公开(公告)号：US20230001356A1

公开(公告)日：2023-01-05

申请号：US17772724

申请日：2020-11-17

Applicant: EMD Millipore Corporation

Inventor： Stefano Berti Perez ,  Alison Dupont

IPC: B01D61/18 ,  C12M1/00

Abstract: The disclosure herein relates to a TFF assembly including a baffle comprising a microporous filter within a bioreactor. The baffle may include a collection receptacle to capture a target product or waste materials within the baffle after passing through the microporous filter.

公开(公告)号：USD962259S1

公开(公告)日：2022-08-30

申请号：US29758169

申请日：2020-11-12

Applicant: Sigma-Aldrich Co. LLC ,  EMD Millipore Corporation

Designer： Sarah Trice ,  Lindsey Rickershauser ,  Xiang Wu ,  Churl Oh ,  Nadia Brugger ,  Emma Gardener

公开(公告)号：US20220170073A1

公开(公告)日：2022-06-02

申请号：US17369771

申请日：2021-07-07

Applicant: The University of Chicago ,  EMD Millipore Corporation

Inventor： David A. Schwartz ,  Jimmy Williams ,  Xinfang Zhao ,  Chunfang Zhao ,  William B. Busa ,  Stephen J. Kron ,  Amy Catherine Flor

IPC: C12Q1/6804 ,  C07H21/00 ,  C12Q1/6834

Abstract: The present disclosure is directed to methods and/or uses of oligonucleotide conjugates for assays and flow cytometry detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein.

公开(公告)号：US20220119759A1

公开(公告)日：2022-04-21

申请号：US17073465

申请日：2020-10-19

Applicant: EMD Millipore Corporation

Inventor： Ying Li ,  Alison Dupont ,  Amy Wood ,  Allyson Fournier ,  Akshat Gupta ,  Hiral Gami

IPC: C12M1/00

Abstract: A multi-stage TFF apparatus, comprising a bioreactor capable of holding cell culture media; a first stage TFF device in fluid communication with the bioreactor; a storage tank in fluid communication with the first stage TFF device; a first recirculating loop in fluid communication with the first stage TFF device and the bioreactor; a second stage TFF device, in fluid communication with and downstream from the storage tank; and a second recirculating loop in fluid communication with the second stage TFF device and the storage tank.

公开(公告)号：USD946167S1

公开(公告)日：2022-03-15

申请号：US29755024

申请日：2020-10-16

Applicant: EMD Millipore Corporation

Designer： Paul Sydlowski ,  John Doyle

公开(公告)号：US20210355159A1

公开(公告)日：2021-11-18

申请号：US17311099

申请日：2019-11-11

Applicant: EMD Millipore Corporation

Inventor： Thomas Elich ,  Herbert Lutz

IPC: C07K1/22 ,  C07K1/36 ,  C07K1/34

Abstract: Method and system for purifying a sample comprising a biomolecule of interest and impurities, comprising expressing said biomolecule of interest in a bioreactor to form a product sample comprising said biomolecule of interest and impurities; subjecting said product sample to single pass tangential flow filtration to form a concentrated product sample; and subjecting said concentrated product sample to affinity chromatography to remove impurities from said concentrated product sample.

公开(公告)号：US20210354055A1

公开(公告)日：2021-11-18

申请号：US17312109

申请日：2020-03-26

Applicant: EMD Millipore Corporation

Inventor： Akshat Gupta ,  John Paul Amara ,  Kara M. Pizzelli ,  Shannon Ryan

IPC: B01D24/10 ,  B01D39/16 ,  B01D39/18 ,  B01D39/20 ,  G01N1/40 ,  G01N1/34

Abstract: Depth filters with optimized head space are provided, as well as methods of optimizing the head space in depth filters, and methods of filtration with depth filters having optimized head space, including clarification of flocculated feed streams where pretreatment may include any of lowering cell culture pH, addition of polymers (uncharged or charged), or addition of salts to precipitate out solubilized impurities resulting in high insoluble biomass.

公开(公告)号：US20210347156A1

公开(公告)日：2021-11-11

申请号：US17287253

申请日：2019-10-23

Applicant: EMD Millipore Corporation

Inventor： Brian Pereira ,  John Saragosa ,  Joseph Muldoon

IPC: B32B27/12 ,  B32B27/30 ,  B32B5/02 ,  B32B27/32 ,  B32B27/08 ,  B32B3/26 ,  G01M3/32 ,  B65D83/38

Abstract: A material for biocontainers comprising a film formed of two or more layers forming a body to the film, the film having an interior and exterior side, and a substrate incorporated in the body of the film wherein the substrate is formed of a fibrous material, wherein each of the at least one of the two or more layers comprises an ethylene vinyl acetate resin. A non-constrained pressure test is also disclosed.

公开(公告)号：US11155403B2

公开(公告)日：2021-10-26

申请号：US16423464

申请日：2019-05-28

Applicant: EMD MILLIPORE CORPORATION

Inventor： John Gugliotti ,  Michael Gugliotti

IPC: B65D85/24 ,  B65D33/16 ,  A61M5/32

Abstract: A needle protector, having a flexible material, a pocket defining an internal volume, a wrapping strap having a plurality of holes, and a main body disposed between the pocket and the wrapping strap; at least one rigid body or cylinder for placement within the internal volume; and; a pin for placement within one of the plurality of holes, wherein the pin is capable of releasabiy locking the pocket and the main body when the wrapping strap is wrapped around the pocket and the main body.

公开(公告)号：US11104491B2

公开(公告)日：2021-08-31

申请号：US15825635

申请日：2017-11-29

Applicant: EMD Millipore Corporation

Inventor： Chris Scott ,  Kurt Greenizen ,  Paul Sydlowski ,  Jay Doyle

IPC: B65D41/04 ,  B65D1/02 ,  B65D41/06 ,  B01L3/00 ,  B65B7/28

Abstract: A container and a container engaging member. The container engaging member may include a sample holder or reservoir, a filtration element and collar. In the assembled condition, the sample holder or reservoir is upstream of the filtration element, the container is downstream of the filtration element, and the sample holder or reservoir is attached to the container. The container engagement member is engageable and disengageable from the bottle or container in a quick attach, quick release manner, such as with only a 90 degree, ¼ turn. A tactile and/or audible indication that the engagement is complete is provided.