公开(公告)号：US20240344025A1

公开(公告)日：2024-10-17

申请号：US18294854

申请日：2022-09-21

Applicant: The Regents of the University of California

Inventor： Wendell A. LIM ,  Nishith REDDY ,  Milos SIMIC

IPC: C12N5/0783 ,  A61K35/17 ,  A61P37/06 ,  C07K14/54 ,  C07K14/55 ,  C07K14/705 ,  C07K16/24

CPC classification number: C12N5/0636 ,  A61K35/17 ,  A61P37/06 ,  C07K14/5428 ,  C07K14/55 ,  C07K14/70596 ,  C07K16/24 ,  C12N2510/00

Abstract: Provided herein is a synthetic immuno-suppressive cell that contains comprises a molecular circuit comprising the following components: (a) a binding-triggered transcriptional switch (BTTS); and one or both of: (b) a nucleic acid encoding a pro-inflammatory cytokine sink, (c) a nucleic acid encoding an anti-inflammatory cytokine, (d) a nucleic acid encoding an immune inhibitory receptor, or ligand thereof, and (c) a nucleic acid encoding an ectonucleotidase. In this circuit, binding of the BTTS to a marker on the surface of a target cell activates expression of one or any combination of (b)-(c) by the synthetic immuno-suppressive cell.

公开(公告)号：US20240344007A1

公开(公告)日：2024-10-17

申请号：US18294270

申请日：2022-08-05

Applicant: The Regents of the University of California

Inventor： Alexander Groisman

IPC: C12M1/12 ,  C12M1/32

CPC classification number: C12M25/02 ,  C12M23/12

Abstract: Compositions and methods are described herein that are useful for microbial culture of “uncultivable” microorganisms. The disclosure specifically ad-dresses the issues pertaining to efficient extraction of the cultivated microorganisms from growth chambers. The compositions and methods described herein are particularly useful for liquid medium but are also useful for solid media such as hydrogels or any such comparable media. In addition, the disclosure relates to, among other things, preventing cross-contamination and contamination from environmental microorganisms, especially during incubation in various natural and man-made environments and during extraction from growth chambers. Since these uncultivatable microorganisms are not initially cultured in synthetic laboratory medium, more care may be necessary to maintain sterility, and prevent the cross-contamination with environmental microorganisms.

公开(公告)号：US20240342678A1

公开(公告)日：2024-10-17

申请号：US18620775

申请日：2024-03-28

Applicant: Celldom, Inc. ,  The Regents of the University of California

Inventor： Natalia Tkachenko ,  Eugene Tkachenko ,  Alexander Groisman ,  Edgar Gutierrez

IPC: B01J19/00 ,  B01L3/00 ,  C12N15/10 ,  C12Q1/02 ,  C40B40/06 ,  G01N33/50 ,  G01N33/543

CPC classification number: B01J19/0046 ,  B01L3/5085 ,  C12N15/1013 ,  C12Q1/02 ,  C40B40/06 ,  G01N33/5005 ,  G01N33/54366 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00648 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0858

Abstract: The present invention provides methods, systems and kits for performing microwell analysis in sealed small volumes. The microwells of the invention are sealed through the pairing of microwell and bead geometry wherein the diameter of the beads is greater than the diameter of the bottom of the microwells. Loading the beads into the microwells seals samples within an analytical space between the bottom of a nested bead and the bottom of the subject microwell.

公开(公告)号：US20240342649A1

公开(公告)日：2024-10-17

申请号：US18574587

申请日：2022-06-28

Applicant: The Regents of the University of California

Inventor： Erika Callagon La Plante ,  Gaurav Sant ,  Xin Chen ,  David Jassby ,  Dante Simonetti ,  Yenwen Tseng ,  Thomas Traynor

IPC: B01D53/62 ,  B01D53/14 ,  B01D53/96 ,  C25B1/18 ,  C25B11/03 ,  C25B11/052 ,  C25B11/063 ,  C25B11/081

CPC classification number: B01D53/62 ,  B01D53/1425 ,  B01D53/1475 ,  B01D53/965 ,  C25B1/18 ,  C25B11/03 ,  C25B11/052 ,  C25B11/063 ,  C25B11/081 ,  B01D2251/304 ,  B01D2251/402 ,  B01D2251/404 ,  B01D2252/1035 ,  B01D2252/20421 ,  B01D2257/504

Abstract: Disclosed herein are methods of capturing CO2 from a gas source using electrochemically-enhanced amine capture to form a concentrated CO2 vapor, followed by sequestering CO2 from the concentrated vapor in a sequestration step. The sequestration step includes contacting the concentrated vapor with an aqueous sequestration solution comprising ions capable of forming an insoluble carbonate salt, such that the aqueous sequestration solution comprises the CO2, electrochemically basifying the sequestration solution, thereby precipitating a carbonate solid, separating the carbonate solids from the aqueous sequestration solution or the surface of the mesh.

公开(公告)号：US12118719B2

公开(公告)日：2024-10-15

申请号：US17639511

申请日：2020-09-03

Applicant: The Regents of the University of California

Inventor： Hyun Kim ,  Yu Shi ,  Jonathan Gerald Goldin ,  Weng Kee Wong

IPC: G06T7/00 ,  A61B5/00 ,  A61B6/00 ,  A61B6/03 ,  G06V10/25 ,  G06V10/77

CPC classification number: G06T7/0012 ,  A61B5/0037 ,  A61B5/7267 ,  A61B5/7275 ,  A61B6/032 ,  A61B6/5217 ,  G06V10/25 ,  G06V10/7715 ,  G06T2207/10081 ,  G06T2207/30101 ,  G06V2201/03 ,  G06V2201/07

Abstract: A method for training a machine learning algorithm that classifies predictive regions-of interest (“ROI”) of progression of idiopathic pulmonary fibrosis. The method includes acquiring a set of computed tomography (CT) images of a plurality of patients and selecting a plurality of ROIs within the set of images. Each of the ROIs designates a label that indicates progression of pulmonary fibrosis and training a machine learning algorithm by inputting the plurality of ROIs and the associated labels into the algorithm. The algorithm identifies the ROIs in the set of images as indicating regions of pulmonary fibrosis within the set of images based on the features.

公开(公告)号：US12118033B2

公开(公告)日：2024-10-15

申请号：US17281883

申请日：2019-09-18

Applicant: The Regents of the University of California

Inventor： Rima Arnaout

IPC: G06F18/21 ,  A61B8/08 ,  G06F16/583 ,  G06F18/2431 ,  G06T7/00 ,  G06T7/13 ,  G06V10/44 ,  G06V10/764

CPC classification number: G06F16/583 ,  G06F18/217 ,  G06F18/2431 ,  G06T7/0012 ,  G06T7/13 ,  G06V10/449 ,  G06V10/764 ,  G06T2207/10016 ,  G06T2207/20132

Abstract: Systems and methods for medical image diagnoses in accordance with embodiments of the invention are illustrated. One embodiment includes a method for evaluating multimedia content. The method includes steps for receiving multimedia content and identifying a set of one or more image frames for each of several target views from the received multimedia content. For each target view, the method includes steps for evaluating the corresponding set of image frames to generate an intermediate result. The method includes steps for determining a composite result based on the intermediate results for each of the several target views.

公开(公告)号：US20240339216A1

公开(公告)日：2024-10-10

申请号：US18579487

申请日：2022-07-14

Applicant: The Regents of the University of California

Inventor： Gregory Poore

IPC: G16H50/20 ,  C12Q1/6806 ,  C12Q1/6886 ,  C12Q1/6895 ,  G16B30/10 ,  G16H50/70

CPC classification number: G16H50/20 ,  C12Q1/6806 ,  C12Q1/6886 ,  C12Q1/6895 ,  G16B30/10 ,  G16H50/70 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Methods and systems are presented herein for predicting cancer of a subject through a combination of fungal and non-fungal features of a biological sample. Some embodiments, describe a method of predicting cancer of a subject from a combined fungal and non-fungal microbial presence of a biological sample by: detecting a fungal presence and a non-fungal microbial presence in a sample, removing contaminating fungal features of the fungal presence and contaminating non-fungal microbial features of the non-fungal microbial presence, and predicting a cancer of the subject by correlating the combined decontaminated fungal presence and the decontaminated non-fungal microbial presence to a known combined fungal presence and non-fungal microbial presence for one or more cancers.

公开(公告)号：US20240337824A1

公开(公告)日：2024-10-10

申请号：US18629189

申请日：2024-04-08

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Neerja Aggarwal ,  Laura Waller ,  Yashovardhan Raniwala ,  Eric Markley ,  Kristina Monakhova

IPC: G02B21/36 ,  G02B27/09 ,  G06T15/00 ,  H04N23/55

CPC classification number: G02B21/365 ,  G02B27/0938 ,  G06T15/00 ,  H04N23/55

Abstract: A snapshot hyperspectral imaging camera assembly and processing methods are provided that has a higher achievable resolution than a traditional snapshot imager. The camera assembly is compact and can be attached to the output port of any traditional benchtop microscope. This camera assembly has a relay lens that relays the Fourier plane from the microscope onto a phase mask that encodes the spatial information of the target, and a spectral filter array that encodes the spectral information of the target. Measurements are processed with a compressed sensing algorithm and an optimization algorithm to reconstruct a 3D hypercube from 2D intensity measurements.

公开(公告)号：US20240336935A1

公开(公告)日：2024-10-10

申请号：US18754883

申请日：2024-06-26

Applicant: The Regents of the University of California ,  The Board of Trustees of the Leland Stanford Junior University

Inventor： Donald B. KOHN ,  Maria Grazia RONCAROLO ,  Roger Paul HOLLIS ,  Katelyn E. MASIUK ,  Rosa BACCHETTA

IPC: C12N15/86 ,  C12N5/0789

CPC classification number: C12N15/86 ,  C12N5/0647 ,  C12N2501/60 ,  C12N2740/16043

Abstract: In various embodiments, lentiviral vectors expressing FoxP3 using the endogenous gene elements to regulate physiologic gene expression of FoxP3 are provided herein as well as uses of such vectors.

公开(公告)号：US20240336657A1

公开(公告)日：2024-10-10

申请号：US18287637

申请日：2022-04-26

Applicant: The Regents of the University of California ,  The University of Tokyo

Inventor： Kevan M. Shokat ,  Qi Hu ,  Shizhong Dai ,  Hiroaki Suga ,  Rong Gao ,  Hayden Peacock

IPC: C07K7/56 ,  A61K38/00 ,  C07K7/64

CPC classification number: C07K7/56 ,  C07K7/64 ,  A61K38/00

Abstract: Described herein, inter alia, are Gas peptide inhibitors and uses thereof.