公开(公告)号：US20180340952A1

公开(公告)日：2018-11-29

申请号：US16052709

申请日：2018-08-02

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Marcel Kaeppeli ,  Tobias Huber ,  Pius Hermann ,  Matthias Edelmann

IPC: G01N35/04 ,  B65G54/02

Abstract: A transport device for a laboratory sample distribution system is presented. The transport device comprises a plurality of actuator modules. Each actuator module comprises a plurality of electro-magnetic actuators. A plurality of base plate modules arranged in a pattern is provided. The base plate modules are coupled to each other and aligned by support elements. The number of base plate modules at least equals the number of actuator modules and each base plate module is configured to support one of the plurality of actuator modules. A laboratory sample distribution system and to a laboratory automation system comprising a laboratory sample distribution system are also presented.

公开(公告)号：US10132805B2

公开(公告)日：2018-11-20

申请号：US14524700

申请日：2014-10-27

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Georg Kurz ,  Eloisa Lopez-Calle

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/543 ,  G01N21/27 ,  G01N33/52 ,  G01N21/78 ,  G01N21/82 ,  G01D18/00 ,  G01N21/63 ,  G01N33/573 ,  G01N33/68 ,  G01N33/92 ,  G06F19/18 ,  G16H50/30

Abstract: A method for determining the amount of specific analyte of a sample which may show interferences by photometric assays, wherein the analyte is quantified from the change in the optical signal of the reaction mixture after the interaction of the analyte with analyte specific reagents. Multiple calibration curves are generated for multiple wavelengths for the specific analyte. An interference test is performed simultaneously to the determination of the specific analyte, for quantifying the amount of interfering substances present in the sample. The amount of each interfering substances is compared to predetermined cut-off values. The optical signal for the specific analyte is measured in the reaction mixture at multiple wavelengths over the complete reaction time, and a calibration curve is selected depending on the interfering substances. The amount of specific analyte is quantified by comparison with the selected calibration curve for the chosen wavelengths.

公开(公告)号：US20180313850A1

公开(公告)日：2018-11-01

申请号：US16027890

申请日：2018-07-05

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dirk Block ,  Julian Braz ,  Hans-Peter Brunner ,  James Creeden ,  Hans-Joerg Loyda ,  Ursula-Henrike Wienhues-Thelen ,  Christian Zaugg

IPC: G01N33/68

CPC classification number: G01N33/6887 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/58 ,  G01N2800/325 ,  G01N2800/52

Abstract: The present invention relates to a method for guiding heart failure treatment in a subject suffering from heart failure. The method is based on the determination of the amount of a BNP-type peptide and a cardiac troponin in a sample from said subject. Further envisaged by the present invention are kits and devices adapted to carry out the present invention. The present invention also relates to a system for guiding heart failure treatment in a subject suffering from heart failure as disclosed herein and to reagents and kits used in performing the methods disclosed herein.

公开(公告)号：US20180291354A1

公开(公告)日：2018-10-11

申请号：US16014355

申请日：2018-06-21

Applicant: Roche Diagnostics Operations, Inc. ,  Roche Diabetes Care, Inc.

Inventor： Peter Kratzsch ,  Mara Boenitz-Dulat ,  Daniela Beck ,  Thomas Streidl ,  Stacy Hunt DuVall

IPC: C12N9/04 ,  C12Q1/32 ,  C12Q1/54

CPC classification number: C12N9/0006 ,  C12Q1/32 ,  C12Q1/54 ,  C12Y101/0103

Abstract: The present disclosure relates to a mutant 3-hydroxybutyrate dehydrogenase (3-HBDH) with improved performance relative to the wild-type 3-HBDH, a nucleic acid encoding the mutant 3-HBDH, a cell having the mutant 3-HBDH or the nucleic acid, and/or a method of determining the amount or concentration of 3-hydroxybutyrate in a sample. Also disclosed is the use of the mutant 3-HBDH for determining the amount or concentration of 3-hydroxybutyrate in a sample, and a device for determining the amount or concentration of 3-hydroxybutyrate in a sample.

公开(公告)号：US10094817B2

公开(公告)日：2018-10-09

申请号：US14611611

申请日：2015-02-02

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Siegfried Dick ,  Markus Fischer

IPC: B05D3/00 ,  B05D7/00 ,  G01N33/487 ,  B01L3/00 ,  B32B38/04 ,  B32B37/12 ,  B32B41/00

Abstract: A process for the production of at least one analytical device is disclosed. The analytical device comprises at least one capillary element. The process comprises providing at least one carrier layer; providing at least one spacer layer; applying the spacer layer on top of the carrier layer; providing at least one cover layer; and applying the cover layer on top of the spacer layer. The process further comprises at least one cutting step. At least one capillary channel of the capillary element is cut out from the spacer layer. The cutting step is performed by using at least two cutting tools. The cutting tools complement one another to form a contour of the capillary channel.

公开(公告)号：US10086373B2

公开(公告)日：2018-10-02

申请号：US15352698

申请日：2016-11-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke ,  Thorsten Brueckner

IPC: B01L3/00 ,  G01N35/00 ,  G01N21/07 ,  G01N21/64 ,  G01N21/03

Abstract: An automatic analyzer cartridge, spinnable around a rotational axis, has a support structure with a front face perpendicular to the rotational axis, a fluidic structure for processing a biological sample into the processed biological sample, a measurement structure with at least one detection zone on the front face, and a rotatable lid covering the front face. The rotatable lid is rotatable about the rotational axis relative to the support structure from a first position relative to the support structure to a second position relative to the support structure. The rotatable lid has a sample inlet opening and a detection zone opening. In the first position, a sample inlet is aligned with the sample inlet opening and the measurement structure is covered by the rotatable lid. In the second position, the sample inlet is covered by the rotatable lid and the measurement structure is aligned with the detection zone opening.

公开(公告)号：US20180265288A1

公开(公告)日：2018-09-20

申请号：US15921816

申请日：2018-03-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： David Huber ,  Bruno Koch ,  Franz Lindegger ,  Marco Sangermano

IPC: B65F1/16 ,  B65F1/14 ,  G01N35/04

CPC classification number: B65F1/1607 ,  B01L1/50 ,  B01L2300/12 ,  B65F1/1421 ,  B65F1/1436 ,  B65F1/1478 ,  G01N35/00 ,  G01N35/04 ,  G01N2035/00277 ,  G01N2035/0406 ,  G01N2035/0422 ,  G01N2035/103

Abstract: A secondary solid waste container for solid waste of an analyzer is disclosed. The secondary solid waste container comprises side walls and an impact absorbing member. The side walls comprise an upper end and a lower end. The impact absorbing member is connected to the side walls such that the impact absorbing member extends between the side walls and is spaced apart from the lower end with respect to a direction from the lower end to the upper end. The impact absorbing member is configured to absorb an impact from solid waste of the analyzer. An analyzer and a method for removing solid waste of an analyzer are also disclosed.

公开(公告)号：US20180252651A1

公开(公告)日：2018-09-06

申请号：US15909295

申请日：2018-03-01

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Rik Harbers ,  Kurt Schildknecht

IPC: G01N21/75 ,  G01J3/28 ,  G01J3/42 ,  G01N21/25

CPC classification number: G01N21/75 ,  G01J3/28 ,  G01J3/42 ,  G01N21/255

Abstract: An optical device for determining the presence and/or concentration of analytes in a sample is presented. The optical device comprises a detector and a detection unit comprising optical path components. The detection unit has wavelength-dependent responsivity. The optical device further comprises a light source for emitting light of different respective usable wavelength ranges. The light is guidable through the optical path to the detector to generate baseline signals and response signals relative to the baseline signal indicative of the presence and/or concentration of analytes in the optical path. The intensity of the light reaching the detector is adjusted inverse to the wavelength-dependent responsivity with respect to at least two respective usable wavelength ranges so that a reduction of the ratio between the maximum baseline signal at one of the selected usable wavelength ranges and the minimum baseline signal at another of the selected usable wavelength ranges is obtained.

公开(公告)号：US10060907B2

公开(公告)日：2018-08-28

申请号：US15438859

申请日：2015-08-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Peter Gebauer ,  Dieter Heindl ,  Carina Horn ,  Maksim Fomin

IPC: G01N33/52 ,  G01N33/50 ,  C07D241/42 ,  C07D403/06

CPC classification number: G01N33/52 ,  C07D241/40 ,  C07D241/42 ,  C07D401/06 ,  C07D403/06 ,  G01N33/5005

Abstract: The present invention relates to a chemical compound or a salt or solvate thereof being a phenazine-, phenanthridine-, phenanthroline-, quinoline-, quinoxaline-, acridine-isoquinoline-, pyrazine- or pyridine-derivative comprising a conjugated π-system and a π-acceptor group, and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the chemical compound of the present invention. The present invention also relates to a method of determining the amount of an analyte in a test sample, comprising contacting said test sample with a chemical compound, with a chemistry matrix, or with a test element of the invention and estimating the amount of redox equivalents liberated or consumed by the chemical compound, by the chemical compound comprised in said chemistry matrix, or by the chemical compound comprised in said test element, in the presence of said test sample, thereby determining the amount of an analyte in said test sample. Moreover, the present invention relates to a system comprising a test element according to the present invention and a device comprising a sensor for measuring the amount of redox equivalents liberated or consumed.

公开(公告)号：US20180224476A1

公开(公告)日：2018-08-09

申请号：US15875215

申请日：2018-01-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Armin Birrer ,  Andreas Drechsler ,  Rik Harbers

IPC: G01N35/10 ,  G01N21/51 ,  G06T7/60

CPC classification number: G01N35/10 ,  B65G54/02 ,  G01N21/51 ,  G01N35/00732 ,  G01N35/04 ,  G01N2035/00801 ,  G01N2035/00821 ,  G01N2035/0401 ,  G01N2035/0406 ,  G01N2035/0493 ,  G06T7/0012 ,  G06T7/60

Abstract: A laboratory automation system for processing sample containers containing laboratory samples and/or for processing the samples is presented. The laboratory automation system comprises a digital camera configured to take an image of the sample container together with a calibration element. The image comprises image data related to the sample container and image data related to the calibration element. The laboratory automation system also comprises an image processing device configured to determine geometrical properties of the sample container depending on the image data related to the sample container and the image data related to the calibration element.