-
1.
公开(公告)号:US07465766B2
公开(公告)日:2008-12-16
申请号:US11176544
申请日:2005-07-07
申请人: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号: C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译: 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络,特别是提供用于各种组织类型的合成的,可植入的组织基质材料。 特别地,描述人造或合成软骨,声带材料,玻璃体材料,软组织材料和二尖瓣材料。 在一个实施方案中,网络由酪胺取代和交联的透明质酸分子组成,其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的,一致的透明质酸基水凝胶。
-
2.
公开(公告)号:US08207262B2
公开(公告)日:2012-06-26
申请号:US12283661
申请日:2008-09-15
申请人: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号: C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译: 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络,特别是提供用于各种组织类型的合成大分子网络。 特别地,描述人造或合成软骨,声带材料,玻璃体材料,软组织材料和二尖瓣材料。 在一个实施方案中,网络由酪胺取代和交联的透明质酸分子组成,其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的,一致的透明质酸基水凝胶。
-
公开(公告)号:US20090142309A1
公开(公告)日:2009-06-04
申请号:US12320609
申请日:2009-01-29
申请人: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号: C08J3/246 , C08B37/0072 , C08G73/02 , C08H1/00 , C08J3/24 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
-
公开(公告)号:US20090042294A1
公开(公告)日:2009-02-12
申请号:US12283661
申请日:2008-09-15
申请人: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号: C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
-
5.
公开(公告)号:US20090143766A1
公开(公告)日:2009-06-04
申请号:US12320613
申请日:2009-01-29
申请人: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukumachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukumachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号: C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译: 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络,特别是提供用于各种组织类型的合成大分子网络。 特别地,描述人造或合成软骨,声带材料,玻璃体材料,软组织材料和二尖瓣材料。 在一个实施方案中,网络由酪胺取代和交联的透明质酸分子组成,其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的,一致的透明质酸基水凝胶。
-
6.
公开(公告)号:US20060084759A1
公开(公告)日:2006-04-20
申请号:US11176544
申请日:2005-07-07
申请人: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq Darr , Kiyotaka Fukamachi , Richard Gross , David Haynes , Keiji Kamohara , Daniel Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人: Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq Darr , Kiyotaka Fukamachi , Richard Gross , David Haynes , Keiji Kamohara , Daniel Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号: C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译: 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络,特别是提供用于各种组织类型的合成的,可植入的组织基质材料。 特别地,描述人造或合成软骨,声带材料,玻璃体材料,软组织材料和二尖瓣材料。 在一个实施方案中,网络由酪胺取代和交联的透明质酸分子组成,其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的,一致的透明质酸基水凝胶。
-
7.
公开(公告)号:US20110167814A1
公开(公告)日:2011-07-14
申请号:US12685410
申请日:2010-01-11
申请人: David Haynes
发明人: David Haynes
CPC分类号: F01K27/00
摘要: Apparatus (100) comprising a power plant or air motor utilizing compressed air or liquid air for energy storage. The apparatus includes an electrical plant (200), a mechanical plant (300), and a pneumatic plant (400). When operating as a compressor, the plant receives electrical and/or direct mechanical power as an input to drive the plant, compress air, and store its output in the form of compressed or liquefied air. When operating as an engine, the plant consumes the compressed or liquid air to drive a mechanism of the engine and deliver mechanical power and/or electrical power as an output.
摘要翻译: 装置(100)包括利用压缩空气或液体空气进行能量储存的动力装置或空气马达。 该设备包括电厂(200),机械设备(300)和气动设备(400)。 当作为压缩机运行时,工厂接收电和/或直接机械动力作为输入以驱动设备,压缩空气并以压缩或液化空气的形式存储其输出。 当作为发动机工作时,工厂消耗压缩或液体空气来驱动发动机的机构并输送机械功率和/或电力作为输出。
-
8.
公开(公告)号:US20060212793A1
公开(公告)日:2006-09-21
申请号:US11381917
申请日:2006-05-05
申请人: Richard Marejka , David Haynes
发明人: Richard Marejka , David Haynes
IPC分类号: G06F17/00
CPC分类号: G06F9/546 , H04L41/0806 , H04L41/0853 , H04L41/0859 , H04L41/5064 , H04L43/0817
摘要: A system and method of accessing remote services through a network including generating a message within a local computer system using a process having a specified type and version. The message is associated with the specified type and version and transported to an remote service provider system. The remote service provider system parses the message to identify the type and version information, then passes the message to a particular process that corresponds to the process used to generate the message based upon the type and version information.
摘要翻译: 一种通过网络访问远程服务的系统和方法,包括使用具有指定类型和版本的进程在本地计算机系统内生成消息。 消息与指定的类型和版本相关联,并传输到远程服务提供商系统。 远程服务提供商系统解析消息以识别类型和版本信息,然后根据类型和版本信息将消息传递到与用于生成消息的过程相对应的特定进程。
-
公开(公告)号:US20210219481A1
公开(公告)日:2021-07-22
申请号:US17154409
申请日:2021-01-21
申请人: David Haynes
发明人: David Haynes
摘要: A tractor includes a frame defines longitudinal (nominally forward and backward), lateral (nominally left and right), and transverse (nominally up and down) directions (mutually orthogonal). First and second side structures connect by a width adjustment structure comprising beams of bearing length and bearing width capable of supporting loads (torque, bending, etc.) at any of a plurality of widths therebetween. Individual drive systems in the first and second sides each include a track, motor, sprocket, main idler, and bogey idlers. A carrier system secures, lifts, and descends an implement. Implements may be of any type, such as tillage, harrowing, furrowing, seeding, cultivation, personnel carrier, or the like. A controller is capable of directing the tractor based on a pre-determined course of travel, or a guided course in response to physical features in a farming field.
-
公开(公告)号:US20170290440A1
公开(公告)日:2017-10-12
申请号:US14835233
申请日:2015-08-25
申请人: David Haynes
发明人: David Haynes
CPC分类号: A47C31/105 , A47C21/08 , A47G9/0238 , A61G7/0507
摘要: A cover for beds includes a cover with a structural profiles formed by perimeter or otherwise rail aspects such as a top rail aspect, bottom rail aspect, lateral rail aspects, geometrically designed to create desired profiles and/or profiles that form its shape and design. Rails aspects may be made from plastic, foam and/or the like that change the shape and the design can be arranged to achieve desired functional objectives and may be designed to fit hospital bed, any mattress or child mattress. The cover is complemented by a material that may be removed, replaced and/or added to another material.
-
-
-
-
-
-
-
-
-