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公开(公告)号：US20240075184A1
公开(公告)日：2024-03-07
申请号：US18272765
申请日：2022-01-10
发明人： Ramaraja P. Ramasamy , Hamid Asadi
CPC分类号： A61L27/34 , A61F2/28 , A61L27/047 , A61L27/50 , A61L31/022 , A61L31/10 , A61L31/14 , A61F2002/30062
摘要： Provided are biodegradable orthopedic implants, corrosion-resistant coating for orthopedic implants, and methods of making. The biodegradable orthopedic implant can include a Mg alloy having a coating including a first layer, a second layer, and a third layer. The first layer can be an oxide layer coated on an external surface of a magnesium alloy implant. The second layer can include lawsone embedded in PCL, and the third layer can include PCL. To manufacture the coated orthopedic implant, the implant can be immersed in an alkaline solution to form an oxide-coated implant and implant can then be coated with a PCL lawsone solution. An additional polymer protective layer can be added.
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公开(公告)号：US11912647B2
公开(公告)日：2024-02-27
申请号：US17325291
申请日：2021-05-20
IPC分类号： C07C239/20 , C07D207/46 , C07B43/00
CPC分类号： C07C239/20 , C07B43/00 , C07D207/46
摘要： In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.
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13.发明公开公开(公告)号：US20240050631A1
公开(公告)日：2024-02-15
申请号：US18016095
申请日：2021-07-14
CPC分类号： A61L29/085 , A61L29/126 , A61L29/16 , A61L2420/06 , A61L2300/114 , A61L2300/404 , A61L2300/216
摘要： Described herein are substrates, devices, methods for treating and preventing bacterial and fungal infections, such as infections associated with medical devices, and the like. Materials, substrates and devices of the present disclosure include materials, such as medical grade polymers, having a coating/layer of polyene antimycotic molecules coupled to a surface of the polymer substrate. In certain aspects, substrates and devices of the present disclosure also include a nitric oxide (NO) releasing material also embedded in/coated on the material. Methods of the present disclosure includes methods of making the compositions and/or devices of the present disclosure including materials functionalized with polyene antimycotic molecules and NO releasing materials. Embodiments also include methods of using the materials, substrates, and devices of the present disclosure to treat/prevent fungal and/or bacterial infections in a subject, particularly infections associated with the use of a medical device.
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公开(公告)号：US20240042053A1
公开(公告)日：2024-02-08
申请号：US18248331
申请日：2021-10-14
IPC分类号： A61K47/68
CPC分类号： A61K47/6889 , A61K47/6805 , A61K47/68033
摘要： Disclosed herein are glycoconjugates having a cell-binding agent, such as an antibody, conjugating to a payload, such as a drug. The drug is conjugated to the cell-binding agent through an oligosaccharide linker. The glycoconjugates conjugated through the oligosaccharide linkers disclosed herein exhibit improved properties over prior glycoconjugates.
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公开(公告)号：US20230372528A1
公开(公告)日：2023-11-23
申请号：US18248335
申请日：2021-10-14
CPC分类号： A61K47/6889 , A61K47/549 , A61K47/6855 , A61K47/6803 , A61P35/00
摘要： This disclosure relates to glycoconjugates comprising glycosylated cell-binding agents conjugated to pyrrolobenzodiazepine (PBD) payloads. Glycoconjugates of particular interest include conjugates where the cell-binding agent is an antibody and the payload comprises a cytotoxic pyrrolobenzodiazepine (PBD) moiety, with the PBD moiety conjugated to the antibody via an oligosaccharide linker. The disclosure also relates to methods for preparing the glycoconjugates, along with methods for their use.
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公开(公告)号：US11788100B2
公开(公告)日：2023-10-17
申请号：US16821755
申请日：2020-03-17
发明人： Peggy Ozias-Akins , Joann A. Conner
IPC分类号： C12N15/82
CPC分类号： C12N15/8287
摘要： Methods and compositions disclosed herein generally relate to genes involved in plant reproduction and methods of using the same.
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公开(公告)号：US20230277472A1
公开(公告)日：2023-09-07
申请号：US18297365
申请日：2023-04-07
发明人： Jin XIE
CPC分类号： A61K9/5115 , A61K9/5161 , A61P19/02 , A61K9/5146 , A61K9/0024 , B82Y5/00
摘要： Disclosed are particles comprising lithium salts and methods for their use in treating inflammatory conditions.
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公开(公告)号：US11707768B2
公开(公告)日：2023-07-25
申请号：US17491961
申请日：2021-10-01
发明人： Zhuo Zhao , Tsz Ho Tse , Don Leo , Kyle Johnsen , Rui Li , Brian L. Boland
CPC分类号： B07C5/3425 , G06T5/002 , G06T7/0004 , G06T7/13 , G06T7/90 , B07C2501/0081 , G06T2207/10024 , G06T2207/30128 , G06T2207/30242 , H04N9/67
摘要： Various examples of a system for peanut sorting and grading are disclosed herein. The system for grading peanut maturity, can include: a sample feeder configured to supply individual peanuts to an imaging area; a sorting board comprising a plurality of chutes and a plurality of gates, each chute of the plurality of chutes designated for a grade of peanut; and program instructions to obtain the digital image of the individual peanut; determine the grade of the individual peanut; and sort the individual peanut based on the grade of the individual peanut. A method for grading peanut maturity, can include feeding an individual peanut to an imaging area; obtaining a digital image of the individual peanut; determining a grade of the individual peanut based on an average color; and sorting the individual peanut in a chute of a sorting board based on the grade of the individual peanut.
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公开(公告)号：US20230211004A1
公开(公告)日：2023-07-06
申请号：US17778211
申请日：2020-11-22
发明人： Paeton L. WANTUCH , Jeremy A. DUKE , Fikri Y. AVCI
IPC分类号： A61K47/64
CPC分类号： A61K47/646 , A61K47/6415
摘要： The present disclosure provides peptides derived from CRM197 and Tetanus toxoid that can be used to generate an immune response in an individual. The present disclosure includes isolated peptides and multimers of isolated peptides. Also provided are compositions that include the isolated peptide or the multimer. Further provided are methods, including methods for increasing the antigenicity of a compound, such as an antigen, and methods for inducing an immune response in a subject
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公开(公告)号：US20230204986A1
公开(公告)日：2023-06-29
申请号：US18071688
申请日：2022-11-30
CPC分类号： G02F1/0018 , G02F1/0305
摘要： A metasurface for propagating phonon polaritons includes correlated oxide on a substrate and a wiring pattern of predetermined geometric shape on the surface thereof. There is a flake of van der Waals phononic exfoliable material on top of the wiring pattern/region. The wiring pattern may be formed by c-AFM or any other appropriate methods.
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