公开(公告)号：US20140057841A1

公开(公告)日：2014-02-27

申请号：US14005538

申请日：2012-03-19

申请人： Kai Fan ,  Yu Cao ,  Yong Chen ,  Hongliang Li ,  Hairong Chen ,  Ying Wan

发明人： Kai Fan ,  Yu Cao ,  Yong Chen ,  Hongliang Li ,  Hairong Chen ,  Ying Wan

IPC分类号： C07K14/62

CPC分类号： C07K14/62 ,  A61K38/28 ,  A61K47/60

摘要： Disclosed is a recombinant human insulin or analog conjugate thereof. Said conjugate is formed by connecting the ε-amino group of lysine 29 of the B chain to activated polyethylene glycol by means of an amide bond. Further disclosed is a method of preparing said conjugate, a pharmaceutical compound, and a use for said conjugate in preparing medication for treating Type 1 and Type 2 diabetes.

摘要翻译： 公开了一种重组人胰岛素或其类似物缀合物。 通过将B链的赖氨酸29的ε-氨基通过酰胺键连接到活化的聚乙二醇而形成所述缀合物。 进一步公开的是制备所述缀合物，药物化合物的方法，以及用于制备用于治疗1型和2型糖尿病的药物的所述缀合物的用途。

公开(公告)号：US08655106B2

公开(公告)日：2014-02-18

申请号：US13279769

申请日：2011-10-24

申请人： Nathan Pieter Den Herder ,  Megan C. Berry ,  Yong Chen ,  Eric Rosenblatt ,  Alford Paul Williams

发明人： Nathan Pieter Den Herder ,  Megan C. Berry ,  Yong Chen ,  Eric Rosenblatt ,  Alford Paul Williams

IPC分类号： G06K9/36

CPC分类号： G06Q50/16 ,  G06Q30/0205 ,  G06Q30/0206 ,  G06Q30/0278

摘要： Automated valuation model with customizable neighborhood determination. A map image is displayed corresponding to a geographical area, and then user input accommodates definition of a particularly defined geographic area to provide custom identification of a neighborhood to be subject to automated valuation. Once the defined geographic area is established, the automated valuation model is applied to property data corresponding to properties within the defined geographic area. A subject property and corresponding properties within the defined geographic area are then displayed on a map image, preferably with articulation of the defined geographic area as the neighborhood of interest. The neighborhood may be defined by, among other criteria, inclusion within a user-defined shape, as well as exclusion of a user-defined shape from a displayed geographic area.

摘要翻译： 自动估价模型，具有可自定义的邻域确定。 显示对应于地理区域的地图图像，然后用户输入容纳特定定义的地理区域的定义，以提供要进行自动估价的邻域的定制标识。 一旦定义的地理区域被建立，自动化估价模型被应用于对应于定义的地理区域内的属性的属性数据。 然后将定义的地理区域内的主题属性和对应的属性显示在地图图像上，优选地将所定义的地理区域作为感兴趣的邻域。 除了其他标准之外，可以将邻域定义为用户定义的形状，以及从显示的地理区域排除用户定义的形状。

公开(公告)号：US08609228B2

公开(公告)日：2013-12-17

申请号：US12757091

申请日：2010-04-09

申请人： Yong Chen ,  Hongyu Chen ,  Xiao Bing Yun ,  Jing Li ,  Morgan M. Hughes ,  Rajen M. Patel

发明人： Yong Chen ,  Hongyu Chen ,  Xiao Bing Yun ,  Jing Li ,  Morgan M. Hughes ,  Rajen M. Patel

IPC分类号： B32B7/02

CPC分类号： B32B27/32 ,  B32B7/02 ,  B32B27/327 ,  B32B2250/03 ,  B32B2250/04 ,  B32B2250/05 ,  B32B2250/242 ,  B32B2307/31 ,  B32B2307/518 ,  B32B2439/70 ,  B32B2553/00 ,  Y10T428/24942 ,  Y10T428/265 ,  Y10T428/266 ,  Y10T428/2817 ,  Y10T428/31917 ,  Y10T428/31924 ,  Y10T428/31938

摘要： A multilayer biaxially oriented polypropylene film is disclosed which comprises at least three layers. The first layer is an outer layer comprising a first polymer which is a homopolymer polypropylene resin having a melting point of at least 155° C. The second layer is a core layer, having a melting point greater than 150° C. The core layer includes a blend comprising a second polymer which is a polypropylene homopolymer having a melting point of at least 155° C. and a third polymer having a melting point no greater than 145° C. The second polymer comprises from 20% to 80% by weight of the core layer while the third polymer comprises from 80% to 20% by weight of the core layer. The last required layer in the film is a sealant layer. The sealant layer comprises a fourth polymer having a melting point no greater than 145° C.

摘要翻译： 公开了一种包括至少三层的多层双轴取向聚丙烯薄膜。 第一层是包含第一聚合物的外层，第一聚合物是熔点至少为155℃的均聚聚丙烯树脂。第二层是熔点大于150℃的芯层。芯层包括 共混物，其包含第二聚合物，其是熔点为至少155℃的聚丙烯均聚物和熔点不大于145℃的第三聚合物。第二聚合物包含20重量％至80重量％ 核心层，而第三聚合物占芯层重量的80％至20％。 膜中最后需要的层是密封剂层。 密封层包括熔点不大于145℃的第四聚合物

公开(公告)号：US20130298406A1

公开(公告)日：2013-11-14

申请号：US13469381

申请日：2012-05-11

申请人： Yong Chen ,  Kenneth Davidov

发明人： Yong Chen ,  Kenneth Davidov

IPC分类号： B26B21/40

CPC分类号： B26B21/405 ,  B26B21/4081 ,  B26B21/46

摘要： A razor for shaving hairs has an ionizing device that produces ions during a shaving operation of the razor powered by a single battery. The battery can be a 1.5 Volt button battery to provide power to an ion generator that boost the voltage to about 9 Volts.

摘要翻译： 用于剃须毛发的剃刀具有在由单个电池供电的剃刀的剃刮操作期间产生离子的电离装置。 电池可以是一个1.5伏特的电池，为离子发生器提供电源，将电压提升到约9伏特。

公开(公告)号：US20130292003A1

公开(公告)日：2013-11-07

申请号：US13927555

申请日：2013-06-26

申请人： Michael M. Sawalski ,  Michael J. Skalitzki ,  Nitin Sharma ,  Padma Prabodh Varanasi ,  Yong Chen ,  Allen D. Miller

发明人： Michael M. Sawalski ,  Michael J. Skalitzki ,  Nitin Sharma ,  Padma Prabodh Varanasi ,  Yong Chen ,  Allen D. Miller

IPC分类号： B67D7/00

CPC分类号： B67D7/00 ,  B05B1/14 ,  B05B1/3421 ,  B05B3/0486 ,  E03D9/005 ,  E03D9/032

摘要： A multiple nozzle differential fluid delivery head is disclosed. The fluid delivery head includes a body that defines a fluid chamber having a longitudinal axis. The body includes an inlet for connection to a fluid source, and the inlet is in fluid communication with the fluid chamber. The fluid delivery head includes a plurality of outlet ports connected to and extending away from the body. Each outlet port has an interior space in fluid communication with the fluid chamber. The fluid delivery head includes a nozzle insert removably secured in an outer end of each outlet port. At least one nozzle insert has a fluid delivery aperture in fluid communication with the interior space of its associated outlet port for delivering fluid out of the interior space of its associated outlet port. One or more of the outlet ports is angled away from a plane normal to the axis of the fluid delivery head.

摘要翻译： 公开了一种多喷嘴差动流体输送头。 流体输送头包括限定具有纵向轴线的流体室的主体。 主体包括用于连接到流体源的入口，并且入口与流体室流体连通。 流体输送头包括连接到主体并远离主体的多个出口。 每个出口端口具有与流体室流体连通的内部空间。 流体输送头包括可移除地固定在每个出口的外端的喷嘴插件。 至少一个喷嘴插件具有与其相关联的出口端口的内部空间流体连通的流体输送孔，用于将流体输送出其相关联的出口端口的内部空间。 一个或多个出口端口与垂直于流体输送头的轴线的平面倾斜。

公开(公告)号：US08562795B2

公开(公告)日：2013-10-22

申请号：US12249947

申请日：2008-10-12

申请人： Yong Chen

发明人： Yong Chen

IPC分类号： C25D5/02 ,  C25D17/12 ,  B23H3/04 ,  B23H3/06

CPC分类号： B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  G03F7/0002 ,  G03G13/28 ,  G03G13/283 ,  G03G13/286

摘要： A nanoscale lithographic method in which a reusable conductive mask, having a pattern of conductive surfaces and insulating surfaces, is positioned upon a substrate whose surface contains an electrically responsive resist layer over a buried conductive layer. When an electric field is applied between the conductive mask and buried conductive layer, the resist layer is altered in portions adjacent the conductive areas of the mask. Selective processing is performed on the surface of the substrate, after mask removal, to remove portions of the resist layer according to the pattern transferred from the mask. The substrate may be a target substrate, or the substrate may be utilized for a lithographic masking step of another substrate. In one aspect of the invention the electrodes to which the charge is applied are divided, such as into a plurality of rows and columns wherein any desired pattern may be created without the need to fabricate specific masks.

摘要翻译： 一种纳米级光刻方法，其中具有导电表面和绝缘表面图案的可重复使用的导电掩模位于其表面在掩埋导电层上包含电响应抗蚀剂层的基底上。 当在导电掩模和掩埋导电层之间施加电场时，抗蚀剂层在与掩模的导电区域相邻的部分中改变。 在掩模移除之后，在基板的表面上进行选择性处理，以根据从掩模转印的图案去除部分抗蚀剂层。 衬底可以是目标衬底，或者衬底可以用于另一衬底的光刻掩模步骤。 在本发明的一个方面，施加电荷的电极被划分成多个行和列，其中可以创建任何期望的图案，而不需要制造特定的掩模。

公开(公告)号：US08502956B2

公开(公告)日：2013-08-06

申请号：US13105110

申请日：2011-05-11

申请人： Jian Guo ,  Weifeng Zhou ,  Xing Ming ,  Yong Chen ,  Guanghui Xiao

发明人： Jian Guo ,  Weifeng Zhou ,  Xing Ming ,  Yong Chen ,  Guanghui Xiao

IPC分类号： G03B27/42 ,  G03B27/32

CPC分类号： G03F7/7015 ,  G03F1/14 ,  G03F1/38 ,  G03F1/50 ,  G03F1/52 ,  G03F7/70275 ,  G03F7/70283 ,  G03F7/70466

摘要： An exposure apparatus comprises: a loading stage for supporting a substrate; a mask plate parallel to the loading stage and above the loading stage, the mask plate including a light transmitting region and a light absorbing region on its lower surface, a light reflecting region being provided in the light absorbing region; a lens device provided between the mask plate and the loading stage; a first illumination light source, light from which vertically striking on the upper surface of the mask plate from above, passing through the mask plate and striking on the loading stage via the lens device; a light reflecting device provided in the lens device; and a second illumination light source, light from which being reflected onto the lower surface of the mask plate by the light reflecting device located in the lens device, the light being reflected by the light reflecting region on the lower surface of the mask plate and striking on the loading stage via the lens device.

摘要翻译： 曝光装置包括：用于支撑基板的装载台; 掩模板，其平行于所述装载台并且在所述装载台的上方，所述掩模板在其下表面上包括透光区域和光吸收区域，所述光反射区域设置在所述光吸收区域中; 设置在所述掩模板和所述装载台之间的透镜装置; 第一照明光源，从上方垂直撞击掩模板的上表面的光，穿过掩模板并经由透镜装置撞击装载台; 设置在所述透镜装置中的光反射装置; 以及第二照明光源，通过位于透镜装置中的光反射装置反射到掩模板的下表面的光，该光被掩模板的下表面上的光反射区域反射并且被击打 通过透镜装置在装载台上。

公开(公告)号：US08330549B1

公开(公告)日：2012-12-11

申请号：US13456272

申请日：2012-04-26

申请人： Yong Chen

发明人： Yong Chen

IPC分类号： H03B5/12

CPC分类号： H03B5/1231 ,  H03B5/1203 ,  H03B5/1234 ,  H03B5/1296

摘要： An oscillator circuit with a voltage booster includes separated coils to oscillate and boost the input direct current voltage. The two coils are wound in opposite directs and magnetically coupled to one another. One of the coils is in series with a capacitor to form a LC oscillator. The circuit enables changing the frequency of oscillation by changing the number of turns on the coil in series with the capacitor or by changing the value of the capacitor. The output voltage level can be changed by changing the number of turns on the remaining coil.

摘要翻译： 具有升压器的振荡器电路包括分离的线圈以振荡和提升输入直流电压。 两个线圈以相反的方向卷绕并彼此磁耦合。 其中一个线圈与电容器串联以形成LC振荡器。 该电路能够通过改变与电容器串联的线圈匝数或者改变电容器的值来改变振荡频率。 可以通过改变剩余线圈的匝数来改变输出电压电平。

公开(公告)号：US20120274925A1

公开(公告)日：2012-11-01

申请号：US13456033

申请日：2012-04-25

申请人： Yong Chen ,  David W. Houck

发明人： Yong Chen ,  David W. Houck

IPC分类号： G01N21/59 ,  G01N21/53

CPC分类号： G01N21/534 ,  G01N15/1434 ,  G01N15/1459 ,  G01N15/147 ,  G01N21/59 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/145

摘要： An axial light loss sensor system, and methods for measuring axial light loss with improved resolution are provided. Aspects of the present invention include an axial light loss sensor positioned along an axis of irradiation to detect axial light loss resulting from a particle passing a light source intersect in a fluid stream, and an obstruction positioned along the axis of irradiation between the light source intersect and the axial light loss sensor. The obstruction is further positioned so as to have an on-axis opaque surface. The obstruction allows for the measurement of a fringe signal in a far-field with respect to the irradiated particle, in order to measure the axial light loss produced by the particle. The systems and methods described herein find use in, for example, flow cytometery.

摘要翻译： 提供轴向光损失传感器系统，以及用于以改进的分辨率测量轴向光损失的方法。 本发明的方面包括沿着照射轴定位的轴向光损失传感器，以检测通过光源在流体流中相交的颗粒所导致的轴向光损失，以及沿着光源相交的沿照射轴设置的障碍物 和轴向光损失传感器。 障碍物进一步定位成具有轴上不透明表面。 障碍物允许测量相对于辐照颗粒的远场中的条纹信号，以便测量由颗粒产生的轴向光损失。 本文所述的系统和方法可用于例如流式细胞术。

公开(公告)号：US08298649B2

公开(公告)日：2012-10-30

申请号：US12529704

申请日：2008-02-29

申请人： Mathilde Reyssat ,  Yong Chen ,  Anne Pepin ,  David Quere ,  Claudine Biver ,  Laurianne Vagharchakian

发明人： Mathilde Reyssat ,  Yong Chen ,  Anne Pepin ,  David Quere ,  Claudine Biver ,  Laurianne Vagharchakian

IPC分类号： D06N7/04

CPC分类号： G02B27/0006 ,  B08B17/06 ,  B08B17/065 ,  G02B1/118 ,  Y10T428/24355 ,  Y10T428/31

摘要： The invention relates to an article having a nanotextured surface with superhydrophobic properties, comprising an array of vertical tabs, preferably regular, wherein the pillar array fulfils the following conditions: the surface fraction of the pillars Øs is such that 3%≦Øs≦13%, preferably 5%≦Øs≦12%, preferably 5%≦Øs≦13%, even better 5.5%≦Øs≦13%, even better 6%≦Øs≦13%, and better still 8%≦Øs≦13%; the pitch p of the array is such that 100 nm≦p≦250 nm; the height h of the pillars is such that 100 nm≦h≦400 nm, preferably 250≦h≦400 nm, even better 300≦h≦400 nm; and the lateral surface of the pillars is inclined at most by an angle of ±20°, preferably ±10° or even better ±5°, in relation to the vertical axis of the pillars.

摘要翻译： 本发明涉及一种具有超疏水性质的纳米纹理表面的制品，其包括优选规则的垂直突片阵列，其中所述支柱阵列满足以下条件：所述支柱Ø的表面分数为3％ ％，优选5％＆ll;Øs＆nlE; 12％，优选5％＆nlE;Øs＆nlE; 13％，甚至更好5.5％＆nlE;Øs＆nlE; 13％，甚至更好6％＆nlE;Øs＆nlE; 13％，还好8％ ;Øs＆nlE; 13％; 阵列的间距p为100nm＆amp; nlE; p＆nlE; 250nm; 柱的高度h为100nm＆nlE; h＆nlE; 400nm，优选250＆amp; NlE; h＆nlE; 400nm，甚至更好的300＆amp; 1000; h＆nlE; 400nm; 并且柱的侧表面相对于柱的垂直轴线最多倾斜±20°，优选±10°或甚至更好±5°的角度。