摘要:
It is intended to avoid dose dumping of a drug and improve the dissolution properties of the drug in the lower gastrointestinal tract, and thereby provide a sustained-release matrix preparation for oral administration that reliably exhibits its main pharmacological effect when orally administered once or twice a day. The present invention provides a sustained-release preparation obtained by mixing of (A) a pharmacologically active drug, (B) hydroxypropyl methylcellulose acetate succinate having a median size (D50) of 40 μm or smaller, (C) a cellulose derivative, and (D) a saccharide or a nonionic water-soluble polymer followed by molding.
摘要:
It is an object of the invention to provide a rubbery polymer-containing resin composition useful as a raw material for a molded article and a cured product having high transparency and excellent mechanical strength: namely, an object of the invention is to provide, for example, a cycloaliphatic epoxy resin composition capable of improving the toughness thereof while maintaining the mechanical strength and transparency of the cycloaliphatic epoxy resin without lowering the heat resistance, a production method thereof and a cured product thereof. A rubbery polymer-containing resin composition of the invention, for example, a cycloaliphatic epoxy resin composition of the invention is a cycloaliphatic epoxy resin composition comprising 100 parts by weight of a cycloaliphatic epoxy resin and 1 to 60 parts by weight of polymer particles with a volume average particle diameter (Mv) of not smaller than 0.01 μm and not larger than 0.5 μm, characterized in that each of the polymer particles comprises at least two layers of an elastic core layer present in the inside thereof and a shell layer present in the outermost side thereof, the elastic core layer consisting of a rubbery polymer with a glass transition temperature of lower than 10° C., and the composition is colorless and transparent.
摘要:
In a ceramic capacitor, first and second electrode terminals each include a bonded-to-substrate portion, a first bonded-to-electrode portion bonded to a first edge of one of first and second external electrodes, a second bonded-to-electrode portion bonded to a second edge of the one of first and second external electrodes and disposed at a distance from the first bonded-to-electrode portion in the first directions, and a connecting portion connecting the first and second bonded-to-electrode portions and the bonded-to-substrate portion. W1/W0 is about 0.3 or more, and h/L is about 0.1 or more.
摘要:
Disclosed is a glass fiber-silsesquioxane composite molded article containing glass fibers and a cured material of a silsesquioxane polymer composited therewith, wherein the silsesquioxane has a polyhedral structure or a partially polyhedral structure. The glass fiber-silsesquioxane composite molded article is preferably obtained by impregnating glass fibers with a composition containing at least one of silsesquioxanes represented by formula (A-1) to (A-3) and at least one of a curing agent, a polymerization initiator, and a hydrosilylation catalyst, or the silsesquioxane polymer and allowing a curing reaction to proceed.
摘要:
Disclosed is a process for the preparation of Compound (III), salt or solvate thereof by reacting Compound (I), salt or solvate thereof with Compound (II) in a toluene solvent in the presence of an additive such as water or an alcohol. Also disclosed is a process for the preparation of Compound (IV) comprising hydrolyzing the obtained Compound (III) if necessary, and then oxidizing. In the formula, R1 is hydrogen, optionally substituted lower alkyl, optionally substituted aryl or optionally substituted aryl lower alkyl, and R2 is optionally substituted lower alkyl, optionally substituted cycloalkyl or optionally substituted aryl lower alkyl.
摘要:
A game system for reliably realizing synchronization of timings at which a common event in a plurality of game machines start. The game system includes a plan management server that measures lapse of system time common in the game system and with the time measurement, updates plan information indicative of remaining time until the system time reaches a process start stage at which a process for the common event starts. Each of the game machines includes an obtaining device to obtain the plan information from the plan management server, a stage determining device to determine whether the system time has reached the process start stage or not on the basis of laps of time of the system time measured in the game machine, and a process executing device to start a process for the common event when it is determined that the system time has reached the process start stage.
摘要:
The object is to provide an ice making water tank for an automatic ice making machine capable of stabilizing the operation of a float switch. As a means for achieving the object, there is provided an overflow portion 64 having a wall portion 58 to define a maximum water storage level of ice making water, and a raised-bottom portion 60 to discharge excess ice making water that has overflowed the wall portion 58 to the outside through a discharge port 62 on a side near the outside of a tank portion 52 of an ice making water tank 32. Furthermore, a partition member 68 is removably disposed on the overflow portion 64 side with respect to the disposed position of the circulation pump 14 in the tank portion 52 to divide the inside of the tank portion 52 into two regions, and to allow ice making water near the bottom portion 56 to flow between the two regions. In addition, a float switch 26 is disposed between the partition member 68 and the overflow portion 64 in the tank portion 52.
摘要:
The present inventors have obtained a PSQ derivative of a completely condensed type into which a functional group is readily introduced by using a novel PSQ derivative of an incompletely condensed type in which four alkaline metal atoms are bonded to silsesquioxane of a cage type having eight Si's. The above silsesquioxane derivative is represented by Formula (1). A silsesquioxane derivative to which alkaline metal atoms are bonded is represented by Formula (2). In Formula (1) and Formula (2), R is a group selected from alkyl, aryl and arylalkyl; Y is a group represented by Formula (a) or Formula (b); and M is a monovalent alkaline metal atom. X in Formula (a) and Formula (b) is hydrogen, halogen, a hydroxyl group or a monovalent organic group, and Z is —O—, —CH2— or a single bond. The preferred organic group is a functional group or a group having a functional group.