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28 条记录 (耗时 0.032 秒)

    Use of photopolymerization for amplification and detection of a Molecular Recognition Event
    13.
    发明授权
    Use of photopolymerization for amplification and detection of a Molecular Recognition Event 有权
    使用光聚合进行扩增和检测分子识别事件

    公开(公告)号：US08652778B2

    公开(公告)日：2014-02-18

    申请号：US13082814

    申请日：2011-04-08

    申请人： Christopher N. Bowman ,  Kathy Rowlen ,  Hadley Sikes ,  Ryan Hansen ,  Heather Jean Avens

    发明人： Christopher N. Bowman ,  Kathy Rowlen ,  Hadley Sikes ,  Ryan Hansen ,  Heather Jean Avens

    IPC分类号： C12Q1/68 ,  C40B30/04 ,  B82Y30/00

    CPC分类号： C12Q1/6816 ,  C12Q2565/401 ,  C12Q2523/313

    摘要： The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular recognition event. The amplification is achieved through photopolymerization, with the polymer formed being associated with the molecular recognition event. In one aspect, a fluorescent polymer, a magnetic polymer, a radioactive polymer or an electrically conducting polymer can form the basis of detection and amplification. In another aspect, a polymer gel swollen with a fluorescent solution, a magnetic solution, a radioactive solution or an electrically conducting solution can form the basis of detection and amplification. In another aspect, detectable particles can be included in the polymer formed. In another aspect, sufficient polymer forms to be detectable by visual inspection.

    摘要翻译： 本发明提供检测分子识别事件的方法。 本发明还提供了基于其与一种或多种探针物种的相互作用来检测靶物种的存在或鉴定目的物种的方法。 本发明的方法基于由于每个分子识别事件引起的信号的放大。 通过光聚合实现扩增，形成的聚合物与分子识别事件相关联。 一方面，荧光聚合物，磁性聚合物，放射性聚合物或导电聚合物可以形成检测和扩增的基础。 另一方面，用荧光溶液，磁性溶液，放射性溶液或导电溶液溶胀的聚合物凝胶可以形成检测和扩增的基础。 在另一方面，所形成的聚合物中可以包括可检测的颗粒。 另一方面，足够的聚合物形式可通过视觉检查来检测。

    Stress relaxation in crosslinked polymers
    15.
    发明授权
    Stress relaxation in crosslinked polymers 有权
    交联聚合物中的应力松弛

    公开(公告)号：US08404758B2

    公开(公告)日：2013-03-26

    申请号：US13109400

    申请日：2011-05-17

    申请人： Christopher N. Bowman ,  Timothy F. Scott

    发明人： Christopher N. Bowman ,  Timothy F. Scott

    IPC分类号： C08F2/50 ,  C07C323/00 ,  C07C323/05

    CPC分类号： C08F2/50 ,  C08F2/38 ,  C08F293/005 ,  C08L51/003 ,  C08L53/00 ,  Y10S522/904 ,  C08L2666/02

    摘要： The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention.

    摘要翻译： 本发明提供诱导交联聚合物材料中聚合物链可逆链断裂的方法。 聚合物主链的可逆切割能够缓解聚合物材料中的应力，因为键在较小应力状态下改性。 本发明还提供了制备能够进行可逆链断裂的聚合材料的方法，通过本发明的方法制备的材料和可用于本发明的材料和方法的可逆链裂解基团的线型单体。

    Resin systems for dental restorative materials
    16.
    发明授权
    Resin systems for dental restorative materials 有权
    用于牙科修复材料的树脂系统

    公开(公告)号：US08192673B2

    公开(公告)日：2012-06-05

    申请号：US12415783

    申请日：2009-03-31

    申请人： Christopher N. Bowman ,  Neil B. Cramer

    发明人： Christopher N. Bowman ,  Neil B. Cramer

    IPC分类号： A61C13/00 ,  A61C13/08 ,  B29C35/08 ,  C08F2/50 ,  C08G75/04

    CPC分类号： A61K6/083 ,  C08F2/48 ,  C08G75/045 ,  C08L33/04

    摘要： The disclosure provides a new photopolymerizable resin system for dental restorative materials. The resin system utilizes a thiol-ene component as the reactive diluent in dimethacrylate systems. The ternary resin system comprises a thiol monomer, an ene monomer and a dimethacrylate monomer. Use of an off-stoichiometric ratio of thiol:ene functional groups in favor of excess thiols results in enhanced overall functional group conversion, improved polymer mechanical properties, and reduced shrinkage stress of the ternary system when compared to either traditional dimethacrylate or thiol-ene resin systems.

    摘要翻译： 本公开提供了一种用于牙科修复材料的新的可光聚合树脂体系。 树脂体系在二甲基丙烯酸酯体系中使用硫醇烯组分作为反应性稀释剂。 三元树脂体系包含硫醇单体，烯单体和二甲基丙烯酸酯单体。 使用离子化学计量比的硫醇：烯官能团有利于过量的硫醇导致当与传统的二甲基丙烯酸酯或硫醇 - 烯树脂相比时，三元体系的总体官能团转化，改进的聚合物机械性能和降低的收缩应力增强 系统。

    Stress Relaxation in Crosslinked Polymers
    17.
    发明申请
    Stress Relaxation in Crosslinked Polymers 有权
    交联聚合物中的应力松弛

    公开(公告)号：US20120016052A1

    公开(公告)日：2012-01-19

    申请号：US13109400

    申请日：2011-05-17

    申请人： Christopher N. Bowman ,  Timothy F. Scott

    发明人： Christopher N. Bowman ,  Timothy F. Scott

    IPC分类号： C08G75/06

    CPC分类号： C08F2/50 ,  C08F2/38 ,  C08F293/005 ,  C08L51/003 ,  C08L53/00 ,  Y10S522/904 ,  C08L2666/02

    摘要： The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention.

    摘要翻译： 本发明提供诱导交联聚合物材料中聚合物链可逆链断裂的方法。 聚合物主链的可逆切割能够缓解聚合物材料中的应力，因为键在较小应力状态下改性。 本发明还提供了制备能够进行可逆链断裂的聚合物材料的方法，通过本发明的方法制备的材料和可用于本发明的材料和方法的可逆链裂解基团的线型单体。

    Stress relaxation in crosslinked polymers
    18.
    发明授权
    Stress relaxation in crosslinked polymers 有权
    交联聚合物中的应力松弛

    公开(公告)号：US07943680B2

    公开(公告)日：2011-05-17

    申请号：US11815914

    申请日：2006-02-10

    申请人： Christopher N. Bowman ,  Timothy F. Scott

    发明人： Christopher N. Bowman ,  Timothy F. Scott

    IPC分类号： C08F2/50 ,  C08J3/28

    CPC分类号： C08F2/50 ,  C08F2/38 ,  C08F293/005 ,  C08L51/003 ,  C08L53/00 ,  Y10S522/904 ,  C08L2666/02

    摘要： The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention.

    摘要翻译： 本发明提供诱导交联聚合物材料中聚合物链可逆链断裂的方法。 聚合物主链的可逆切割能够缓解聚合物材料中的应力，因为键在较小应力状态下改性。 本发明还提供了制备能够进行可逆链断裂的聚合物材料的方法，通过本发明的方法制备的材料和可用于本发明的材料和方法的可逆链裂解基团的线型单体。

    Stress relief for crosslinked polymers
    20.
    发明授权
    Stress relief for crosslinked polymers 有权
    交联聚合物减轻应力

    公开(公告)号：US08877830B2

    公开(公告)日：2014-11-04

    申请号：US13344328

    申请日：2012-01-05

    申请人： Christopher N. Bowman ,  Christopher Kloxin ,  Hee Young Park ,  Diana Leung

    发明人： Christopher N. Bowman ,  Christopher Kloxin ,  Hee Young Park ,  Diana Leung

    IPC分类号： A61K6/083 ,  A61K6/08 ,  A61K6/00 ,  C07C321/00 ,  C08F265/06 ,  C08F2/38 ,  C08F2/50

    CPC分类号： C08F2/38 ,  C08F2/50 ,  C08F265/06 ,  C08F2438/03

    摘要： The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material or during polymerization of a polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides mixtures for making crosslinked polymeric materials, methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention. The mixtures of the invention may be dental restorative compositions used for forming dental restorative materials.

    摘要翻译： 本发明提供用于诱导交联聚合材料中的聚合物链的可逆链断裂或在聚合物材料的聚合期间的方法。 聚合物主链的可逆切割能够缓解聚合物材料中的应力，因为键在较小应力状态下改性。 本发明还提供用于制备交联聚合材料的混合物，制备能够进行可逆链断裂的聚合物材料的方法，通过本发明方法制备的材料和可用于本发明的材料和方法的可逆链裂解基团的线性单体 。 本发明的混合物可以是用于形成牙齿修复材料的牙齿修复组合物。