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公开(公告)号：US10228554B2
公开(公告)日：2019-03-12
申请号：US15257289
申请日：2016-09-06
Inventor： Laura Waller , Jingshan Zhong , Lei Tian , Justin Dauwels
Abstract: A system and method for incorporating partially coherent illumination models into the problem of phase and amplitude retrieval from a stack of intensity images. The recovery of phase could be realized by many methods, including Kalman filters or other nonlinear optimization algorithms that provide least squares error between the measurement and estimation.
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公开(公告)号：US10935776B2
公开(公告)日：2021-03-02
申请号：US16255557
申请日：2019-01-23
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Laura Waller , Hillel Adesnik , Nicolas C. Pégard
IPC: G02B21/06
Abstract: Apparatus and methods for 3D-Scanless Holographic Optogenetics with Temporal focusing (3D-SHOT), which allows precise, simultaneous photo-activation of arbitrary sets of neurons anywhere within the addressable volume of the microscope. Soma-targeted (ST) optogenetic tools, ST-ChroME and IRES-ST-eGtACR 1, optimized for multiphoton activation and suppression are also provided. The methods use point-cloud holography to place multiple copies of a temporally focused disc matching the dimensions of a designated neuron's cell body. Experiments in cultured cells, brain slices, and in living mice demonstrate single-neuron spatial resolution even when optically targeting randomly distributed groups of neurons in 3D.
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公开(公告)号：US20170003491A1
公开(公告)日：2017-01-05
申请号：US15199703
申请日：2016-06-30
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Laura Waller , Hillel Adesnik , Nicolas Pegard
CPC classification number: G02B21/367 , A61B5/0042 , A61B5/0071 , A61B5/4064 , A61B5/7246 , A61B5/743 , A61B2560/0223 , G02B3/0056 , G02B21/16 , G02B21/361 , G02B27/0075 , G06T7/0016 , G06T2207/10016 , G06T2207/10052 , G06T2207/10056 , G06T2207/30016
Abstract: A system and method for quantitative functional neuroimaging through thick brain tissue in live animals. A computational imaging method is disclosed that uses plenoptic image acquisition including a first initialization step that identifies individual neurons by their optical signature and provides a reliable estimate of their position in space and a second stimulation-based image processing step that used acquired calibration data to quickly quantify activity in each identified neuron at video frame-rate.
Abstract translation: 一种通过活体动物厚厚脑组织进行定量功能性神经成像的系统和方法。 公开了一种计算成像方法，其使用全光图像获取，其包括第一初始化步骤，其通过其光学特征识别各个神经元，并提供其在空间中的位置的可靠估计，以及基于第二刺激的图像处理步骤，其使用所获取的校准数据来快速 以视频帧率量化每个确定的神经元中的活动。
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公开(公告)号：US10317667B2
公开(公告)日：2019-06-11
申请号：US15199703
申请日：2016-06-30
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Laura Waller , Hillel Adesnik , Nicolas Pegard
Abstract: A system and method for quantitative functional neuroimaging through thick brain tissue in live animals. A computational imaging method is disclosed that uses plenoptic image acquisition including a first initialization step that identifies individual neurons by their optical signature and provides a reliable estimate of their position in space and a second stimulation-based image processing step that used acquired calibration data to quickly quantify activity in each identified neuron at video frame-rate.
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公开(公告)号：US20170059845A1
公开(公告)日：2017-03-02
申请号：US15257289
申请日：2016-09-06
Inventor： Laura Waller , Jingshan Zhong , Lei Tian , Justin Dauwels
CPC classification number: G02B21/367 , G02B21/14 , G02B27/0012 , G02B27/52 , G06T5/10 , G06T2207/10056 , G06T2207/20024
Abstract: A system and method for incorporating partially coherent illumination models into the problem of phase and amplitude retrieval from a stack of intensity images. The recovery of phase could be realized by many methods, including Kalman filters or other nonlinear optimization algorithms that provide least squares error between the measurement and estimation.
Abstract translation: 一种用于将部分相干照明模型并入从强度图像堆中的相位和幅度检索问题的系统和方法。 相位的恢复可以通过许多方法实现，包括在测量和估计之间提供最小平方误差的卡尔曼滤波器或其他非线性优化算法。
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Patent Agency Ranking
公开(公告)号：US20240337824A1
公开(公告)日：2024-10-10
申请号：US18629189
申请日：2024-04-08
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Neerja Aggarwal , Laura Waller , Yashovardhan Raniwala , Eric Markley , Kristina Monakhova
CPC classification number: G02B21/365 , G02B27/0938 , G06T15/00 , H04N23/55
Abstract: A snapshot hyperspectral imaging camera assembly and processing methods are provided that has a higher achievable resolution than a traditional snapshot imager. The camera assembly is compact and can be attached to the output port of any traditional benchtop microscope. This camera assembly has a relay lens that relays the Fourier plane from the microscope onto a phase mask that encodes the spatial information of the target, and a spectral filter array that encodes the spectral information of the target. Measurements are processed with a compressed sensing algorithm and an optimization algorithm to reconstruct a 3D hypercube from 2D intensity measurements.
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公开(公告)号：US11592654B2
公开(公告)日：2023-02-28
申请号：US17153421
申请日：2021-01-20
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Laura Waller , Hillel Adesnik , Nicolas C. Pégard
IPC: G02B21/06
Abstract: Apparatus and methods for 3D-Scanless Holographic Optogenetics with Temporal focusing (3D-SHOT), which allows precise, simultaneous photo-activation of arbitrary sets of neurons anywhere within the addressable volume of the microscope. Soma-targeted (ST) optogenetic tools, ST-ChroME and IRES-ST-eGtACR1, optimized for multiphoton activation and suppression are also provided. The methods use point-cloud holography to place multiple copies of a temporally focused disc matching the dimensions of a designated neuron's cell body. Experiments in cultured cells, brain slices, and in living mice demonstrate single-neuron spatial resolution even when optically targeting randomly distributed groups of neurons in 3D.
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公开(公告)号：US20190227490A1
公开(公告)日：2019-07-25
申请号：US16255557
申请日：2019-01-23
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Laura Waller , Hillel Adesnik , Nicolas C. Pégard
Abstract: Apparatus and methods for 3D-Scanless Holographic Optogenetics with Temporal focusing (3D-SHOT), which allows precise, simultaneous photo-activation of arbitrary sets of neurons anywhere within the addressable volume of the microscope. Soma-targeted (ST) optogenetic tools, ST-ChroME and IRES-ST-eGtACR 1, optimized for multiphoton activation and suppression are also provided. The methods use point-cloud holography to place multiple copies of a temporally focused disc matching the dimensions of a designated neuron's cell body. Experiments in cultured cells, brain slices, and in living mice demonstrate single-neuron spatial resolution even when optically targeting randomly distributed groups of neurons in 3D.
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公开(公告)号：US20170146788A1
公开(公告)日：2017-05-25
申请号：US15354273
申请日：2016-11-17
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Laura Waller , Lei Tian
CPC classification number: G02B21/367 , G02B21/125 , G02B21/14 , G02B27/58 , G06T5/50 , G06T7/11 , G06T19/20 , G06T2207/10056 , G06T2207/10152 , G06T2207/20221 , H04N5/2256
Abstract: A system and methods for wide field of view, high resolution Fourier ptychographic microscopic imaging with a programmable LED array light source. The individual lights in the LED array can be actuated according to random, non-random and hybrid random and non-random illumination strategies to produce high resolution images with fast acquisition speeds. The methods greatly reduce the acquisition time and number of images captured compared to conventional sequential scans. The methods also provide for fast, wide field 3D imaging of thick biological samples.
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公开(公告)号：US20210239956A1
公开(公告)日：2021-08-05
申请号：US17153421
申请日：2021-01-20
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Laura Waller , Hillel Adesnik , Nicolas C. Pégard
IPC: G02B21/06
Abstract: Apparatus and methods for 3D-Scanless Holographic Optogenetics with Temporal focusing (3D-SHOT), which allows precise, simultaneous photo-activation of arbitrary sets of neurons anywhere within the addressable volume of the microscope. Soma-targeted (ST) optogenetic tools, ST-ChroME and IRES-ST-eGtACR1, optimized for multiphoton activation and suppression are also provided. The methods use point-cloud holography to place multiple copies of a temporally focused disc matching the dimensions of a designated neuron's cell body. Experiments in cultured cells, brain slices, and in living mice demonstrate single-neuron spatial resolution even when optically targeting randomly distributed groups of neurons in 3D.
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