Ex vivo modifiable multiple medicament final dosage form
    140.
    发明授权
    Ex vivo modifiable multiple medicament final dosage form 失效
    体外可修改的多种药物最终剂型

    公开(公告)号:US08753677B2

    公开(公告)日:2014-06-17

    申请号:US12387325

    申请日:2009-04-29

    IPC分类号: A61K9/48 A61K9/52

    摘要: Described embodiments include a final dosage form for administering a medicament to an animal, an article of manufacture, and method. A described final dosage form includes a dosage portion having a medicament and a release element in a first medicament-release state. The medicament has a first bioavailability to the animal. The release element is modifiable ex vivo to a second medicament-release state by an exposure to a stimulus, wherein the medicament has a second bioavailability to the animal. The final dosage form includes another dosage portion having another medicament and another release element in another first medicament-release state. In the another first medicament-release state, the another medicament has another first bioavailability to the animal. The another release element is modifiable ex vivo to another second medicament-release state by an exposure to another stimulus, wherein the another medicament has another second bioavailability to the animal.

    摘要翻译: 描述的实施方案包括用于向动物施用药物的最终剂型,制品和方法。 描述的最终剂型包括具有药物和处于第一药物释放状态的释放元件的剂量部分。 药物对动物具有第一生物利用度。 释放元件通过暴露于刺激物离体修饰成第二药物释放状态,其中药物对动物具有第二生物利用度。 最终剂型包括具有另一药物的另一剂量部分和处于另一第一药物释放状态的另一释放元件。 在另一第一药物释放状态中,另一种药物对动物具有另一种第一生物利用度。 另一种释放元件可通过暴露于另一种刺激物离体修饰成另一种第二药物释放状态,其中另一种药物对动物具有另一种第二生物利用度。