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    Biodegradable poly (phosphoester-co-desaminotyrosyl L-tyrosine ester) compounds, compositions, articles and methods for making and using the same
    11.
    发明授权
    Biodegradable poly (phosphoester-co-desaminotyrosyl L-tyrosine ester) compounds, compositions, articles and methods for making and using the same 失效
    可生物降解的聚（磷酸酯 - 共 - 脱氨基鸟氨酰基L-酪氨酸酯）化合物，组合物，制品及其制备和使用方法

    公开(公告)号：US5912225A

    公开(公告)日：1999-06-15

    申请号：US834164

    申请日：1997-04-14

    申请人： Hai-quan Mao ,  Kam W. Leong

    发明人： Hai-quan Mao ,  Kam W. Leong

    IPC分类号： A61K9/20 ,  A61L15/26 ,  A61L17/10 ,  A61L26/00 ,  A61L27/18 ,  A61L27/34 ,  A61L29/06 ,  A61L31/06 ,  C08G79/04 ,  C07C219/00

    CPC分类号： C08G79/04 ,  A61K9/204 ,  A61L15/26 ,  A61L17/10 ,  A61L26/0019 ,  A61L27/18 ,  A61L27/34 ,  A61L29/06 ,  A61L31/06

    摘要： Biodegradable polymers are described comprising the recurring monomeric units shown in formula I: ##STR1## wherein: R is selected from the group consisting of H, alkyl, aryl or heterocyclic; andR' is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; andn is 5 to 500,wherein said biodegradable polymer is biocompatible before and upon biodegradation.Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.

    摘要翻译： 描述了可生物降解的聚合物，其包含式I所示的重复单体单元：其中：R选自H，烷基，芳基或杂环; 并且R'选自H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; 并且n为5至500，其中所述可生物降解的聚合物在生物降解之前和之后是生物相容的。 还描述了制备聚合物的方法，含有聚合物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品，以及使用该聚合物可控地释放生物活性物质的方法。

    Biodegradable polyphosphoramidates for controlled release of bioactive substances
    12.
    发明授权
    Biodegradable polyphosphoramidates for controlled release of bioactive substances 失效
    用于生物活性物质控制释放的可生物降解的聚磷酸酰胺酯

    公开(公告)号：US07417110B2

    公开(公告)日：2008-08-26

    申请号：US10500565

    申请日：2002-05-14

    申请人： Jun Wang ,  Hai-Quan Mao ,  Kam Weng Leong

    发明人： Jun Wang ,  Hai-Quan Mao ,  Kam Weng Leong

    IPC分类号： C08G79/02 ,  C08G79/04 ,  C08J3/07

    CPC分类号： C08G79/02 ,  A61K9/146 ,  A61K31/7088 ,  A61K47/34 ,  A61K47/605 ,  C08G79/04 ,  C08L85/02 ,  C08L2203/02 ,  C12N15/111 ,  C12N2320/32

    摘要： The present invention is directed to a series of new polycationic biodegradable polyphosphoramidates. Process for making the polymers, compositions containing these polymers and bioactive ligands to enhance the cellular uptake ad intracellular trafficking, articles and methods for delivery of drugs and genes using these polymers are described. A gene delivery system based on these polymers is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. Targeting ligands and molecules that could facilitate gene transfer can be conjugated to polymers to achieve selective and enhanced gene delivery. The current invention also provides a complex composition with buffering capacity.

    摘要翻译： 本发明涉及一系列新的聚阳离子可生物降解的聚磷酸酰胺酯。 描述了制备聚合物的方法，含有这些聚合物的组合物和生物活性配体以增强细胞摄取和细胞内运输，用于递送药物和使用这些聚合物的基因的方法。 基于这些聚合物的基因递送系统通过核酸（DNA或RNA）与聚合物的复合凝聚来制备。 可以促进基因转移的靶向配体和分子可以与聚合物缀合以实现选择性和增强的基因递送。 本发明还提供具有缓冲能力的复合组合物。

    METHODS FOR THE DELIVERY OF BIOACTIVE SUBSTANCES WITH BIODEGRADABLE POLYPHOSPHATES
    13.
    发明申请
    METHODS FOR THE DELIVERY OF BIOACTIVE SUBSTANCES WITH BIODEGRADABLE POLYPHOSPHATES 审中-公开
    用生物可降解的多磷酸盐递送生物活性物质的方法

    公开(公告)号：US20080176800A1

    公开(公告)日：2008-07-24

    申请号：US12016186

    申请日：2008-01-17

    申请人： Jun WANG ,  Hai-Quan MAO ,  Kam Weng LEONG

    发明人： Jun WANG ,  Hai-Quan MAO ,  Kam Weng LEONG

    IPC分类号： A61K31/7088 ,  A61K47/30 ,  A61K38/16 ,  A61P43/00 ,  A61K38/02

    CPC分类号： C08L85/02 ,  A61K9/1647 ,  A61K9/204 ,  A61K47/34 ,  A61K47/605 ,  A61K47/645 ,  A61K48/0041 ,  C08G79/04 ,  C12N15/87

    摘要： The present invention is directed to a biodegradable system for the controlled release of bioactive substances. This system comprises novel biodegradable and biocompatible polyphosphoesters that carry positive charges. Process for making these polyphosphoesters, compositions containing these polyphosphoesters and biologically active substances, articles and methods for delivery of drugs and genes using this system are described. A controlled gene delivery system based on these polyphosphoesters is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. The release rates can be manipulated by adjusting the charge ratios of polyphosphoesters to nucleic acids. This gene delivery system yields a higher gene expression in muscle when injected intramuscularly.

    摘要翻译： 本发明涉及用于控制释放生物活性物质的可生物降解的系统。 该系统包含携带正电荷的新型生物可降解和生物相容性聚磷酸酯。 描述了制备这些聚磷酸酯的方法，含有这些聚磷酸酯和生物活性物质的组合物，使用该系统递送药物和基因的制品和方法。 通过核酸（DNA或RNA）与聚合物的复合凝聚来制备基于这些多聚磷酸酯的受控基因递送系统。 可以通过调节多聚磷酸酯与核酸的电荷比来操纵释放速率。 当肌内注射时，该基因递送系统在肌肉中产生较高的基因表达。

    Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
    15.
    发明授权
    Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same 有权
    可生物降解的对苯二甲酸酯聚酯 - 聚（亚磷酸酯）组合物，制品及其使用方法

    公开(公告)号：US06419709B1

    公开(公告)日：2002-07-16

    申请号：US09165373

    申请日：1998-10-02

    申请人： Hai-quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  Wensin Dang ,  James P. English ,  David P. Nowotnik

    发明人： Hai-quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  Wensin Dang ,  James P. English ,  David P. Nowotnik

    IPC分类号： C08G7902

    CPC分类号： C08G63/6926 ,  A61K9/0024 ,  A61K9/1647 ,  A61L17/105 ,  A61L24/046 ,  A61L31/06 ,  C08L67/00

    摘要： An essentially non-osteoconductive medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; x is ≧1; and n is 3-7,500, where the biodegradable polymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. Compositions containing the copolymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the copolymers, are also described.

    摘要翻译： 描述了一种基本上非骨传导性医疗装置，其包含可生物降解的对苯二甲酸酯共聚物，其包含式I所示的重复单体单元：其中R是二价有机部分;x≥1; andn为3-7,500，其中生物可降解聚合物足够纯以生物相容性，并且在生物降解时能够形成生物相容性残基。含有共聚物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品，以及 还描述了使用共聚物可控地释放生物活性物质的方法。

    Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same
    16.
    发明授权
    Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same 有权
    通过磷酸盐，组合物，制品和制造和使用它们的方法延伸的可生物降解的聚合物

    公开(公告)号：US06376644B1

    公开(公告)日：2002-04-23

    申请号：US09654326

    申请日：2000-09-01

    申请人： Hai-Quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    发明人： Hai-Quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    IPC分类号： C08G7904

    CPC分类号： A61K9/0024 ,  A61K9/1647 ,  A61L17/12 ,  A61L26/0019 ,  A61L27/18 ,  C08G63/6922 ,  C08G63/912 ,  Y10S623/924 ,  C08L85/02

    摘要： Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: wherein X is —O— or —NR′—, where R′ is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M1 and M2 are each independently (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; Y is —O—, —S— or —NR′—, where R′ is H or alkyl; R is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and the molar ratio q:r is between about 1:99 and 99:1; wherein said biodegradable polymer is biocompatible before and upon biodegradat. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.

    摘要翻译： 描述包含式I或II所示的重复单体单元的生物可降解聚合物：其中X是-O-或-NR'-，其中R'是H或烷基; L是具有1-20个碳原子的支链或直链脂族基团; M1和M2各自独立地为（1）具有1-20个碳原子的支链或直链脂族基团; 或（2）具有1-20个碳原子的支链或直链，氧基，羧基或氨基 - 脂族基团; Y是-O - ， - S-或-NR'-，其中R'是H或烷基; R是H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; x：y的摩尔比为约1; 摩尔比n：（x或y）在约200:1和1:200之间; 并且摩尔比q：r在约1:99和99:1之间; 其中所述可生物降解聚合物在生物降解之前和之后是生物相容的。 还描述了制备聚合物的方法，含有聚合物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品，以及使用该聚合物可控地释放生物活性物质的方法。

    BIODEGRADABLE POLYPHOSPHORAMIDATES FOR CONTROLLED RELEASE OF BIOACTIVE SUBSTANCES
    18.
    发明申请
    BIODEGRADABLE POLYPHOSPHORAMIDATES FOR CONTROLLED RELEASE OF BIOACTIVE SUBSTANCES 审中-公开
    用于控制释放生物物质的生物可降解聚磷酸酯

    公开(公告)号：US20090012027A1

    公开(公告)日：2009-01-08

    申请号：US12137445

    申请日：2008-06-11

    申请人： Jun Wang ,  Hai-Quan Mao ,  Kam Weng Leong

    发明人： Jun Wang ,  Hai-Quan Mao ,  Kam Weng Leong

    IPC分类号： A61K47/48 ,  C08G79/02 ,  C12N5/06 ,  C12N15/11 ,  A61K31/7088

    CPC分类号： C08G79/02 ,  A61K9/146 ,  A61K31/7088 ,  A61K47/34 ,  A61K47/605 ,  C08G79/04 ,  C08L85/02 ,  C08L2203/02 ,  C12N15/111 ,  C12N2320/32

    摘要： The present invention is directed to a series of new polycationic biodegradable polyphosphoramidates. Process for making the polymers, compositions containing these polymers and bioactive ligands to enhance the cellular uptake ad intracellular trafficking, articles and methods for delivery of drugs and genes using these polymers are described. A gene delivery system based on these polymers is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. Targeting ligands and molecules that could facilitate gene transfer can be conjugated to polymers to achieve selective and enhanced gene delivery. The current invention also provides a complex composition with buffering capacity.

    摘要翻译： 本发明涉及一系列新的聚阳离子可生物降解的聚磷酸酰胺酯。 描述了制备聚合物的方法，含有这些聚合物的组合物和生物活性配体以增强细胞摄取和细胞内运输，用于递送药物和使用这些聚合物的基因的方法。 基于这些聚合物的基因递送系统通过核酸（DNA或RNA）与聚合物的复合凝聚来制备。 可以促进基因转移的靶向配体和分子可以与聚合物缀合以实现选择性和增强的基因递送。 本发明还提供具有缓冲能力的复合组合物。