公开(公告)号：US12059433B2

公开(公告)日：2024-08-13

申请号：US17077504

申请日：2020-10-22

Applicant: ACADEMIA SINICA

Inventor： Yi-Ping Hsueh ,  Tzyy-Nan Huang

IPC: A61K31/198 ,  A01K67/0276 ,  A01K67/0278 ,  A23K20/142 ,  A23K20/20 ,  A23L33/16 ,  A23L33/175 ,  A61K9/00 ,  A61K9/68 ,  A61K33/30 ,  A61K49/00 ,  A61P25/00 ,  G01N33/68

CPC classification number: A61K33/30 ,  A01K67/0276 ,  A01K67/0278 ,  A23K20/142 ,  A23K20/30 ,  A23L33/16 ,  A23L33/175 ,  A61K9/0056 ,  A61K9/0058 ,  A61K9/0095 ,  A61K31/198 ,  A61K49/0008 ,  A61P25/00 ,  G01N33/6806 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306 ,  A23V2002/00

Abstract: The present invention relates to a method for treating autism spectrum disorders (ASD) or ASD-like symptom, particularly by administering a zinc ion source and/or a serine component e.g. D-serine or its precursor/analogue, optionally in combination with a mixture of branched-chain amino acids (BCAAs). The present invention also relates to a combination, kit or composition for performing the method for treatment as described herein. Further described is use of a zinc ion source and/or a serine component and optional BCAAs for manufacturing a medicament for treating a symptom or disease characteristics associated with ASD or ASD-associated disorder or as a food supplement for ameliorating relevant symptoms in a subject in need thereof. The present invention further provides an animal model for autistic spectrum disorder (ASD) with deficient CTTNBP2 gene, and a method for identifying an ingredient effective in the treatment of ASD by using such animal model.

公开(公告)号：US20240219703A1

公开(公告)日：2024-07-04

申请号：US18608452

申请日：2024-03-18

Applicant: Academia Sinica

Inventor： Jung-Chi LIAO ,  Yi-De CHEN ,  Chih-Wei CHANG ,  Weng Man CHONG

IPC: G02B21/36 ,  G02B21/06 ,  G02B21/26 ,  G06V10/141 ,  G06V10/25 ,  G06V20/69 ,  H04N23/56 ,  H04N23/74

CPC classification number: G02B21/365 ,  G02B21/06 ,  G02B21/26 ,  G06V10/141 ,  G06V10/25 ,  G06V20/693 ,  H04N23/56 ,  H04N23/74

Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.

公开(公告)号：US20240190866A1

公开(公告)日：2024-06-13

申请号：US18282219

申请日：2022-03-11

Applicant: Academia Sinica

Inventor： Wei-Chieh CHENG ,  Wei-An CHEN ,  Yu-Hsin CHEN ,  Ting-Jen CHENG ,  Chia-Ning SHEN ,  Chiao-Yun HSIEH ,  Pi-Fang HUNG

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: Disclosed herein are novel polyhydroxylated indolizidine and pyrrolizidine derivates and methods for using the same in the treatment of cancer. The present polyhydroxylated indolizidine and pyrrolizidine derivates has the structure of formula (I),




wherein: X is O or b and c are independently an integral of 0 or and 1; R is selected from the group consisting of H, C1-6 alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, aralkyl, aralkenyl, aralkynyl, heteroaralkyl, heteroaralkenyl, beteroaralkynyl, heterocyclyl, alkoxy, aryloxy, and sulfonyl.

公开(公告)号：US11974506B2

公开(公告)日：2024-04-30

申请号：US17528366

申请日：2021-11-17

Applicant: NATIONAL TAIWAN UNIVERSITY ,  Academia Sinica

Inventor： Po-Hsun Wu ,  Ssu-Yen Huang ,  Chia-Ling Chien ,  Danru Qu

IPC: H10N52/00 ,  H10N50/85

CPC classification number: H10N52/101 ,  H10N50/85

Abstract: A spin-orbit torque device is disclosed, which includes: a magnetic layer; and a non-magnetic layer adjacent to the magnetic layer and comprising a spin-Hall material, wherein the spin-Hall material comprises NixCu1-x alloy, and x is in a range from 0.4 to 0.8.

公开(公告)号：US20240101602A1

公开(公告)日：2024-03-28

申请号：US18038592

申请日：2021-11-24

Applicant: ACADEMIA SINICA ,  NATIONAL TAIWAN UNIVERSITY

Inventor： Rita P.Y. Chen ,  Chiu-Ping CHENG ,  Chien-Chih YANG ,  Kung-Ta LEE ,  Ying-Lien CHEN ,  Li-Hang Hsu ,  Hsin-Liang CHEN ,  Sung CHEN

IPC: C07K7/06 ,  A01P1/00 ,  A61K45/06 ,  A61P31/00

CPC classification number: C07K7/06 ,  A01P1/00 ,  A61K45/06 ,  A61P31/00

Abstract: Provided is a peptide and method in preventing or treating infections caused by a wide spectrum of pathogens, including bacteria and fungus in hosts such as plants and animals. Methods of preventing or treating plant diseases and infection in animals are also provided.

公开(公告)号：US20240043944A1

公开(公告)日：2024-02-08

申请号：US18268842

申请日：2021-12-20

Applicant: Chiaho SHIH ,  Chun-Che LIAO ,  Chih-Shin CHANG ,  ACADEMIA SINICA

Inventor： Chiaho SHIH ,  Chun-Che LIAO ,  Chih-Shin CHANG

IPC: C12Q1/70

CPC classification number: C12Q1/701 ,  C12Q2600/156

Abstract: A method of detecting severe disease-associated mutations in an enterovirus 71 (EV-A71), comprising: performing an assay on a test sample containing an EV-A71 genomic RNA, a fragment thereof or an amplicon thereof, or an EV-A71 VP1 protein or fragment thereof to detect one or more severe disease-associated mutations in the EV-A71 genomic RNA, the fragment thereof or the amplicon thereof, or the EV-A71 protein or fragment thereof, wherein the one or more mutations are selected from mutations at positions corresponding to 5′ UTR nucleotide positions C580, A707, and C709 in an EV-A71 5′ UTR nucleic acid sequence and at residues corresponding to A280 and E145 in an EV-A71 VP1 protein sequence.

公开(公告)号：US20240010669A1

公开(公告)日：2024-01-11

申请号：US18227782

申请日：2023-07-28

Applicant: Academia Sinica

Inventor： Chih-Cheng CHEN ,  Jim-Min FANG ,  Cheng-Han LEE ,  Jen-Yao CHANG

IPC: C07H19/16 ,  A61K47/55 ,  A61P29/00 ,  A61K31/7076 ,  A61K38/04

CPC classification number: C07H19/16 ,  A61K47/55 ,  A61P29/00 ,  A61K31/7076 ,  A61K38/046

Abstract: Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N6-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5′-glycylcarbonyl-N6-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5′-deoxy-5′-(N′-glycylureido)-N6-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.

公开(公告)号：US11866489B2

公开(公告)日：2024-01-09

申请号：US17342514

申请日：2021-06-08

Applicant: Academia Sinica

Inventor： Ruey-Bing Yang ,  Yuh-Charn Lin

IPC: C07K16/22 ,  A61K39/395 ,  C07K16/18 ,  A61P35/00 ,  A61K39/00

CPC classification number: C07K16/22 ,  A61K39/395 ,  A61P35/00 ,  C07K16/18 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/76

Abstract: An isolated anti-SCUBE2 antibody or a binding fragment thereof is disclosed. The anti-SCUBE2 antibody comprises an antigen binding region that specifically binds to a target domain located within SCUBE2 (SEQ ID NO: 66) and exhibits a property of inhibiting VEGF-induced angiogenesis. The target domain is selected from the group consisting of the EGF-like motifs 4 to 6 ranging from a.a. position 175 to 323, or the spacer region ranging from a.a. position 441 to 659, or the first cys-rich motif ranging from a.a. position 668 to 725 of SCUBE2 (SEQ ID NO: 66). The anti-SCUBE2 antibody or binding fragment thereof is for use in treating a disease associated with VEGF-induced angiogenesis, or for use in treating a tumor or inhibiting tumor angiogenesis and cancer cell growth in a subject in need thereof.

公开(公告)号：US11859237B2

公开(公告)日：2024-01-02

申请号：US16677767

申请日：2019-11-08

Applicant: Academia Sinica

Inventor： Chia-Fu Chou ,  Jia-Wei Yeh ,  Yii-Lih Lin

IPC: C12Q1/68 ,  B01L3/00 ,  G01N15/14 ,  G01N33/487 ,  G01N15/10 ,  G01N27/327

CPC classification number: C12Q1/68 ,  B01L3/50273 ,  G01N15/1404 ,  G01N33/487 ,  B01L2300/041 ,  B01L2300/047 ,  B01L2300/06 ,  B01L2400/0406 ,  G01N27/3272 ,  G01N2015/1006 ,  G01N2015/1493

Abstract: A method for sizing a DNA molecule is disclosed, which comprises the following steps of: providing a DNA sizing device, comprising: a cover substrate; a substrate disposed on the cover substrate and comprising a first hole and a second hole; and a first slit-like channel disposed between the cover substrate and the substrate, wherein two ends of the first slit-like channel respectively connects to the first hole and the second hole; loading a sample comprising a DNA molecule to the first slit-like channel through the first hole, wherein the DNA molecule moves in a direction from the first hole to the second hole; detecting and recording an intensity and an area of a distribution of the DNA molecule; and analyzing the intensity and the area to obtain the size of a DNA molecule.

公开(公告)号：US20230409951A1

公开(公告)日：2023-12-21

申请号：US18250648

申请日：2021-11-23

Applicant: Northeastern University ,  Academia Sinica ,  Temple University-Of The Commonwealth System Of Higher Education

Inventor： Jeng-Yuan Tsai ,  Jinbo Pan ,  Hsin Lin ,  Arun Bansil ,  Qimin Yan

IPC: G06N10/40 ,  G06N10/20 ,  H01L29/66

CPC classification number: G06N10/40 ,  G06N10/20 ,  H01L29/66977 ,  H01L29/66984

Abstract: Anion antisite defects in monolayer Transition Metal Dichalcogenide (TMD) systems are here identified as two-dimen-sional solid-state defect qubits. The proposed antisites in these TMDs host paramagnetic triplet ground states with flexible level splitting. A viable transition loop between the triplet and singlet defect states is demonstrated, including optical excitations/relaxations and nonradiative decay paths for the antisites as qubits. A complete set of qubit operational processes, including initialization, manipulation, and readout, is delineated.