PHARMACEUTICAL COMPOSITION COMPRISING EFFECTIVE DOSE OF POMIFERIN FOR TREATING CANCERS
    122.
    发明申请
    PHARMACEUTICAL COMPOSITION COMPRISING EFFECTIVE DOSE OF POMIFERIN FOR TREATING CANCERS 审中-公开
    包含POMIFININ治疗癌症有效剂量的药物组合物

    公开(公告)号:US20170014375A1

    公开(公告)日:2017-01-19

    申请号:US14799541

    申请日:2015-07-14

    CPC classification number: A61K31/352

    Abstract: The present invention provides a compound of formula (I) as a SERCA inhibitor for treating cancers, a pharmaceutical composition comprising said compound, and methods of using said compound for treating cancers and/or inducing cell death in cells of said cancers. Said cancers include but not limited to cervical, lung, liver, breast, and prostate cancer. Said cancers also include drug-resistant and/or apoptosis-resistant cancers such as isogenic drug-resistant colon cancer. The subject being administered with said compound or the composition comprising thereof can be human or animal subject. Said methods for treating cancers and/or inducing cell death can be a targeting treatment for certain cancers.

    Abstract translation: 本发明提供了作为用于治疗癌症的SERCA抑制剂的式(I)化合物,包含所述化合物的药物组合物,以及使用所述化合物治疗癌症和/或诱导所述癌症细胞中的细胞死亡的方法。 所述癌症包括但不限于宫颈癌,肺癌,肝癌,乳腺癌和前列腺癌。 所述癌症还包括耐药性和/或细胞凋亡抵抗性癌症,例如同基因耐药结肠癌。 给予所述化合物或包含其的组合物的受试者可以是人或动物受试者。 用于治疗癌症和/或诱导细胞死亡的所述方法可以是某些癌症的靶向治疗。

    Method and Device for Information System Access Authentication
    124.
    发明申请
    Method and Device for Information System Access Authentication 审中-公开
    信息系统访问认证的方法和设备

    公开(公告)号:US20160269181A1

    公开(公告)日:2016-09-15

    申请号:US15032182

    申请日:2014-10-10

    Abstract: A method and a device for information system access authentication are disclosed. The method includes: performing anonymous authentication to a random verification code generated according to a login request for accessing an information system of a client, and authenticating acquired user name and password information when the anonymous authentication is successful. The device includes an verification code authentication module and a user name and password authentication module connected to the verification code authentication module, wherein the verification code authentication module is configured to perform anonymous authentication to a random verification code generated according to a login request for accessing an information system of client; and the user name and password authentication module is configured to authenticate acquired user name and password information when the anonymous authentication is successful. The present disclosure uses a two-stage and two-factor authentication method such that the security of the login information is improved without increasing the complexity of the user's login.

    Abstract translation: 公开了一种用于信息系统访问认证的方法和装置。 该方法包括:对根据用于访问客户端的信息系统的登录请求生成的随机验证码进行匿名认证,并且在匿名认证成功时对所获取的用户名和密码信息进行认证。 所述设备包括验证码认证模块和连接到所述验证码认证模块的用户名和密码认证模块,其中所述验证码认证模块被配置为对根据用于访问的登录请求生成的随机验证码执行匿名认证 客户信息系统; 并且用户名和密码认证模块被配置为在匿名认证成功时验证获取的用户名和密码信息。 本公开使用两阶段和双因素认证方法,使得登录信息的安全性得到改善,而不增加用户登录的复杂性。

    Method for scheduling a random-access communication system with absolute and proportional throughput guarantees
    126.
    发明授权
    Method for scheduling a random-access communication system with absolute and proportional throughput guarantees 有权
    用于以绝对和比例的吞吐量保证来调度随机接入通信系统的方法

    公开(公告)号:US09307560B2

    公开(公告)日:2016-04-05

    申请号:US14308713

    申请日:2014-06-19

    CPC classification number: H04W74/0833 H04W74/0816 H04W74/0875 H04W84/12

    Abstract: A method for scheduling a random-access communication system having high-priority (HP) and low-priority (LP) nodes is provided, where the scheduling is configured such that the system provides an absolute throughput guarantee for the HP nodes, and a proportional throughput guarantee for the LP nodes. The method is based on obtaining a length of a contention window assigned to an individual node, which is either a HP or a LP node, from a per-slot attempt rate of this individual node. In particular, the attempt rate of each individual node is determined by an algorithm configured such that a resultant sum of the per-slot attempt rates of all the individual nodes is a fixed value independent of the number of the individual nodes. By this scheduling method, the maximum system throughput is approached. The method can be advantageously used in a wireless local area network (WLAN).

    Abstract translation: 提供了一种用于调度具有高优先级(HP)和低优先级(LP)节点的随机接入通信系统的方法,其中调度被配置为使得系统为HP节点提供绝对吞吐量保证,并且成比例 LP节点的吞吐量保证。 该方法基于从该单独节点的每时隙尝试速率获得分配给单个节点(即HP或LP节点)的争用窗口的长度。 具体地,每个单独节点的尝试速率由配置为使得所有单个节点的每时隙尝试速率的合成和是独立于各个节点的数量的固定值的算法来确定。 通过该调度方法,接近最大系统吞吐量。 该方法可以有利地用于无线局域网(WLAN)。

    Optical fiber-based environmental detection system and the method thereof
    127.
    发明授权
    Optical fiber-based environmental detection system and the method thereof 有权
    基于光纤的环境检测系统及其方法

    公开(公告)号:US09285273B2

    公开(公告)日:2016-03-15

    申请号:US14146727

    申请日:2014-01-03

    Inventor: Jianqing Li Ben Xu

    Abstract: An optical fiber environmental detection system comprising an interferometer, a broadband light source and a detector is disclosed. The interferometer further comprises a thin core fiber, a first single mode fiber and a second single mode fiber; wherein the thin core fiber is coupled to the first and second single mode fiber via a first junction and a second junction respectively. When an emission light reaches the first junction, high-order cladding modes will be excited. The excited cladding modes will interfere with the core mode at the second junction. The interferences determine the intensity maximum or minimum of the received signal. When there is an ambient environmental change, a shift of the received signal would be induced. According to the shift, environmental change, for instance ambient temperature, could be determined.

    Abstract translation: 公开了一种包括干涉仪,宽带光源和检测器的光纤环境检测系统。 干涉仪还包括薄芯纤维,第一单模光纤和第二单模光纤; 其中所述薄芯纤维分别经由第一接头和第二接头耦合到所述第一和第二单模光纤。 当发射光到达第一结时,高阶包层模式将被激发。 激发的包层模式将干扰第二结的核心模式。 干扰决定了接收信号的强度最大值或最小值。 当周围环境变化时,会引起接收信号的偏移。 根据这一转变,可以确定环境变化,例如环境温度。

    Neferine and the use thereof in treating huntington disease
    128.
    发明授权
    Neferine and the use thereof in treating huntington disease 有权
    奈非炔及其在治疗亨廷顿疾病中的应用

    公开(公告)号:US09119847B2

    公开(公告)日:2015-09-01

    申请号:US14562780

    申请日:2014-12-08

    CPC classification number: A61K31/4725 A61K36/62

    Abstract: The present invention discloses a method of treating neurodegenerative disorder comprising administering an effective amount of an alkaloid which is a bisbenzylisoquinline alkaloid isolated from the traditional Chinese medicinal herb Nelumbo nucifera. The pharmaceutical composition thereof for treating Huntington's disease is also disclosed.

    Abstract translation: 本发明公开了一种治疗神经变性疾病的方法,包括给予有效量的生物碱,所述生物碱是从中草药Nelumbo Nucumera分离的双苄基异喹啉生物碱。 还公开了其用于治疗亨廷顿病的药物组合物。

    Optical Fiber-Based Environmental Detection System and the Method Thereof
    129.
    发明申请
    Optical Fiber-Based Environmental Detection System and the Method Thereof 有权
    基于光纤的环境检测系统及其方法

    公开(公告)号:US20150168216A1

    公开(公告)日:2015-06-18

    申请号:US14146727

    申请日:2014-01-03

    Inventor: Jianqing LI Ben XU

    Abstract: An optical fiber environmental detection system comprising an interferometer, a broadband light source and a detector is disclosed. The interferometer further comprises a thin core fiber, a first single mode fiber and a second single mode fiber; wherein the thin core fiber is coupled to the first and second single mode fiber via a first junction and a second junction respectively. When an emission light reaches the first junction, high-order cladding modes will be excited. The excited cladding modes will interfere with the core mode at the second junction. The interferences determine the intensity maximum or minimum of the received signal. When there is an ambient environmental change, a shift of the received signal would be induced. According to the shift, environmental change, for instance ambient temperature, could be determined.

    Abstract translation: 公开了一种包括干涉仪,宽带光源和检测器的光纤环境检测系统。 干涉仪还包括薄芯纤维,第一单模光纤和第二单模光纤; 其中所述薄芯纤维分别经由第一接头和第二接头耦合到所述第一和第二单模光纤。 当发射光到达第一结时,高阶包层模式将被激发。 激发的包层模式将干扰第二结的核心模式。 干扰决定了接收信号的强度最大值或最小值。 当周围环境变化时,会引起接收信号的偏移。 根据这一转变,可以确定环境变化,例如环境温度。

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