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    INHIBITION OF PLATELET ACTIVATION, AGGREGATION AND/OR ADHESION BY HYPOTHERMIA
    122.
    发明申请
    INHIBITION OF PLATELET ACTIVATION, AGGREGATION AND/OR ADHESION BY HYPOTHERMIA 审中-公开
    抑制血小板活化，聚集和/或粘附

    公开(公告)号：US20130304166A1

    公开(公告)日：2013-11-14

    申请号：US13868764

    申请日：2013-04-23

    Applicant: ZOLL CIRCULATION INC.

    Inventor： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    IPC: A61F7/12

    CPC classification number: A61F7/12 ,  A61F7/123 ,  A61F2007/126

    Abstract: A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36 degrees C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 degrees C.). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.

    Abstract translation: 一种通过将热交换装置放置在患者的脉管系统中并使用该热交换装置来冷却患者来治疗人或动物患者的急性冠状动脉综合征（即不稳定型心绞痛或非Q波MI）或短暂性脑缺血发作的方法 达到血小板抑制（即，抑制血小板活化和/或聚集和/或粘附）的温度（例如30-36℃）。 可以将抗发抖药物或麻醉剂施用于体温低于该患者发抖阈值（通常约35.5摄氏度）的患者。 如果确定不再期望血小板抑制，例如当患者即将进行其中出血可能成问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低温诱导的血小板抑制 将患者的身体重温为正常体温或接近正常体温。

    INDWELLING HEAT EXCHANGE CATHETER AND METHOD OF USING SAME
    123.
    发明申请
    INDWELLING HEAT EXCHANGE CATHETER AND METHOD OF USING SAME 有权
    独立热交换器及其使用方法

    公开(公告)号：US20130158480A1

    公开(公告)日：2013-06-20

    申请号：US13771447

    申请日：2013-02-20

    Applicant: Zoll Circulation, Inc. ,  The Regents of the University of California

    Inventor： Wayne A. Noda ,  Mike L. Jones ,  Scott M. Evans ,  Blair D. Walker ,  William J. Worthen ,  Yves Pierre Gobin

    IPC: A61F7/12 ,  A61M5/44

    CPC classification number: A61F7/12 ,  A61B2018/00011 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44 ,  A61M25/0009 ,  A61M25/1011

    Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.

    Abstract translation: 导管适于与诸如血管的体导管中流动的体液（例如血液）进行热交换。 导管包括设置在其远端处具有热交换区域的轴。 该区域可以包括中空纤维，其适于接收远离冷却的热交换流体，优选地在与体液相反的方向上流动。 中空纤维增强了接触的表面积，以及两种热交换流体和体液的混合。 导管可以定位成在身体的选择性区域产生低体温，或者定位成系统地冷却整个身体系统。

    Heat Exchange Catheter and Their Methods of Manufacture and Use
    125.
    发明申请
    Heat Exchange Catheter and Their Methods of Manufacture and Use 有权
    热交换导管及其制造和使用方法

    公开(公告)号：US20130090593A1

    公开(公告)日：2013-04-11

    申请号：US13631410

    申请日：2012-09-28

    Applicant: Zoll Circulation, Inc.

    Inventor： Jeremy Thomas Dabrowiak

    IPC: A61M25/00 ,  A61F7/00

    CPC classification number: A61M25/0026 ,  A61F7/0085 ,  A61F7/12 ,  A61F2007/0054 ,  A61F2007/0056 ,  A61F2007/0096 ,  A61F2007/0098 ,  A61F2007/0261 ,  A61F2007/126 ,  A61M25/0015 ,  A61M25/007 ,  A61M25/09 ,  A61M2025/0183 ,  Y10T29/49826

    Abstract: A closed loop catheter useable for heat exchange is manufactured by forming a plurality of generally transverse bore holes though a flexible, multilumen catheter body, lacing a tube trough the bore holes so that loops of the tube protrude from the catheter body, connecting one end of the tube to an inflow lumen of the catheter and connecting the other end of the tube to an outflow lumen of the catheter. A heated or cooled heat exchange medium may then be circulated through the tube while the catheter is inserted in the vasculature of a subject, thereby resulting in heat exchange between the subject's flowing blood and the heat exchange medium being circulated through the tube.

    Abstract translation: 可用于热交换的闭环导管通过通过柔性多腔导管主体形成多个大致横向的钻孔来制造，所述多孔导管主体通过钻孔将管套管，使得管的环从导管主体突出， 所述管连接到所述导管的流入腔并将所述管的另一端连接到所述导管的流出腔。 然后，当将导管插入受试者的脉管系统中时，加热或冷却的热交换介质可以循环通过管，从而导致受试者的流动的血液和通过管循环的热交换介质之间的热交换。

    CATHETERS AND SYSTEMS FOR DIRECT INJECTION OF GAS-ENRICHED LIQUID INTO A PATIENT
    130.
    发明公开
    CATHETERS AND SYSTEMS FOR DIRECT INJECTION OF GAS-ENRICHED LIQUID INTO A PATIENT 审中-公开

    公开(公告)号：US20240307656A1

    公开(公告)日：2024-09-19

    申请号：US18276558

    申请日：2022-02-18

    Applicant: Zoll Circulation, Inc.

    Inventor： Stephen Myrick ,  Jeffrey Creech ,  Jeremy Dabrowiak ,  John Buckley ,  Masoumeh Mafi

    IPC: A61M25/00

    CPC classification number: A61M25/0026 ,  A61M25/0068 ,  A61M2205/3331 ,  A61M2230/00

    Abstract: A catheter includes a catheter body, a first lumen extending through the catheter body, one or more second lumens extending through the catheter body, and two or more capillaries extending from the catheter body and coupled to the second lumens. The first lumen performs at least one of receiving a sample of the blood from a vasculature of the patient or measuring a parameter of the blood. The second lumens receive a gas enriched liquid from a gas enriched liquid source. The capillaries receive the gas enriched liquid from the one or more second lumens and to simultaneously dispense respective streams of the gas enriched liquid directly into the vasculature, such that the streams of the gas enriched liquid intersect and mix with the blood in a region beyond an end of the catheter body and beyond the first lumen.

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