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公开(公告)号：US20200060724A1
公开(公告)日：2020-02-27
申请号：US16609492
申请日：2018-05-03
Inventor： Waseem ABBOUD
Abstract: A guide device for TMJ arthroscopy including one or more pairs of arms pivotly connected at one end to a working cannula holder and defining a working cannula axis; and at the opposite end to at one or more arms via one or more pivot connections to form with the arm one or more adjustable parallelograms, an end of the arm is connected to an irrigation cannula holder defining an irrigation cannula axis, the irrigation cannula axis intersecting with the working cannula axis at an intersection, intersection and one or more of the pivot connections between connecting the arms are located at opposing vertices of one or more of the adjustable parallelograms.
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公开(公告)号：US10363169B2
公开(公告)日：2019-07-30
申请号：US13669961
申请日：2012-11-06
Applicant: Ramot at Tel-Aviv University Ltd. , Tel Hashomer Medical Research Infrastructure and Services Ltd.
Inventor： Michael Belkin , Mordechai Goldenfeld
Abstract: A system and method are presented for use in delivering electromagnetic radiation to a limbal area of an eye, for example for treatment of glaucoma. The system includes an illumination unit, a beam shaping device and a control unit. The illumination unit includes a first source of electromagnetic radiation configured and operable for producing a beam of electromagnetic radiation having first optical properties to be delivered to the limbal area of a patient's eye to interact therewith and produce a desired effect, and a second source of electromagnetic radiation configured and operable for producing a beam of electromagnetic radiation having second optical properties. The beam shaping device when accommodated in an optical path of said first and second beams defines one or more regions along a path substantially aligned with a limbus of the patient's eye. The control unit is configured and operable for operating the illumination unit in first and second illumination modes, such that in the first illumination mode the second beam propagates towards said beam shaping device and upon identifying that the second beam illuminates the limbus, the second illumination mode is activated in which the first beam is directed via said beam shaping device to pass through said one or more regions along said path to thereby interact with the limbus.
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公开(公告)号：US20190134097A1
公开(公告)日：2019-05-09
申请号：US16203654
申请日：2018-11-29
Inventor： Sarah FERBER
Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic β-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
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公开(公告)号：US10258230B2
公开(公告)日：2019-04-16
申请号：US15031842
申请日：2014-10-30
Inventor： Ygal Rotenstreich
Abstract: In one embodiment, a portable pupillometer including a testing compartment, at least one ocular disposed on the testing compartment, two or more light sources disposed in the testing compartment and forming a plurality of visual stimuli for a subject looking through the at least one ocular, at least one camera configured to capture images of a pupil of the subject via infrared detection, the images indicating pupillary responses to the two or more light sources, and an interface for connection with a computing device external to the pupillometer, the interface adapted to (i) provide, to the computing device, images from the at least one camera, and (ii) receive, from the computing device, control signals for controlling the plurality of light sources.
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公开(公告)号：US20180042965A1
公开(公告)日：2018-02-15
申请号：US15728508
申请日：2017-10-10
Inventor： Benjamin DEKEL , Orit HARARI-STEINBERG
CPC classification number: A61K35/22 , C12N5/0686 , C12N5/0687 , C12N5/0696 , C12N15/85 , C12N2500/90 , C12N2501/06 , C12N2501/065 , C12N2501/415 , C12N2506/25
Abstract: Isolated populations of fetal renal stem cells and progenitor cells are provided. Also provided are methods of generating and using these isolated populations of cells.
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Patent Agency Ranking
公开(公告)号：US20170362657A1
公开(公告)日：2017-12-21
申请号：US15626229
申请日：2017-06-19
Inventor： Anat ACHIRON , Michael GUREVICH
IPC: C12Q1/68
Abstract: Provided are methods and kits for classifying a subject as being more likely to have benign multiple sclerosis (BMS) or as being more likely to have typical relapsing remitting multiple sclerosis (RRMS). Classification of multiple sclerosis disease course is performed by comparing a level of expression of at least one gene involved in the RNA polymerase I pathway in a cell of the subject to a reference expression data of said at least one gene obtained from a cell of at least one subject pre-diagnosed as having BMS and/or from a cell of at least one subject pre-diagnosed as having typical RRMS, thereby classifying the subject as being more likely to have BMS or as being more likely to have typical RRMS. Also provided are methods of diagnosing and treating multiple sclerosis and methods of monitoring treatment efficiency.
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公开(公告)号：US20170335328A1
公开(公告)日：2017-11-23
申请号：US15328602
申请日：2015-07-23
Inventor： Yechezkel SIDI , Dror AVNI , Gali LERMAN
IPC: C12N15/113 , A61K9/00 , A61K41/00
CPC classification number: C12N15/1136 , A61K9/0014 , A61K31/7105 , A61K31/713 , A61K41/0047 , A61P17/00 , A61P17/06 , C12N15/113 , C12N2310/141 , C12N2310/531 , C12N2330/50
Abstract: The present invention relates to methods of treating, preventing, reducing the severity of, reducing the incidence of, delaying the onset of, or reducing pathogenesis of an inflammatory skin disease, condition or lesion in a human subject, which include the step of administering to the subject a therapeutically effective amount of mi RNA compositions. In addition, methods of this invention may be used to treat symptoms of inflammatory skin diseases and reduce and/or inhibit keratinocyte proliferation.
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公开(公告)号：US20170296584A1
公开(公告)日：2017-10-19
申请号：US15517339
申请日：2015-09-24
Inventor： Ilan BANK , Michal BESSER , Victoria MARCU
IPC: A61K35/17 , C12N5/0783
CPC classification number: A61K35/17 , C12N5/0636 , C12N2501/2302 , C12N2501/515 , C12N2501/999
Abstract: The present invention provides methods for expanding populations of T cell. The present invention further provides pharmaceutical compositions comprising the expanded T cells, including, γδ T cells, and use thereof for treating infectious, autoimmune or malignant diseases.
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公开(公告)号：US09777050B2
公开(公告)日：2017-10-03
申请号：US14708014
申请日：2015-05-08
Inventor： Amir Zlotkin , Hen Kestenboim
IPC: C07K14/435 , A61L27/22 , A61L27/34 , A61L29/04 , A61L29/08 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , C02F1/50 , C07K7/06 , C07K7/08 , C07K14/415 , C07K14/46 , C09D5/16 , C02F3/34
CPC classification number: C07K14/43595 , A61L27/227 , A61L27/34 , A61L29/048 , A61L29/085 , A61L29/16 , A61L31/047 , A61L31/10 , A61L31/16 , C02F1/50 , C02F3/34 , C02F2303/20 , C07K7/06 , C07K7/08 , C07K14/415 , C07K14/461 , C09D5/1625
Abstract: Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of YDYNWY (SEQ ID NO: 1), YDYNLY (SEQ ID NO: 2), FDYNFY (SEQ ID NO: 3), FDYNLY (SEQ ID NO: 4), FDYNWY (SEQ ID NO: 5), YDWNLY (SEQ ID NO: 6), YDWHLY (SEQ ID NO: 7), and WDYNLY (SEQ ID NO: 8), extracted from organisms such as aquatic organisms and moss or any other sequence described herein, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.
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公开(公告)号：US09771567B2
公开(公告)日：2017-09-26
申请号：US14394465
申请日：2013-04-16
Inventor： Ido Wolf , Tamar Rubinek
CPC classification number: C12N9/2434 , A61K38/00 , A61K48/005 , C07K14/71 , C12N9/24 , C12Y302/01031
Abstract: Disclosed are Klotho variant proteins in which residue Glu414 and/or residue Asp238 is substituted with an amino acid different than L-Glu or L-Asp, respectively, as well as polynucleotides encoding the variant proteins, and the use thereof in therapy, especially for the treatment of cancers, especially breast cancer and pancreatic cancer.
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