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公开(公告)号：US10131882B2
公开(公告)日：2018-11-20
申请号：US15947741
申请日：2018-04-06
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号：US09770489B2
公开(公告)日：2017-09-26
申请号：US14761461
申请日：2015-01-30
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: A61K48/00 , A61K31/7105 , A61K31/713 , C12N15/00 , C12N15/90 , A61K38/39 , A61K38/38 , C12N15/87 , A61K38/44 , A61K38/45 , A61K45/06 , A61K31/573 , A61K31/575 , A61K31/7068 , A61K31/7072 , A61K31/711 , A61K9/00 , A61K9/127 , A61K47/46 , A61B18/18 , A61M35/00 , A61K8/60 , A61Q19/00 , A61Q19/06 , A61Q19/08 , A61B18/00
CPC classification number: A61K38/39 , A61B18/18 , A61B2018/00452 , A61B2018/1807 , A61K8/606 , A61K9/0019 , A61K9/0021 , A61K9/127 , A61K31/573 , A61K31/575 , A61K31/7068 , A61K31/7072 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K38/38 , A61K38/44 , A61K38/45 , A61K45/06 , A61K47/46 , A61K48/00 , A61K48/005 , A61K2800/83 , A61K2800/91 , A61M35/00 , A61Q19/00 , A61Q19/008 , A61Q19/06 , A61Q19/08 , C12N15/87 , A61K2300/00
Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：US20170267979A1
公开(公告)日：2017-09-21
申请号：US15605513
申请日：2017-05-25
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
CPC classification number: C12N5/0696 , C12N5/0018 , C12N5/0625 , C12N5/0647 , C12N5/0656 , C12N5/0657 , C12N5/0676 , C12N5/0695 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/84 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/608 , C12N2501/998 , C12N2506/09 , C12N2506/45
Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号：US20170151285A1
公开(公告)日：2017-06-01
申请号：US15429798
申请日：2017-02-10
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: A61K35/28
CPC classification number: C12N5/0647 , A61K35/28 , A61K2035/124 , C08G77/08 , C08K5/5399 , C12N5/0657 , C12N9/16 , C12N9/22 , C12N15/87 , C12N15/907 , C12N2500/25 , C12N2500/44 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2501/2303 , C12N2501/26 , C12N2501/91 , C12N2501/998 , C12N2506/09 , C12N2800/80 , C12P21/00 , C12Y301/21 , H01L31/048 , Y02E10/50 , C08L83/04
Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号：US09605278B2
公开(公告)日：2017-03-28
申请号：US15222453
申请日：2016-07-28
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: C12N5/00 , C12N15/90 , C08K5/5399 , H01L31/048 , C12N15/87 , C12P21/00 , C12N9/16 , C12N5/0789 , C12N5/077 , C08G77/08
CPC classification number: C12N5/0647 , A61K35/28 , A61K2035/124 , C08G77/08 , C08K5/5399 , C12N5/0657 , C12N9/16 , C12N9/22 , C12N15/87 , C12N15/907 , C12N2500/25 , C12N2500/44 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2501/2303 , C12N2501/26 , C12N2501/91 , C12N2501/998 , C12N2506/09 , C12N2800/80 , C12P21/00 , C12Y301/21 , H01L31/048 , Y02E10/50 , C08L83/04
Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
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Patent Agency Ranking
公开(公告)号：US09562218B2
公开(公告)日：2017-02-07
申请号：US15178190
申请日：2016-06-09
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
CPC classification number: C12N5/0696 , C12N5/0018 , C12N5/0625 , C12N5/0647 , C12N5/0656 , C12N5/0657 , C12N5/0676 , C12N5/0695 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/84 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/608 , C12N2501/998 , C12N2506/09 , C12N2506/45
Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
Abstract translation: 本发明部分地涉及从患者样品中产生组织特异性细胞的方法以及使用这些方法产生的组织特异性细胞。 公开了使用RNA重编程细胞的方法。 还公开了包含使用这些方法生产的细胞的治疗剂。
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公开(公告)号：US20160324934A1
公开(公告)日：2016-11-10
申请号：US14761461
申请日：2015-01-30
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
CPC classification number: A61K38/39 , A61B18/18 , A61B2018/00452 , A61B2018/1807 , A61K8/606 , A61K9/0019 , A61K9/0021 , A61K9/127 , A61K31/573 , A61K31/575 , A61K31/7068 , A61K31/7072 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K38/38 , A61K38/44 , A61K38/45 , A61K45/06 , A61K47/46 , A61K48/00 , A61K48/005 , A61K2800/83 , A61K2800/91 , A61M35/00 , A61Q19/00 , A61Q19/008 , A61Q19/06 , A61Q19/08 , C12N15/87 , A61K2300/00
Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
Abstract translation: 本发明部分涉及核酸，包括编码蛋白质的核酸，包含核酸的治疗剂和化妆品，将核酸递送至细胞，组织，器官和患者的方法，用核酸诱导细胞表达蛋白质的方法 ，用于转染，基因编辑和重编程细胞的试剂盒和装置，以及使用这些方法，试剂盒和装置生产的细胞，生物体，治疗剂和化妆品。 描述了用于改变细胞DNA序列的方法和产物，以及使用合成的RNA分子（包括体内存在的细胞）诱导细胞表达蛋白质的方法和产物。 还描述了包含编码基因编辑蛋白的核酸的治疗剂。
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公开(公告)号：US09376669B2
公开(公告)日：2016-06-28
申请号：US14735603
申请日：2015-06-10
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: C07H21/04 , C12N15/63 , C12N9/22 , A61K31/7115 , C07K14/195 , C12N15/10 , A01K67/00
CPC classification number: C12N15/907 , A61K31/7115 , A61K35/14 , A61K38/465 , A61K48/005 , A61K2035/124 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/1024 , C12N15/86 , C12N2800/80 , C12Y301/00 , C12Y301/21004 , G01N33/5014
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：US11814333B2
公开(公告)日：2023-11-14
申请号：US17553564
申请日：2021-12-16
Applicant: FACTOR BIOSCIENCE INC.
Inventor： Matthew Angel , Franklin Kostas , Christopher Rohde
IPC: C07C215/24 , A61K9/127
CPC classification number: C07C215/24 , A61K9/1272
Abstract: The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.
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公开(公告)号：US20230323399A1
公开(公告)日：2023-10-12
申请号：US18332621
申请日：2023-06-09
Applicant: Factor Bioscience Inc.
Inventor： Matthew ANGEL , Christopher ROHDE
IPC: C12N15/87 , C08K5/5399 , C12N5/074 , H01L31/048 , C12P21/00 , C12N9/16 , C12N5/0789 , C12N5/077 , C12N15/90 , C12N9/22 , A61K35/28
CPC classification number: C12N15/87 , C08K5/5399 , C12N5/0696 , H01L31/048 , C12P21/00 , C12N9/16 , C12Y301/21 , C12N5/0647 , C12N5/0657 , C12N15/907 , C12N9/22 , A61K35/28 , C08G77/08
Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
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