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公开(公告)号：US20150250625A1
公开(公告)日：2015-09-10
申请号：US14716620
申请日：2015-05-19
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Daniel Castro , Stephen D. Pacetti
CPC classification number: A61F2/82 , A61F2/06 , A61F2210/0004 , A61F2210/0076 , A61F2250/0067 , A61L31/04 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61L2420/08 , A61M29/00 , B32B17/06 , B32B27/38 , Y10T428/31511 , C08L67/04
Abstract: Stents are disclosed with an adhesion promoting layer that improves adhesion of polymer coatings over polymer surfaces of a stent substrate.
Abstract translation: 公开了支架，其具有增强聚合物涂层在支架基底的聚合物表面上的粘附性的粘附促进层。
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公开(公告)号：US09051065B2
公开(公告)日：2015-06-09
申请号：US13846711
申请日：2013-03-18
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti
IPC: A61L33/00 , B05D3/00 , B05D3/02 , B05D1/18 , B65B3/00 , A61L31/10 , A61L31/14 , A61L31/16 , A61F2/91
CPC classification number: B65B3/003 , A61F2/91 , A61F2250/0068 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61L2300/416 , A61L2300/43 , A61L2300/602 , B05D3/0218
Abstract: A method of loading a composition into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The structural element, or a stent having such a structural element, is immersed in a solution or a composition, and the composition or solution is allowed to fill the lumen. The composition or solution may comprise a therapeutic agent.
Abstract translation: 一种将组合物装载到支架的结构元件中的方法，其中结构元件由腔和至少一个开口限定，以进入内腔。 将结构元件或具有这种结构元件的支架浸入溶液或组合物中，并使组合物或溶液填充内腔。 组合物或溶液可以包含治疗剂。
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143.发明授权公开(公告)号：US09011928B2
公开(公告)日：2015-04-21
申请号：US14074201
申请日：2013-11-07
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Wouter E. Roorda , Stephen D. Pacetti
IPC: A61K47/26 , A61K47/36 , A61K9/14 , A61K9/16 , A61K31/727 , A61K31/573 , A61K38/18 , A61K48/00
CPC classification number: A61K9/14 , A61K9/1617 , A61K9/1647 , A61K9/1658 , A61K9/1694 , A61K31/573 , A61K31/727 , A61K38/1825 , A61K47/26 , A61K47/36 , A61K48/00
Abstract: Compositions and methods of using the compositions are provided for forming an embolus within a region of an anatomical lumen for a transitory period in order to achieve a therapeutic effect.
Abstract translation: 提供使用组合物的组合物和方法，用于在解剖腔的一个区域内形成一个临时期的栓塞，以达到治疗效果。
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公开(公告)号：US08986724B2
公开(公告)日：2015-03-24
申请号：US13923559
申请日：2013-06-21
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Thierry Glauser , Stephen D. Pacetti , Paul M. Consigny
CPC classification number: A61K33/00 , A61K45/06 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/114 , A61L2300/606
Abstract: Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.
Abstract translation: 提供了具有能够催化体内产生一氧化氮的催化剂的医疗装置和使用该装置治疗血管状态的方法。
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145.发明申请Treatment of coronary artery lesions with a scaffold having vessel scaffold interactions that reduce or prevent angina 审中-公开用具有减少或预防心绞痛的血管支架相互作用的支架治疗冠状动脉病变公开(公告)号：US20150073535A1
公开(公告)日：2015-03-12
申请号：US14120555
申请日：2014-06-02
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Paul Consigny , Richard J. Rapoza , Syed Faiyaz Ahmed Hossainy , Chad J. Abunassar , Alexander J. Sheehy , Laura E. Perkins , Santosh V. Prabhu , Wai-Fung Cheong , Pooja A. Sadarangani , Stephen D. Pacetti
CPC classification number: A61L31/148 , A61F2/915 , A61F2002/91566 , A61L31/10 , A61L31/16 , A61L2300/402 , A61L2300/416
Abstract: Methods of treating coronary artery disease (CAD) with bioresorbable stents resulting in reduced angina or non-ischemic chest pain are described. Methods of treatment and devices for treatment of angina and post-procedural chest pain that include anti-angina agents incorporated into the device are disclosed.
Abstract translation: 描述了具有导致心绞痛或非缺血性胸痛减轻的生物可再吸收支架的冠状动脉疾病（CAD）的方法。 公开了治疗方法和治疗心绞痛和手术后胸痛的装置，其包括并入装置中的抗心绞痛药物。
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Patent Agency Ranking
146.发明申请REGIONAL DELIVERY OF THERAPEUTIC AGENTS FOR THE TREATMENT OF VASCULAR DISEASES 审中-公开用于治疗血管疾病的治疗药物的区域性递送公开(公告)号：US20150045877A1
公开(公告)日：2015-02-12
申请号：US14521126
申请日：2014-10-22
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti , Paul M. Consigny , Ronald W. Heil, JR. , Florian Niklas Ludwig , Dariush Davalian , Li Zhao , Irinia Astafieva , Jinping Wan , Fozan EI-Nounou , Katsuyuki Murase , Syed F.A. Hossainy , Rachel Bright , Jeffrey Ellis
CPC classification number: A61M25/1002 , A61F2/82 , A61F2250/0067 , A61K31/27 , A61K31/44 , A61K31/56 , A61K31/66 , A61K38/1709 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/62 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2025/1086 , A61M2037/0023 , A61M2037/0061 , A61M2210/12
Abstract: The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.
Abstract translation: 本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织 受影响组织的外围也是如此。
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公开(公告)号：US20140379064A1
公开(公告)日：2014-12-25
申请号：US13924421
申请日：2013-06-21
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti , Annie P. Liu , Mark C. Johnson
CPC classification number: A61F2/958 , A61F2/0095 , A61F2/82 , A61F2/95 , A61F2/962 , A61F2/966 , A61F2/97 , A61F2002/9583 , A61F2210/0004 , A61F2250/0059 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/148
Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A sheath is placed over the crimped scaffold after crimping to reduce recoil of the crimped polymer scaffold and maintain scaffold-balloon engagement relied on to hold the scaffold to the balloon when the scaffold is being delivered to a target in a body. The sheath is removed by a health professional either by removing the sheath directly or using a tube containing the catheter.
Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 在卷曲之后，将护套放置在卷曲框架上方以减少卷曲的聚合物支架的反冲，并且当支架被递送到身体中的目标时，保持脚手架气球接合以将支架保持在气囊上。 卫生专业人员可以通过直接取下护套或使用含有导管的管道去除护套。
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148.发明申请公开(公告)号：US20140238535A1
公开(公告)日：2014-08-28
申请号：US14268820
申请日：2014-05-02
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Stephen D. Pacetti
CPC classification number: A61F2/91 , A23G9/283 , A61F2240/001 , A61F2250/0068 , B05D1/18 , B05D3/0486 , B05D3/0493 , B05D7/22
Abstract: An apparatus for loading material into a stent strut can comprise a cover sleeve. The cover sleeve is elastic so that it can reduce in diameter so as to press against the stent strut, and expand in diameter so as to be spaced apart from the stent strut. The stent strut can include a lumen into which material is injected. When pressed against the stent strut, the cover sleeve seals side openings to the lumen and prevents injected material from leaking out of the side openings during the injection process.
Abstract translation: 用于将材料装载到支架支柱中的装置可以包括盖套筒。 盖套是弹性的，使得其可以减小直径以便压靠支架支柱，并且直径扩大以与支架支柱间隔开。 支架支架可以包括注射材料的内腔。 当压靠支架支柱时，盖套筒将侧开口密封到内腔，并防止在注射过程中注入材料从侧开口泄漏出来。
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公开(公告)号：US20140205740A1
公开(公告)日：2014-07-24
申请号：US14226734
申请日：2014-03-26
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Dennis R. Orosa , John E. Papp , Hung T. Nguyen , Stephen D. Pacetti , Dudley Shelton Jayasinghe , Matthew J. Gillick
IPC: A61F2/82
CPC classification number: A61F2/82 , A61L31/10 , A61L31/16 , A61L2300/608 , A61L2420/02 , A61L2420/08
Abstract: A coated implantable medical device and a method of coating an implantable medical device is disclosed, the method includes applying a composition onto the device and drying the composition at elevated temperature in an environment having increased relative humidity. A pre-screening method for a manufacturing lot of coated stents to determine the number of drug coating layers for a desired drug release rate is disclosed. The method including coating and testing small groups of stents, and applying the results of the tests to determine the number of drug coating layers to apply to the manufacturing lot of stents.
Abstract translation: 公开了涂覆的可植入医疗装置和涂覆可植入医疗装置的方法，所述方法包括将组合物施加到装置上并在具有相对湿度增加的环境中在升高的温度下干燥组合物。 公开了一种用于确定所需药物释放速率的药物涂层数量的涂层支架制造批次的预筛选方法。 该方法包括涂覆和测试小组支架，并应用测试结果确定应用于支架制造批次的药物涂层数量。
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150.发明授权公开(公告)号：US08784859B2
公开(公告)日：2014-07-22
申请号：US13905423
申请日：2013-05-30
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti
IPC: A61F13/00
CPC classification number: A61K9/284 , A61L31/10 , A61L31/16 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/416 , C08L53/02
Abstract: A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, an implantable device coated with the composition, and a method of treating a disorder are provided.
Abstract translation: 提供了一种用于涂覆可植入装置的生物有益涂层组合物，例如药物洗脱支架，用该组合物涂覆该装置的方法，涂有该组合物的可植入装置以及一种治疗病症的方法。
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