公开(公告)号：US20120101092A1

公开(公告)日：2012-04-26

申请号：US13336047

申请日：2011-12-23

Applicant: Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

Inventor： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

IPC: A61K31/5377 ,  A61K31/407 ,  C07D413/00 ,  A61P35/00 ,  C07D487/04 ,  A61K31/4985 ,  C12N5/09 ,  C07D487/10 ,  A61K31/437

CPC classification number: C07D209/54 ,  C07D487/10 ,  C07D491/10

Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。

公开(公告)号：US20110014599A1

公开(公告)日：2011-01-20

申请号：US12836747

申请日：2010-07-15

Applicant: Hashem AKHAVAN-TAFTI ,  Renuka DE SlLVA ,  Guoping WANG ,  Robert A. EICKHOLT ,  Ravinder K. GUPTA ,  Lakshmi S. KAANUMALLE

Inventor： Hashem AKHAVAN-TAFTI ,  Renuka DE SlLVA ,  Guoping WANG ,  Robert A. EICKHOLT ,  Ravinder K. GUPTA ,  Lakshmi S. KAANUMALLE

IPC: C12Q1/70 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07K2/00 ,  C07K14/00 ,  C07H21/00 ,  C07H3/06 ,  C07K16/00 ,  C12N9/96 ,  G01N33/569 ,  G01N33/53

CPC classification number: C07D417/04 ,  C09B7/00

Abstract: The present invention provides fluorescent dyes that are based on firefly luciferin structure. These dyes are optimally excited at shorter wavelengths and have Stokes shift of at least 50 nm. The fluorescent dyes of the invention are useful for preparation of dye-conjugates, which can be used in detection of an analyte in a sample.

Abstract translation: 本发明提供了基于萤火虫荧光素结构的荧光染料。 这些染料在较短波长下被最佳激发，并具有至少50nm的斯托克斯位移。 本发明的荧光染料可用于制备染料缀合物，其可用于检测样品中的分析物。

公开(公告)号：US20100070178A1

公开(公告)日：2010-03-18

申请号：US12210293

申请日：2008-09-15

Applicant: Guoping WANG ,  Bingcheng NI ,  Peter J. DIX ,  Keith W. WENDTE

Inventor： Guoping WANG ,  Bingcheng NI ,  Peter J. DIX ,  Keith W. WENDTE

IPC: G01C21/00

CPC classification number: A01B69/007

Abstract: The orientation of a self-propelled vehicle or a towed vehicle relative to the direction of travel of the vehicle can be determined by mounting two ground speed sensors on the vehicle. The orientation of the vehicle relative to the direction of travel of the vehicle can be used to correct the error in the location of an implement mounted on the vehicle determined by a GPS system mounted on the vehicle or the vehicle towing the implement due to crabbing of the vehicle as the vehicle travels substantially perpendicular to a significant slope.

Abstract translation: 通过在车辆上安装两个地面速度传感器，可以确定自行车辆或牵引车辆相对于车辆行进方向的方位。 可以使用车辆相对于车辆行进方向的方向来校正由安装在车辆上的GPS系统或车辆上拖动工具的车辆由于螃蟹而被安装在车辆上的位置的错误 作为车辆的车辆大致垂直于显着的斜坡行进。

公开(公告)号：US20100042297A1

公开(公告)日：2010-02-18

申请号：US12228370

申请日：2008-08-12

Applicant: Christopher A. Foster ,  Riccardo Morselli ,  Olivier Arnel Vanhercke ,  Guoping Wang ,  Bart M.A. Missotten ,  Bert Juul Frans Paquet ,  John H. Posselius

Inventor： Christopher A. Foster ,  Riccardo Morselli ,  Olivier Arnel Vanhercke ,  Guoping Wang ,  Bart M.A. Missotten ,  Bert Juul Frans Paquet ,  John H. Posselius

IPC: G06F19/00

CPC classification number: A01B79/005 ,  G06Q10/08 ,  G06Q50/02 ,  H04L63/08 ,  H04L67/12 ,  H04L67/125 ,  H04L67/18 ,  H04W4/02 ,  H04W4/023 ,  H04W4/08 ,  H04W4/70 ,  H04W4/80 ,  H04W84/18

Abstract: A system, and method of use thereof, for enabling short range intercommunication and the exchange of logistical information between and among a plurality of authorized agricultural machines that are designed to be operable in conjunction with one another to effect, as a specific identified group, a given agricultural operation, including a plurality of individual agricultural machines each of which has a communications control portion operable to transmit and receive short distance communications signals and each of which also has authentication credentials associated therewith establishing such machine's entitlement to share in the logistical information and to be considered and treated as a member of the specific identified group involved in the performance of the given agricultural operation, with such individual agricultural machines, when positioned in range of the short distance communications signals of the individual agricultural machines, forming a peer-to-peer network in which such individual agricultural machines are joined as group members and are operable to effect the distribution over a wireless bus of the peer-to-peer network of logistical information of a group member of such network.

Abstract translation: 一种系统及其使用方法，用于实现多个被授权的农业机器之间和之间的短距离互通和物流信息的交换，所述多个授权的农业机器被设计成可以彼此结合操作以实现作为特定的识别组， 给予农业操作，包括多个单独的农业机械，每个农机具有可操作以发送和接收短距离通信信号的通信控制部分，并且每个农机还具有与其相关联的认证证书，其建立该机器的权利以分享后勤信息，以及 被视为具体确定的集团参与执行给定农业经营的成员，与这些单独的农业机械相比，当位于各农业机械的短距离通信信号的范围内时，形成对等 - 对等网络在whic h这样的单个农业机器作为组成员加入，并且可操作以通过该对等网络的无线总线分发这样的网络的组成员的后勤信息。

公开(公告)号：US09002591B2

公开(公告)日：2015-04-07

申请号：US13171645

申请日：2011-06-29

Applicant: Guoping Wang ,  John H. Posselius ,  Keith W. Wendte

Inventor： Guoping Wang ,  John H. Posselius ,  Keith W. Wendte

IPC: G06F7/70 ,  G06F19/00 ,  G06G7/00 ,  G06G7/76 ,  A01D41/127 ,  A01D43/08 ,  G05D1/02

CPC classification number: A01D41/1278 ,  A01B69/008 ,  A01D43/085 ,  G05D1/0278 ,  G05D1/0293 ,  G05D2201/0201

Abstract: A control system and method is provided for controlling the operational configuration of a spout of a harvester being used to perform unload on the go operations with an associated transport vehicle. The velocities of the harvester and transport vehicle and the lateral and longitudinal distances between the harvester and transport vehicle are used to predict future lateral and longitudinal distances between the harvester and transport vehicle. A control signal is issued to a harvester spout control system if either of the predicted lateral distance or longitudinal distance is outside of an associated acceptable range. The harvester spout control system then either shuts off the spout or changes the orientation of the spout in response to the control signal.

Abstract translation: 提供了一种控制系统和方法，用于控制用于通过相关联的运输车辆在行驶中执行卸载的收割机的喷口的操作配置。 收割机和运输车辆的速度以及收割机和运输车辆之间的横向和纵向距离用于预测收割机和运输车辆之间的未来横向和纵向距离。 如果预测的横向距离或纵向距离之一超出相关联的可接受范围，则控制信号被发送到收割机喷口控制系统。 收割机喷口控制系统然后关闭喷嘴或响应于控制信号改变喷口的方向。

公开(公告)号：US20120215394A1

公开(公告)日：2012-08-23

申请号：US13249884

申请日：2011-09-30

Applicant: Guoping Wang ,  Christopher A. Foster ,  Riccardo Morselli ,  Olivier Vanhercke ,  Todd Aznavorian ,  Arun Natarajan ,  Kousha Moaveni-Nejad

Inventor： Guoping Wang ,  Christopher A. Foster ,  Riccardo Morselli ,  Olivier Vanhercke ,  Todd Aznavorian ,  Arun Natarajan ,  Kousha Moaveni-Nejad

IPC: G05D1/02 ,  G06F19/00

CPC classification number: A01D41/1278 ,  A01B69/008 ,  A01D43/085 ,  G05D1/0278 ,  G05D1/0293 ,  G05D2201/0201

Abstract: A control system and method is provided to control a longitudinal position of a transport vehicle relative to a harvester during an unload on the go operation and to control both the lateral position and the longitudinal position of a transport vehicle relative to a harvester during an unload on the go operation to evenly fill a receiving area of the transport vehicle with crop material from the harvester. The longitudinal position of the transport vehicle is maintained within an acceptable range by adjusting the velocity of the transport vehicle. The receiving area of the transport vehicle can be more evenly filled with crop material by adjusting the lateral position and the longitudinal position of the transport vehicle within predetermined trim distances associated with the receiving area of the transport vehicle.

Abstract translation: 提供了一种控制系统和方法，用于在卸载操作期间控制运输车辆相对于收割机的纵向位置，并且在卸载期间控制运输车辆相对于收割机的横向位置和纵向位置 通过收割机将作物材料均匀地填满运输车辆的接收区域。 运输车辆的纵向位置通过调节运输车辆的速度而保持在可接受的范围内。 运输车辆的接收区域可以通过调节运输车辆的横向位置和纵向位置在与运输车辆的接收区域相关联的预定的修剪距离内，更均匀地填充作物材料。

公开(公告)号：US20110112721A1

公开(公告)日：2011-05-12

申请号：US12615830

申请日：2009-11-10

Applicant: Guoping Wang ,  Keith Wendte ,  Charles Johnson ,  Marvin Prickel ,  John Posselius

Inventor： Guoping Wang ,  Keith Wendte ,  Charles Johnson ,  Marvin Prickel ,  John Posselius

IPC: B62D6/00 ,  G06F19/00

CPC classification number: B62D13/04 ,  A01B69/004 ,  B62D13/005

Abstract: A steering system for a towable implement includes a steering sensor, an implement steering controller, a steering control valve, a steering cylinder, and an implement steering mechanism that steers the implement. The steering sensor measures, directly or indirectly, the angular position of the steerable wheels of the implement. The implement steering controller processes feedback from the steering sensor and with a desired steering angle, outputs a steering control signal that is input to the steering control valve. The steering control valve controls the flow of hydraulic fluid to the steering cylinder, which, in turn, powers the implement steering mechanism to turn the wheels of the implement. The steering system may be operated in various control modes, such as, a transportation steering mode, a corner and 180 turn steering mode, a swath tracking steering mode, crab steering mode, and a manual steering mode, which allows manual control of the steering system.

Abstract translation: 用于拖曳工具的转向系统包括转向传感器，工具转向控制器，转向控制阀，转向缸和转向工具的工具转向机构。 转向传感器直接或间接地测量工具的可转向轮的角位置。 工具转向控制器处理来自转向传感器的反馈并具有期望的转向角，输出输入到转向控制阀的转向控制信号。 转向控制阀控制到转向缸的液压流体的流动，转向缸又向车把转向机构供电以转动车把的转轮。 转向系统可以在各种控制模式下操作，例如运输转向模式，转角和180转向转向模式，条跟踪转向模式，螃蟹转向模式和手动转向模式，这允许手动控制转向 系统。

公开(公告)号：US20100070145A1

公开(公告)日：2010-03-18

申请号：US12284310

申请日：2008-09-17

Applicant: Christopher A. Foster ,  Riccardo Morselli ,  Olivier Arnel Vanhercke ,  Guoping Wang ,  Bart M.A. Missotten ,  Bert Juul Frans Paquet ,  John H. Posselius

Inventor： Christopher A. Foster ,  Riccardo Morselli ,  Olivier Arnel Vanhercke ,  Guoping Wang ,  Bart M.A. Missotten ,  Bert Juul Frans Paquet ,  John H. Posselius

IPC: G06F19/00 ,  A01D41/127 ,  A01D43/06 ,  A01D91/00

CPC classification number: G05D1/0278 ,  A01B79/005 ,  G05D1/0295 ,  G05D2201/0201

Abstract: A system, and method of use thereof, that employs short distance communications signals, thereby limiting and localizing the dissemination area for such signals, for interactively coordinating crop material transfer operations between a harvester and a grain transport, including the automated conduct of an unloading operation, including commencement of the actual unloading of the grain through continuation of such unloading to termination of such unloading, which system and method of the present invention employs operating systems in the harvester and grain transport that so operate to become electronically linked to one another to thereafter operate in unison with one another to effect and control the conduct of the crop material transfer operation between the harvester and grain transport, with each of such operating systems having associated therewith a short range communications system for the transmission and receipt at close range of electronic data signals, such operating systems, when appropriately electronically linked to one another, being operable in conjunction with one another to exchange information, to maintain a communications link therebetween, and to automatedly coordinate and effect various activities of the harvester and grain transport as a crop material transfer operation is effected and proceeds.

Abstract translation: 一种使用短距离通信信号的系统及其使用方法，从而限制和定位这些信号的传播区域，用于交互地协调收割机和粮食运输之间的作物材料转移操作，包括自动进行卸载操作 包括通过继续这种卸载开始实际卸载粮食以终止这种卸载，本发明的系统和方法采用这样操作的操作系统以使其彼此电子地连接在此之后 彼此协调一致地实现和控制收割机和粮食运输之间的作物材料转移操作的进行，其中每个这样的操作系统具有相关联的短距离通信系统用于近距离的电子数据的传输和接收 信号，这样的操作系统 s，当彼此适当地电子连接时，可彼此结合操作以交换信息，以保持它们之间的通信连接，并且在进行作物材料转移操作时自动协调和实现收割机和粮食运输的各种活动 并进行。

公开(公告)号：US20090254254A1

公开(公告)日：2009-10-08

申请号：US12080489

申请日：2008-04-03

Applicant: Guoping Wang

Inventor： Guoping Wang

IPC: B62D6/00

CPC classification number: B62D6/002 ,  A01B69/008

Abstract: A steering control system and method for automated steering of work vehicles that adapts to nonlinearities and uncertainties of steering mechanisms including a tolerance control law, a dynamic control law, and a saturation control law selected and executed in real time based on the magnitude of steering angle error, steering mode command, and manual override signal in real time. The dynamic control law includes a dynamic compensator having a double compensation zero, an integral, and a compensation gain, and further includes a deadband compensator and a control signal limiter.

Abstract translation: 一种用于工作车辆的自动转向的转向控制系统和方法，其适应于转向机构的非线性和不确定性，其包括基于转向角的大小实时选择和执行的公差控制律，动态控制律和饱和度控制律 错误，转向模式命令和手动超控信号。 动态控制规律包括具有双补偿零点，积分和补偿增益的动态补偿器，并且还包括死区补偿器和控制信号限制器。

公开(公告)号：US09849909B2

公开(公告)日：2017-12-26

申请号：US12615830

申请日：2009-11-10

Applicant: Guoping Wang ,  Keith Wendte ,  Charles Johnson ,  Marvin Prickel ,  John Posselius

Inventor： Guoping Wang ,  Keith Wendte ,  Charles Johnson ,  Marvin Prickel ,  John Posselius

IPC: G05D1/00 ,  B62D13/00 ,  B62D13/04 ,  A01B69/00

CPC classification number: B62D13/04 ,  A01B69/004 ,  B62D13/005

Abstract: A steering system for a towable implement includes a steering sensor, an implement steering controller, a steering control valve, a steering cylinder, and an implement steering mechanism that steers the implement. The steering sensor measures, directly or indirectly, the angular position of the steerable wheels of the implement. The implement steering controller processes feedback from the steering sensor and with a desired steering angle, outputs a steering control signal that is input to the steering control valve. The steering control valve controls the flow of hydraulic fluid to the steering cylinder, which, in turn, powers the implement steering mechanism to turn the wheels of the implement. The steering system may be operated in various control modes, such as, a transportation steering mode, a corner and 180 turn steering mode, a swath tracking steering mode, crab steering mode, and a manual steering mode, which allows manual control of the steering system.