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    Tissue processing apparatus
    11.
    发明授权
    Tissue processing apparatus 有权
    组织处理装置

    公开(公告)号：US09182323B2

    公开(公告)日：2015-11-10

    申请号：US14503925

    申请日：2014-10-01

    申请人： DAKO DENMARK A/S

    发明人： Tim Svenstrup Poulsen ,  Steen Hauge Matthiesen

    IPC分类号： B01L3/02 ,  G01N1/30 ,  G01N1/28 ,  G01N1/31

    CPC分类号： G01N1/2813 ,  G01N1/30 ,  G01N1/312

    摘要： An apparatus for processing a biological sample is provided. The biological sample being arranged on a first planar surface of a carrier, the apparatus having a second planar surface arranged substantially parallel to said first planar surface and at a first distance from said first planar surface. The first planar surface and said second planar surface are arranged at an angle (A) greater than zero degree from the horizontal plane (HP). The apparatus having a supply for supplying an amount of a liquid that is to be applied to said biological sample. The first planar surface and said second planar surface are configured to be arranged at a second distance from each other, said second distance being such that said supplied amount of liquid is distributed over said biological sample when said first planar surface and said second planar surface are brought to said second distance from each other.

    摘要翻译： 提供了一种用于处理生物样品的装置。 生物样品布置在载体的第一平坦表面上，该装置具有基本上平行于所述第一平坦表面并且距离所述第一平面的第一距离布置的第二平坦表面。 第一平坦表面和所述第二平坦表面以与水平面（HP）大于零度的角度（A）布置。 该装置具有用于供应一定量待应用于所述生物样品的液体的供给装置。 第一平坦表面和第二平坦表面被配置为彼此间隔开第二距离，所述第二距离使得当所述第一平面和所述第二平面是所述第一平面和所述第二平面时，所述供应量的液体分布在所述生物样品上 带到彼此的第二距离。

    Antibody cocktail
    12.
    发明授权
    Antibody cocktail 有权
    抗体鸡尾酒

    公开(公告)号：US09040667B2

    公开(公告)日：2015-05-26

    申请号：US13318215

    申请日：2010-04-27

    申请人： Zhiming Liao ,  Jeanette Musser

    发明人： Zhiming Liao ,  Jeanette Musser

    IPC分类号： C07K16/00 ,  G01N33/574

    CPC分类号： G01N33/57434 ,  G01N2333/47 ,  G01N2333/4742 ,  G01N2333/99 ,  G01N2800/52

    摘要： The present invention relates to a composition comprising at least three primary antibodies or fragments thereof, wherein the at least three antibodies or fragments thereof binds specifically to at least three different proteins, and wherein the at least three different proteins are AMCAR, CK 5/6, and HMWC. Methods for using the composition in diagnosis, prognosis, and assessing efficacy of treatment is further included as well as kits comprising said composition, and optionally, instructions of its use.

    摘要翻译： 本发明涉及包含至少三种一抗或其片段的组合物，其中所述至少三种抗体或其片段特异性结合至少三种不同的蛋白质，并且其中所述至少三种不同的蛋白质是AMCAR，CK5 / 6 ，和HMWC。 进一步包括在组合物诊断，预后和评价治疗功效中使用该组合物的方法以及包含所述组合物和任选的其使用说明书的试剂盒。

    METHOD FOR DETECTION OF L523S EXPRESSION IN BIOLOGICAL SAMPLES
    13.
    发明申请
    METHOD FOR DETECTION OF L523S EXPRESSION IN BIOLOGICAL SAMPLES 有权
    用于检测生物样品中L523S表达的方法

    公开(公告)号：US20150072891A1

    公开(公告)日：2015-03-12

    申请号：US14492171

    申请日：2014-09-22

    申请人： DAKO DENMARK A/S

    发明人： Katherine Marks SOJKA ,  Elizabeth Oliver SPAULDING

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57476 ,  G01N33/5743

    摘要： The present invention discloses methods for differentiating between normal or reactive cells and malignant cells in biological samples comprising: exposing the biological sample to an antibody to L523S protein and detecting the presence of the antibody bound to L523S protein within the malignant cells, in embodiments, such methods may further comprise: exposing the biological sample to an antibody to a second protein that is a marker of cell lineage and detecting the presence of the antibody to the second protein within cells corresponding to a particular ceil lineage and/or may comprise: exposing the biological sample to an antibody to a third protein which is a marker of cells that are normal or reactive and detecting the presence of the antibody to the third protein within cells that are normal or reactive.

    摘要翻译： 本发明公开了用于区分生物样品中的正常或反应性细胞与恶性细胞的方法，包括：将生物样品暴露于L523S蛋白的抗体，并检测在恶性细胞内与L523S蛋白结合的抗体的存在， 方法可以进一步包括：将生物样品暴露于作为细胞谱系标志物的第二蛋白质的抗体，并检测在对应于特定细胞谱系的细胞内第二种蛋白质的抗体的存在和/或可以包括： 生物样品与第三种蛋白质的抗体，其是正常或反应性细胞的标志物，并检测在正常或反应性细胞内第三种蛋白质的存在。

    Apparatus and method for processing biological samples
    14.
    发明授权
    Apparatus and method for processing biological samples 有权
    用于处理生物样品的装置和方法

    公开(公告)号：US08877485B2

    公开(公告)日：2014-11-04

    申请号：US12962825

    申请日：2010-12-08

    申请人： Søren Damgaard Larsen ,  Peter Axel Valbjørn

    发明人： Søren Damgaard Larsen ,  Peter Axel Valbjørn

    IPC分类号： C12M1/34 ,  G01N1/28 ,  G01N1/31 ,  G01N35/00

    CPC分类号： G01N1/312 ,  G01N1/2813 ,  G01N35/00029 ,  G01N2035/00079 ,  G01N2035/00138

    摘要： A method and an automated apparatus for processing at least one biological sample arranged on a slide. At least one capillary staining module has a slide rack holder configured to detachably hold a slide rack configured to hold slides, and a capillary lid rack holder configured to detachably hold a capillary lid rack configured to hold capillary lids, wherein the slide rack can be removed independently of removing the capillary lid rack. A first fluid container has a first fluid. The apparatus being configured to automatically rotate the one or more slides, and to move the lids towards the slides to automatically form a capillary gap between each slide and each capillary lid, said capillary gap functioning as a capillary chamber; and to supply an amount of the first fluid to the slide.

    摘要翻译： 一种用于处理布置在载玻片上的至少一个生物样品的方法和自动化装置。 至少一个毛细管染色模块具有滑动架保持器，其被配置为可拆卸地保持构造成保持滑块的滑动架，以及毛细管盖架架保持器，其构造成可拆卸地保持构造成保持毛细管盖的毛细管盖架，其中可移除滑架 独立于去除毛细管盖架。 第一流体容器具有第一流体。 所述设备被配置为自动旋转所述一个或多个滑块，并且将所述盖子朝向所述滑块移动，以在每个滑块和每个毛细管盖之间自动形成毛细管间隙，所述毛细管间隙用作毛细管腔室; 并且将一定量的第一流体供应到载玻片。

    HYBRIDIZATION COMPOSITIONS AND METHODS USING FORMAMIDE
    15.
    发明申请
    HYBRIDIZATION COMPOSITIONS AND METHODS USING FORMAMIDE 审中-公开
    杂化组合物和使用甲酰胺的方法

    公开(公告)号：US20140234844A1

    公开(公告)日：2014-08-21

    申请号：US14348134

    申请日：2012-09-28

    申请人： DAKO DENMARK A/S

    发明人： Steen Hauge Matthiesen

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6832 ,  C12Q1/6841 ,  C12Q1/6876 ,  C12Q2523/113 ,  C12Q2527/125 ,  C12Q2527/137

    摘要： The invention provides methods and compositions for hybridizing at least one molecule to a target. The composition comprises at least one nucleic acid sequence, formamide, and a hybridization solution, wherein the concentration of formamide is less than or equal to 25%.

    摘要翻译： 本发明提供了用于将至少一种分子与目标物杂交的方法和组合物。 组合物包含至少一种核酸序列，甲酰胺和杂交溶液，其中甲酰胺的浓度小于或等于25％。

    SYSTEMS AND METHODS FOR TRACKING AND PROVIDING WORKFLOW INFORMATION
    17.
    发明申请
    SYSTEMS AND METHODS FOR TRACKING AND PROVIDING WORKFLOW INFORMATION 有权
    跟踪和提供工作流信息的系统和方法

    公开(公告)号：US20140188545A1

    公开(公告)日：2014-07-03

    申请号：US14143274

    申请日：2013-12-30

    申请人： Laura CHIRICA ,  Mats GRAHN ,  Stephen JONES

    发明人： Laura CHIRICA ,  Mats GRAHN ,  Stephen JONES

    IPC分类号： G06Q10/06

    CPC分类号： G06Q10/0633 ,  G06F19/00 ,  G06Q10/06 ,  G16H10/40 ,  G16H40/20 ,  G16H40/67

    摘要： A tangible computer-readable storage device storing computer-executable program instructions that generate a user interface for displaying workflow information associated with a tissue specimen in a pathology laboratory. The program instructions may be configured to perform a method including displaying a virtual laboratory component representing a physical pathology laboratory having one or more laboratory stations for processing the tissue specimen, wherein the tissue specimen is processed by the one or more laboratory stations according to a workflow, and displaying a specimen indicator that indicates a current specimen state based on a current relationship of the tissue specimen to the workflow. The method may further include enabling a first active component associated with the virtual laboratory component, wherein the first active component is configured to receive a user selection of a laboratory station and generating a supplemental view component of the selected laboratory station in response to the user selection, wherein the supplemental view provides supplemental information on processing by the selected laboratory station of the tissue specimen.

    摘要翻译： 存储计算机可执行程序指令的有形计算机可读存储设备，其生成用于在病理学实验室中显示与组织标本相关联的工作流信息的用户界面。 程序指令可以被配置为执行一种方法，包括显示代表具有用于处理组织样本的一个或多个实验室的物理病理学实验室的虚拟实验室部件，其中根据工作流程由所述一个或多个实验室站处理所述组织标本 并且基于组织样本与工作流的当前关系，显示指示当前样本状态的样本指示符。 该方法还可以包括启用与虚拟实验室组件相关联的第一活动组件，其中第一活动组件被配置为接收实验室的用户选择并响应于用户选择生成所选实验室的补充视图组件 其中补充视图提供了所选实验室对组织标本进行加工的补充信息。

    COMBINED HISTOLOGICAL STAIN
    19.
    发明申请
    COMBINED HISTOLOGICAL STAIN 审中-公开
    组合的HISTOLOGICAL STAIN

    公开(公告)号：US20130337441A1

    公开(公告)日：2013-12-19

    申请号：US13991701

    申请日：2011-12-06

    申请人： Jesper Lohse

    发明人： Jesper Lohse

    IPC分类号： G01N33/58

    CPC分类号： G01N33/581 ,  G01N33/52 ,  G01N33/53 ,  G01N33/86

    摘要： The present invention relates to methods of visualizing targets in histological samples, e.g. biopsy samples, wherein the methods comprise staining of the sample with (i) one or more target specific immunochemical stains, and (ii) a histological stain for specific tissue components e.g. iron, mucins glycogen, amyloid, nucleic acids, etc., e.g. hematoxilyn and/or eosin stains or the like, that is used to enhance contrast in the microscopic image of a tissue sample, highlight morphologic structures in the sample for viewing, define and examine tissues, cell populations, or organelles within individual cells. Methods may further comprise evaluation of expression of one or more targets in the sample. The disclosed methods are useful for medical diagnostics.

    摘要翻译： 本发明涉及在组织学样品中可视化靶标的方法，例如， 活检样品，其中所述方法包括用（i）一种或多种靶特异性免疫化学污渍染色样品，和（ii）特定组织组分的组织学染色，例如， 铁，粘蛋白糖原，淀粉样蛋白，核酸等。 用于增强组织样品的显微图像中的对比度的苏木精和/或伊红染色等，突出显示样品中的形态学结构以观察，限定和检查个体细胞内的组织，细胞群或细胞器。 方法还可以包括评估样品中一种或多种靶的表达。 所公开的方法对于医学诊断是有用的。