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公开(公告)号：US09689009B2
公开(公告)日：2017-06-27
申请号：US13278106
申请日：2011-10-20
Applicant: Jin Sook Chang , Jae Hyun Jo , Hyun Ae Bae , Byeong Cheol Song , Sol Kim , Hye Won Kim , Hye Won Um , Sung Hoo Jhon , Yong Uk Shin , Eun Bin Yang , Kyoung Min Lee , Soo An Shin
Inventor： Jin Sook Chang , Jae Hyun Jo , Hyun Ae Bae , Byeong Cheol Song , Sol Kim , Hye Won Kim , Hye Won Um , Sung Hoo Jhon , Yong Uk Shin , Eun Bin Yang , Kyoung Min Lee , Soo An Shin
CPC classification number: C12P13/12 , C12N9/1085 , C12N9/16 , C12N15/70 , C12N15/77 , C12P13/06 , C12Y205/01065 , C12Y301/03003
Abstract: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and the activity of PhnC, PhnD, and PhnE is reduced, and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having these reduced and enhanced properties noted above are also provided herein.
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12.发明申请MICROORGANISM PRODUCING O-PHOSPHOSERINE AND METHOD OF PRODUCING L-CYSTEINE OR DERIVATIVES THEREOF FROM O-PHOSPHOSERINE USING THE SAME 审中-公开生产O-磷酸的微生物及其使用其的O-磷酸酯生产L-胞嘧啶或其衍生物的方法公开(公告)号：US20120190081A1
公开(公告)日：2012-07-26
申请号：US13278102
申请日：2011-10-20
Applicant: Jin Sook CHANG , Jae Hyun JO , Hyun Ae BAE , Byeong Cheol SONG , Sol KIM , Hye Won KIM
Inventor： Jin Sook CHANG , Jae Hyun JO , Hyun Ae BAE , Byeong Cheol SONG , Sol KIM , Hye Won KIM
CPC classification number: C12P13/12 , C12N9/1085 , C12N9/16 , C12N15/70 , C12N15/77 , C12P13/06 , C12Y205/01065 , C12Y301/03003
Abstract: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein.
Abstract translation: 本发明提供了通过培养具有降低的内源磷酸丝氨酸磷酸酶活性的微生物来制备半胱氨酸或其衍生物的方法。 由这样的生物体产生的O-磷酸丝氨酸然后可以在硫酸酯或表达巯基化酶的微生物的存在下与硫化物反应，以产生半胱氨酸或其衍生物。 具有上述性质的微生物也在本文中提供。
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13.发明授权Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism 有权生产L-甲硫氨酸前体的微生物和使用该微生物生产L-甲硫氨酸前体的方法公开(公告)号：US07851180B2
公开(公告)日：2010-12-14
申请号：US12062927
申请日：2008-04-04
Applicant: Young Uk Shin , So Young Kim , Jin Sook Chang , Young Wook Cho , Han Jin Lee , In Kyung Heo , Kwang Ho Na , Chang Il Seo , Chul Ha Kim , Hye Won Um
Inventor： Young Uk Shin , So Young Kim , Jin Sook Chang , Young Wook Cho , Han Jin Lee , In Kyung Heo , Kwang Ho Na , Chang Il Seo , Chul Ha Kim , Hye Won Um
CPC classification number: C12P13/06 , C12N9/1029
Abstract: The present invention relates to a microorganism producing L-methionine precursor, O-succinylhomoserine, and a method of producing L-methionine precursor using the microorganism,
Abstract translation: 本发明涉及生产L-甲硫氨酸前体的微生物，O-琥珀酰高丝氨酸，以及使用该微生物生产L-甲硫氨酸前体的方法，
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Patent Agency Ranking
14.发明申请MICROORGANISM PRODUCING L-METHIONINE PRECURSOR AND THE METHOD OF PRODUCING L-METHIONINE PRECURSOR USING THE MICROORGANISM 有权生产L-甲磺酸前体的微生物和使用微生物生产L-甲磺酸前体的方法公开(公告)号：US20110207184A1
公开(公告)日：2011-08-25
申请号：US12983788
申请日：2011-01-03
Applicant: Chul Ha Kim , So Young Kim , Young Uk Shin , Hye Won Um , Jin Sook Chang , Young Wook Cho , Han Jin Lee , In Kyung Heo , Chang II Seo , Kwang Ho Na
Inventor： Chul Ha Kim , So Young Kim , Young Uk Shin , Hye Won Um , Jin Sook Chang , Young Wook Cho , Han Jin Lee , In Kyung Heo , Chang II Seo , Kwang Ho Na
IPC: C12P13/12
CPC classification number: C12N1/20 , C12N9/0006 , C12N9/1029 , C12N9/1217 , C12P13/06 , C12P13/12 , C12R1/19
Abstract: The present invention relates to a microorganism producing L-methionine precursor, O-acetylhomoserine, and a method of producing L-methionine precursor using the microorganism.
Abstract translation: 本发明涉及生产L-甲硫氨酸前体的微生物O-乙酰高丝氨酸，以及使用该微生物生产L-甲硫氨酸前体的方法。
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15.发明授权Microorganism producing L-methionine precursor and method of producing L-methionine and organic acid from the L-methionine precursor 有权生产L-甲硫氨酸前体的微生物和L-甲硫氨酸前体产生L-甲硫氨酸和有机酸的方法公开(公告)号：US08426171B2
公开(公告)日：2013-04-23
申请号：US12066111
申请日：2007-07-30
Applicant: So-young Kim , Kwang-myung Cho , Yong-uk Shin , Hye-won Um , Kyung-oh Choi , Jin-sook Chang , Young-wook Cho , Young-hoon Park
Inventor： So-young Kim , Kwang-myung Cho , Yong-uk Shin , Hye-won Um , Kyung-oh Choi , Jin-sook Chang , Young-wook Cho , Young-hoon Park
CPC classification number: C12P13/12 , C07C323/58 , C12N9/1029 , C12N9/1085 , C12P7/46 , C12P13/06
Abstract: The present invention relates to a method for producing L-methionine and organic acid comprising the following steps: Step 1) preparing a strain producing L-methionine precursor and producing L-methionine precursor by the fermentation of the strain; Step 2) producing L-methionine and organic acid by the enzyme reaction process with the L-methionine precursor as a substrate, and microorganism strains used in each step.
Abstract translation: 本发明涉及L-甲硫氨酸和有机酸的制造方法，其特征在于，包括以下工序：工序1）制备生产L-甲硫氨酸前体的菌株，通过菌株的发酵生产L-甲硫氨酸前体; 步骤2）通过与L-甲硫氨酸前体作为底物的酶反应方法生产L-甲硫氨酸和有机酸，以及每个步骤中使用的微生物菌株。
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16.发明申请MICROORGANISM PRODUCING O-PHOSPHOSERINE AND METHOD OF PRODUCING L-CYSTEINE OR DERIVATIVES THEREOF FROM O-PHOSPHOSERINE USING THE SAME 有权生产O-磷酸的微生物及其使用其的O-磷酸酯生产L-胞嘧啶或其衍生物的方法公开(公告)号：US20120190083A1
公开(公告)日：2012-07-26
申请号：US13278106
申请日：2011-10-20
Applicant: Jin Sook CHANG , Jae Hyun JO , Hyun Ae BAE , Byeong Cheol SONG , Sol KIM , Hye Won KIM , Hye Won UM , Sung Hoo JHON , Yong Uk SHIN , Eun Bin YANG , Kyoung Min LEE , Soo An SHIN
Inventor： Jin Sook CHANG , Jae Hyun JO , Hyun Ae BAE , Byeong Cheol SONG , Sol KIM , Hye Won KIM , Hye Won UM , Sung Hoo JHON , Yong Uk SHIN , Eun Bin YANG , Kyoung Min LEE , Soo An SHIN
CPC classification number: C12P13/12 , C12N9/1085 , C12N9/16 , C12N15/70 , C12N15/77 , C12P13/06 , C12Y205/01065 , C12Y301/03003
Abstract: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and the activity of PhnC, PhnD, and PhnE is reduced, and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having these reduced and enhanced properties noted above are also provided herein.
Abstract translation: 本发明提供了通过培养具有降低的内源性磷酸丝氨酸磷酸酶活性的微生物来生产半胱氨酸或其衍生物的方法，并且PhnC，PhnD和PhnE的活性降低，并且提高了磷酸甘油酸脱氢酶和/或磷酸丝氨酸氨基转移酶的活性。 由这样的生物体产生的O-磷酸丝氨酸然后可以在硫酸酯或表达巯基化酶的微生物的存在下与硫化物反应，以产生半胱氨酸或其衍生物。 本文还提供了具有上述这些降低和增强性能的微生物。
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17.发明申请MICROORGANISM PRODUCING O-PHOSPHOSERINE AND METHOD OF PRODUCING L-CYSTEINE OR DERIVATIVES THEREOF FROM O-PHOSPHOSERINE USING THE SAME 有权生产O-磷酸的微生物及其使用其的O-磷酸酯生产L-胞嘧啶或其衍生物的方法公开(公告)号：US20120190082A1
公开(公告)日：2012-07-26
申请号：US13278105
申请日：2011-10-20
Applicant: Jin Sook CHANG , Jae Hyun JO , Hyun Ae BAE , Byeong Cheol SONG , Sol KIM , Hye Won KIM
Inventor： Jin Sook CHANG , Jae Hyun JO , Hyun Ae BAE , Byeong Cheol SONG , Sol KIM , Hye Won KIM
CPC classification number: C12P13/12 , C12N9/1085 , C12N9/16 , C12N15/70 , C12N15/77 , C12P13/06 , C12Y205/01065 , C12Y301/03003
Abstract: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein.
Abstract translation: 本发明提供了通过培养具有降低的内源性磷酸丝氨酸磷酸酶活性和提高磷酸甘油酸脱氢酶和/或磷酸丝氨酸氨基转移酶活性的微生物来生产半胱氨酸或其衍生物的方法。 由这样的生物体产生的O-磷酸丝氨酸然后可以在硫酸酯或表达巯基化酶的微生物的存在下与硫化物反应，以产生半胱氨酸或其衍生物。 具有上述性质的微生物也在本文中提供。
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18.发明申请MICROORGANISM PRODUCING L-METHIONINE PRECURSOR AND THE METHOD OF PRODUCING L-METHIONINE PRECURSOR USING THE MICROORGANISM 有权生产L-甲磺酸前体的微生物和使用微生物生产L-甲磺酸前体的方法公开(公告)号：US20090253186A1
公开(公告)日：2009-10-08
申请号：US12062835
申请日：2008-04-04
Applicant: Chul Ha KIM , So Young KIM , Young Uk SHIN , Hye Won UM , Jin Sook CHANG , Young Wook CHO , Han Jin LEE , In Kyung HEO , Chang Il SEO , Kwang Ho NA
Inventor： Chul Ha KIM , So Young KIM , Young Uk SHIN , Hye Won UM , Jin Sook CHANG , Young Wook CHO , Han Jin LEE , In Kyung HEO , Chang Il SEO , Kwang Ho NA
CPC classification number: C12N1/20 , C12N9/0006 , C12N9/1029 , C12N9/1217 , C12P13/06 , C12P13/12 , C12R1/19
Abstract: The present invention relates to a microorganism producing L-methionine precursor, O-acetylhomoserine, and a method of producing L-methionine precursor using the microorganism.
Abstract translation: 本发明涉及生产L-甲硫氨酸前体的微生物O-乙酰高丝氨酸，以及使用该微生物生产L-甲硫氨酸前体的方法。
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