertion reaction, such as a hydrogen insertion reaction, for the synthesis of reduced, hydrogenated compounds. Such reactions include the production of ammonia and hydrazine from nitrogen, formic acid and methanol from carbon dioxide, and hydrogen peroxide from oxygen. The insertion reactions are carried out at a bipolar mobile atom transmissive membrane comprising a membrane formed of a mobile atom pump material, as a hydrogen pump material, conductive atom transmissive means on one surface of the membrane and conductive atom transmissive means on the opposite surface of the membrane. The mobile atom, such as hydrogen, diffuses across the membrane, to provide a source of hydrogen on the insertion reaction side of the membrane. The insertion reaction side of the membrane is positively biased with respect to a counterelectrode so that a reactant molecule, such as carbon dioxide, is electrosorbed on that surface of the membrane. The electrosorbed reactant molecule chemically reacts with the surface hydrogen by the insertion reaction to form a reduced, hydrogenated product such as formic acid. Also disclosed is a chemical reactor, containing the membrane, and several electric field assisted chemical reactions utilizing the membrane and reactor.

Abstract translation: 公开了用于合成还原的氢化化合物的进行诸如氢插入反应的可移动的原子插入反应的方法。 这样的反应包括从氮气中生成氨和肼，从二氧化碳生成甲酸和甲醇，以及从氧气生产过氧化氢。 插入反应在双极移动原子透射膜上进行，该双极移动原子透射膜包括由移动原子泵材料形成的膜，作为氢泵材料，在膜的一个表面上的导电原子透射装置和在膜的相对表面上的导电原子透射装置 膜。 诸如氢的移动原子扩散到膜上，以在膜的插入反应侧提供氢源。 膜的插入反应侧相对于反电极被正偏置，使得诸如二氧化碳的反应物分子在膜的表面上被电泳。 电泳反应物分子通过插入反应与表面氢发生化学反应，形成还原的氢化产物如甲酸。 还公开了含有膜的化学反应器和利用膜和反应器的几个电场辅助化学反应。

公开(公告)号：US4327725A

公开(公告)日：1982-05-04

申请号：US210176

申请日：1980-11-25

Applicant: Richard Cortese ,  Felix Theeuwes

Inventor： Richard Cortese ,  Felix Theeuwes

IPC: A01N25/34 ,  A61K9/00 ,  A61M31/00 ,  B01J4/04 ,  A61M7/00

CPC classification number: A61K9/0004 ,  Y10S604/904

Abstract: An osmotic device is disclosed comprising a semipermeable wall surrounding a compartment housing an agent that is insoluble to very soluble in aqueous and biological fluids, and a layer of a fluid swellable, hydrogel. A passageway in the wall connects the agent with the exterior of the device.

Abstract translation: 公开了一种渗透装置，其包括围绕容纳不溶于非常可溶于水和生物流体的试剂的腔室的半透壁，以及流体可溶胀水凝胶层。 墙壁上的一个通道可将药剂与装置的外部连接起来。