公开(公告)号：US20250134363A1

公开(公告)日：2025-05-01

申请号：US18494343

申请日：2023-10-25

Applicant: McMaster University

Inventor： Ian Hamilton Dale Phillips ,  Qiyin Fang ,  David Armstrong

IPC: A61B1/045 ,  A61B1/00 ,  A61B1/05 ,  A61B34/20 ,  G06T3/40 ,  G06T7/00

Abstract: An endoscope tracker that measures the endoscope's motion using a pair of trackballs and two video cameras is provided. The trackballs measure real-time changes in the scope's position and rotation during an endoscopic procedure. The cameras detect scale lines on the scope's surface to correct accumulated trackball measurement errors. A dual modality tracking method measures the motion of the endoscope's insertion tube in real time, including insertion length, rotation angle, and their velocities. Optical trackballs measure the endoscope insertion tube's motion, and cameras correct cumulative errors. A purely optical endoscope tracker that measures the endoscope's motion is also provided, using video cameras and software that processes the images obtained from the video cameras to determine how the endoscope moves over time.

公开(公告)号：US20250101437A1

公开(公告)日：2025-03-27

申请号：US18728342

申请日：2023-01-11

Applicant: McMaster University

Inventor： Yingfu Li ,  John Brennan ,  Zijie Zhang ,  Jiuxing Li ,  Jimmy Gu ,  Dawn White ,  Bruno Salena ,  Matthew Miller ,  Deborah Yamamura

IPC: C12N15/115 ,  C12N15/10 ,  C40B30/04 ,  G01N33/569

Abstract: This disclosure relates to a method of identifying or producing an aptamer capable of binding to at least two target analyte variants, the method comprises generating a mixture of systematic evolution of ligands by exponential enrichment (SELEX)-selected aptamers by at least one-round of SELEX with a SELEX-compatible aptamer pool against the at least two target analyte variants in parallel or sequentially, sequencing the mixture of SELEX-selected aptamers that form complexes with each of the at least two target analyte variants by high-throughput sequencing, aligning the mixture of SELEX-selected aptamers that form complexes with each of the at least two target analyte variants by sequence alignment analysis, and identifying or producing the aptamer capable of binding to the at least two target analyte variants. Aptamers thereof and uses of the aptamers thereof are also disclosed.

公开(公告)号：US20250066306A1

公开(公告)日：2025-02-27

申请号：US18738421

申请日：2024-06-10

Applicant: McMaster University ,  University of Florida Research Foundation ,  UNITED STATES GOVT - THE DEPT OF VETERANS AFFAIRS ,  University of Pittsburgh

Inventor： James McNulty ,  Chanti Babu Dokuburra ,  Leonardo D'Aiuto ,  Vishwajit Nimgaonkar ,  David C Bloom ,  Maribeth Wesesky ,  Joel Wood

IPC: C07D221/12 ,  A61K31/473 ,  A61K31/522 ,  A61P31/14 ,  A61P31/22

Abstract: This application relates to compounds of Formula (I) that activates the integrated stress response, compositions comprising these compounds and methods of use thereof, for example, for treating diseases, disorders or conditions treatable by activating the integrated stress response.

公开(公告)号：US20250060512A1

公开(公告)日：2025-02-20

申请号：US18807318

申请日：2024-08-16

Applicant: McMaster University

Inventor： Wael EL-DAKHAKHNI ,  Maysara GHAITH ,  Ahmed YOSRI

IPC: G01W1/10 ,  G01W1/14 ,  G06N3/0442 ,  G06N3/084

Abstract: In some cases, flood risk quantification computing systems and methods are computationally intensive and in some cases are inaccurate. A flood risk computing system and method are provided that quantifies a flood vulnerability within a specified area of interest, irrespective of flood event characteristics; estimates and maps a flood hazard probability; integrates the flood vulnerability and the flood hazard probability to quantify a flood risk; and develops a rapid flood risk software tool, stored in the memory, to directly quantify flood risk characteristics using deep learning. The rapid flood risk took using a plurality of hierarchical deep neural networks.

公开(公告)号：US20240388063A1

公开(公告)日：2024-11-21

申请号：US18785715

申请日：2024-07-26

Applicant: HUAWEI TECHNOLOGIES CANADA CO., LTD. ,  McMaster University

Inventor： Xun LI ,  Chuanning NIU ,  Sangzhi ZHAO ,  Tan Huy HO

IPC: H01S5/183 ,  G02B5/18 ,  H01S5/062

Abstract: An optical grating comprising a refractive index with a periodic pattern that includes a base period Λ0; a periodic sampling of the base period, with a first period Λ1 and a first duty cycle p1, thereby defining a single-sampled grating (SSG); and a periodic sampling of the SSG, with a second period Λ2 and a second duty cycle p2. The resulting dual-sampled grating (DSG) can have a reflection spectrum containing reflection peaks. If two DSGs having different reflection spectra share a common interface, a tunable optical filter can be produced, where electrical or heating means can cause a reflection peak of one spectrum to be shifted to coincide with a reflection peak of the other spectrum, thereby filtering the corresponding wavelength. By inserting between the two DSGs a gain medium and a phase-tuning medium, a laser source structure is realized. Either device can be produced by etching or stacking methods.

公开(公告)号：US20240383971A1

公开(公告)日：2024-11-21

申请号：US18199248

申请日：2023-05-18

Applicant: McMaster University

Inventor： Manali Mukherjee

IPC: C07K16/18 ,  A61P37/02

Abstract: A method of attenuating the formation of neutrophil extracellular traps (NETs) in a mammal is provided comprising administering to the mammal a therapeutically effective amount of DFS70 autoantibody, a functionally equivalent variant thereof or nucleic acid encoding DFS70 antibody.

公开(公告)号：US20240196887A1

公开(公告)日：2024-06-20

申请号：US18537567

申请日：2023-12-12

Applicant: MCMASTER UNIVERSITY

Inventor： Michael J. Majcher ,  Todd Hoare

IPC: A01N25/26 ,  A01N43/84

CPC classification number: A01N25/26 ,  A01N43/84

Abstract: This specification describes the modification of starch-based nanoparticles (SNPs) by introducing one or more reactive chemical groups onto the surface of SNPs. In some examples, the SNPs are hydrophobic and have a size in the range of 10-50 nm. The SNPs may be adapted for the delivery of agrochemical agents to plants. The SNPs created herein are attractive since they are generated from a sustainable source and are generally regarded as safe (GRAS) in terms of their degradation products once they break down. In some examples, the SNPs are based on SNPs produced by existing industrial-scale production.

公开(公告)号：US11964880B2

公开(公告)日：2024-04-23

申请号：US17305982

申请日：2021-07-19

Applicant: McMaster University

Inventor： Peter Kruse ,  Dipankar Saha ,  Ponnambalam Ravi Selvaganapathy

IPC: C01G39/06 ,  G01N27/30 ,  H01B1/10 ,  H01B13/00

CPC classification number: C01G39/06 ,  G01N27/302 ,  H01B1/10 ,  H01B13/0036 ,  C01P2006/40

Abstract: Methods of manufacturing conductive molybdenum disulfide (MoS2) are described herein. The methods include mixing a molybdenum disulfide powder in a liquid to form a molybdenum disulfide suspension, sonicating the molybdenum disulfide suspension for a first period of time at a first temperature, and retrieving the conductive molybdenum disulfide from the sonicated molybdenum disulfide suspension. Methods of manufacturing conductive forms of other transition metal dichalcogenides are also described. Materials produced by the methods described herein are also described.

公开(公告)号：US20240036061A1

公开(公告)日：2024-02-01

申请号：US18365799

申请日：2023-08-04

Applicant: McMaster University

Inventor： David Alexander Clark ,  Warren George Foster

IPC: G01N33/68 ,  G01N33/563

CPC classification number: G01N33/6893 ,  G01N33/563 ,  G01N2333/705

Abstract: The present invention relates to methods of detecting CD200L in a female subject from a secretory phase biological sample. Increased levels of CD200L have been determined to be associated with endometriosis. CD200L is therefore a useful biomarker for the diagnosis of endometriosis and a useful target for therapeutic intervention.

公开(公告)号：US20230406899A1

公开(公告)日：2023-12-21

申请号：US18211970

申请日：2023-06-20

Applicant: McMaster University

Inventor： Ishac Nazy ,  Donald Arnold ,  John Kelton ,  Angela Huynh ,  Mercy Charity Daka

IPC: C07K14/52 ,  G01N33/68 ,  G01N33/564

CPC classification number: C07K14/522 ,  G01N33/6863 ,  G01N2333/522 ,  G01N2800/226 ,  G01N33/564

Abstract: Described are mutant Platelet Factor 4 (PF4) proteins that exhibit different binding affinities to vaccine induced immune thrombotic thrombocytopenia (VITT) antibodies or non-heparin-induced thrombocytopenia (non-HIT) antibodies relative to heparin-induced thrombocytopenia (HIT) antibodies. Also provided herein are methods for differentiating between VITT, HIT, and/or non-HIT in subjects suspected of having VITT, HIT, or non-HIT.