公开(公告)号：US07540286B2

公开(公告)日：2009-06-02

申请号：US10861554

申请日：2004-06-03

申请人： Steven D. Cross ,  Mathieu Herbette ,  Andrew J. G. Kelly ,  Daniel J. Myers ,  William W. Shen ,  Ryan D. Timmons ,  Curtis Tom ,  Justin M. Virgili ,  Martin J. Wensley

发明人： Steven D. Cross ,  Mathieu Herbette ,  Andrew J. G. Kelly ,  Daniel J. Myers ,  William W. Shen ,  Ryan D. Timmons ,  Curtis Tom ,  Justin M. Virgili ,  Martin J. Wensley

IPC分类号： A61M11/00

CPC分类号： H05B1/0244 ,  A61M11/002 ,  A61M11/041 ,  A61M11/042 ,  A61M15/0021 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0065 ,  A61M15/008 ,  A61M15/0081 ,  A61M16/1075 ,  A61M16/14 ,  H05B2203/021

摘要： Devices and methods of entraining a substance within an airflow are disclosed. Condensation aerosol delivery devices and methods of consistently producing multiple doses of a substance, such as a drug, having high purity, high yield, characterized by a particle size distribution appropriate for pulmonary delivery, and which can be administered to a user in a single dose are also disclosed.

摘要翻译： 公开了在气流中夹带物质的装置和方法。 冷凝气溶胶输送装置和一贯生产多剂量物质（例如药物）的方法，其具有高纯度，高产率，其特征在于适于肺部输送的粒度分布，并且其可以以单剂量施用于使用者 也被披露。

公开(公告)号：US20090005734A1

公开(公告)日：2009-01-01

申请号：US11823380

申请日：2007-06-27

申请人： Mathieu Herbette ,  Curtis Tom

发明人： Mathieu Herbette ,  Curtis Tom

IPC分类号： A61M5/44 ,  A61M25/01 ,  A61M39/22 ,  A61M5/142 ,  A61M5/178 ,  A61M5/32

CPC分类号： A61M5/16827 ,  A61M5/16854 ,  A61M5/44 ,  A61M25/003 ,  A61M25/0071 ,  A61M25/0084 ,  A61M25/10 ,  A61M2025/0037 ,  A61M2025/1052

摘要： Apparatus and methods for delivering particles to a target region in a patient's body. The apparatus includes a hub and a catheter having a proximal end coupled to and in fluid communication with the hub. The distal end of the catheter is inserted into the target region. The apparatus also includes: means for directing substrate to the target region, the means being coupled to the hub and in fluid communication with the catheter; a pressure sensor for measuring a pressure of the substrate and generating a signal commensurate with the pressure; and a pressure display for displaying the pressure in response to the signal.

摘要翻译： 将颗粒递送到患者体内的目标区域的装置和方法。 该装置包括一个轮毂和一个导管，其具有与轮毂相连并与轮毂流体连通的近端。 导管的远端插入目标区域。 该装置还包括：用于将基板引导到目标区域的装置，该装置联接到毂并与导管流体连通; 压力传感器，用于测量衬底的压力并产生与压力相称的信号; 以及用于响应于该信号显示压力的压力显示。

公开(公告)号：US20080281318A1

公开(公告)日：2008-11-13

申请号：US11823379

申请日：2007-06-27

申请人： Mathieu Herbette ,  Curtis Tom

发明人： Mathieu Herbette ,  Curtis Tom

IPC分类号： A61B18/18

CPC分类号： A61B18/18 ,  A61N1/08 ,  A61N1/406 ,  G01K7/38

摘要： Apparatus and methods for treating body tissue by heat energy. The apparatus includes: a coil for transmitting an alternating electrical current therethrough to generate an alternating electromagnetic field that is capable of exciting material positioned in the body, the material being operative to inductively generate the heat energy in response to the electromagnetic field; means for measuring an amplitude of the current; and means for mapping the amplitude into a temperature of the magnetic material.

摘要翻译： 用热能治疗身体组织的装置和方法。 该装置包括：线圈，用于传递交流电流通过其中以产生能够激发位于体内的材料的交变电磁场，所述材料可操作以响应于电磁场感应地产生热能; 用于测量电流幅度的装置; 以及用于将振幅映射到磁性材料的温度的装置。

公开(公告)号：US20070028916A1

公开(公告)日：2007-02-08

申请号：US10633876

申请日：2003-08-04

申请人： Ron Hale ,  Peter Lloyd ,  Amy Lu ,  Daniel Myers ,  Reynaldo Quintana ,  Joshua Rabinowitz ,  Dennis Solas ,  Soonho Song ,  Curtis Tom ,  Martin Wensley

发明人： Ron Hale ,  Peter Lloyd ,  Amy Lu ,  Daniel Myers ,  Reynaldo Quintana ,  Joshua Rabinowitz ,  Dennis Solas ,  Soonho Song ,  Curtis Tom ,  Martin Wensley

IPC分类号： A61M11/00

CPC分类号： A61M11/041 ,  A61K9/007 ,  A61K9/0073 ,  A61M11/042 ,  A61M11/047 ,  A61M15/002 ,  A61M15/0028 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04 ,  Y10S514/958

摘要： A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300° C., and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.

摘要翻译： 公开了一种用于生产冷凝气雾剂的装置，方法和系统。 该装置包括具有允许气体流过腔室的上游开口和下游开口的腔室，以及位于上游和下游开口之间位置的导热基底。 在基质上形成药物组合物膜，当药物以气溶胶形式施用时，其含有治疗有效剂量的药物。 装置中的热源可操作以向衬底供应热量以产生大于300℃的衬底温度，并且在2秒或更短的时间内使药物组合物膜从衬底基本挥发。 该装置产生含有小于约10重量％的药物组合物降解产物和所述膜的药物组合物的至少50％的气溶胶。

公开(公告)号：US20070023710A1

公开(公告)日：2007-02-01

申请号：US11483267

申请日：2006-07-06

申请人： Curtis Tom ,  Mathieu Herbette ,  Orion Weihe

发明人： Curtis Tom ,  Mathieu Herbette ,  Orion Weihe

IPC分类号： A61L2/10 ,  A61L2/24

CPC分类号： A61L2/10 ,  A61L2/24 ,  A61L2/28

摘要： Apparatus and methods for controlling an ultraviolet (UV) sterilization system that has one or more UV sources to achieve proper sterilization with minimal time and usage of power for the UV sterilization system. The UV sources are operated according to a set of control parameters including intensity of the UV light energy and an exposure time. The device may include: one or more sensors that are configured to measure UV light energy emitted by the UV sources and develop one or more signals; and a microcontroller that has an access to information of UV energy doses for various types of microorganisms. The microcontroller is configured to receive the signals from the sensors, determine a set of optimum values corresponding to the set of control parameters using the signals and the information, and send the set of optimum values to the UV sources to control the UV sources.

摘要翻译： 用于控制紫外线（UV）灭菌系统的装置和方法，其具有一个或多个UV源以在UV消毒系统的最小时间和功率下实现适当的灭菌。 UV源根据一组控制参数进行操作，包括UV光能的强度和曝光时间。 该装置可以包括：一个或多个传感器，其配置成测量由UV源发射的UV光能量并开发一个或多个信号; 以及能够获得各种微生物的紫外线能量信息的微控制器。 微控制器被配置为从传感器接收信号，使用信号和信息确定对应于该组控制参数的一组最佳值，并将该组最优值发送到UV源以控制UV源。

公开(公告)号：US06488507B1

公开(公告)日：2002-12-03

申请号：US09450911

申请日：1999-11-29

申请人： David Stoloff ,  Albert M. Destefano, Jr. ,  Curtis Tom

发明人： David Stoloff ,  Albert M. Destefano, Jr. ,  Curtis Tom

IPC分类号： G09B2328

CPC分类号： G09B23/28

摘要： A portable enclosure for simulating surgical conditions using endoscopic instruments. The enclosure contains a pump and fluid reservoir and a canister in which an animal or synthetic tissue sample is placed within an adjustable cavity. The pump circulates fluid to an endoscopic instrument external to the enclosure enabling an individual to practice either monopolar or bipolar instrument techniques within the cavity and under conditions that simulate real life operating conditions.

摘要翻译： 便携式外壳，用于使用内窥镜仪器模拟外科手术。 外壳包含泵和流体储存器和罐，其中动物或合成组织样品放置在可调节腔内。 泵将流体循环到外壳外部的内窥镜仪器，使得个体能够在空腔内和在模拟现实生活操作条件的条件下练习单极或双极仪器技术。

公开(公告)号：US08387612B2

公开(公告)日：2013-03-05

申请号：US12485704

申请日：2009-06-16

申请人： Ramesh Damani ,  Ron L. Hale ,  Daniel J. Myers ,  Reynaldo J. Quintana ,  Dennis W. Solas ,  Soonho Song ,  Pravin Soni ,  Curtis Tom ,  Kirshnamohan Sharma

发明人： Ramesh Damani ,  Ron L. Hale ,  Daniel J. Myers ,  Reynaldo J. Quintana ,  Dennis W. Solas ,  Soonho Song ,  Pravin Soni ,  Curtis Tom ,  Kirshnamohan Sharma

IPC分类号： F24J1/00

CPC分类号： A61M11/00 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047 ,  A61M11/048 ,  A61M15/06 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2202/064 ,  A61M2205/36 ,  A61M2205/364 ,  A61M2205/3653 ,  A61M2205/8268 ,  B01B1/005 ,  B65B29/10 ,  C06B33/00 ,  C06B45/14 ,  C09K5/18 ,  F23B2900/00003 ,  F23C2900/99008 ,  F24V30/00 ,  Y02E20/346

摘要： Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.

公开(公告)号：US07913688B2

公开(公告)日：2011-03-29

申请号：US10442385

申请日：2003-05-20

申请人： Stephen Cross ,  Craig C. Hodges ,  Ron L. Hale ,  Peter M. Lloyd ,  Daniel J. Myers ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz ,  Curtis Tom ,  Martin J. Wensley

发明人： Stephen Cross ,  Craig C. Hodges ,  Ron L. Hale ,  Peter M. Lloyd ,  Daniel J. Myers ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz ,  Curtis Tom ,  Martin J. Wensley

IPC分类号： A61M15/08 ,  F23D11/00 ,  F23D14/00

CPC分类号： A61M15/00 ,  A61M11/002 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047

摘要： A device for delivering a drug by inhalation is disclosed. The device includes a body defining an interior flow-through chamber having upstream and downstream chamber openings, and a drug supply unit contained within the chamber for producing, upon actuation, a heated drug vapor in a condensation region of the chamber. Gas drawn through the chamber region at a selected gas-flow rate is effective to form drug condensation particles from the drug vapor having a selected MMAD between 0.02 and 0.1 MMAD or between 1 and 3.5 μm. A gas-flow control valve disposed upstream of the unit functions to limit gas-flow rate through the condensation region to the selected gas-flow rate. An actuation switch in the device activates the drug-supply unit, such that the drug-supply unit can be controlled to produce vapor when the gas-flow rate through the chamber is at the selected flow rate.

摘要翻译： 公开了一种通过吸入传送药物的装置。 该装置包括限定具有上游和下游室开口的内部流通室的主体，以及容纳在该室内的药物供应单元，用于在致动时产生在该室的冷凝区域中的加热的药物蒸气。 以选定的气体流速通过室区域抽吸的气体有效地从具有0.02至0.1MMAD的选定MMAD或1至3.5μm之间的药物蒸气形成药物凝结颗粒。 设置在单元上游的气体流量控制阀用于将通过冷凝区域的气体流量限制到所选择的气体流量。 装置中的致动开关激活药物供应单元，使得当通过腔室的气体流量处于所选择的流速时，可以控制药物供应单元产生蒸汽。

公开(公告)号：US07645442B2

公开(公告)日：2010-01-12

申请号：US10633876

申请日：2003-08-04

申请人： Ron L. Hale ,  Peter M. Lloyd ,  Amy Lu ,  Daniel J. Myers ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz ,  Dennis W. Solas ,  Soonho Song ,  Curtis Tom ,  Martin J. Wensley

发明人： Ron L. Hale ,  Peter M. Lloyd ,  Amy Lu ,  Daniel J. Myers ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz ,  Dennis W. Solas ,  Soonho Song ,  Curtis Tom ,  Martin J. Wensley

IPC分类号： A61K9/12 ,  A61K9/14 ,  A61M15/00

CPC分类号： A61M11/041 ,  A61K9/007 ,  A61K9/0073 ,  A61M11/042 ,  A61M11/047 ,  A61M15/002 ,  A61M15/0028 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04 ,  Y10S514/958

摘要： A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300° C., and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.

摘要翻译： 公开了一种用于生产冷凝气雾剂的装置，方法和系统。 该装置包括具有允许气体流过腔室的上游开口和下游开口的腔室，以及位于上游和下游开口之间位置的导热基底。 在基质上形成药物组合物膜，当药物以气溶胶形式施用时，其含有治疗有效剂量的药物。 装置中的热源可操作以向衬底供应热量以产生大于300℃的衬底温度，并且在2秒或更短的时间内使药物组合物膜从衬底基本挥发。 该装置产生含有小于约10重量％的药物组合物降解产物和所述膜的药物组合物的至少50％的气溶胶。

公开(公告)号：US20090235926A1

公开(公告)日：2009-09-24

申请号：US12474680

申请日：2009-05-29

申请人： Steven D. Cross ,  Matthieu Herbette ,  Andrew J.G. Kelly ,  Daniel J. Myers ,  William W. Shen ,  Ryan D. Timmons ,  Curtis Tom ,  Justin M. Virgili ,  Martin J. Wensley

发明人： Steven D. Cross ,  Matthieu Herbette ,  Andrew J.G. Kelly ,  Daniel J. Myers ,  William W. Shen ,  Ryan D. Timmons ,  Curtis Tom ,  Justin M. Virgili ,  Martin J. Wensley

IPC分类号： A61M11/00

CPC分类号： H05B1/0244 ,  A61M11/002 ,  A61M11/041 ,  A61M11/042 ,  A61M15/0021 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0065 ,  A61M15/008 ,  A61M15/0081 ,  A61M16/1075 ,  A61M16/14 ,  H05B2203/021

摘要： Devices and methods of entraining a substance within an airflow are disclosed. Condensation aerosol delivery devices and methods of consistently producing multiple doses of a substance, such as a drug, having high purity, high yield, characterized by a particle size distribution appropriate for pulmonary delivery, and which can be administered to a user in a single dose are also disclosed.

摘要翻译： 公开了在气流中夹带物质的装置和方法。 冷凝气溶胶输送装置和一贯生产多剂量物质（例如药物）的方法，其具有高纯度，高产率，其特征在于适于肺部输送的粒度分布，并且其可以以单剂量施用于使用者 也被披露。