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151.发明申请p53-DEPENDENT APOPTOSIS-INDUCING PROTEIN AND METHOD OF SCREENING FOR APOPTOSIS REGULATOR 审中-公开p53依赖性病毒诱导蛋白和筛选调节因子的方法公开(公告)号：US20080220455A1
公开(公告)日：2008-09-11
申请号：US12103867
申请日：2008-04-16
申请人： Yusuke Nakamura , Hirofumi Arakawa
发明人： Yusuke Nakamura , Hirofumi Arakawa
IPC分类号： G01N33/574 , C12N15/11 , C07K14/00 , C12N15/00 , C12N5/06 , C12P21/04 , C07K16/18 , C07H21/00 , G01N33/566
CPC分类号： G01N33/5008 , C07K14/4747 , C07K16/18 , C12Q1/485 , G01N33/5011 , G01N33/68 , G01N33/6842 , G01N33/6875 , G01N2500/00 , G01N2510/00
摘要： p53-dependent Damage-Inducible Nuclear Protein 1 (p53DINP1 protein) is a p53-induced nuclear protein that induces p53-dependent apoptosis by regulating p53 function through Ser 46 phosphorylation. A DNA encoding p53DINP1 can be applied as anticancer agents for destroying neoplasms such as tumors, and as therapeutic or preventive agents for diseases associated with p53-mediated apoptosis abnormalities. It is also possible to apply the above protein and DNA in methods of screening for candidate compounds for regulating p53-mediated apoptosis.
摘要翻译： p53依赖性损伤诱导核蛋白1（p53DINP1蛋白）是p53诱导的核蛋白，其通过调节p53功能通过Ser 46磷酸化诱导p53依赖性凋亡。 编码p53DINP1的DNA可用作破坏肿瘤等肿瘤的抗癌剂，也可用作与p53介导的凋亡异常有关的疾病的治疗或预防剂。 还可以将上述蛋白质和DNA应用于筛选用于调节p53介导的凋亡的候选化合物的方法中。
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公开(公告)号：US20070202109A1
公开(公告)日：2007-08-30
申请号：US10573522
申请日：2004-08-10
IPC分类号： A61K48/00 , C12Q1/68 , G01N33/574 , A61K39/395
CPC分类号： G01N33/57415 , A61K39/00 , C12Q1/6809 , C12Q1/6827 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2537/143 , C12Q2545/114 , C12Q2565/549
摘要： Compositions and objective methods for detecting, diagnosing, and treating breast cancer (BRC) are described herein. In particular, the present invention describes three BRC-associated genes, referred to herein as A5657, B9769, and C7965, up-regulated in BRC cells as compared to normal cells. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells; in an alternate embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS cells and IDC cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and methods for vaccinating a subject against breast cancer.
摘要翻译： 本文描述了用于检测，诊断和治疗乳腺癌（BRC）的组合物和客观方法。 特别地，本发明描述了与正常细胞相比，在BRC细胞中上调的三种BRC相关基因（本文称为A5657，B9769和C7965）。 在一个实施方案中，诊断方法包括确定区分BRC细胞和正常细胞的BRC相关基因的表达水平; 在替代实施方案中，诊断方法包括确定区分BRC细胞，DCIS细胞和IDC细胞之间的BRC相关基因的表达水平。 本发明还提供了筛选用于治疗乳腺癌的治疗剂的方法，以及用于治疗乳腺癌的方法以及接种受试者抵抗乳腺癌的方法。
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公开(公告)号：US20060204960A1
公开(公告)日：2006-09-14
申请号：US10533026
申请日：2003-09-19
申请人： Yusuke Nakamura , Yoichi Furukawa
发明人： Yusuke Nakamura , Yoichi Furukawa
CPC分类号： G01N33/57446 , A61K48/00 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2500/00
摘要： Objective methods for detecting and diagnosing diffuse-type gastric cancer (DGC) are described herein. In one embodiment, the diagnostic method involves the determining an expression level of DGC-associated gene that discriminate between DGC and normal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of DGC, methods of treating DGC and method of vaccinating a subject against DGC.
摘要翻译： 本文描述了弥漫性胃癌（DGC）的检测和诊断的客观方法。 在一个实施方案中，诊断方法涉及确定区分DGC和正常细胞的DGC相关基因的表达水平。 本发明还提供筛选用于治疗DGC的治疗剂的方法，DGC治疗方法和用DGC接种受试者的方法。
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公开(公告)号：US20050272063A1
公开(公告)日：2005-12-08
申请号：US11067231
申请日：2005-02-28
IPC分类号： C12Q1/68
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/28 , C07K2317/34 , C07K2317/732 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： Methods of detecting synovial sarcoma using differentially expressed genes are disclosed. Also disclosed are methods of identifying agents for treating synovial sarcoma. Further, a method for treating or preventing a disease that is associated with Frizzled homologue 10 (FZD10) in a subject is provided.
摘要翻译： 公开了使用差异表达基因检测滑膜肉瘤的方法。 还公开了鉴定用于治疗滑膜肉瘤的药剂的方法。 此外，提供了治疗或预防与受试者中的卷曲同源物10（FZD10）相关的疾病的方法。
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公开(公告)号：US20050259483A1
公开(公告)日：2005-11-24
申请号：US11088634
申请日：2005-03-23
CPC分类号： C07K14/4748
摘要： Objective methods for detecting and diagnosing prostate cancer (PRC) or prostatic intraepithelial neoplasia (PIN) are described herein. In one embodiment, the diagnostic method involves the determining an expression level of PRC-associated gene that discriminate between PRC or PIN and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of either or both of PRC and PIN, methods of treating either or both of PRC and PIN and method of vaccinating a subject against either or both of PRC and PIN.
摘要翻译： 本文描述了用于检测和诊断前列腺癌（PRC）或前列腺上皮内瘤变（PIN）的客观方法。 在一个实施方案中，诊断方法涉及确定区分PRC或PIN和正常细胞的PRC相关基因的表达水平。 本发明还提供筛选用于治疗PRC和PIN中的任一者或两者的治疗剂的方法，治疗PRC和PIN中的任一者或两者的方法以及针对PRC和PIN中的任一者或两者接种受试者的方法。
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公开(公告)号：US20050074762A1
公开(公告)日：2005-04-07
申请号：US10467102
申请日：2002-02-01
IPC分类号： A61K48/00 , A61P9/10 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12P21/08 , C12Q1/68 , G01N33/68 , C07H21/04 , C07K14/705
CPC分类号： C07K16/18 , A61K48/00 , C07K14/47 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/6887 , G01N2800/323
摘要： A novel adiponectin-like protein having therapeutic and/or preventive effects on arteriosclerosis and a gene encoding this protein are provided. A protein (a) comprising the amino acid sequence represented by SEQ ID No:3 or a protein (b) comprising an amino acid sequence resulting from deletion, substitution or addition of amino acid(s) in the amino acid sequence of SEQ ID NO:3 and having an activity of inhibiting the proliferation of vascular smooth muscle cells or salts of these proteins; and a DNA encoding the above proteins are provided.
摘要翻译： 提供了具有对动脉硬化的治疗和/或预防效果的新型脂联素样蛋白质和编码该蛋白质的基因。 包含由SEQ ID No：3表示的氨基酸序列的蛋白质（a）或包含由SEQ ID NO：1的氨基酸序列中的氨基酸缺失，取代或添加而产生的氨基酸序列的蛋白质（b） 3，具有抑制血管平滑肌细胞或这些蛋白质的盐的增殖的活性; 并提供编码上述蛋白质的DNA。
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公开(公告)号：US06710171B1
公开(公告)日：2004-03-23
申请号：US09380287
申请日：1999-11-16
IPC分类号： C07H2104
CPC分类号： C07K14/4703 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/705 , C07K14/82 , C07K2319/00
摘要： The present invention provides novel physiologically active protein molecules originating in mammals, which are specifically expressed in arteriosclerosis and/or coronary restenosis, and are predicted to relate closely to the onset and progress of these diseases; DNAs encoding the protein molecules; antibodies reactive with the molecules; and pharmaceutical compositions comprising the above protein molecule or the antibody. The protein molecules, DNAs, and antibodies are useful for treating and preventing arteriosclerosis.
摘要翻译： 本发明提供了起源于哺乳动物的新型生理活性蛋白质分子，其在动脉硬化和/或冠状动脉再狭窄中特异性表达，并被预测与这些疾病的发病和进展密切相关; 编码蛋白质分子的DNA; 与分子反应的抗体; 和包含上述蛋白质分子或抗体的药物组合物。 蛋白质分子，DNAs和抗体可用于治疗和预防动脉硬化。
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158.发明授权公开(公告)号：US06682917B1
公开(公告)日：2004-01-27
申请号：US10019733
申请日：2001-12-28
IPC分类号： C12N916
CPC分类号： C12N9/0093 , A01K2217/075 , A61K38/00 , A61K2039/505 , C07K16/30 , C07K16/40
摘要： Because the protein of the present invention has in its amino acid sequence a homology with, for example, ribonucleotide reductase, the protein of the present invention, its DNA, antibodies to these and the like are useful in the prevention, treatment and diagnosis, etc. of cancer.
摘要翻译： 因为本发明的蛋白质在其氨基酸序列中具有与例如核糖核苷酸还原酶的同源性，本发明的蛋白质，其DNA，对这些蛋白质的抗体等可用于预防，治疗和诊断等 癌症。
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公开(公告)号：US5691454A
公开(公告)日：1997-11-25
申请号：US452654
申请日：1995-05-25
申请人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
发明人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
CPC分类号： C07K14/47 , C07K14/82 , C12Q1/68 , C12Q1/6827 , C12Q1/6886 , A01K2217/05 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , Y10S530/828
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
摘要翻译： 公开了一种称为APC的人类基因。 提供了用于评估人类组织和身体样品中APC基因突变的方法和试剂盒。 家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。 这些结果表明APC是肿瘤抑制因子。
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公开(公告)号：US5571905A
公开(公告)日：1996-11-05
申请号：US220674
申请日：1994-03-31
IPC分类号： C07K16/00 , C07K14/00 , C07K14/47 , C07K14/82 , C07K16/30 , C07K16/32 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/574 , C07H21/04 , C12P19/34
CPC分类号： C07K16/3046 , C07K14/47 , C12Q1/6886 , C12Q2600/118
摘要： A new human gene termed MCC is disclosed. Methods, primers, probes and kits are provided for assessing mutations of the MCC gene in human tissues and body samples. Gross rearrangement and point mutations in MCC are observed in human tumor cells. MCC is expressed in most normal tissues. These results suggest that MCC is a tumor suppressor.
摘要翻译： 公开了一种称为MCC的新人基因。 提供了方法，引物，探针和试剂盒，用于评估人类组织和身体样品中MCC基因的突变。 在人类肿瘤细胞中观察到MCC中的重排和点突变。 大多数正常组织中表达MCC。 这些结果表明MCC是肿瘤抑制因子。
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