公开(公告)号：US07410912B2

公开(公告)日：2008-08-12

申请号：US11217483

申请日：2005-09-02

Applicant: Chunhua Xu ,  San-Qiang Shi ,  Yang Liu ,  Chung Ho Woo

Inventor： Chunhua Xu ,  San-Qiang Shi ,  Yang Liu ,  Chung Ho Woo

IPC: H01L21/31 ,  H01L21/469

CPC classification number: C01G1/02 ,  B22F2998/00 ,  B82Y30/00 ,  C01P2004/16 ,  C30B29/16 ,  C30B29/60 ,  D01F9/08 ,  Y10S977/762 ,  Y10S977/811 ,  B22F1/0025 ,  B22F1/0088

Abstract: Metal oxide nanowires are being investigated to make nanodevices and nanosensors. High operation temperatures or vacuum is required in the manufacturing of metal oxide nanowires by existing vapor phase evaporation methods. This invention provides a method of manufacturing metal oxide nanowires by first providing a metal to form a non-linear substantially planar structure defining a surface. The metal is then heated and maintained at a temperature from 300 to 800° C., and then exposed to oxygen and water vapor containing air stream for a sufficient period of time to form the metal oxide nanowires. The oxygen containing air stream flows in a direction substantially parallel to the plane of the structure. Relatively low temperatures may be used and no vacuum is required in this method, thereby reducing the overall manufacturing costs. Further, this method is able to manufacture different densities of the metal oxide nanowires simultaneously.

Abstract translation: 正在研究金属氧化物纳米线以制备纳米器件和纳米传感器。 通过现有的气相蒸发方法在金属氧化物纳米线的制造中需要高的操作温度或真空度。 本发明提供一种通过首先提供金属以形成限定表面的非线性基本平面结构来制造金属氧化物纳米线的方法。 然后将金属加热并保持在300至800℃的温度，然后暴露于含氧气和水蒸汽的空气流中足够长的时间以形成金属氧化物纳米线。 含氧空气流在基本平行于结构平面的方向上流动。 可以使用相对低的温度，并且在该方法中不需要真空，从而降低整体制造成本。 此外，该方法能够同时制造不同密度的金属氧化物纳米线。

公开(公告)号：US20080180664A1

公开(公告)日：2008-07-31

申请号：US11891884

申请日：2007-08-13

Applicant: Vadim Backman ,  Yang Liu ,  Young Kim

Inventor： Vadim Backman ,  Yang Liu ,  Young Kim

IPC: G01J3/30

CPC classification number: G01N21/49 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0084 ,  G01N2021/4709

Abstract: Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations.

Abstract translation: 在本申请中描述了用于识别目标的折射率波动的系统和方法。 一个实施例包括识别出射光的一个或多个属性，从目标出射的出射光，以及基于出射光的一个或多个属性来确定目标的折射率波动。 确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。 确定折射率波动还包括确定折射率波动的方差和折射率波动的空间相关长度的一个或多个。

公开(公告)号：US20080152655A1

公开(公告)日：2008-06-26

申请号：US10536115

申请日：2005-09-07

Applicant: Yang Liu ,  Pan Zheng ,  Ergun Kocak

Inventor： Yang Liu ,  Pan Zheng ,  Ergun Kocak

IPC: A61K39/395 ,  A61P35/00

CPC classification number: C07K16/2878 ,  A61K2039/505 ,  C07K16/2818

Abstract: Methods for screening monoclonal antibodies to CTLA4, monoclonal antibodies to human CTLA4, therapeutic compositions containing the same.

Abstract translation: 用于筛选CTLA4单克隆抗体，人CTLA4单克隆抗体的方法，含有其的治疗组合物。

公开(公告)号：US20070275567A1

公开(公告)日：2007-11-29

申请号：US11217483

申请日：2005-09-02

Applicant: Chunhua Xu ,  San-Qiang Shi ,  Yang Liu ,  Chung Woo

Inventor： Chunhua Xu ,  San-Qiang Shi ,  Yang Liu ,  Chung Woo

IPC: H01L21/31

CPC classification number: C01G1/02 ,  B22F2998/00 ,  B82Y30/00 ,  C01P2004/16 ,  C30B29/16 ,  C30B29/60 ,  D01F9/08 ,  Y10S977/762 ,  Y10S977/811 ,  B22F1/0025 ,  B22F1/0088

Abstract: Metal oxide nanowires are being investigated to make nanodevices and nanosensors. High operation temperatures or vacuum is required in the manufacturing of metal oxide nanowires by existing vapour phase evaporation methods. This invention provides a method of manufacturing metal oxide nanowires by first providing a metal to form a non-linear substantially planar structure defining a surface. The metal is then heated and maintained at a temperature from 300 to 800° C., and then exposed to oxygen and water vapour containing air stream for a sufficient period of time to form the metal oxide nanowires. The oxygen containing air stream flows in a direction substantially parallel to the plane of the structure. Relatively low temperatures may be used and no vacuum is required in this method, thereby reducing the overall manufacturing costs. Further, this method is able to manufacture different densities of the metal oxide nanowires simultaneously.

Abstract translation: 正在研究金属氧化物纳米线以制备纳米器件和纳米传感器。 通过现有的气相蒸发方法在金属氧化物纳米线的制造中需要高的操作温度或真空度。 本发明提供一种通过首先提供金属以形成限定表面的非线性基本平面结构来制造金属氧化物纳米线的方法。 然后将金属加热并保持在300至800℃的温度，然后暴露于含氧气和水蒸汽的空气流中足够的时间以形成金属氧化物纳米线。 含氧空气流在基本平行于结构平面的方向上流动。 可以使用相对低的温度，并且在该方法中不需要真空，从而降低整体制造成本。 此外，该方法能够同时制造不同密度的金属氧化物纳米线。

公开(公告)号：US20070129615A1

公开(公告)日：2007-06-07

申请号：US11604659

申请日：2006-11-27

Applicant: Vadim Backman ,  Hemant Roy ,  Young Kim ,  Yang Liu

Inventor： Vadim Backman ,  Hemant Roy ,  Young Kim ,  Yang Liu

IPC: A61B5/00

CPC classification number: A61B5/0261 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/1459 ,  A61B2560/0443 ,  A61B2562/0242 ,  G01N33/48

Abstract: The present invention relates to probe apparatuses and component combinations thereof that are used to recognize possibly abnormal living tissue using a detected early increase in microvascular blood supply and corresponding applications. In one embodiment there is disclosed an apparatus that emits broadband light obtained from a light source onto microvasculature of tissue disposed within a human body and receives interacted light that is obtained from interaction of the broadband light with the microvasculature for transmission to a receiver. Different further embodiments include combinations of optical fibers, polarizers and lenses that assist in the selection of a predetermined depth profile of interacted light. In another embodiment, a kit apparatus is described that has various probe tips and/or light transmission elements that provide for various combinations of predetermined depth profiles of interacted light. In a further embodiment, a method of making a spectral data probe for a depth range detection selectivity for detection of blood within microvasculature of tissue is described.

Abstract translation: 本发明涉及用于利用检测到的微血管血液供应的早期增加和相应应用来识别可能的异常活体组织的探针装置及其组分组合。 在一个实施例中，公开了一种将从光源发射的宽带光发射到设置在人体内的组织的微血管上的装置，并且接收从宽带光与微血管系统的相互作用获得的相互作用的光，以便传输到接收器。 不同的另外的实施例包括有助于选择相互作用的光的预定深度分布的光纤，偏振器和透镜的组合。 在另一个实施例中，描述了具有各种探针尖端和/或光透射元件的套件装置，其提供了相互作用的光的预定深度分布的各种组合。 在另一个实施方案中，描述了制备用于检测组织微血管内的血液的深度范围检测选择性的光谱数据探针的方法。

公开(公告)号：US07162916B2

公开(公告)日：2007-01-16

申请号：US10848310

申请日：2004-05-18

Applicant: Masoud K. Zavarehi ,  Yang Liu ,  Conrad G. Grembowicz

Inventor： Masoud K. Zavarehi ,  Yang Liu ,  Conrad G. Grembowicz

IPC: G01M15/00

CPC classification number: F02D41/1497 ,  F02D41/1498

Abstract: Individual cylinder output deviations from a normal operating engine cylinder are detected via an analysis of crank shaft speed fluctuations. In the detection phase, the engine is operated at a steady state low idle condition, and engine speed data is collected over a plurality of engine cycles. This data is then averaged, filtered and compared to expected engine speed data. A substantial deviation from the expected speed data in the region of crank shaft angles associated with an individual cylinder during its power stroke adjacent its top dead center position indicates a power level deviation in that cylinder. The magnitude of the power level deviation can then be assessed through a similar procedure where engine speed data is collected, averaged, filtered and compared to expected engine speed data when the engine is operating in a steady state rated condition.

Abstract translation: 通过对曲轴转速波动的分析来检测与正常运行的发动机气缸的独立气缸输出偏差。 在检测阶段，发动机在稳定状态低怠速状态下工作，并且在多个发动机循环中收集发动机速度数据。 然后对该数据进行平均，过滤并与预期的发动机转速数据进行比较。 在与独立气缸相邻的曲柄轴角度区域内的预期速度数据的显着偏差在其邻近其上死点位置的功率冲程期间指示在该气缸中的功率水平偏差。 然后可以通过类似的程序来评估功率水平偏差的大小，其中发动机速度数据被收集，平均，过滤并且当发动机在稳态额定条件下运行时与预期发动机转速数据进行比较。

公开(公告)号：US07161058B2

公开(公告)日：2007-01-09

申请号：US11052559

申请日：2005-02-07

Applicant: Yang Liu ,  Pan Zheng ,  Ping Lu ,  Bedrich Mosinger ,  Ken May

Inventor： Yang Liu ,  Pan Zheng ,  Ping Lu ,  Bedrich Mosinger ,  Ken May

IPC: A01K67/027 ,  A01K67/033

CPC classification number: A01K67/0278 ,  A01K67/0271 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/025 ,  A01K2267/0325 ,  A01K2267/0337 ,  A01K2267/0356 ,  C07K14/70521 ,  C12N15/8509 ,  C12N2517/02 ,  C12N2800/30

Abstract: The present invention relates to a non-human transgenic animal, particularly a knock in mouse, whose genome comprises a heterologous, chimeric CTLA4 gene. The chimeric CTLA4 gene comprises exon 2 of the human CTLA4 gene, exon 1 and exon 4 of the non-human animal, and exon 3 of the CTLA4 gene of the non-human animal, or preferably, exon 3 of the human CTLA4 gene. The invention also relates to methods by which the transgenic mice are used to screen for monoclonal antibodies or other molecules that enhance immunity to tumors and infectious agents by interacting with the human CTLA4 receptor. The transgenic mice of the present invention are also useful for screening for monoclonal antibodies or other molecules that inhibit autoimmunity and transplant rejection.

Abstract translation: 本发明涉及非人转基因动物，特别是小鼠的敲除，其基因组包含异源的嵌合CTLA4基因。 嵌合CTLA4基因包含人CTLA4基因的外显子2，非人动物的外显子1和外显子4以及非人动物CTLA4基因的外显子3，或优选人CTLA4基因的外显子3。 本发明还涉及使用转基因小鼠筛选通过与人CTLA4受体相互作用增强对肿瘤和感染因子的免疫的单克隆抗体或其它分子的方法。 本发明的转基因小鼠也可用于筛选抑制自身免疫和移植排斥的单克隆抗体或其它分子。

公开(公告)号：US20050257604A1

公开(公告)日：2005-11-24

申请号：US10848310

申请日：2004-05-18

Applicant: Masoud Zavarehi ,  Yang Liu ,  Conrad Grembowicz

Inventor： Masoud Zavarehi ,  Yang Liu ,  Conrad Grembowicz

IPC: F02B33/22 ,  F02D41/00 ,  F02D41/14 ,  F02D41/22

CPC classification number: F02D41/1497 ,  F02D41/1498

Abstract: Individual cylinder output deviations from a normal operating engine cylinder are detected via an analysis of crank shaft speed fluctuations. In the detection phase, the engine is operated at a steady state low idle condition, and engine speed data is collected over a plurality of engine cycles. This data is then averaged, filtered and compared to expected engine speed data. A substantial deviation from the expected speed data in the region of crank shaft angles associated with an individual cylinder during its power stroke adjacent its top dead center position indicates a power level deviation in that cylinder. The magnitude of the power level deviation can then be assessed through a similar procedure where engine speed data is collected, averaged, filtered and compared to expected engine speed data when the engine is operating in a steady state rated condition.

Abstract translation: 通过对曲轴转速波动的分析来检测与正常运行的发动机气缸的独立气缸输出偏差。 在检测阶段，发动机在稳定状态低怠速状态下工作，并且在多个发动机循环中收集发动机速度数据。 然后对该数据进行平均，过滤并与预期的发动机转速数据进行比较。 在与独立气缸相邻的曲柄轴角度区域内的预期速度数据的显着偏差在其邻近其上死点位置的功率冲程期间指示在该气缸中的功率水平偏差。 然后可以通过类似的程序来评估功率水平偏差的大小，其中发动机速度数据被收集，平均，过滤并且当发动机在稳态额定条件下运行时与预期发动机转速数据进行比较。

公开(公告)号：US20050204415A1

公开(公告)日：2005-09-15

申请号：US11129080

申请日：2005-05-13

Applicant: Yang Liu ,  Pan Zheng ,  Xuefeng Bai ,  Xingluo Liu

Inventor： Yang Liu ,  Pan Zheng ,  Xuefeng Bai ,  Xingluo Liu

IPC: A61K38/00 ,  A61K38/095 ,  A61K39/00 ,  C07K14/705 ,  C07K16/28 ,  A01K67/027 ,  C07H21/04 ,  A61K39/395 ,  C07K14/74

CPC classification number: A61K38/177 ,  A61K38/00 ,  A61K39/0008 ,  C07K14/70596 ,  C07K16/2896 ,  C07K2319/00 ,  C07K2319/30

Abstract: Methods for blocking autoreactive T cell-initiated destruction of tissues in a mammal are provided. In one embodiment, the methods involve administering an anti-HAS/CD24 antibody.

Abstract translation: 提供了阻止哺乳动物中组织的自身反应性T细胞引发的破坏的方法。 在一个实施方案中，所述方法包括施用抗HAS / CD24抗体。

公开(公告)号：USD948687S1

公开(公告)日：2022-04-12

申请号：US29741031

申请日：2020-07-09

Applicant: Yang Liu

Designer： Yang Liu