中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

146 records (took 0.035 seconds)

    NOVEL VACCINES AGAINST HPV AND HPV-RELATED DISEASES
    17.
    发明申请
    NOVEL VACCINES AGAINST HPV AND HPV-RELATED DISEASES 审中-公开
    新的疫苗对HPV和HPV相关疾病

    公开(公告)号：US20160331825A1

    公开(公告)日：2016-11-17

    申请号：US15111357

    申请日：2015-01-13

    Applicant: BAYLOR RESEARCH INSTITUTE

    Inventor： SangKon OH ,  Sandra ZURAWSKI ,  Gerard ZURAWSKI

    IPC: A61K39/12 ,  A61K39/395 ,  C12N7/00 ,  C07K16/28 ,  C07K14/005

    CPC classification number: A61K39/12 ,  A61K39/395 ,  A61K39/39541 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/55511 ,  A61K2039/585 ,  A61K2039/6056 ,  A61K2039/70 ,  C07K14/005 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2319/74 ,  C07K2319/91 ,  C12N7/00 ,  C12N2710/20034

    Abstract: Embodiments relate to novel vaccines against human papillomavirus (HPV) and HPV-related diseases, including multiple types of cancers. The HPV vaccines are composed of anti-human dendritic cell (DC) surface receptor antibodies, including CD40, and E6/7 proteins of HPV 16 and 18. The technology described is not limited to making vaccines against HPV16- and HPV18-related diseases and can be applied to making vaccines carrying E6/7 from any type of HPV. The HPV vaccines described can target DCs, major and professional antigen presenting cells (APCs), and can induce and activate potent HPV E6/7-specific and strong CD4+ and CD8+ T cell responses. The HPV vaccines can be used for the prevention of HPV infection and HPV-related diseases as well as for the treatment of HPV-related diseases, including cancers.

    Abstract translation: 实施例涉及针对人乳头状瘤病毒（HPV）和HPV相关疾病（包括多种类型的癌症）的新型疫苗。 HPV疫苗由抗人树突状细胞（DC）表面受体抗体，包括HPV16和18的CD40和E6 / 7蛋白组成。所述技术不限于制备针对HPV16和HPV18相关疾病的疫苗， 可用于从任何类型的HPV中制备携带E6 / 7的疫苗。 描述的HPV疫苗可以靶向DCs，主要和专业抗原呈递细胞（APC），并且可以诱导和激活有效的HPV E6 / 7特异性和强的CD4 +和CD8 + T细胞应答。 HPV疫苗可用于预防HPV感染和HPV相关疾病以及用于治疗HPV相关疾病，包括癌症。

    Fatty acid treatment for cardiac patients
    19.
    发明授权
    Fatty acid treatment for cardiac patients 有权
    心脏病患者的脂肪酸治疗

    公开(公告)号：US09402822B2

    公开(公告)日：2016-08-02

    申请号：US14523810

    申请日：2014-10-24

    Applicant: Baylor Research Institute

    Inventor： Charles R. Roe

    IPC: A61K31/194 ,  A61K31/19 ,  A61K31/20 ,  A61K31/23

    CPC classification number: A61K31/20 ,  A61K31/19 ,  A61K31/194 ,  A61K31/23

    Abstract: A method of treating patients in need of treatment for a cardiac disorder has been found which comprises administering to the patient a seven carbon fatty acid compound or derivative thereof, wherein the compound or derivative thereof is able to readily enter the mitochondrion without special transport enzymes. A dietary formulation suitable for treatment of heart tissue in cardiac or surgical patients has been found which comprises a seven-carbon fatty acid chain, wherein the seven-carbon fatty acid chain is characterized by the ability to transverse the inner mitochondrial membrane by a transport mechanism which does not require carnitine palmitoyltransferase I, carnitine palmitoyltransferase II, or carnitine/acylcarnitine translocase and the ability to undergo mitochondrial β-oxidation, and wherein the compound is selected from the group consisting of n-heptanoic acid or a derivative thereof, a triglyceride comprising n-heptanoic acid or a derivative thereof, and triheptanoin or a derivative thereof.

    Abstract translation: 已经发现治疗需要治疗心脏病症的患者的方法包括向患者施用七碳脂肪酸化合物或其衍生物，其中所述化合物或其衍生物能够容易地进入线粒体而没有特殊的转运酶。 已经发现适合于治疗心脏或外科手术患者心脏组织的膳食制剂包括七碳脂肪酸链，其中七碳脂肪酸链的特征在于通过运输机制横向内线粒体膜的能力 其不需要肉碱棕榈酰转移酶I，肉碱棕榈酰转移酶II或肉碱/酰基肉毒碱转位酶和进行线粒体β-氧化的能力，并且其中所述化合物选自正庚酸或其衍生物，甘油三酯包含 正庚酸或其衍生物，三庚醇或其衍生物。

Patent Agency Ranking