公开(公告)号：US20120050074A1

公开(公告)日：2012-03-01

申请号：US13034748

申请日：2011-02-25

Applicant: Jon H. Bechtel ,  Jeremy C. Andrus ,  Gregory S. Bush ,  David J. Wright ,  Jim L. Schneider ,  Tom B. Sherman

Inventor： Jon H. Bechtel ,  Jeremy C. Andrus ,  Gregory S. Bush ,  David J. Wright ,  Jim L. Schneider ,  Tom B. Sherman

IPC: G08G1/123 ,  G06K9/00 ,  H04N7/18

CPC classification number: G06K9/2018 ,  B60R1/04 ,  B60R2001/1215 ,  B60R2001/1223 ,  B60R2001/1253 ,  B60R2001/1284 ,  B60W30/12 ,  B60W30/14 ,  G06K9/00798 ,  G06K9/00825 ,  G06K9/209 ,  G08G1/166

Abstract: An automatic vehicle equipment control system and methods thereof are provided, the system includes at least one imager configured to acquire a continuous sequence of high dynamic range single frame images, a processor, a color spectral filter array including a plurality of color filters, at least a portion of which are different colors, and pixels of an imager pixel array being in optical communication with substantially one spectral color filter, and a lens, wherein the imager is configured to capture a non-saturated image of nearby oncoming headlamps and at least one of a diffuse lane marking and a distant tail lamp in one image frame of the continuous sequence of high dynamic range single frame images, and the system configured to detect at least one of said highway markings and said tail lamps, and quantify light from the oncoming headlamp from data in the one image frame.

Abstract translation: 提供了一种自动车辆设备控制系统及其方法，该系统包括至少一个成像器，被配置成获取高动态范围单帧图像的连续序列，处理器，包括多个滤色器的色谱滤波器阵列，至少 其一部分是不同的颜色，并且成像器像素阵列的像素与基本上一个光谱滤色器光学通信，以及透镜，其中所述成像器被配置为捕获附近的即将到来的前大灯的不饱和图像和至少一个 在高动态范围单帧图像的连续序列的一个图像帧中的漫射车道标记和远距离尾灯，并且被配置为检测所述公路标记和所述尾灯中的至少一个的系统，并且量化来自迎面而来的 头灯从一个图像帧中的数据。

公开(公告)号：US07851593B2

公开(公告)日：2010-12-14

申请号：US10776643

申请日：2004-02-12

Applicant: Helen Vivian Hsieh ,  J. Bruce Pitner ,  Terry J. Amiss ,  Colleen M. Nycz ,  Douglas B. Sherman ,  David J. Wright

Inventor： Helen Vivian Hsieh ,  J. Bruce Pitner ,  Terry J. Amiss ,  Colleen M. Nycz ,  Douglas B. Sherman ,  David J. Wright

IPC: C07K14/00 ,  A61K38/00

CPC classification number: G01N33/54373 ,  C07K14/245 ,  G01N33/543 ,  G01N33/5438 ,  G01N33/66

Abstract: The invention is directed to compositions of mutated binding proteins containing reporter groups, analyte biosensor devices derived therefrom, and their use as analyte biosensors both in vitro and in vivo.

Abstract translation: 本发明涉及含有报告基团的突变结合蛋白的组合物，从其衍生的分析物生物传感器装置及其作为体外和体内分析物生物传感器的用途。

公开(公告)号：US07223536B2

公开(公告)日：2007-05-29

申请号：US09778168

申请日：2001-02-07

Applicant: David J. Wright ,  Maria A. Milla ,  James G. Nadeau ,  G. Terrance Walker

Inventor： David J. Wright ,  Maria A. Milla ,  James G. Nadeau ,  G. Terrance Walker

IPC: C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC classification number: C12Q1/6827 ,  C12Q2565/1025 ,  C12Q2535/125 ,  C12Q2531/119 ,  C12Q2531/101

Abstract: The present invention provides methods for detecting and identifying sequence variations in a nucleic acid sequence of interest using a detector primer. It has been found that the reduced efficiency of primer extension by DNA polymerases when the 3′ end of a primer does not hybridize perfectly with the target can be adapted for use as a means for distinguishing or identifying the nucleotide in the target which is at the site where the diagnostic mismatch between the detector primer and the target occurs. The detector primer hybridizes to the sequence of interest and is extended with polymerase. The efficiency of detector primer extension is detected as an indication of the presence and/or identity of the sequence variation in the target. The inventive methods make use of nucleotide mismatches at or near the 3′ end of the detector primer to discriminate between the nucleotide sequence of interest and a second nucleotide sequence which may occur at that same site in the target. The methods are particularly well suited for detecting and identifying single nucleotide differences between a target sequence of interest (e.g., a mutant allele of a gene) and a second nucleic acid sequence (e.g., a wild type allele for the same gene).

Abstract translation: 本发明提供使用检测器引物检测和鉴定感兴趣的核酸序列中的序列变异的方法。 已经发现，当引物的3'端没有与靶完全杂交时，通过DNA聚合酶的引物延伸的效率降低可以适用于区分或鉴定靶中的核苷酸的手段 发现检测器引物与靶标之间的诊断不匹配的位置。 检测引物与感兴趣的序列杂交，并用聚合酶扩增。 检测器引物延伸的效率被检测为目标中序列变异的存在和/或身份的指示。 本发明的方法利用在检测器引物的3'末端附近或其附近的核苷酸错配来区分目的核苷酸序列和可能发生在靶的相同位点的第二核苷酸序列。 所述方法特别适用于检测和鉴定靶标目标序列（例如，基因的突变等位基因）和第二核酸序列（例如，相同基因的野生型等位基因）之间的单核苷酸差异。

公开(公告)号：US07095450B1

公开(公告)日：2006-08-22

申请号：US09446296

申请日：1998-06-18

Applicant: Steven Holmes ,  Simon Anthony Vivian Cornwell ,  Richard Andrew Kydd ,  David J Wright

Inventor： Steven Holmes ,  Simon Anthony Vivian Cornwell ,  Richard Andrew Kydd ,  David J Wright

IPC: H04N9/74 ,  H04N5/44 ,  H04N7/173 ,  G09G5/00 ,  G06F3/00 ,  G06F9/00 ,  G06F17/00

CPC classification number: H04N9/74 ,  A63F13/12 ,  A63F13/338 ,  A63F13/52 ,  A63F2300/409 ,  A63F2300/66 ,  A63F2300/69

Abstract: Apparatus for interactively generating a display signal. The apparatus comprises: a receiver (2) for receiving a broadcast signal (15), the broadcast signal comprising a plurality of datastreams each including image data defining a background object (22–270), and control parameters (28–39); a foreground computer generated imagery (CGI) device (3) for generating a foreground computer generated object (CGO); a mixer (4) for combining the foreground CGO with background object image data to generate the display signal; and interaction means (3) for receiving the control parameters from the receiver, monitoring the position of the foreground CGO, and adapting the display signal with reference to the monitored position of the foreground CGO and the received control parameters.

Abstract translation: 用于交互地产生显示信号的装置。 该装置包括：接收器（2），用于接收广播信号（15），所述广播信号包括多个数据流，每个数据流包括定义背景对象（22-270）的图像数据和控制参数（28-39）; 用于生成前台计算机生成对象（CGO）的前台计算机生成图像（CGI）装置（3）; 混合器（4），用于将前景CGO与背景对象图像数据组合以产生显示信号; 以及用于从接收器接收控制参数的相互作用装置（3），监视前景CGO的位置，以及参照前景CGO和所接收的控制参数的监视位置调整显示信号。

公开(公告)号：US06855556B2

公开(公告)日：2005-02-15

申请号：US10040077

申请日：2002-01-04

Applicant: Terry J. Amiss ,  Colleen M. Nycz ,  J. Bruce Pitner ,  Douglas B. Sherman ,  David J. Wright

Inventor： Terry J. Amiss ,  Colleen M. Nycz ,  J. Bruce Pitner ,  Douglas B. Sherman ,  David J. Wright

IPC: G01N33/53 ,  C07K14/245 ,  G01N21/78 ,  G01N33/543 ,  G01N33/566 ,  G01N33/58 ,  G01N33/48

CPC classification number: G01N33/5438 ,  C07K14/245 ,  Y10S435/817 ,  Y10T436/144444

Abstract: The invention is directed to compositions of mutated binding proteins containing reporter groups, analyte biosensor devices derived there from, and their use as analyte biosensor both in vitro and in vivo.

Abstract translation: 本发明涉及含有报道基团的突变结合蛋白的组合物，从其衍生的分析物生物传感器装置，以及它们在体外和体内作为分析物生物传感器的用途。

公开(公告)号：US06479020B1

公开(公告)日：2002-11-12

申请号：US09498942

申请日：2000-02-04

Applicant: James E. Stanchfield ,  Paul B. Robbins ,  Chris N. Bailey ,  David J. Wright

Inventor： James E. Stanchfield ,  Paul B. Robbins ,  Chris N. Bailey ,  David J. Wright

IPC: B01L300

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00335 ,  B01J2219/00416 ,  B01J2219/00423 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01L3/5025 ,  C40B60/14

Abstract: An improved multi-well synthesis and filtration apparatus (10) includes a deep-well synthesis block (12) having a plurality of flowthrough wells (24) optionally fitted with filter disks (48) each of the wells (24) being integrally formed in the synthesis block (12), such that any material placed in the wells (24) is in immediate contact with the material of the synthesis block (12), an upper cover (14), a lower cover (16), and a pair of first and second sheet gaskets (18, 20). The first and second sheet gaskets (18, 20) are interposed between the upper and lower covers (14, 16) to seal inlet portions (38) and outlet spouts (40) of the wells (24). The upper and lower covers (14, 16) are independently releasable, and, with the gaskets (18, 20) form a gas tight seal, so that material is retained in the wells (24) when the lower cover (16) is removed, but the upper seal maintained. Apertures (70) in the upper cover (14) provide that the first sheet gasket (18) may be punctured for introduction of materials and/or maintenance of an inert atmosphere. An alternative synthesis block (412) having half the number of wells (424) but configured to be able to use a collection plate (123) of the same array as the first embodiment is also described.

Abstract translation: 改进的多孔合成和过滤装置（10）包括深井合成块（12），其具有可选地装配有过滤盘（48）的多个通孔（24），每个孔（24）整体形成在 合成块（12），使得放置在孔（24）中的任何材料与合成块（12）的材料，上盖（14），下盖（16）和一对 的第一和第二片状垫片（18,20）。 第一和第二片状垫片（18,20）介于上盖和下盖（14,16）之间，以密封孔（24）的入口部分（38）和出口（40）。 上盖和下盖独立地可拆卸，并且垫圈（18,20）形成气密密封，使得当下盖（16）被移除时材料保留在井（24）中 ，但保持上密封。 上盖（14）中的孔（70）提供了第一片垫片（18）可被穿孔以引入材料和/或维持惰性气氛。具有一半孔数的备选合成块（412） 424）但是被配置为能够使用与第一实施例相同的阵列的收集板（123）。

公开(公告)号：US6054100A

公开(公告)日：2000-04-25

申请号：US972996

申请日：1997-11-18

Applicant: James E. Stanchfield ,  Paul B. Robbins ,  Chris N. Bailey ,  David J. Wright

Inventor： James E. Stanchfield ,  Paul B. Robbins ,  Chris N. Bailey ,  David J. Wright

IPC: B01J19/00 ,  B01L3/00 ,  C40B60/14

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01L3/5025 ,  B01J2219/00286 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00335 ,  B01J2219/00416 ,  B01J2219/00423 ,  B01J2219/00585 ,  B01J2219/00596 ,  C40B60/14

Abstract: A multi-well synthesis and filtration apparatus (10) dimensionally arrayed in a standard multi-well format for performing multiple chemical reactions includes a deep-well synthesis block (12) with flowthrough wells (24) fitted with filter disks (48), an upper cover (14), and a lower cover (16). First and second sheet gaskets (18 and 20) seal inlet portions (38) and outlet spouts (40) of the wells (24). An optional skirt (26) provides a site for the independently releasable attachment of the upper and lower covers (14 and 16) to the block (12) while maintaining the seal on the unreleased cover. An alternative synthesis apparatus (310) additionally includes a reinforcement assembly (372) to improve the clamping action of the covers (14 and 16) upon the synthesis block (12). A rotating carrier apparatus (200) and a modified oven assembly (202) are provided to enable agitation and heating of multiple synthesis blocks (12) simultaneously.

Abstract translation: 尺寸排列成用于执行多个化学反应的标准多孔格式的多孔合成和过滤装置（10）包括具有装配有过滤盘（48）的流通井（24）的深井合成块（12）， 上盖（14）和下盖（16）。 第一和第二片状垫片（18和20）密封孔（24）的入口部分（38）和出口（40）。 可选的裙部（26）提供了用于将上盖和下盖（14和16）独立地可拆卸地连接到块（12）的位置，同时保持未未覆盖的盖上的密封。 替代合成设备（310）还包括加强组件（372），用于改善盖子（14和16）在合成块（12）上的夹紧动作。 提供旋转载体装置（200）和改进的炉组件（202），以同时搅拌和加热多个合成块（12）。

公开(公告)号：US5811269A

公开(公告)日：1998-09-22

申请号：US640378

申请日：1996-04-30

Applicant: James G. Nadeau ,  Cheryl H. Dean ,  James L. Schram ,  Deborah R. Howard ,  Margaret S. Dey ,  David J. Wright

Inventor： James G. Nadeau ,  Cheryl H. Dean ,  James L. Schram ,  Deborah R. Howard ,  Margaret S. Dey ,  David J. Wright

IPC: C12N15/09 ,  C07H21/04 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/32 ,  C12R1/325 ,  C12R1/33 ,  C12P19/34

CPC classification number: C12Q1/689 ,  C12Q2600/16

Abstract: Primers and methods for adapter-mediated multiplex amplification of the IS6110 insertion element of the Mycobacterium tuberculosis (M.tb) complex and a 16S rDNA target common to essentially all mycobacteria are described. In certain embodiments, the primers are optimized for efficient multiplex amplification in thermophilic SDA. The multiplex Strand Displacement Amplification methods of the invention are capable, in a single amplification reaction, of simultaneously identifying M. tuberculosis and providing a screen for substantially all of the clinically relevant species of mycobacteria. Also disclosed are internal control sequences designed for coamplification with the two targets, allowing assessment of amplification efficiency and/or quantitation of the targets.

Abstract translation: 描述了针对结核分枝杆菌（M.tb）复合物的IS6110插入元件和基本上所有分枝杆菌共同的16S rDNA靶的衔接子介导的多重扩增的引物和方法。 在某些实施方案中，针对嗜热SDA中的有效多重扩增优化引物。 本发明的多重链位移扩增方法能够在单个扩增反应中同时鉴定结核分枝杆菌并提供基本上所有临床相关分枝杆菌物种的筛选。 还公开了设计用于与两个靶标共扩增的内部控制序列，允许评估靶标的扩增效率和/或定量。

公开(公告)号：US5626739A

公开(公告)日：1997-05-06

申请号：US360781

申请日：1995-02-27

Applicant: Colin J. Burns ,  David J. Wright

Inventor： Colin J. Burns ,  David J. Wright

IPC: B01D43/00 ,  C22B3/04 ,  C22B3/22 ,  C22B11/08 ,  C25C1/00

CPC classification number: B01D43/00 ,  C22B11/04 ,  C22B11/08 ,  C22B3/045 ,  Y02P10/234

Abstract: A method of treating a solid material containing a substance of economic importance so as to recover or extract the substance from the material involving the following: forming a conducting mixture of the solid with a liquid so that at least some of the substance of economic importance is dissolved in the liquid, applying an electrical potential difference between at least two electrodes in contact with the mixture at spaced apart locations so as to impart opposite charges to the respective electrodes thereby attracting the liquid containing the dissolved substance to one of the electrodes, removing the liquid from an area surrounding or from a vicinity of the one electrode, and treating the liquid containing the substance of economic importance so as to recover or extract the substance. The liquid used is at least partially conducting. The present method is particularly useful for extracting or recovering gold from gold-containing or gold bearing ores.

Abstract translation: PCT No.PCT / AU93 / 00318 Sec。 371日期：1995年2月27日 102（e）日期1995年2月27日PCT提交1993年6月29日PCT公布。 出版物WO94 / 00608 日期1994年1月6日一种处理含有经济重要物质的固体材料的方法，以便从涉及以下物质的物质中回收或提取物质：形成固体与液体的导电混合物，使得至少一些 具有经济重要性的物质溶解在液体中，在间隔开的位置处在与混合物接触的至少两个电极之间施加电位差，从而对各个电极赋予相反的电荷，从而将含有溶解物质的液体吸引到 电极，从一个电极周围或附近的区域除去液体，以及处理含有经济重要物质的液体，以回收或提取物质。 使用的液体至少部分导电。 本方法特别适用于从含金或含金矿石中提取或回收金。

公开(公告)号：US5564826A

公开(公告)日：1996-10-15

申请号：US534578

申请日：1995-09-27

Applicant: Hans D. Neumann ,  Arthur J. Robbins ,  David J. Wright

Inventor： Hans D. Neumann ,  Arthur J. Robbins ,  David J. Wright

IPC: B01F11/00 ,  B01L7/02

CPC classification number: B01F11/0014 ,  B01L7/02

Abstract: A bath shaker (10) is provided for agitating liquid baths. The bath shaker (10) incorporates a "flexible parallelogram" mode of movement wherein a bath shelf (20) is attached to and supported by two, parallel opposing flexible arms (112). Present on each flexible arm (112) is a first attachment portion (124) sandwichedly held by an upright extension (120) and a first hold plate (110), the arrangement causing the first attachment portion (124) to serve as a flexible hinge. A drive mechanism (16) produces a reciprocating action of the bath shelf (20) through the use of an eccentric (80) and a pivoting lever (46) attached to both the eccentric (80) and the bath shelf (20). The flexible parallelogram arrangement defines the reciprocating motion to be substantially rectilinear and makes for an entirely noiseless mode of travel, while producing an extremely smooth transition between reciprocations. Two bath containers (24) are supported by the bath shelf (20) and are provided with a highly accurate temperature control system (26).

Abstract translation: 提供用于搅拌液浴的洗浴摇床（10）。 洗浴摇床（10）包含“柔性平行四边形”运动模式，其中浴架（20）附接到两个平行的相对的柔性臂（112）并由其支撑。 存在于每个柔性臂（112）上的是由直立延伸部（120）和第一保持板（110）夹持的第一附接部分（124），该第一连接部分使得第一附接部分（124）用作柔性铰链 。 驱动机构（16）通过使用连接到偏心轮（80）和浴架（20）两者的偏心轮（80）和枢转杆（46）来产生浴架（20）的往复运动。 柔性平行四边形布置将往复运动定义为基本上直线的，并且使得完全无噪声的行进模式，同时在往复运动之间产生非常平滑的过渡。 两个洗浴容器（24）由浴架（20）支撑，并设置有高精度的温度控制系统（26）。