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11.发明授权公开(公告)号：US07465766B2
公开(公告)日：2008-12-16
申请号：US11176544
申请日：2005-07-07
Applicant: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
Inventor： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC classification number: C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
Abstract translation: 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成的，可植入的组织基质材料。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。
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公开(公告)号：USD570598S1
公开(公告)日：2008-06-10
申请号：US29272698
申请日：2007-02-12
Applicant: James Chan
Designer： James Chan
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13.发明申请公开(公告)号：US20060084759A1
公开(公告)日：2006-04-20
申请号：US11176544
申请日：2005-07-07
Applicant: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq Darr , Kiyotaka Fukamachi , Richard Gross , David Haynes , Keiji Kamohara , Daniel Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
Inventor： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq Darr , Kiyotaka Fukamachi , Richard Gross , David Haynes , Keiji Kamohara , Daniel Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC classification number: C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
Abstract translation: 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成的，可植入的组织基质材料。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。
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公开(公告)号：US06476028B1
公开(公告)日：2002-11-05
申请号：US09529338
申请日：2000-08-08
Applicant: William E. Bondinell , James Chan , Roderick A. Porter , Joseph W. Venslavsky , Steven Dabbs , David T. Davies
Inventor： William E. Bondinell , James Chan , Roderick A. Porter , Joseph W. Venslavsky , Steven Dabbs , David T. Davies
IPC: A61K3153
CPC classification number: C07D401/04 , A61K31/454 , C07D401/14
Abstract: A method of treating a CCR5-mediated disease state in mammals which comprises administering to a mammal in need of such treatment, an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.
Abstract translation: 一种治疗哺乳动物中CCR5介导的疾病状态的方法，其包括向需要这种治疗的哺乳动物施用有效量的式（I）化合物或其药学上可接受的盐。
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公开(公告)号：US20140277301A1
公开(公告)日：2014-09-18
申请号：US13801512
申请日：2013-03-13
Applicant: Christopher M. Varga , Michael McMahon , Thomas Dillingham , James Chan , Todd Schmaltz , Karthikeyan Rajendran
Inventor： Christopher M. Varga , Michael McMahon , Thomas Dillingham , James Chan , Todd Schmaltz , Karthikeyan Rajendran
IPC: A61F7/02
CPC classification number: A61F7/02 , A61F2007/0029 , A61F2007/0031 , A61F2007/0034 , A61F2007/0036 , A61F2007/0037 , A61F2007/0039 , A61F2007/0041 , A61F2007/0043 , A61F2007/0045 , A61F2007/0054 , A61F2007/0215 , A61F2007/0217 , A61F2007/0219 , A61F2007/0226 , A61F2007/0228 , A61F2007/0231 , A61F2007/0268 , A61F2007/0273 , A61F2007/0274 , A61F2007/0288
Abstract: A patient warming device with patient access for maintaining normothermia and/or treating hypothermia is provided. The device includes a first compliant layer and a second compliant layer sealed together around an outer border to contain a liquid between the two layers and to form a wrap that surrounds and conforms to a body portion of a patient. A plurality of flaps extends from opposite sides of a generally longitudinal central portion of the wrap, such that one or more flaps from the opposite sides fasten to each other to surround the body portion. The flaps are openable during functional use to provide access to an underlying patient body surface. A continuous fluid flow path extends between the first compliant layer and the second compliant layer between a fluid inlet and a fluid outlet to carry liquid and deliver heat through the wrap.
Abstract translation: 提供了具有维持正常体温和/或治疗体温降低的患者进入的患者加温装置。 该装置包括第一顺应层和围绕外边界密封在一起的第二顺应层，以在两层之间容纳液体并形成围绕并符合患者身体部分的包裹物。 多个翼片从包裹体的大致纵向中心部分的相对侧延伸，使得一个或多个翼片从相对侧彼此紧固以围绕主体部分。 襟翼在功能使用期间是可打开的，以提供对下面的患者身体表面的接近。 连续流体流动路径在流体入口和流体出口之间的第一顺应层和第二顺应层之间延伸以承载液体并通过包裹物输送热量。
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Patent Agency Ranking
公开(公告)号：US20120329548A1
公开(公告)日：2012-12-27
申请号：US13540248
申请日：2012-07-02
Applicant: Matthew James Chan
Inventor： Matthew James Chan
IPC: A63F9/24
CPC classification number: G07F17/32 , G07F17/3258 , G07F17/3267 , G07F17/34
Abstract: A method for use with a gaming system that provides a game in which a plurality of symbols are selected and presented on a display to form one or more combinations includes: providing a base game, providing a feature game on the occurrence of a first event during play of the base game, awarding a jackpot on the occurrence of a second event during play of the feature game, and varying the probability of both the first and the second events dependent on at least an aspect of a wager placed by a player to play the base game, wherein said variation maintains at least an approximately constant probability of the jackpot being won despite variations in said aspect of the wager.
Abstract translation: 一种用于提供游戏的游戏系统的方法，其中多个符号被选择并呈现在显示器上以形成一个或多个组合，包括：提供基本游戏，在第一事件发生时提供特征游戏 基本游戏的玩法，在玩游戏中发生第二个事件的奖励奖励，并且改变第一和第二个事件的概率取决于玩家放置的下注的至少一个方面来播放 基本游戏，其中所述变化维持尽管在赌注的所述方面的变化，获得了累积奖金的至少近似恒定的概率。
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公开(公告)号：US08235797B2
公开(公告)日：2012-08-07
申请号：US12471882
申请日：2009-05-26
Applicant: Matthew James Chan
Inventor： Matthew James Chan
IPC: A63F9/24
CPC classification number: G07F17/32 , G07F17/3258 , G07F17/3267 , G07F17/34
Abstract: A method for use with a gaming system that provides a game in which a plurality of symbols are selected and presented on a display to form one or more combinations includes: providing a base game, providing a feature game on the occurrence of a first event during play of the base game, awarding a jackpot on the occurrence of a second event during play of the feature game, and varying the probability of both the first and the second events dependent on at least an aspect of a wager placed by a player to play the base game, wherein said variation maintains at least an approximately constant probability of the jackpot being won despite variations in said aspect of the wager.
Abstract translation: 一种与游戏系统一起使用的方法，其提供其中多个符号被选择并呈现在显示器上以形成一个或多个组合的游戏，包括：提供基本游戏，在第一事件发生时提供特征游戏 基本游戏的玩法，在玩游戏时发布第二个事件的奖励，并且改变第一和第二个事件的概率取决于玩家放置的下注的至少一个方面来播放 基本游戏，其中所述变化维持尽管在赌注的所述方面的变化，获得了累积奖金的至少近似恒定的概率。
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18.发明授权公开(公告)号：US08207262B2
公开(公告)日：2012-06-26
申请号：US12283661
申请日：2008-09-15
Applicant: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
Inventor： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC classification number: C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
Abstract translation: 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成大分子网络。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。
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19.发明申请公开(公告)号：US20100003437A1
公开(公告)日：2010-01-07
申请号：US12392180
申请日：2009-02-25
Applicant: Hong-Ta James CHAN , Tomoyuki Watanabe , William Scott Lambert , Nahoto Hayashi
Inventor： Hong-Ta James CHAN , Tomoyuki Watanabe , William Scott Lambert , Nahoto Hayashi
CPC classification number: B05D1/10 , B05D7/54 , Y10T428/1352 , Y10T428/1379 , Y10T428/1383 , Y10T428/26 , Y10T428/31504 , Y10T428/31938
Abstract: A powder of a barrier material (B) is after, having been melted, applied to a substrate of a of a polyolefin (A) according to flame spray coating process to give a shaped article, in which the barrier material (B) firmly adheres to the polyolefin (A) even when the surface of the substrate is not subjected to primer treatment. The shaped article is favorable to components to fuel containers, fuel tanks for automobiles, fuel pipes, etc.
Abstract translation: 根据火焰喷涂法，将阻隔材料（B）的粉末熔融后施加到聚烯烃（A）的基材上，得到成形制品，其中阻挡材料（B）牢固地粘合 即使在基材的表面未进行底漆处理的情况下，也可以使用聚烯烃（A）。 成型制品有利于燃料容器，汽车燃料箱，燃料管等部件。
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20.发明申请公开(公告)号：US20100003419A1
公开(公告)日：2010-01-07
申请号：US12434725
申请日：2009-05-04
Applicant: Hong-Ta James Chan , Tomoyuki Watanabe , William Scott Lambert , Nahoto Hayashi
Inventor： Hong-Ta James Chan , Tomoyuki Watanabe , William Scott Lambert , Nahoto Hayashi
IPC: B05D1/10
CPC classification number: B05D7/52 , B05D1/10 , B05D7/02 , C23C4/00 , C23C4/02 , C23C4/123 , C23C4/129 , C23C4/18
Abstract: A powder of a barrier material (B) is, after having been melted, applied to a substrate of a polyolefin (A) to give a shaped article, in which the barrier material (B) firmly adheres to the polyolefin (A) even when the surface of the substrate is not subjected to primer treatment. The shaped article is favorable to components to fuel containers, fuel tanks for automobiles, fuel pipes, etc.
Abstract translation: 阻隔材料（B）的粉末在被熔化后被施加到聚烯烃（A）的基材上，得到成型制品，其中阻挡材料（B）牢固地粘附到聚烯烃（A）上，即使当 基材的表面不进行底漆处理。 成型制品有利于燃料容器，汽车燃料箱，燃料管等部件。
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