公开(公告)号：US20120298859A1

公开(公告)日：2012-11-29

申请号：US13575600

申请日：2011-01-31

Applicant: Koichi Tanji ,  Manabu Komatsu ,  Hiroyuki Hashimoto

Inventor： Koichi Tanji ,  Manabu Komatsu ,  Hiroyuki Hashimoto

IPC: H01J49/26

CPC classification number: H01J49/0036 ,  H01J49/0004

Abstract: A more effective noise reduction method is provided. In the method, when mass spectrum information having a spatial distribution is processed, the whole data is taken as three-dimensional data (positional information is stored in an xy plane, and spectral information is stored along a z-axis direction), and three-dimensional wavelet noise reduction is performed by applying preferable basis functions to a spectral direction and a peak distribution direction (in-plane direction).

Abstract translation: 提供了更有效的降噪方法。 在该方法中，当处理具有空间分布的质谱信息时，将整个数据作为三维数据（位置信息存储在xy平面中，并且光谱信息沿z轴方向存储），并且三个 通过对光谱方向和峰分布方向（面内方向）应用优选的基函数来进行维小波噪声降低。

公开(公告)号：US20120244102A1

公开(公告)日：2012-09-27

申请号：US13514083

申请日：2011-01-26

Applicant: Hiroyuki Hashimoto ,  Toshihiko Kumazawa ,  Motohiro Takeda ,  Takahito Jomori ,  Chihiro Hibi ,  Kuniharu Mizuno

Inventor： Hiroyuki Hashimoto ,  Toshihiko Kumazawa ,  Motohiro Takeda ,  Takahito Jomori ,  Chihiro Hibi ,  Kuniharu Mizuno

IPC: A61K31/765 ,  A61P1/04

CPC classification number: A61K31/80

Abstract: The present invention is to provide an agent for treating Crohn's disease that is of unknown cause and for which no radical therapeutic drug is present. Provided is an agent for preventing or treating Crohn's disease, comprising an organic acid polymer represented by the following formula: [(O1/2)3Ge-A-CO2H]n, wherein n is 100-1,000, and A is a lower alkyl group. Preferably, A is a C1-C3 lower alkyl group and the degree of polymerization n is 200-900. The organic acid polymer according to the present invention is effective as an agent for treating Crohn's disease.

Abstract translation: 本发明提供一种用于治疗克罗恩病的药剂，其原因不明，没有基础治疗药物存在。 本发明提供一种预防或治疗克罗恩病的药剂，其含有下式所示的有机酸聚合物：[（O1 / 2）3Ge-A-CO2H] n，其中n为100-1,000，A为低级烷基 。 优选地，A是C1-C3低级烷基，聚合度n是200-900。 根据本发明的有机酸聚合物作为治疗克罗恩病的药剂是有效的。

公开(公告)号：US08159256B2

公开(公告)日：2012-04-17

申请号：US12576111

申请日：2009-10-08

Applicant: Tomohisa Hoshino ,  Hiroyuki Hashimoto ,  Muneo Harada

Inventor： Tomohisa Hoshino ,  Hiroyuki Hashimoto ,  Muneo Harada

IPC: G01R31/02

CPC classification number: G01R1/06716 ,  G01R1/06727 ,  Y10T29/49002

Abstract: A method for manufacturing a probe needle having beams and a contactor placed on tips of the beams comprises preparing a Si wafer 20, forming a seed layer 21 on the Si wafer 20, and forming grooves in a desired shape of the beams on the seed layer 21 by patterning a photoresist 23. Subsequently, the grooves are filled up with metal-plated layers 24a, 24b to form the desired shape of beams.

Abstract translation: 用于制造具有光束的探针的方法和放置在光束的尖端上的接触器包括准备Si晶片20，在Si晶片20上形成晶种层21，并且在晶种层上形成期望形状的光束的凹槽 接着，用金属镀层24a，24b填充凹槽以形成所需的光束形状。

公开(公告)号：US20110315871A1

公开(公告)日：2011-12-29

申请号：US13255094

申请日：2010-03-30

Applicant: Manabu Komatsu ,  Hiroyuki Hashimoto

Inventor： Manabu Komatsu ,  Hiroyuki Hashimoto

IPC: H01J49/26 ,  H01J49/40

CPC classification number: G06F19/26 ,  G01N33/6848 ,  H01J49/0004 ,  Y10T436/24

Abstract: An object of the present invention is to provide a method of comprehensively visualizing a constituent in tumor tissue or the like at a cellular level.The present invention provides a method of forming a two-dimensional distribution image of a target constituent based on information on the mass of constituents of the tissue section wherein, as the internal standard material, any one of actin, tubulin and GAPDH is used in the intracellular region, one of histone and nucleic acid is used in the nuclear region, and one of albumin and cytokine is used in the extracellular region.

Abstract translation: 本发明的目的是提供一种在细胞水平上全面显示肿瘤组织等中的成分的方法。 本发明提供一种基于组织部位成分质量的信息形成目标成分的二维分布图像的方法，其中作为内标物质，使用肌动蛋白，微管蛋白和GAPDH中的任一种 细胞内区域，组蛋白和核酸之一用于核区域，白蛋白和细胞因子之一用于细胞外区域。

公开(公告)号：US20110003078A1

公开(公告)日：2011-01-06

申请号：US12921643

申请日：2009-03-13

Applicant: Kippei Sugita ,  Hiroyuki Hashimoto ,  Muneo Harada

Inventor： Kippei Sugita ,  Hiroyuki Hashimoto ,  Muneo Harada

IPC: B05D3/10 ,  B05C11/11

CPC classification number: H01L21/312 ,  B05D1/60 ,  B05D3/007 ,  B05D5/10 ,  H01L21/02126 ,  H01L21/02312

Abstract: An aqueous solution containing an adhesion promoter in an amount of 20 vol. % or more is heated and vaporized to a temperature of 80 to 100° C. to produce a water-containing adhesion promoter vapor, and the water-containing adhesion promoter vapor is adhered to and condensed on a surface of a substrate, to cause a heating and dehydrating reaction by which the adhesion promoter is adhered to the surface of the substrate.

Abstract translation: 含有20体积％的粘合促进剂的水溶液 加热并蒸发％以上至80〜100℃的温度，生成含水粘合促进剂蒸气，将含水粘合促进剂蒸气粘附于基板表面并冷凝， 加热和脱水反应，其中粘附促进剂通过其附着到基材的表面。

公开(公告)号：US20100263400A1

公开(公告)日：2010-10-21

申请号：US12669788

申请日：2008-07-16

Applicant: Yoshihisa Tachibana ,  Takashi Nishiyama ,  Kazuhide Saito ,  Kazuaki Mizukami ,  Hiroyuki Hashimoto ,  Takeshi Ishii ,  Hiroshi Yamamoto

Inventor： Yoshihisa Tachibana ,  Takashi Nishiyama ,  Kazuhide Saito ,  Kazuaki Mizukami ,  Hiroyuki Hashimoto ,  Takeshi Ishii ,  Hiroshi Yamamoto

IPC: F25D3/00 ,  B67D7/80 ,  F25B29/00

CPC classification number: B67D1/0884 ,  B01D61/025 ,  B67D1/0004 ,  B67D1/0015 ,  B67D1/0016 ,  B67D1/0021 ,  B67D1/04 ,  B67D1/0406 ,  B67D1/0864 ,  B67D1/0888 ,  B67D2210/00049 ,  F25B25/005 ,  F25B2400/06 ,  F25C1/00 ,  F25D31/002

Abstract: To provide a beverage dispenser capable of appropriately and smoothly supplying a supercooled beverage.[Solving Means] The present invention provides a beverage dispenser 1 which supplies a beverage brought into a supercooled state at a solidifying point or less and which releases the supercooled state in the outside, and the beverage dispenser includes a primary cooling device 13 which cools the beverage to an ice point or so, a beverage supply circuit 7 which supplies the beverage cooled by the primary cooling device 13 to the outside, a brine circuit 31 through which an antifreezing liquid cooled to the solidifying point or less of the beverage is circulated, and a heat exchanger 16 for supercooling the beverage, which performs heat exchange between the beverage flowing through the beverage supply circuit 7 and the antifreezing liquid flowing through the brine circuit 31.

Abstract translation: 提供能够适当且平稳地供应过冷饮料的饮料分配器。 本发明提供了一种饮料分配器1，其将凝固点或更低固化点处于过冷状态的饮料供给并且在外部释放过冷状态，并且饮料分配器包括主冷却装置13，冷却装置 将饮料供给到冰点的饮料供给回路7，将由一次冷却装置13冷却的饮料供给到外部，将冷却至饮料的凝固点以下的防冻液循环通过的盐水回路31， 以及用于过冷却饮料的热交换器16，其在流过饮料供应回路7的饮料和流过盐水回路31的防冻液之间进行热交换。

公开(公告)号：US20090308141A1

公开(公告)日：2009-12-17

申请号：US12542201

申请日：2009-08-17

Applicant: Manabu Komatsu ,  Hiroyuki Hashimoto

Inventor： Manabu Komatsu ,  Hiroyuki Hashimoto

IPC: G01N1/00

CPC classification number: H01J49/10 ,  B01L3/5085 ,  H01J49/40 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A test specimen is provided which has one or more chemical substances fixed to prescribed plural independent positions on a substrate, and the quantities of the chemical substances fixed at the respective prescribed positions are the total of integer multiples of existence quantity units defined for the respective chemical substances in the range from 1 amol to 1 nmol (excluding the case in which the total quantity is zero).

Abstract translation: 提供了一种试样，其具有在基板上固定为规定的多个独立位置的一种或多种化学物质，并且在各规定位置固定的化学物质的量为为各化学物质定义的存在量单位的整数倍的总和 物质在1〜1nmol范围内（不包括总量为零的情况）。

公开(公告)号：US20090266982A1

公开(公告)日：2009-10-29

申请号：US12427583

申请日：2009-04-21

Applicant: Kimihiro Yoshimura ,  Manabu Komatsu ,  Hiroyuki Hashimoto ,  Yohei Murayama

Inventor： Kimihiro Yoshimura ,  Manabu Komatsu ,  Hiroyuki Hashimoto ,  Yohei Murayama

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/0418 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25875

Abstract: A mass spectrometry method that makes it possible to perform high-sensitivity detection of a desorbed/ionized object substance to be measured in mass spectrometry in which the object substance to be measured is desorbed and ionized. The method includes placing at least an ionizing agent having two or more functional groups represented by Formula (1) below in a molecule: —(CF2)COOH  (1) wherein the ionizing agent has a boiling point of equal to or higher than 150° C. and an object molecule to be measured on a substrate and irradiating the ionizing agent and the object molecule to be measured with a primary beam selected from ions, neutral particles, electrons, and a laser beam.

Abstract translation: 能够对被测定物被解吸和离子化的质谱法进行能够进行待测量的解吸附电离对象物质的高灵敏度检测的质谱法。 该方法包括在分子中至少放置一个具有两个或多个由式（1）表示的官能团的电离剂： - （CF 2）COOH（1）其中电离剂的沸点等于或高于150℃ 和待测量的物体分子，并用从离子，中性粒子，电子和激光束中选择的一次束照射被测量的电离剂和待测物体。

公开(公告)号：US20090093373A1

公开(公告)日：2009-04-09

申请号：US12264241

申请日：2008-11-03

Applicant: Masahiro Kawaguchi ,  Tadashi Okamoto ,  Hiromitsu Takase ,  Hiroyuki Hashimoto

Inventor： Masahiro Kawaguchi ,  Tadashi Okamoto ,  Hiromitsu Takase ,  Hiroyuki Hashimoto

IPC: C40B30/04 ,  C40B30/10

CPC classification number: C12Q1/6837

Abstract: To provide a DNA micro-array having a nucleic acid probe immobilized on a substrate, which is used to detect a molecule of a target nucleic acid contained in a sample and has a substantially complementary base sequence to the target base sequence of the nucleic acid molecule, including at least one probe selected from the group consisting of: at least one internal standard probe for assay of PCR of the target nucleic acid; at least one external standard probe for a detection operation and assay of an amount of the probe; and a probe for measurement of the amount or density of the nucleic acid probe, formed by the same method as the nucleic acid probe.

Abstract translation: 提供具有固定在底物上的核酸探针的DNA微阵列，其用于检测样品中所含的靶核酸的分子，并且与核酸分子的靶碱基序列具有基本上互补的碱基序列 包括至少一种选自以下的探针：用于测定靶核酸的PCR的至少一个内标物探针; 用于检测操作的至少一个外部标准探针和探针的量的测定; 以及通过与核酸探针相同的方法形成的用于测量核酸探针的量或密度的探针。

公开(公告)号：US07428841B2

公开(公告)日：2008-09-30

申请号：US10545088

申请日：2004-02-10

Applicant: Muneo Harada ,  Naoki Ikeuchi ,  Hiroyuki Hashimoto

Inventor： Muneo Harada ,  Naoki Ikeuchi ,  Hiroyuki Hashimoto

IPC: G01P3/00 ,  G01P1/02

CPC classification number: G01C9/06 ,  G01P15/123 ,  G01P15/18 ,  G01P2015/084 ,  G01P2015/0842

Abstract: In an acceleration sensor detecting inclined displacement of a predetermined article from a basic position, the acceleration sensor (10) includes a sensor chip having a detection plane including one detection axis or two crossing detection axes detecting the inclined displacement. An axis orthogonal to the detection plane of the sensor chip is disposed in parallel with a standard plane of the article in the basic position. Then, the sensor chip obtains an output signal according to the inclined displacement of the standard plane.

Abstract translation: 在加速度传感器检测预定物品从基本位置的倾斜位移时，加速度传感器（10）包括具有检测平面的传感器芯片，检测平面包括一个检测轴或检测倾斜位移的两个检测轴。 与传感器芯片的检测平面垂直的轴与基本位置的物品的标准平面平行设置。 然后，传感器芯片根据标准平面的倾斜位移获得输出信号。