公开(公告)号：US07465766B2

公开(公告)日：2008-12-16

申请号：US11176544

申请日：2005-07-07

申请人： Anthony Calabro ,  Lee Akst ,  Daniel Alam ,  James Chan ,  Aniq B. Darr ,  Kiyotaka Fukamachi ,  Richard A. Gross ,  David Haynes ,  Keiji Kamohara ,  Daniel P. Knott ,  Hilel Lewis ,  Alex Melamud ,  Anthony Miniaci ,  Marshall Strome

发明人： Anthony Calabro ,  Lee Akst ,  Daniel Alam ,  James Chan ,  Aniq B. Darr ,  Kiyotaka Fukamachi ,  Richard A. Gross ,  David Haynes ,  Keiji Kamohara ,  Daniel P. Knott ,  Hilel Lewis ,  Alex Melamud ,  Anthony Miniaci ,  Marshall Strome

IPC分类号： C08L89/00 ,  C08G63/48

CPC分类号： C08B37/0072 ,  A61K47/6903 ,  C08G73/02 ,  C08H1/00 ,  C08J3/24 ,  C08J3/246 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/30

摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.

摘要翻译： 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成的，可植入的组织基质材料。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。

公开(公告)号：US08207262B2

公开(公告)日：2012-06-26

申请号：US12283661

申请日：2008-09-15

申请人： Anthony Calabro ,  Lee Akst ,  Daniel Alam ,  James Chan ,  Aniq B. Darr ,  Kiyotaka Fukamachi ,  Richard A. Gross ,  David Haynes ,  Keiji Kamohara ,  Daniel P. Knott ,  Hilel Lewis ,  Alex Melamud ,  Anthony Miniaci ,  Marshall Strome

发明人： Anthony Calabro ,  Lee Akst ,  Daniel Alam ,  James Chan ,  Aniq B. Darr ,  Kiyotaka Fukamachi ,  Richard A. Gross ,  David Haynes ,  Keiji Kamohara ,  Daniel P. Knott ,  Hilel Lewis ,  Alex Melamud ,  Anthony Miniaci ,  Marshall Strome

IPC分类号： C08G63/91 ,  C08G63/48

CPC分类号： C08B37/0072 ,  A61K47/6903 ,  C08G73/02 ,  C08H1/00 ,  C08J3/24 ,  C08J3/246 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/30

摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.

摘要翻译： 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成大分子网络。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。

公开(公告)号：US20090142309A1

公开(公告)日：2009-06-04

申请号：US12320609

申请日：2009-01-29

申请人： Anthony Calabro ,  Lee Akst ,  Daniel Alam ,  James Chan ,  Aniq B. Darr ,  Kiyotaka Fukamachi ,  Richard A. Gross ,  David Haynes ,  Keiji Kamohara ,  Daniel P. Knott ,  Hilel Lewis ,  Alex Melamud ,  Anthony Miniaci ,  Marshall Strome

发明人： Anthony Calabro ,  Lee Akst ,  Daniel Alam ,  James Chan ,  Aniq B. Darr ,  Kiyotaka Fukamachi ,  Richard A. Gross ,  David Haynes ,  Keiji Kamohara ,  Daniel P. Knott ,  Hilel Lewis ,  Alex Melamud ,  Anthony Miniaci ,  Marshall Strome

IPC分类号： A61K35/12 ,  C12P19/26 ,  A61K38/44

CPC分类号： C08J3/246 ,  C08B37/0072 ,  C08G73/02 ,  C08H1/00 ,  C08J3/24 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/30

摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.

公开(公告)号：US20090042294A1

公开(公告)日：2009-02-12

申请号：US12283661

申请日：2008-09-15

申请人： Anthony Calabro ,  Lee Akst ,  Daniel Alam ,  James Chan ,  Aniq B. Darr ,  Kiyotaka Fukamachi ,  Richard A. Gross ,  David Haynes ,  Keiji Kamohara ,  Daniel P. Knott ,  Hilel Lewis ,  Alex Melamud ,  Anthony Miniaci ,  Marshall Strome

发明人： Anthony Calabro ,  Lee Akst ,  Daniel Alam ,  James Chan ,  Aniq B. Darr ,  Kiyotaka Fukamachi ,  Richard A. Gross ,  David Haynes ,  Keiji Kamohara ,  Daniel P. Knott ,  Hilel Lewis ,  Alex Melamud ,  Anthony Miniaci ,  Marshall Strome

IPC分类号： A61F2/02 ,  C08L5/00 ,  C08G63/12 ,  C08G65/38 ,  C08L89/00 ,  C12N5/08

CPC分类号： C08B37/0072 ,  A61K47/6903 ,  C08G73/02 ,  C08H1/00 ,  C08J3/24 ,  C08J3/246 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/30

摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.

公开(公告)号：US20090143766A1

公开(公告)日：2009-06-04

申请号：US12320613

申请日：2009-01-29

申请人： Anthony Calabro ,  Lee Akst ,  Daniel Alam ,  James Chan ,  Aniq B. Darr ,  Kiyotaka Fukumachi ,  Richard A. Gross ,  David Haynes ,  Keiji Kamohara ,  Daniel P. Knott ,  Hilel Lewis ,  Alex Melamud ,  Anthony Miniaci ,  Marshall Strome

发明人： Anthony Calabro ,  Lee Akst ,  Daniel Alam ,  James Chan ,  Aniq B. Darr ,  Kiyotaka Fukumachi ,  Richard A. Gross ,  David Haynes ,  Keiji Kamohara ,  Daniel P. Knott ,  Hilel Lewis ,  Alex Melamud ,  Anthony Miniaci ,  Marshall Strome

IPC分类号： A61M37/00 ,  A61L27/52

CPC分类号： C08B37/0072 ,  A61K47/6903 ,  C08G73/02 ,  C08H1/00 ,  C08J3/24 ,  C08J3/246 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/30

摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.

摘要翻译： 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成大分子网络。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。

公开(公告)号：US20060084759A1

公开(公告)日：2006-04-20

申请号：US11176544

申请日：2005-07-07

申请人： Anthony Calabro ,  Lee Akst ,  Daniel Alam ,  James Chan ,  Aniq Darr ,  Kiyotaka Fukamachi ,  Richard Gross ,  David Haynes ,  Keiji Kamohara ,  Daniel Knott ,  Hilel Lewis ,  Alex Melamud ,  Anthony Miniaci ,  Marshall Strome

发明人： Anthony Calabro ,  Lee Akst ,  Daniel Alam ,  James Chan ,  Aniq Darr ,  Kiyotaka Fukamachi ,  Richard Gross ,  David Haynes ,  Keiji Kamohara ,  Daniel Knott ,  Hilel Lewis ,  Alex Melamud ,  Anthony Miniaci ,  Marshall Strome

IPC分类号： A61K47/48 ,  C08F32/00

CPC分类号： C08B37/0072 ,  A61K47/6903 ,  C08G73/02 ,  C08H1/00 ,  C08J3/24 ,  C08J3/246 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/30

摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.

摘要翻译： 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成的，可植入的组织基质材料。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。

公开(公告)号：US07169106B2

公开(公告)日：2007-01-30

申请号：US10841996

申请日：2004-05-07

申请人： Aaron J. Fleischman ,  Shuvo Roy ,  Hilel Lewis

发明人： Aaron J. Fleischman ,  Shuvo Roy ,  Hilel Lewis

IPC分类号： A61B3/16 ,  A61B5/00

CPC分类号： A61B3/16 ,  A61B2562/028

摘要： An apparatus (180) for measuring intraocular pressure (IOP) comprises a contact lens (40) including an inner surface (42) contoured to a surface portion (34) of an eye (36) and a sensor (10) disposed in the contact lens. The sensor (10) comprises a contact surface (14) for making contact with the surface portion (34) of the eye (36). The contact surface (14) includes an outer non-compliant region (16) and an inner compliant region (18) fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor (10) further comprises a region of conductive material (38) electrically coupled to the impedance element of the compliant region (18) and responsive to an external signal for energizing the impedance element so that the IOP may be determined.

摘要翻译： 一种用于测量眼内压（IOP）的装置（180）包括隐形眼镜（40），所述隐形眼镜包括形成于眼睛（36）的表面部分（34）的外表面（42）和设置在所述触点 镜片。 传感器（10）包括用于与眼睛（36）的表面部分（34）接触的接触表面（14）。 接触表面（14）包括外部非顺应性区域（16）和内部顺应性区域（18），该内部顺应性区域（18）被制造为当内部顺应性区域改变形状时阻抗变化的阻抗元件。 传感器（10）还包括电耦合到柔性区域（18）的阻抗元件的导电材料（38）的区域，并且响应于外部信号来激励阻抗元件，使得可以确定IOP。

公开(公告)号：US06749568B2

公开(公告)日：2004-06-15

申请号：US10128321

申请日：2002-04-22

申请人： Aaron J. Fleischman ,  Shuvo Roy ,  Hilel Lewis

发明人： Aaron J. Fleischman ,  Shuvo Roy ,  Hilel Lewis

IPC分类号： A61B316

CPC分类号： A61B3/16 ,  A61B2562/028

摘要： An apparatus for measuring intraocular pressure (IOP) comprises a contact lens including an inner surface contoured to a surface portion of an eye and a sensor disposed in the contact lens. The sensor comprises a contact surface for making contact with the surface portion of the eye. The contact surface includes an outer non-compliant region and an inner compliant region fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor further comprises a region of conductive material electrically coupled to the impedance element of the compliant region and responsive to an external signal for energizing the impedance element so that the IOP may be determined.

摘要翻译： 用于测量眼内压（IOP）的装置包括隐形眼镜，其包括形成眼睛表面部分的内表面和设置在隐形眼镜中的传感器。 传感器包括用于与眼睛的表面部分接触的接触表面。 接触表面包括外部非顺应性区域和制造为阻抗元件的内部顺应性区域，其随着内部顺应性区域改变形状而阻抗变化。 该传感器还包括导电材料的区域，该区域电耦合到柔性区域的阻抗元件，并且响应外部信号以激发阻抗元件，使得可以确定IOP。

公开(公告)号：US20070129623A1

公开(公告)日：2007-06-07

申请号：US11699811

申请日：2007-01-30

申请人： Aaron Fleischman ,  Shuvo Roy ,  Hilel Lewis

发明人： Aaron Fleischman ,  Shuvo Roy ,  Hilel Lewis

IPC分类号： A61B3/16

CPC分类号： A61B3/16 ,  A61B2562/028

摘要： An apparatus (180) for measuring intraocular pressure (IOP) comprises a contact lens (40) including an inner surface (42) contoured to a surface portion (34) of an eye (36) and a sensor (10) disposed in the contact lens. The sensor (10) comprises a contact surface (14) for making contact with the surface portion (34) of the eye (36). The contact surface (14) includes an outer non-compliant region (16) and an inner.compliant region (18) fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor (10) further comprises a region of conductive material (38) electrically coupled to the impedance element of the compliant region (18) and responsive to an external signal for energizing the impedance element so that the IOP may be determined.

摘要翻译： 一种用于测量眼内压（IOP）的装置（180）包括隐形眼镜（40），所述隐形眼镜包括形成于眼睛（36）的表面部分（34）的外表面（42）和设置在所述触点 镜片。 传感器（10）包括用于与眼睛（36）的表面部分（34）接触的接触表面（14）。 接触表面（14）包括外部非顺应性区域（16）和制造为随着内部顺应性区域改变形状而阻抗变化的阻抗元件的内部区域（18）。 传感器（10）还包括电耦合到柔性区域（18）的阻抗元件的导电材料（38）的区域，并且响应于外部信号来激励阻抗元件，使得可以确定IOP。