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公开(公告)号：US06419923B1
公开(公告)日：2002-07-16
申请号：US08768619
申请日：1996-12-18
IPC分类号： A61K3846
CPC分类号： G01N33/5091 , A61K38/00 , A61K39/00 , A61K39/0003 , A61K2039/51 , C07K14/4354 , C07K16/18 , C07K16/40 , C07K2319/00 , C12N9/6402 , C12N9/641 , C12N2799/021 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5308 , G01N33/56905 , G01N2333/4353 , G01N2333/95 , G01N2333/96402 , Y02A50/422
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译： 本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US5866126A
公开(公告)日：1999-02-02
申请号：US833622
申请日：1997-04-08
IPC分类号： G01N33/53 , A61K38/55 , A61K39/00 , A61K39/002 , A61K39/395 , A61P33/02 , C07H21/04 , C07K14/44 , C07K16/20 , C12N5/10 , C12N9/08 , C12N15/09 , C12P21/08 , G01N33/566 , G01N33/573 , A61K39/40 , C07K16/00
CPC分类号： C12N9/0065
摘要： The present invention relates to D. immitis Gp29 proteins, nucleic acid molecules having sequences that encode such proteins, antibodies raised against such proteins and inhibitors of D. immitis glutathione peroxidase. The present invention also includes methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitors. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasitic helminths, such as heartworm.
摘要翻译： 本发明涉及D.mymitis Gp29蛋白质，具有编码这种蛋白质的序列的核酸分子，针对这种蛋白质产生的抗体和D.mitmitis谷胱甘肽过氧化物酶的抑制剂。 本发明还包括获得这种核酸分子，蛋白质，抗体和抑制剂的方法。 本发明还包括包含这种核酸分子，蛋白质，抗体和抑制剂的治疗组合物，以及它们用于保护动物免受寄生蠕虫（例如心丝虫）引起的疾病的用途。
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公开(公告)号：US5750391A
公开(公告)日：1998-05-12
申请号：US463989
申请日：1995-06-05
IPC分类号： C12N15/09 , A61K38/46 , A61K38/55 , A61K39/00 , A61K39/002 , A61K39/395 , A61K48/00 , A61P5/12 , A61P33/00 , A61P33/02 , A61P33/10 , A61P43/00 , C07H21/04 , C07K14/44 , C12N1/21 , C12N5/10 , C12N9/50 , C12N9/64 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , C12N9/48
CPC分类号： C12N9/641 , C12N9/6416 , A61K39/00
摘要： The present invention relates to parasite astacin metalloendopeptidase and filariid cysteine protease proteins, nucleic acid molecules having sequences that encode such proteins, antibodies raised against such proteins and compounds that can inhibit the activities of parasite astacin metalloendopeptidases or cysteine proteases. The present invention also includes methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitors. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasites, such as heartworm.
摘要翻译： 本发明涉及寄生虫星细胞金属内肽酶和丝状半胱氨酸蛋白酶蛋白质，具有编码这种蛋白质的序列的核酸分子，针对这种蛋白质产生的抗体以及可抑制寄生虫星形金属内毒肽酶或半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种核酸分子，蛋白质，抗体和抑制剂的方法。 本发明还包括包含这种核酸分子，蛋白质，抗体和抑制剂的治疗组合物以及它们用于保护动物免受由寄生虫如心脏病引起的疾病的用途。
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14.发明授权Parasitic helminth larval thiol specific antioxidant proteins and nucleic acid molecules 失效寄生蠕虫幼虫硫醇特异性抗氧化蛋白和核酸分子
公开(公告)号：US5744593A
公开(公告)日：1998-04-28
申请号：US602262
申请日：1996-02-15
申请人： Laura Klimowski , Cynthia Ann Tripp
发明人： Laura Klimowski , Cynthia Ann Tripp
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K39/002 , A61K39/395 , A61K45/00 , A61P33/00 , A61P33/02 , C07K14/435 , C07K14/44 , C07K16/18 , C07K16/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/569 , C07H21/04 , C12N15/00 , C12N15/36 , C12P21/02
CPC分类号： C07K14/43536 , C07K14/4354 , C07K16/18 , A61K38/00 , C07K2319/00 , C12N2799/023
摘要： The present invention relates to parasitic helminth thiol specific antioxidant (TSA) larval proteins; to parasitic helminth larval TSA nucleic acid molecules, including those that encode such TSA proteins; to antibodies raised against such TSA proteins; and to compounds that inhibit parasitic helminth larval TSA activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及寄生蠕虫硫醇特异性抗氧化剂（TSA）幼虫蛋白质; 寄生虫寄生虫幼虫TSA核酸分子，包括编码这种TSA蛋白的那些; 针对这种TSA蛋白产生的抗体; 以及抑制寄生蠕虫幼虫TSA活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及使用这些治疗组合物来保护动物免受寄生蠕虫引起的疾病。
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公开(公告)号：US5686080A
公开(公告)日：1997-11-11
申请号：US459019
申请日：1995-06-02
IPC分类号： C12N15/09 , A61K31/70 , A61K35/12 , A61K35/68 , A61K38/00 , A61K38/08 , A61K38/17 , A61K39/00 , A61K39/395 , A61P33/00 , C07H21/04 , C07K14/435 , C07K16/18 , C12N5/00 , C12N5/10 , C12N9/64 , C12N15/12 , C12N15/63 , C12P21/02 , C12P21/04 , C12P21/08 , C12R1/91 , G01N33/50 , G01N33/53 , G01N33/569 , A61K39/002 , A61K39/38 , C07K14/00
CPC分类号： G01N33/56905 , A61K39/0003 , A61K39/39533 , C07K14/4354 , C07K16/18 , C12N9/641 , G01N33/5008 , G01N33/5014 , G01N33/5088 , G01N33/5091 , G01N33/5308 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2799/021 , G01N2333/4353 , G01N2333/95 , G01N2333/96402
摘要： The present invention relates to isolated parasitic helminth nucleic acid sequences capable of hybridizing, under stringent conditions, to at least a portion of D. immitis nucleic acid sequence p4 and/or to at least a portion of D. immitis nucleic acid sequence p22U; to isolated parasitic helminth proteins that are encoded by such parasitic helminth nucleic acid sequences and that are capable of selectively binding to at least one component of immune serum capable of inhibiting helminth development; and to antibodies raised against such isolated parasitic helminth proteins. The present invention also relates to therapeutic compositions comprising such isolated nucleic acid sequences, proteins and/or antibodies. The present invention also includes methods to produce and use such nucleic acids, proteins, antibodies and therapeutic compositions capable of protecting animals from parasitic helminth infection and, particularly, from heartworm infection.
摘要翻译： 本发明涉及分离的寄生蠕虫核酸序列，其能够在严格条件下与至少一部分核酸核酸序列p4和/或至少部分核型核酸序列p22U杂交; 至由这种寄生蠕虫核酸序列编码并且能够选择性结合能够抑制蠕虫发育的至少一种免疫血清成分的分离的寄生蠕虫蛋白; 以及针对这种分离的寄生蠕虫蛋白产生的抗体。 本发明还涉及包含这种分离的核酸序列，蛋白质和/或抗体的治疗组合物。 本发明还包括生产和使用能够保护动物免受寄生蠕虫感染，特别是来自心丝虫感染的核酸，蛋白质，抗体和治疗组合物的方法。
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16.发明授权Parasitic helminth macrophage inhibitory factor nucleic acid molecules and uses thereof 失效寄生蠕虫巨噬细胞抑制因子核酸分子及其用途
公开(公告)号：US5681724A
公开(公告)日：1997-10-28
申请号：US558735
申请日：1995-11-16
IPC分类号： G01N33/53 , A61K31/00 , A61K31/70 , A61K38/00 , A61K39/002 , A61P33/00 , A61P33/02 , A61P33/10 , C07K14/44 , C07K14/52 , C07K16/20 , C12N7/00 , C12N15/00 , C12N15/09 , C12P21/02 , C12R1/10 , H01G9/04 , H01G9/055 , C07H21/04
CPC分类号： H01G9/055 , C07K14/52 , C07K2319/00 , Y10S435/975
摘要： The present invention relates to parasitic helminth macrophage migration inhibitory factor (MIF) proteins; to parasitic helminth MIF nucleic acid molecules, including those that encode such MIF proteins; to antibodies raised against such MIF proteins; and to compounds that inhibit parasitic helminth MIF activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及寄生蠕虫巨噬细胞迁移抑制因子（MIF）蛋白; 包括那些编码这种MIF蛋白的MIF核酸分子， 针对这种MIF蛋白产生的抗体; 以及抑制寄生蠕虫MIF活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US06673345B2
公开(公告)日：2004-01-06
申请号：US09864541
申请日：2001-05-23
IPC分类号： A61K39395
CPC分类号： C12N9/641 , A61K39/00 , C12N9/6416
摘要： The present invention relates to parasite astacin metalloendopeptidase proteins, nucleic acid molecules having sequences that encode such proteins, antibodies raised against such proteins and compounds that can inhibit the activities of parasite astacin metalloendopeptidases. The present invention also includes methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitors. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasites, such as heartworm infection.
摘要翻译： 本发明涉及寄生虫星细胞金属内肽酶蛋白质，具有编码这种蛋白质的序列的核酸分子，针对这种蛋白质产生的抗体和可以抑制寄生虫星形金属内切肽酶活性的化合物。 本发明还包括获得这种核酸分子，蛋白质，抗体和抑制剂的方法。 本发明还包括包含这种核酸分子，蛋白质，抗体和抑制剂的治疗组合物，以及它们用于保护动物免受寄生虫（例如心丝虫感染）引起的疾病的用途。
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18.发明授权Antiparasitic helminth larval thiol specific antioxidant-antibodies, and uses thereof 有权抗寄生虫蠕虫幼虫硫醇特异性抗氧化剂抗体及其用途公开(公告)号：US06489448B1
公开(公告)日：2002-12-03
申请号：US09477510
申请日：2000-01-04
申请人： Laura Klimowski , Cynthia Ann Tripp
发明人： Laura Klimowski , Cynthia Ann Tripp
IPC分类号： C07K1600
CPC分类号： C07K14/43536 , A61K38/00 , C07K14/4354 , C07K16/18 , C07K2319/00 , C12N2799/023
摘要： The present invention relates to parasitic helminth thiol specific antioxidant (TSA) larval proteins; to parasitic helminth larval TSA nucleic acid molecules, including those that encode such TSA proteins; to antibodies raised against such TSA proteins; and to compounds that inhibit parasitic helminth larval TSA activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及寄生蠕虫硫醇特异性抗氧化剂（TSA）幼虫蛋白质; 寄生虫寄生虫幼虫TSA核酸分子，包括编码这种TSA蛋白的那些; 针对这种TSA蛋白产生的抗体; 以及抑制寄生蠕虫幼虫TSA活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US06265198B1
公开(公告)日：2001-07-24
申请号：US09003574
申请日：1998-01-06
IPC分类号： A61K3170
CPC分类号： C12N9/641 , A61K39/00 , C12N9/6416
摘要： The present invention relates to parasite astacin metalloendopeptidase proteins, nucleic acid molecules having sequences that encode such proteins, antibodies raised against such proteins and compounds that can inhibit the activities of parasite astacin metalloendopeptidases. The present invention also includes methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitors. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasites, such as heartworm infection.
摘要翻译： 本发明涉及寄生虫星细胞金属内肽酶蛋白质，具有编码这种蛋白质的序列的核酸分子，针对这种蛋白质产生的抗体和可以抑制寄生虫星形金属内切肽酶活性的化合物。 本发明还包括获得这种核酸分子，蛋白质，抗体和抑制剂的方法。 本发明还包括包含这种核酸分子，蛋白质，抗体和抑制剂的治疗组合物，以及它们用于保护动物免受寄生虫如心脏感染引起的疾病的用途。
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公开(公告)号：US5691186A
公开(公告)日：1997-11-25
申请号：US463262
申请日：1995-06-05
IPC分类号： C12N15/09 , A61K38/46 , A61K38/55 , A61K39/00 , A61K39/002 , A61K39/395 , A61K48/00 , A61P5/12 , A61P33/00 , A61P33/02 , A61P33/10 , A61P43/00 , C07H21/04 , C07K14/44 , C12N1/21 , C12N5/10 , C12N9/50 , C12N9/64 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , C12N15/63
CPC分类号： C12N9/641 , C12N9/6416 , A61K39/00
摘要： The present invention relates to parasite astacin metalloendopeptidase and filariid cysteine protease proteins, nucleic acid molecules having sequences that encode such proteins, antibodies raised against such proteins and compounds that can inhibit the activities of parasite astacin metalloendopeptidases or cysteine proteases. The present invention also includes methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitors. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasites, such as heartworm.
摘要翻译： 本发明涉及寄生虫星细胞金属内肽酶和丝状半胱氨酸蛋白酶蛋白质，具有编码这种蛋白质的序列的核酸分子，针对这种蛋白质产生的抗体以及可抑制寄生虫星形金属内毒肽酶或半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种核酸分子，蛋白质，抗体和抑制剂的方法。 本发明还包括包含这种核酸分子，蛋白质，抗体和抑制剂的治疗组合物以及它们用于保护动物免受由寄生虫如心脏病引起的疾病的用途。
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