公开(公告)号：US20160193289A1

公开(公告)日：2016-07-07

申请号：US15018991

申请日：2016-02-09

Applicant: Wake Forest University Health Sciences

Inventor： Waldemar Debinski ,  Jill Wykosky ,  Denise Mazess Herpai

IPC: A61K38/17 ,  A61K47/48 ,  A61K38/45 ,  A61K38/20

CPC classification number: A61K38/177 ,  A61K38/00 ,  A61K38/2086 ,  A61K38/45 ,  A61K45/06 ,  A61K47/64 ,  A61K47/642 ,  A61K47/6801 ,  A61K49/0002 ,  C07K14/52 ,  C07K14/705 ,  C12Y204/02036

Abstract: The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.

公开(公告)号：US20160175399A1

公开(公告)日：2016-06-23

申请号：US15045557

申请日：2016-02-17

Applicant: Wake Forest University Health Sciences

Inventor： Waldemar Debinski ,  Hetal Pandya ,  Denise Mazess Herpai

IPC: A61K38/20 ,  A61K38/10 ,  C07K14/54 ,  A61K38/08 ,  C07K7/06 ,  C07K7/08

CPC classification number: A61K38/2086 ,  A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61K47/64 ,  A61K47/6415 ,  C07K7/06 ,  C07K7/08 ,  C07K14/5437 ,  C07K2319/01 ,  C07K2319/55

Abstract: A targeting peptide that specifically binds to an IL13 receptor (e.g., wherein said targeting peptide is not an IL13 fragment) is described. The targeting peptide is optionally conjugated to at least one effector molecule. In some embodiments, the peptide specifically binds to the IL13Rα2 protein.

Abstract translation: 描述了特异性结合IL13受体（例如，其中所述靶向肽不是IL13片段）的靶向肽。 靶向肽任选地缀合至至少一个效应分子。 在一些实施方案中，肽特异性结合IL13Rα2蛋白。

公开(公告)号：US20160144015A1

公开(公告)日：2016-05-26

申请号：US15014665

申请日：2016-02-03

Applicant: Wake Forest University Health Sciences

Inventor： Rajendar K. Deora ,  Meenu Mishra ,  Neelima Sukumar

IPC: A61K39/02

CPC classification number: A61K39/099 ,  A61K2039/505 ,  A61K2039/55505 ,  A61K2039/575 ,  C07K14/235 ,  C07K16/1225 ,  G01N33/56911 ,  G01N2333/235

Abstract: An isolated protein or peptide selected from the group consisting of Bordetella colonization factor A (BcfA) protein and antigenic fragments thereof is described, along with an isolated nucleic acid encoding the same, antibodies that bind to the same, methods of producing an immune response in a mammalian subject in need thereof by administering the proteins, peptides or antibodies, and pharmaceutical compositions comprising the same.

公开(公告)号：US20160039938A1

公开(公告)日：2016-02-11

申请号：US14776356

申请日：2014-03-14

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Waldemar Debinski ,  Denise Mazess Herpai

IPC: C07K16/28 ,  A61K47/48 ,  C12N9/00 ,  A61K49/00

CPC classification number: C07K16/2866 ,  A61K39/3955 ,  A61K47/6813 ,  A61K47/6829 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6911 ,  A61K49/0004 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C12N9/93 ,  C12Y603/01004

Abstract: Provided herein is an antibody (e.g., an isolated antibody) that specifically binds an epitope (e.g., linear epitope) within amino acids spanning the extracellular portion of human IL-13RA2. In some embodiments, the amino acids spanning the extracellular portion of human IL-13RA2 have at least 90% identity with the corresponding canine sequence of IL-13RA2. In some embodiments, the antibody specifically binds both human and canine IL-13RA2. In some embodiments, the antibody is a monoclonal antibody. In some embodiments, the antibody is a recombinant antibody. In some embodiments, the antibody is humanized. In some embodiments, the antibody is the monoclonal antibody produced by hybridoma 1E10B9 or a recombinant form thereof.

Abstract translation: 本文提供了特异性结合跨越人IL-13RA2的细胞外部分的氨基酸内的表位（例如，线性表位）的抗体（例如，分离的抗体）。 在一些实施方案中，跨越人IL-13RA2的细胞外部分的氨基酸与IL-13RA2的相应犬序列具有至少90％的同一性。 在一些实施方案中，抗体特异性结合人和犬IL-13RA2。 在一些实施方案中，抗体是单克隆抗体。 在一些实施方案中，抗体是重组抗体。 在一些实施方案中，抗体是人源化的。 在一些实施方案中，抗体是由杂交瘤1E10B9或其重组形式产生的单克隆抗体。

公开(公告)号：US20160024591A1

公开(公告)日：2016-01-28

申请号：US14775969

申请日：2014-03-14

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES ,  THE JOHNS HOPKINS UNIVERSITY

Inventor： Jianfeng Xu ,  Wennuan Liu ,  William B. Isaacs

IPC: C12Q1/68 ,  G06F19/00

CPC classification number: C12Q1/6886 ,  C12Q2600/156 ,  G06F19/3456

Abstract: The present invention provides a method of identifying a subject as having an increased risk of having or developing aggressive prostate cancer, comprising detecting in the subject the presence of various genetic markers associated with an increased risk of having or developing aggressive prostate cancer.

Abstract translation: 本发明提供了将受试者鉴定为具有增加或发展侵袭性前列腺癌的风险增加的方法，其包括在受试者中检测与具有或发展侵袭性前列腺癌的风险增加相关的各种遗传标记物的存在。

公开(公告)号：US20150367031A1

公开(公告)日：2015-12-24

申请号：US14765734

申请日：2014-04-02

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Louis Argenta ,  Nicole H. Levi ,  Michael Morykwas ,  Elizabeth Walles ,  Maria McGee ,  William D. Wagner ,  Elizabeth Graham

IPC: A61L27/34 ,  A61L27/56 ,  C01B31/02 ,  A61L27/54

CPC classification number: A61L27/34 ,  A61L27/303 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/108 ,  A61L2300/606 ,  A61L2400/12 ,  A61L2420/06 ,  A61L2430/04 ,  A61L2430/34 ,  C01B32/158 ,  C01B2202/06

Abstract: Biomedical implants, regenerative scaffolds, and compositions comprise a substrate with a coating, a scaffold, and/or a carrier composition which include anisotropic nanoparticles in or on the coating, scaffold or carrier, to inhibit fibrosis, scarring, and/or fibrotic contracture, or the formation of adhesions, in a tissue contacting or administered the same. In some embodiments the nanoparticles may be electrically conductive nanoparticles such as multi wall carbon nanotubes.

Abstract translation: 生物医学植入物，再生支架和组合物包含具有包衣，支架和/或载体组合物的底物，其包含涂层，支架或载体中或其上的各向异性纳米颗粒，以抑制纤维化，瘢痕形成和/或纤维化挛缩， 或形成粘连，在与之接触或施用的组织中。 在一些实施方案中，纳米颗粒可以是导电纳米颗粒，例如多壁碳纳米管。

公开(公告)号：US20150283344A1

公开(公告)日：2015-10-08

申请号：US14740783

申请日：2015-06-16

Applicant: Wake Forest University Health Sciences

Inventor： Michael A. Olympio

IPC: A61M16/04 ,  A61B17/32 ,  A61B17/28 ,  A61B1/267

CPC classification number: A61B17/28 ,  A61B17/32 ,  A61M16/0484 ,  A61M16/0493

Abstract: Devices for tracheal tubes include: (a) a mouthpiece sized and configured to allow an endotracheal tube to extend outwardly therefrom; and (b) a handle comprising a cutting member that can attach to the mouthpiece. The mouthpiece can include at least one outwardly projecting substantially rigid short tube defining an open channel. The handle can releasably attach to the short tube.

Abstract translation: 用于气管管的装置包括：（a）口部的尺寸和构造允许气管内管从其向外延伸; 和（b）手柄，其包括能够附接到所述接口管的切割构件。 接口管可以包括限定开放通道的至少一个向外突出的基本上刚性的短管。 手柄可以可释放地附接到短管。

公开(公告)号：US20150258215A1

公开(公告)日：2015-09-17

申请号：US14595540

申请日：2015-01-13

Applicant: Wake Forest University Health Sciences ,  Genethon ,  Children's Medical Center Corporation

Inventor： Martin K. Childers ,  Alan H. Beggs ,  Ana Maria Buj Bello

IPC: A61K48/00

CPC classification number: A61K38/465 ,  A61K48/005 ,  A61K48/0058 ,  C12N7/00 ,  C12N9/16 ,  C12N2750/14143 ,  C12Y301/03 ,  C12Y301/03064

Abstract: The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and prolonging survival in a subject with X-linked myotubular myopathy (XLM™). The present invention provides a method comprising systemic administration of a composition that induces the increased expression of myotubularin in the muscle of a subject. The invention provides sustained regional and global increases in muscle function.

Abstract translation: 本发明提供了治疗肌病的组合物和方法。 在某些实施方案中，本发明提供用X联合肌管肌病（XLM TM）治疗，改善肌肉功能并延长受试者的存活的组合物和方法。 本发明提供了一种包括全身施用组合物的方法，所述组合物诱导肌体蛋白在受试者的肌肉中的增加的表达。 本发明提供持续的区域和全球肌肉功能的增加。

公开(公告)号：US20150257758A1

公开(公告)日：2015-09-17

申请号：US14728398

申请日：2015-06-02

Applicant: Wake Forest University Health Sciences

Inventor： Mohammed Abdul Qadeer

IPC: A61B17/10 ,  A61B17/064 ,  A61B17/068 ,  A61B17/08

CPC classification number: A61B17/10 ,  A61B17/0401 ,  A61B17/0644 ,  A61B17/0682 ,  A61B17/08 ,  A61B2017/00004 ,  A61B2017/00269 ,  A61B2017/00278 ,  A61B2017/00477 ,  A61B2017/00862 ,  A61B2017/00867 ,  A61B2017/0641 ,  A61B2017/0645 ,  A61B2017/081

Abstract: Devices include at least two spaced apart flexible legs formed of a shape memory material, each leg having a respective free end configured to engage local tissue. The devices can also include at least one resilient member having opposing end portions, a respective end portion being attached to each leg at a location away from the free end. The resilient member is configured to take on a stretched configuration inside an endoscope during delivery. Alternatively or additionally, the devices include a cinch that is configured to snugly hold portions of both legs to force the legs closer together.

Abstract translation: 装置包括由形状记忆材料形成的至少两个间隔开的柔性腿，每个腿具有构造成接合局部组织的相应的自由端。 装置还可以包括至少一个具有相对端部的弹性构件，相应的端部在远离自由端的位置处附接到每个腿。 弹性构件被配置成在输送期间在内窥镜内部进行拉伸构造。 或者或另外，装置包括被配置成紧贴地保持两个腿的部分以将腿靠近在一起的系带。

公开(公告)号：US09126006B2

公开(公告)日：2015-09-08

申请号：US13848285

申请日：2013-03-21

Applicant: Wake Forest University Health Sciences

Inventor： Charles L. Branch ,  John P. Eickman

IPC: A61M27/00 ,  A61B5/00 ,  A61M25/01 ,  A61M25/04

CPC classification number: A61M27/00 ,  A61M25/01 ,  A61M25/04

Abstract: A subdural drainage system includes (a) a subdural drainage device having an opening formed therethrough, said subdural drainage device having an upper portion, a body portion, and a lower portion; (b) a housing having an upper portion and lower portion, with said housing connected to said subdural drainage device; said housing movable between (i) a first configuration and (ii) a second configuration; and (c) a stylet positioned inside said housing, said stylet having an upper portion and a lower portion and configured such that said stylet is moved between (i) a withdrawn position with said stylet withdrawn from a portion of said subdural evacuation port device, and (ii) an extended position with said stylet extending through said subdural drainage device such that blockages are disrupted in the subdural drainage device when said housing is moved between said first and second housing configurations; and (d) an external drain opening formed on either said subdural drainage device or said housing.

Abstract translation: 硬膜下引流系统包括（a）具有穿过其中形成的开口的硬膜下引流装置，所述硬膜下引流装置具有上部，主体部分和下部; （b）具有上部和下部的壳体，其中所述壳体连接到所述硬膜下引流装置; 所述外壳可在（i）第一配置和（ii）第二配置之间移动; 和（c）定位在所述壳体内的探针，所述探针具有上部和下部，并且构造成使得所述探针在（i）从所述硬膜下排泄口装置的一部分撤出的所述探针之间的撤回位置之间移动， 以及（ii）延伸位置，其中所述探针延伸穿过所述硬膜下引流装置，使得当所述壳体在所述第一和第二壳体构造之间移动时，所述硬膜下引流装置中的阻塞被破坏; 和（d）形成在所述硬膜下引流装置或所述壳体上的外部排出开口。