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    Agents that disrupt dimer formation in DPP-IV family of prolyl dipeptidases
    131.
    发明申请
    Agents that disrupt dimer formation in DPP-IV family of prolyl dipeptidases 审中-公开
    破坏脯氨酰二肽酶DPP-IV家族中二聚体形成的药剂

    公开(公告)号：US20060024313A1

    公开(公告)日：2006-02-02

    申请号：US11176951

    申请日：2005-07-06

    Applicant: Xin Chen ,  Yuan-Shou Chen

    Inventor： Xin Chen ,  Yuan-Shou Chen

    IPC: A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C12N9/64 ,  C07K16/40

    CPC classification number: C12N9/48 ,  A61K2039/505 ,  C07K16/40

    Abstract: The present invention relates to the finding that C-terminal loop and propeller loop and regions thereof of the DPP-IV family of prolyl dipeptidases play an important role in dimer formation. The present invention further provides purified polypeptides comprising an amino acid sequence that mimics conserved amino acids in at least one of a C-terminal loop and a propeller loop of the dimer interface of the DPP-IV family of prolyl dipeptidases sufficient to prevent dimerization of a member of that family. Such polypeptides and other agents serve to disrupt the activity of the DPP-IV family of prolyl dipeptidases.

    Abstract translation: 本发明涉及DPP-IV家族脯氨酰二肽酶的C末端环和螺旋桨环及其区域在二聚体形成中起重要作用。 本发明进一步提供纯化的多肽，其包含模拟DPP-IV家族脯氨酰二肽酶的二聚体界面的C末端环和螺旋桨环中的至少一个中的保守氨基酸的氨基酸序列，其足以防止二聚化 该家庭成员。 这种多肽和其它试剂用来破坏DPP-IV家族脯氨酰二肽酶的活性。

    Catalyst for producing acrylonitrile
    132.
    发明授权
    Catalyst for producing acrylonitrile 有权
    丙烯腈生产催化剂

    公开(公告)号：US06596897B1

    公开(公告)日：2003-07-22

    申请号：US09508038

    申请日：2000-06-30

    Applicant: Xingya Guan ,  Xin Chen ,  Lianghua Wu

    Inventor： Xingya Guan ,  Xin Chen ,  Lianghua Wu

    IPC: C07C25300

    CPC classification number: B01J23/8876 ,  C07C253/26 ,  Y02P20/52 ,  C07C255/08

    Abstract: A fluidized-bed catalyst for producing acrylonitrile by the ammoxidation of propylene, which comprises a silica carrier and a composite having the following formula: AaCcDdNafFegBihMiMo12Ox wherein A selected from the group consisting of potassium, rubidium, cesium, samarium, thallium and mixtures thereof; C is selected from the group consisting of phosphorus, arsenic, boron, antimony, chromium and mixtures thereof; D is selected from nickel, cobalt or mixtures thereof; M is selected from tungsten, vanadium or mixtures thereof. The catalyst of the present invention particularly suits the use under higher pressure and higher duties, and still maintains very high single-pass yield of acrylonitrile and a high ammonia conversion. This catalyst particularly suits the requirement for existing acrylonitrile plants to raise capacity. For new plants it can also reduce the investment on the catalyst and the pollution.

    Abstract translation: 一种用于通过丙烯氨氧化制备丙烯腈的流化床催化剂，其包含二氧化硅载体和具有下式的复合物：其中A选自钾，铷，铯，钐，铊及其混合物; C选自磷，砷，硼，锑，铬及其混合物; D选自镍，钴或其混合物; M选自钨，钒或其混合物。 本发明的催化剂特别适用于在更高压力和更高的作用下的使用，并且仍保持丙烯腈的非常高的单程产率和高的氨转化率。 该催化剂特别适合现有丙烯腈装置提高产能的要求。 对于新工厂，还可以减少对催化剂和污染的投资。

    Fluidized-bed catalyst for propylene ammoxidation to acrylonitrile
    133.
    发明授权
    Fluidized-bed catalyst for propylene ammoxidation to acrylonitrile 有权
    用于丙烯氨氧化成丙烯腈的流化床催化剂

    公开(公告)号：US06420307B1

    公开(公告)日：2002-07-16

    申请号：US09642289

    申请日：2000-08-18

    Applicant: Lianghua Wu ,  Guojun Wang ,  Xin Chen

    Inventor： Lianghua Wu ,  Guojun Wang ,  Xin Chen

    IPC: B01J2300

    CPC classification number: C07C253/26 ,  B01J23/002 ,  B01J23/8878 ,  B01J23/8885 ,  B01J27/192 ,  B01J37/031 ,  B01J37/04 ,  B01J37/08 ,  B01J2523/00 ,  Y02P20/52 ,  C07C255/08 ,  B01J2523/12 ,  B01J2523/13 ,  B01J2523/15 ,  B01J2523/3718 ,  B01J2523/42 ,  B01J2523/54 ,  B01J2523/67 ,  B01J2523/68 ,  B01J2523/842 ,  B01J2523/845 ,  B01J2523/847 ,  B01J2523/22 ,  B01J2523/3712 ,  B01J2523/32 ,  B01J2523/34 ,  B01J2523/69 ,  B01J2523/72 ,  B01J2523/52 ,  B01J2523/17 ,  B01J2523/51 ,  B01J2523/55 ,  B01J2523/3706

    Abstract: The present invention relates to a new fluidized-bed catalyst used in a process of propylene ammoxidation to acrylonitrile. The catalyst comprises a silica as carrier and a composition represented by the following general formulas: AaBbCcGedNaeFefBigMohOx Wherein A represents at least one element selected from a group consisting Li,K,Rb,Cs,Sm, In or Tl; B represents at least one element selected from a group consisting of P, Sb, Cr, W. Pr, Ce, As, B, Te, Ga, Al, Nb, Th, La or V; C represents one element selected from a group consisting of Ni, Co, Sr, Mn, Mg, Ca, Zn, Cd or Cu and the mixture thereof; a is a number of from 0.01 to 1.5; b is a number of from 0.01 to 3.0; c is a number of from 0.1 to 12.0; preferably from 2 to 10; d is a number of from 0.01 to 2.0; preferably from 0.01 to 1.0; e is a number of from 0.01 to 0.7; preferably from 0.05 to 0.5; f is a number of from 0.1 to 8; preferably from 1.0 to 3.0; g is a number of from 0.01 to 6; preferably from 0.1 to 2.0; h is a number of from 12 to 14.5; X denotes the number of oxygen atoms which satisfies the valence requirement of the other elements in the catalyst; The content of silica used as carrier is, 30-70 wt %. The catalyst of the invention can be used in the reaction for propylene ammoxidation to acrylonitrile operated at a higher reaction pressure and higher load condition, and can still sustain a high once-through yield of acrylonitrile.

    Abstract translation: 本发明涉及一种用于丙烯氨氧化成丙烯腈的方法中的新的流化床催化剂。 该催化剂包括二氧化硅作为载体和由以下通式表示的组合物：其中，A表示选自Li，K，Rb，Cs，Sm，In或Tl中的至少一种元素; B表示选自 由P，Sb，Cr，W，Pr，Ce，As，B，Te，Ga，Al，Nb，Th，La或V组成的组; C表示选自Ni，Co，Sr， Mn，Mg，Ca，Zn，Cd或Cu及其混合物; a为0.01〜1.5的数; b为0.01〜3.0的数; c为0.1〜12.0的数; 优选2至10; d为0.01至2.0的数; 优选为0.01〜1.0; e为0.01〜0.7的数; 优选为0.05至0.5; f为0.1至8的数; 优选为1.0至3.0; g为0.01至6的数; 优选为0.1〜2.0; h为12〜14.5的数; X表示满足催化剂中其他元素的价数要求的氧原子数;作为载体的二氧化硅的含量为30〜70重量％ 本发明的催化剂可以用于在较高反应压力和较高负载条件下进行丙烯氨氧化反应的丙烯腈反应中，并且仍能维持高的丙烯腈的一次通过率。

    Automated fruit and vegetable calyx or stem removal machine
    137.
    发明授权
    Automated fruit and vegetable calyx or stem removal machine 有权

    公开(公告)号：US10285429B2

    公开(公告)日：2019-05-14

    申请号：US15152400

    申请日：2016-05-11

    Applicant: Yang Tao ,  John Lin ,  Xin Chen ,  Gary E. Seibel

    Inventor： Yang Tao ,  John Lin ,  Xin Chen ,  Gary E. Seibel

    IPC: A23N15/02 ,  B26D7/06 ,  B26F3/00 ,  B26D5/00 ,  B26D5/34 ,  A23L19/00

    Abstract: A system and methods are provided for removal of undesired portions of a fruit or vegetable, such as removal of calyxes from strawberries before they are flash frozen. An automated process for high-throughput fruit or vegetable calyx removal includes a loading system, an identification system, and a removal system. The loading system is configured to transport the fruit or vegetable through the automated process. The loading system may also orient the fruits or vegetables along an axis of the fruit and or align the fruit or vegetables in a desired pattern, orientation, and/or arrangement. The identification system is configured to locate the calyx and determines calyx position data and an optimal cutting path for individual fruit. The removal system uses data received from the identification system to separate the calyx from the fruit or vegetable.

    Device and method for guiding latch-on
    138.
    发明授权
    Device and method for guiding latch-on 有权

    公开(公告)号：US10143630B2

    公开(公告)日：2018-12-04

    申请号：US13996566

    申请日：2011-12-19

    Applicant: Aizhi Yang ,  Renjun Yu ,  Xin Chen ,  Axelle Stephanie Maud Ducos

    Inventor： Aizhi Yang ,  Renjun Yu ,  Xin Chen ,  Axelle Stephanie Maud Ducos

    IPC: A61J13/00 ,  A61J11/00

    Abstract: The invention proposes a device (1) and a corresponding method, wherein the device (1) comprises: a first element (10) to be attached to a breast of a breastfeeding mother; and a first marker (11) located on the outer surface (100) of the first element (10), wherein the first marker (11) is used for indicating a position of a mother's breast that the baby's lip is expected to contact in order to correctly hold the mother's breast. With the device (1) attached to the mother's breast, the first marker (11) indicates a position that the baby's lip is expected to contact, and the breastfeeding mother can have a clear view of whether the baby correctly holds the mother's breast according to the distance between the first marker (11) and the baby's lip.

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