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公开(公告)号:US10077378B2
公开(公告)日:2018-09-18
申请号:US15037214
申请日:2014-08-06
Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION
Inventor: Marek W. Urban , Ying Yang
IPC: C09D175/08 , C08B11/02 , C08B37/00 , C08B37/08 , C08G18/48 , C08G18/64 , C09D175/04 , C08G18/32 , C08G18/40 , C08G18/24 , C08G18/72 , C09D5/00
CPC classification number: C09D175/08 , C08B11/02 , C08B37/00 , C08B37/003 , C08B37/0045 , C08B37/0075 , C08G18/242 , C08G18/3215 , C08G18/4081 , C08G18/4833 , C08G18/6484 , C08G18/72 , C09D5/00 , C09D175/04
Abstract: The present invention provides alkyl substituted polysaccharide compositions and methods of repairing substrates involving use of the alkyl substituted polysaccharide compositions.
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公开(公告)号:US20160263231A1
公开(公告)日:2016-09-15
申请号:US14703549
申请日:2015-05-04
Inventor: Dev P. Arya , Nihar Ranjan , Sunil Kumar
IPC: A61K47/48
CPC classification number: A61K47/48061 , A61K31/7034 , A61K47/545 , C07H15/232 , G06F19/00 , G06Q50/24 , Y02A90/22 , Y10T436/143333
Abstract: Disclosed herein are compounds, compositions and methods related to viral inhibition. In some forms, the compounds, compositions and methods are related to binding RNA.
Abstract translation: 本文公开了与病毒抑制有关的化合物,组合物和方法。 在一些形式中,化合物,组合物和方法与结合RNA有关。
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公开(公告)号:US09320635B2
公开(公告)日:2016-04-26
申请号:US13971410
申请日:2013-08-20
Applicant: Clemson University Research Foundation
Inventor: Chelsea Lea Ex-Lubeskie , Meredith Cole Donaldson , Riley Morgan Csernica , Kaitlin Kathleen Grove , Charles Alden Thigpen
CPC classification number: A61F5/0102 , A61F5/3723 , A61L15/14
Abstract: Shoulder braces for inhibiting secondary anterior shoulder dislocations that are configured to allow for a wide range of motion for mobility and stabilization, include a brace body with a single arm portion configured to reside about a shoulder of a user and a torso portion, a plurality of shoulder straps extending over the single arm portion shoulder, a substantially rigid thermoplastic insert releasably held by the arm portion of the brace body. The insert can have a user-specific custom shape that substantially conforms to shoulder anatomy of the shoulder of the user. The brace can also include at least one adjustable length laterally extending torso strap attached to the torso portion.
Abstract translation: 用于抑制被配置为允许移动性和稳定性的宽范围运动的继发性前肩脱位的肩撑包括具有单个臂部分的构架,其配置成围绕使用者的肩部和躯干部分驻留,多个 在单臂部分肩部上延伸的肩带,由支架主体的臂部可释放地保持的基本上刚性的热塑性插件。 插入物可以具有基本上符合使用者肩部的肩部解剖结构的用户特定的定制形状。 支架还可以包括附接到躯干部分的至少一个可调节长度的横向延伸的躯干带。
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公开(公告)号:US20240247077A1
公开(公告)日:2024-07-25
申请号:US18420450
申请日:2024-01-23
Applicant: Clemson University Research Foundation
Inventor: Charles David Rice
IPC: C07K16/40 , G01N33/573 , A61K39/00
CPC classification number: C07K16/40 , G01N33/573 , A61K2039/505 , C07K2317/14 , C07K2317/33 , C07K2317/565
Abstract: This invention is directed to a monoclonal antibody or an antigen binding fragment thereof targeting the expression and function of CYP1A1 with cross reactivity across the vertebrate taxa. This invention is also directed to nucleic acid molecules, vectors, host cells and compositions comprising the same, as well as methods for use of the same and for producing the same.
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公开(公告)号:US11835526B2
公开(公告)日:2023-12-05
申请号:US17672586
申请日:2022-02-15
Inventor: Daniel T. Chiu , Changfeng Wu , Jason McNeill , Jiangbo Yu
CPC classification number: G01N33/587 , C09K11/06 , G01N33/582
Abstract: The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
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公开(公告)号:US11773362B2
公开(公告)日:2023-10-03
申请号:US17244447
申请日:2021-04-29
Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION
Inventor: Leslie Sierad , Christopher Delaney , Richard Pascal, III , Dan Simionescu , Agneta Simionescu
CPC classification number: C12M41/40 , C12M21/08 , C12M23/00 , C12M23/44 , C12M29/00 , C12M29/12 , C12M35/04
Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).
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公开(公告)号:US20230114987A1
公开(公告)日:2023-04-13
申请号:US17962046
申请日:2022-10-07
Applicant: Clemson University Research Foundation
Inventor: Jeremy J. Mercuri , Richard diMonda , Matt Pursley , Ishmael Bentley
Abstract: Integratable treatment devices, assemblies including a treatment device, at least one anchor, and a tether coupled thereto, and various methods and devices for inserting such devices and assemblies are disclosed herein. The treatment devices can be made of an integratable material that is not fully bioresorbable but promotes native tissue growth in and around the material. Certain methods involve first inserting at least one anchor and then advancing a treatment device via a tether coupled to the at least one anchor. Further various insertion devices that can be used to implant any of the treatment devices herein using any of the methods herein are disclosed.
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18.
公开(公告)号:US11415523B2
公开(公告)日:2022-08-16
申请号:US16639436
申请日:2018-09-04
Applicant: Clemson University Research Foundation
Inventor: Robert A. Latour , George Chumanov , Alexandra Czynski
IPC: G01N21/78 , G01N33/493 , G01N33/52 , G01N33/70 , G01N21/77
Abstract: A system for monitoring an analyte concentration in liquid is provided. The system includes a coupon comprising an absorbent body with a window through the absorbent body wherein the liquid is maintained in said window by capillary action and surface tension. A reactant is in the absorbent body wherein the reactant is capable of diffusing into the window to react with an analyte in the liquid, or the reactant is able to react with the analyte within the coupon itself, with color-indicating by-products of the reaction diffusing into the window, wherein the analyte is present in an analyte concentration, to form a reactant with a color wherein the color has an intensity which correlates to the analyte concentration. A light source is provided which is capable of passing light into the window wherein the light is attenuated by the color proportional to the analyte concentration to form attenuated light. A detector is provided which is capable measuring an intensity of the attenuated light. Alternatively, the color change can be read by eye and compared to a color chart relating the color to an analyte concentration.
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19.
公开(公告)号:US20210405064A1
公开(公告)日:2021-12-30
申请号:US17476971
申请日:2021-09-16
Inventor: Ying Mei , Jia Jia , Chung-Jen James Chou
IPC: G01N33/68 , C07K7/06 , C07K7/08 , A61P9/10 , G01N33/74 , C07K14/78 , C07K17/02 , C07K14/71 , C07K14/755 , C07K14/52 , C07K14/75 , C07K14/705
Abstract: The present invention provides an in vitro method for identifying a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation for the manufacture of a diagnostic or therapeutic agent. The present invention further provides the identified compounds and pharmaceutical compositions, and assays and kits for identifying a compound or using a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation and is useful for bioprinting.
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20.
公开(公告)号:US10883962B2
公开(公告)日:2021-01-05
申请号:US15875398
申请日:2018-01-19
Inventor: Guigen Zhang , Samuel Bearden
IPC: G01N27/447 , G01N33/487 , C12Q1/6869
Abstract: Systems for detecting analytes in electrical double layer nanopore devices and methods of use are provided.
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