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    Continuous synthesis of isooctyl nitrate in a flow reactor
    132.
    发明授权
    Continuous synthesis of isooctyl nitrate in a flow reactor 有权

    公开(公告)号：US10017457B2

    公开(公告)日：2018-07-10

    申请号：US15123100

    申请日：2015-03-05

    Applicant: Corning Incorporated

    Inventor： Bing Ma ,  Wei Shen ,  Yanhua Wang ,  Mo Zhang

    IPC: C07C201/02

    CPC classification number: C07C201/02 ,  C07C203/04

    Abstract: A process for synthesizing isooctyl nitrate in a continuous flow reactor comprises flowing a H2SO4-HNO3 mixture within a flow reactor, flowing isooctyl alcohol into said flow reactor so as to mix the isooctyl alcohol with the H2SO4-HNO3 mixture and produce a reaction mixture stream flowing in said reactor, maintaining the reaction mixture stream flowing in said flow reactor at a reaction temperature within in the range −10° to 35° C. inclusive, and wherein the residence time of the reaction mixture stream in the flow reactor is greater than or equal to 5 seconds and less than or equal to 40 seconds, and wherein the H2SO4 of the H2SO4-HNO3 mixture is H2SO4 having a concentration of in the range of 85 to 95% inclusive, more desirably 88 to 92% inclusive, most desirably of 90%.

    CONTINUOUS SYNTHESIS OF ISOOCTYL NITRATE IN A FLOW REACTOR
    133.
    发明申请
    CONTINUOUS SYNTHESIS OF ISOOCTYL NITRATE IN A FLOW REACTOR 有权
    在流动反应器中连续合成硝酸亚硝酯

    公开(公告)号：US20170066710A1

    公开(公告)日：2017-03-09

    申请号：US15123100

    申请日：2015-03-05

    Applicant: Corning Incorporated

    Inventor： Bing Ma ,  Wei Shen ,  Yanhua Wang ,  Mo Zhang

    IPC: C07C201/02

    CPC classification number: C07C201/02 ,  C07C203/04

    Abstract: A process for synthesizing isooctyl nitrate in a continuous flow reactor comprises flowing a H2SO4—HNO3 mixture within a flow reactor, flowing isooctyl alcohol into said flow reactor so as to mix the isooctyl alcohol with the H2SO4—HNO3 mixture and produce a reaction mixture stream flowing in said reactor, maintaining the reaction mixture stream flowing in said flow reactor at a reaction temperature within in the range −10° to 35° C. inclusive, and wherein the residence time of the reaction mixture stream in the flow reactor is greater than or equal to 5 seconds and less than or equal to 40 seconds, and wherein the H2SO4 of the H2SO4—HNO3 mixture is H2SO4 having a concentration of in the range of 85 to 95% inclusive, more desirably 88 to 92% inclusive, most desirably of 90%.

    Abstract translation: 在连续流动反应器中合成硝酸异辛酯的方法包括使流动反应器内的H 2 SO 4 -HNO 3混合物流动，将异辛醇流入所述流动反应器中，以将异辛醇与H 2 SO 4 -HNO 3混合物混合，并产生流动的反应混合物流 在所述反应器中，将反应混合物流保持在​​所述流动反应器中，反应温度在-10℃至35℃的范围内，其中反应混合物流在流动反应器中的停留时间大于或等于 等于5秒且小于或等于40秒，并且其中H 2 SO 4 -HNO 3混合物的H 2 SO 4为浓度为85-95％（含）范围内的H 2 SO 4，更优选为88-92％，最优选为 90％。

    Utilizing Nitrate Salts in Order to Produce Explosives
    135.
    发明申请
    Utilizing Nitrate Salts in Order to Produce Explosives 审中-公开
    利用硝酸盐生产炸药

    公开(公告)号：US20160039722A1

    公开(公告)日：2016-02-11

    申请号：US14452499

    申请日：2014-08-05

    Applicant: Iman Sheikh

    Inventor： Iman Sheikh

    IPC: C06B25/10

    CPC classification number: C06B25/10 ,  C07C201/02 ,  C07C201/08 ,  C07C203/06 ,  C07C205/06

    Abstract: Mass production of industrial explosives with one-tenth of the cost of the current production method—Nitric acid 98% removal of the chemical reaction producing explosive materials—Increasing the production safety—Producing ammonium sulfate, a chemical fertilizer, as a byproduct—Supporting the production of different explosives such as TNT, nitroglycerine and etc.—decreasing the acid concentration in the product.

    Abstract translation: 大规模生产工业爆炸物，占当前生产方法成本的十分之一 - 硝酸98％去除化学反应生产爆炸性材料 - 提高生产安全性 - 生产硫酸铵，化肥作为副产品 - 支持 生产不同的炸药如TNT，硝酸甘油等 - 降低产品中的酸浓度。

    Method for purifying 4-(nitrooxy)butyl(2S)-2-(6-methoxy-2-naphthyl) propanoate
    137.
    发明授权
    Method for purifying 4-(nitrooxy)butyl(2S)-2-(6-methoxy-2-naphthyl) propanoate 失效
    纯化（2S）-2-（6-甲氧基-2-萘基）丙酸4-（硝基氧基）丁酯的方法

    公开(公告)号：US08329937B2

    公开(公告)日：2012-12-11

    申请号：US12682249

    申请日：2009-06-18

    Applicant: Pietro Allegrini ,  Tiziano Scubla ,  Nicoletta Toniutti ,  Romano Rivolta ,  Thierry Delahaique

    Inventor： Pietro Allegrini ,  Tiziano Scubla ,  Nicoletta Toniutti ,  Romano Rivolta ,  Thierry Delahaique

    IPC: C07C203/04

    CPC classification number: C07C203/04 ,  C07C201/02

    Abstract: The present invention relates to a method for purifying naproxcinod comprising the steps of: a) dissolving or dispersing a mixture containing naproxcinod in an amount higher than 90% by weight in a solvent; b) cooling the solution or two phases dispersion under stirring to a temperature ranging from −20° C. to 10° C. c) optionally seeding the solution with crystals of naproxcinod d) stirring, by maintaining the temperature in the range from −40° C. to 10° C. e) collecting the formed solid by maintaining the temperature under 15° C. A further object of the invention is a crystalline form of naproxcinod.

    Abstract translation: 本发明涉及一种纯化萘普生的方法，包括以下步骤：a）在溶剂中将含有高于90重量％的萘普生的混合物溶解或分散; b）在搅拌下将溶液或两相分散体冷却至-20℃至10℃的温度。c）任选地用萘普生染料的晶体接种该溶液d）搅拌，通过将温度保持在-40℃ ℃至10℃。e）通过将温度保持在15℃下收集形成的固体。本发明的另一个目的是萘普生的结晶形式。

    METHOD FOR PURIFYING 4-(NITROOXY)BUTYL(2S)-2-(6-METHOXY-2-NAPHTHYL) PROPANOATE
    138.
    发明申请
    METHOD FOR PURIFYING 4-(NITROOXY)BUTYL(2S)-2-(6-METHOXY-2-NAPHTHYL) PROPANOATE 失效
    4-（硝基）丁基（2S）-2-（6-甲氧基-2-萘基）丙酸酯的方法

    公开(公告)号：US20100256411A1

    公开(公告)日：2010-10-07

    申请号：US12682249

    申请日：2009-06-18

    Applicant: Pietro Allegrini ,  Tiziano Scubla ,  Nicoletta Toniutti ,  Romano Rivolta ,  Thierry Delahaique

    Inventor： Pietro Allegrini ,  Tiziano Scubla ,  Nicoletta Toniutti ,  Romano Rivolta ,  Thierry Delahaique

    IPC: C07C203/04

    CPC classification number: C07C203/04 ,  C07C201/02

    Abstract: The present invention relates to a method for purifying naproxcinod comprising the steps of: a) dissolving or dispersing a mixture containing naproxcinod in an amount higher than 90% by weight in a solvent; b) cooling the solution or two phases dispersion under stirring to a temperature ranging from −20° C. to 10° C. c) optionally seeding the solution with crystals of naproxcinod d) stirring, by maintaining the temperature in the range from −40° C. to 10° C. e) collecting the formed solid by maintaining the temperature under 15° C. A further object of the invention is a crystalline form of naproxcinod.

    Abstract translation: 本发明涉及一种纯化萘普生的方法，包括以下步骤：a）在溶剂中将含有高于90重量％的萘普生的混合物溶解或分散; b）在搅拌下将溶液或两相分散体冷却至-20℃至10℃的温度。c）任选地用萘普生染料的晶体接种该溶液d）搅拌，通过将温度保持在-40℃ ℃至10℃。e）通过将温度保持在15℃下收集形成的固体。本发明的另一个目的是萘普生的结晶形式。

    PROCESS FOR PREPARING NITROOXYALKYL SUBSTITUTED ESTERS OF CARBOXYLIC ACIDS, INTERMEDIATES USEFUL IN SAID PROCESS AND PREPARATION THEREOF
    139.
    发明申请
    PROCESS FOR PREPARING NITROOXYALKYL SUBSTITUTED ESTERS OF CARBOXYLIC ACIDS, INTERMEDIATES USEFUL IN SAID PROCESS AND PREPARATION THEREOF 审中-公开
    用于制备羧甲基取代的羧酸的方法，用于合成方法的中间体及其制备方法

    公开(公告)号：US20100217028A1

    公开(公告)日：2010-08-26

    申请号：US12750381

    申请日：2010-03-30

    Applicant: Piero DEL SOLDATO ,  Giancarlo SANTUS ,  Francesca BENEDINI

    Inventor： Piero DEL SOLDATO ,  Giancarlo SANTUS ,  Francesca BENEDINI

    IPC: C07C205/04 ,  C07C309/30

    CPC classification number: C07C269/06 ,  C07C67/10 ,  C07C69/734 ,  C07C201/02 ,  C07C203/04 ,  C07C271/28 ,  C07C303/28 ,  C07C309/73

    Abstract: The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R—COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.

    Abstract translation: 本发明涉及制备通式（A）化合物的方法，如说明书所述，其中R为药物基团，R 1 -R 12为氢或烷基，m，n，o，q， r和s各自独立地为0〜6的整数，p为0或1，X为O，S，SO，SO 2，NR 13或PR 13或芳基杂芳基，所述方法包括使式 B）R-COOZ（B）其中R如上所定义，Z是氢或选自：Li +，Na +，K +，Ca ++，Mg ++，四烷基铵，四烷基鏻与式（C）化合物的阳离子，如 其描述其中R1-R12和m，n，o，p，q，r，s如上所定义，Y是合适的离去基团。

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