公开(公告)号：US5352963A

公开(公告)日：1994-10-04

申请号：US785553

申请日：1991-10-31

Applicant: Steven A. Garand ,  Carl P. Daniel

Inventor： Steven A. Garand ,  Carl P. Daniel

IPC: H02P8/16 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H02P8/00

CPC classification number: G01N35/1002 ,  G01N35/028 ,  G01N2021/1759 ,  G01N2035/00079 ,  G01N2035/00455 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0463 ,  G01N2035/0475 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/08 ,  G01N2201/1283 ,  G01N35/025

Abstract: An improved control system for a stepper motor coil includes a flyback circuit that dissipates coil energy slowly while the coil is energized and operated in the chopping mode, while dissipating coil energy rapidly when the coil is switched to its de-energized phase.

Abstract translation: 用于步进电动机线圈的改进的控制系统包括回扫电路，其在线圈被通电并且以斩波模式操作时缓慢地消散线圈能量，同时当线圈切换到其断电阶段时迅速消散线圈能量。

公开(公告)号：US5258308A

公开(公告)日：1993-11-02

申请号：US968842

申请日：1992-10-30

Applicant: Mary J. Freeman ,  Gary M. Freeman

Inventor： Mary J. Freeman ,  Gary M. Freeman

IPC: G01N21/27 ,  G01N33/16 ,  G01N21/78 ,  G01N21/80

CPC classification number: G01N21/278 ,  G01N2201/0446 ,  Y10T436/10 ,  Y10T436/108331 ,  Y10T436/109163

Abstract: A method and apparatus for calibrating or checking the calibration of vertical photometers. The invention may also provide easy and convenient assay results for diagnostic profiles. The invention comprises pre-dispensed amounts of a suitable reagent, chosen for the particular use, disposed in a vessel with an amount of a wetting agent or other means to yield a reproducible meniscus in the resulting control solution. The control solution is dried to leave a precise amount of dried reagent and other constituents in the vessel which can then be stored and distributed until subsequent use. The dried control solution can then be reconstituted to provide a standard having known absorbance and physical characteristics.

Abstract translation: 用于校准或检查垂直光度计校准的方法和装置。 本发明还可以为诊断特征提供简单和方便的测定结果。 本发明包括预先分配量的用于特定用途的合适的试剂，其设置在具有一定量的润湿剂或其它装置的容器中以在所得对照溶液中产生可再现的弯液面。 将对照溶液干燥以在容器中留下精确量的干燥试剂和其它成分，然后将其存储和分配直至随后使用。 然后可以将干燥的对照溶液重构以提供具有已知吸光度和物理特性的标准品。

公开(公告)号：US5110556A

公开(公告)日：1992-05-05

申请号：US749166

申请日：1991-08-22

Applicant: George Lyman ,  Anthony Labriola

Inventor： George Lyman ,  Anthony Labriola

IPC: B01L3/00 ,  G01N21/03

CPC classification number: B01L3/50855 ,  B01L3/50255 ,  B01L3/5085 ,  G01N21/03 ,  G01N2021/0357 ,  G01N2201/0446 ,  Y10S435/809 ,  Y10S436/809 ,  Y10T436/25375

Abstract: A multi-well test plate which includes a base and a plurality of well strips. The well strips are removable from the base and the individual wells of each strip are separable. The wells in each strip are joined by T-shaped connecting members which hold the wells in a flat linear array when the well strips are either held in or removed from the base and the T-shaped members are readily severable to permit easy separation of individual wells. The bottom wall of each well is a microporous membrane.

Abstract translation: 一种多井测试板，其包括基座和多个井条。 井条可从基座移除，每个条带的各个井可分离。 每个条带中的孔由T形连接构件连接，当井条被保持在基座中或从基座移除时，T形连接构件将井保持在平坦的线性阵列中，并且T形构件易于分离以允许容易地分离个体 井。 每个孔的底壁是微孔膜。

公开(公告)号：US5000576A

公开(公告)日：1991-03-19

申请号：US372929

申请日：1989-06-28

Applicant: Antti Keipi ,  Jukka Tuunanen ,  Juha Koivisto

Inventor： Antti Keipi ,  Jukka Tuunanen ,  Juha Koivisto

IPC: G01N35/02 ,  B01L99/00 ,  G01B7/004 ,  G01N35/10

CPC classification number: G01N35/109 ,  B01L9/50 ,  B01L99/00 ,  G01B7/004 ,  G01N2201/0446

Abstract: The invention is related to a system of identification of the location of a matrix-like sample tray on a plane (2) in an equipment for the treatment of the samples. The sample tray is placed in a frame having an L-shaped electrically conductive piece (8). The equipment for the treatment comprises a number, corresponding to the number of vertical lines of the tray, electrically conductive strips (9), a number, corresponding to the number of horizontal lines, electrically conductive strips (10), and means for transmitting an electric signal to the strips of the vertical line and for receiving from the strips of the horizontal lines.

Abstract translation: 本发明涉及一种在用于处理样品的设备中的平面（2）上识别基质样品托盘的位置的系统。 样品托盘放置在具有L形导电片（8）的框架中。 用于处理的设备包括对应于托盘的垂直线的数量的导电条（9），对应于水平线的数量的导电条（9），导电条（10），以及用于发送 电信号到垂直线的条带并用于从水平线的条带接收。

公开(公告)号：US4895706A

公开(公告)日：1990-01-23

申请号：US187083

申请日：1988-04-28

Applicant: David Root ,  George Lyman

Inventor： David Root ,  George Lyman

IPC: G01N1/10 ,  B01D29/01 ,  B01D61/18 ,  B01D63/08 ,  B01L3/00 ,  B01L9/06 ,  G01N21/03

CPC classification number: B01L9/06 ,  B01D61/18 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/50855 ,  G01N2021/0357 ,  G01N2201/0446 ,  Y10S436/809 ,  Y10T436/255

Abstract: A filter strip and composite assemblies for filtering microliter quantities of fluids wherein a linear array of wells having open top and bottom ends are connected by frangible webs in spaced-apart relation with discrete filter membranes closing the bottom ends of each well. Tabs are provided on the ends of the filter strip for holding the same and supporting the strip in a rectangular holder having alphanumeric designations for identifying each well in a plurality of such filter strips contained within the holder. The filter strip may be used in a vacuum manifold for applying a pressure differential across the filter membrane and directing the filtrate into an aligned aperture of a closed bottom well of an array of wells held within the manifold. Alternatively, the filter strip may be used with a transfer plate for directing the filtrate from each well of the filter strip to an aligned well of a closed bottom array of wells. Another composite assembly includes a pressure manifold for applying an increased pressure above the membranes.

Abstract translation: 用于过滤微量流体的过滤条和复合组件，其中具有开口顶部和底部的井的线性阵列通过易碎的腹板以与闭合每个孔的底端的离散过滤膜隔开的关系连接。 在过滤条的端部设置有用于保持其的突片，并将条带支撑在具有字母数字标号的矩形保持器中，用于识别容纳在保持器内的多个这种过滤条中的每个孔。 过滤条可以用在真空歧管中，用于在过滤膜上施加压力差，并将滤液引导到保持在歧管内的阱阵列的封闭的底部井的对准孔。 或者，过滤条可以与转移板一起使用，用于将滤液从过滤条的每个孔导向孔的封闭底部阵列的对准井。 另一复合组件包括用于在膜上施加增加压力的压力歧管。

公开(公告)号：US4762420A

公开(公告)日：1988-08-09

申请号：US30176

申请日：1987-03-25

Applicant: Alan R. Bowley

Inventor： Alan R. Bowley

IPC: G01N21/13 ,  G01N21/25 ,  G01N21/59

CPC classification number: G01N21/253 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/0621

Abstract: A photometric reading device comprises a plurality of reading elements (30), each comprising a light emitting diode and a corresponding photodiode on opposing sides of a sample pathway along which a sample microplate (10) can travel. The microplate (10) includes rows of sample wells arranged transverse to the line of relative motion of the microplate (10) and the reading elements (30).The reading elements (30) are arranged such that, during continuous relative motion of the reading elements (30) and the microplate (10), the reading elements (30) come into registration sequentially with the wells in the first row of wells in the microplate (10), then with the wells in the second row of wells, and so on.

Abstract translation: 光度读取装置包括多个读取元件（30），每个读取元件（30）包括发光二极管和相应的光电二极管，所述对应的光电二极管位于样品通路的相对侧，样品微孔板可以沿着样本路径行进。 微板（10）包括横列于微板（10）和读取元件（30）的相对运动线的样本阱排。 读取元件（30）被布置成使得在读取元件（30）和微板（10）的连续相对运动期间，读取元件（30）顺序地与第一排孔中的孔对准 微板（10），然后与第二排孔中的孔等等。

公开(公告)号：US4730921A

公开(公告)日：1988-03-15

申请号：US793653

申请日：1985-10-31

Applicant: Gerald L. Klein ,  Gene D. Russell ,  Steven R. Day ,  Jerrold D. Liebermann

Inventor： Gerald L. Klein ,  Gene D. Russell ,  Steven R. Day ,  Jerrold D. Liebermann

IPC: G01N21/59 ,  G01N21/25 ,  G01N33/53 ,  G01N33/48

CPC classification number: G01N21/253 ,  G01N2201/0446 ,  G01N2201/0621

Abstract: An automated vertical photo densitometer for reading solutions contained in microwell plates. The densitometer utilizes an optical system for minimizing the optical effect of a meniscus on the fluid sample. The invention also discloses a method for determining a centrally located position of a microwell beneath an interrogating beam of light by controlling the size of the light beam and by stepping the well through the beam. A measurement of the light intensity received by a detector is taken at each step. A maximum light intensity value is selected as corresponding to a well position wherein a central area of the fluid sample is substantially within the interrogating beam.

Abstract translation: 一种用于读取微孔板中所含解决方案的自动垂直光密度计。 密度计利用光学系统来最小化弯液面对流体样品的光学效应。 本发明还公开了一种用于通过控制光束尺寸并通过使井穿过光束来确定询问光束下面的微孔的居中定位位置的方法。 在每个步骤中测量由检测器接收的光强度。 选择最大光强度值对应于其中流体样品的中心区域基本上在询问光束内的阱位置。

公开(公告)号：US4554257A

公开(公告)日：1985-11-19

申请号：US489734

申请日：1983-04-29

Applicant: Frederick J. Aladjem ,  Padmasini K. Ayengar

Inventor： Frederick J. Aladjem ,  Padmasini K. Ayengar

IPC: A61K39/00 ,  G01N15/10 ,  G01N21/82 ,  G01N33/543 ,  G01N35/00

CPC classification number: G01N33/54313 ,  G01N15/10 ,  G01N21/82 ,  G01N2201/0446 ,  G01N2201/0461 ,  Y10S436/805 ,  Y10S436/807 ,  Y10S436/827

Abstract: The disclosed methods improve conventional agglutination processes for assaying immunoreactive and like substances, primarily by improving the measurement of the agglutination itself. Suspensions containing agglutinated particles are automatically inspected, preferably intermittently during the agglutinating reaction, and the resulting data are processed to identify individual particle aggregates of a selected limited class, which may, for example, comprise aggregates having sizes within a limited size interval. The numbers of such aggregates are compared with corresponding reference values obtained with standard solutions and suitable controls to evaluate the concentration of one of the reactive substances, or other information. The aggregate size intervals and other parameters which are used to define aggregate classes are preferably selected with attention to the detailed behavior of each test system.

Abstract translation: 所公开的方法改进了用于测定免疫反应性和类似物质的常规凝集方法，主要通过改进凝集本身的测量。 自动检查含有凝集颗粒的悬浮液，优选在凝集反应期间间歇地进行检查，并且对所得数据进行处理以鉴定所选择的有限类别的单个颗粒聚集体，其可以例如包含尺寸在有限尺寸间隔内的聚集体。 将这些聚集体的数量与用标准溶液和合适的对照获得的相应参考值进行比较，以评估其中一种反应物质或其它信息的浓度。 用于定义聚合类的聚合大小间隔和其他参数优选地被选择，注意每个测试系统的详细行为。

公开(公告)号：US4415809A

公开(公告)日：1983-11-15

申请号：US289155

申请日：1981-08-03

Applicant: John Shields

Inventor： John Shields

IPC: G01J1/24 ,  G01N21/03 ,  G01N21/25 ,  G01N33/04 ,  G01N21/01

CPC classification number: G01N21/253 ,  G01N21/03 ,  G01N21/251 ,  G01N33/04 ,  G01J1/24 ,  G01N2201/0446 ,  G01N2201/127 ,  Y10S250/91

Abstract: Electro-optical apparatus for measurement of fat, protein, lactose and water or solids in milk wherein a milk sample is pumped by a homogenizer into an optical measurement cell. The specimen in the cell is then irradiated with reference and measurement beams at differing wavelengths for fat, protein, lactose and water respectively, and signals are stored indicative of uncorrected concentrations. A scaling and correction circuit includes cross-correction circuitry for compensating the effects on each reading caused by the other constitutents. The signals so corrected are then provided in percentage by weight or weight over volume on suitable digital displays.

Abstract translation: 用于测量乳中脂肪，蛋白质，乳糖和水或固体的电光装置，其中将牛奶样品通过均化器泵送到光学测量单元中。 然后分别用脂肪，蛋白质，乳糖和水分别以不同波长的参考和测量光束照射细胞中的样品，并且存储指示未校正浓度的信号。 缩放和校正电路包括交叉校正电路，用于补偿由其他组成部分引起的每次读数的影响。 然后如此校正的信号以合适的数字显示器上的体积重量或重量的百分比提供。