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    IMPLANTABLE ELASTOMERIC CAPROLACTONE DEPOT COMPOSITIONS AND USES THEREOF
    14.
    发明申请
    IMPLANTABLE ELASTOMERIC CAPROLACTONE DEPOT COMPOSITIONS AND USES THEREOF 审中-公开
    可植入式弹性体夹心剂组合物及其用途

    公开(公告)号：US20070184084A1

    公开(公告)日：2007-08-09

    申请号：US11554540

    申请日：2006-10-30

    Applicant: Guohua Chen ,  Lothar Kleiner ,  Paul Houston ,  Aruna Nathan ,  Joel Rosenblatt

    Inventor： Guohua Chen ,  Lothar Kleiner ,  Paul Houston ,  Aruna Nathan ,  Joel Rosenblatt

    IPC: A61K48/00 ,  A61K38/16 ,  A61K38/17 ,  A61K31/715 ,  A61K38/43 ,  A61K31/56

    CPC classification number: A61K9/0024

    Abstract: Methods and compositions for systemically or locally administering a beneficial agent to a subject are described, and include, for example, implantable elastomeric depot compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible, elastomeric caprolactone copolymer, a biocompatible solvent having low water miscibility that forms an elastomeric viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

    Abstract translation: 描述了用于向受试者全身或局部施用有益剂的方法和组合物，并且包括例如可植入的弹性体贮库组合物，其可以注射到期望的位置并且可以在延长的持续时间内提供有益剂的受控释放 时间。 组合物包括生物相容的弹性体己内酯共聚物，具有低水混溶性的生物相容性溶剂，其与聚合物形成弹性粘性凝胶并限制植入物吸收水分，以及有益剂。

    End-capped poly(ester amide) copolymers
    16.
    发明申请
    End-capped poly(ester amide) copolymers 审中-公开
    封端的聚（酯酰胺）共聚物

    公开(公告)号：US20060089485A1

    公开(公告)日：2006-04-27

    申请号：US10975247

    申请日：2004-10-27

    Applicant: Jessica DesNoyer ,  Stephen Pacetti ,  Vidya Nayak ,  Lothar Kleiner

    Inventor： Jessica DesNoyer ,  Stephen Pacetti ,  Vidya Nayak ,  Lothar Kleiner

    IPC: C08G63/02 ,  C08G69/08

    CPC classification number: A61L27/34 ,  A61L31/10 ,  C08L77/12

    Abstract: Provided herein is an end-capped poly(ester amide) PEA) polymer and the method of making the polymer. The PEA polymer is substantially free of active amino end groups and/or activated carboxyl groups. The PEA polymer can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

    Abstract translation: 本文提供封端的聚（酯酰胺）PEA）聚合物和制备聚合物的方法。 PEA聚合物基本上不含活性氨基端基和/或活化的羧基。 PEA聚合物可以在可植入装置上形成涂层，其一个例子是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。

    Electrical devices containing conductive polymers
    17.
    发明授权
    Electrical devices containing conductive polymers 失效
    含有导电聚合物的电气装置

    公开(公告)号：US4689475A

    公开(公告)日：1987-08-25

    申请号：US787218

    申请日：1985-10-15

    Applicant: Lothar Kleiner ,  Martin Matthiesen

    Inventor： Lothar Kleiner ,  Martin Matthiesen

    IPC: H05B3/03 ,  B01D35/06 ,  F02B3/06 ,  H01C1/14 ,  H01C7/02 ,  H01L51/05 ,  H05B3/14 ,  H05B3/10

    CPC classification number: B01D35/06 ,  H01C1/1406 ,  H01C7/027 ,  F02B3/06

    Abstract: Electrical devices which comprise at least one metal electrode and a conductive polymer element in contact therewith, wherein the metal surface which contacts the conductive polymer has a roughened or otherwise treated surface to improve its adhesion to the conductive polymer. The metal electrode is preferably an electrodeposited foil. The conductive polymer preferably exhibits PTC behavior. The devices include heaters and circuit protection devices. The improved adhesion results in improved physical and electrical stability, and broadens the range of conductive polymer compositions which can be used in a number of important applications.

    Abstract translation: 包括至少一个金属电极和与其接触的导电聚合物元件的电子器件，其中与导电聚合物接触的金属表面具有粗糙化或其它处理的表面，以改善其与导电聚合物的粘合性。 金属电极优选为电沉积箔。 导电聚合物优选表现出PTC行为。 这些装置包括加热器和电路保护装置。 改进的粘附性导致改善的物理和电学稳定性，并且拓宽了可用于许多重要应用的导电聚合物组合物的范围。

    STENT COATING METHOD
    19.
    发明申请
    STENT COATING METHOD 有权
    STENT涂层方法

    公开(公告)号：US20110244112A1

    公开(公告)日：2011-10-06

    申请号：US13162937

    申请日：2011-06-17

    Applicant: Jason Van Sciver ,  Yung-Ming Chen ,  Lothar Kleiner

    Inventor： Jason Van Sciver ,  Yung-Ming Chen ,  Lothar Kleiner

    IPC: B05D1/00

    CPC classification number: B05D1/002

    Abstract: A stent is coated by ejecting droplets of a coating substance from a reservoir containing a coating substance. A reservoir housing can have a plurality of reservoir compartments. A transducer is used to eject the coating substance from the reservoir. Energy from the transducer is focused at a meniscus or an interface between the coating substance and another coating substance in the reservoir.

    Abstract translation: 通过从包含涂层物质的储存器喷射涂层物质的液滴来涂覆支架。 储存器壳体可以具有多个储存室。 传感器用于从储存器中喷射涂层物质。 传感器的能量集中在弯液面或涂层物质与储层中另一种涂料之间的界面。

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