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    Sample collection and testing system having a displacement member causing reagent to come into contact with a sample collection surface
    11.
    发明授权
    Sample collection and testing system having a displacement member causing reagent to come into contact with a sample collection surface 有权
    样品收集和测试系统具有使得试剂与样品收集表面接触的位移元件

    公开(公告)号：US07399984B2

    公开(公告)日：2008-07-15

    申请号：US11354413

    申请日：2006-02-14

    Applicant: Philip T. Feldsine ,  Tim A. Kelly ,  Jim Christensen ,  Joseph B. Di Carlo ,  Mark Andersen ,  Anita Kressner

    Inventor： Philip T. Feldsine ,  Tim A. Kelly ,  Jim Christensen ,  Joseph B. Di Carlo ,  Mark Andersen ,  Anita Kressner

    IPC: G01N15/06

    CPC classification number: G01N21/8507 ,  G01N21/645 ,  G01N21/76 ,  G01N21/763 ,  G01N2001/028

    Abstract: Methods and apparatus for evaluating the quality of a sample of a product, an ingredient, an environment or process by measuring multiple parameters thereof, including light emitted from a reacting sample containing ATP, ADP, alkaline phosphatase or other parameters such as pH, temperature, conductivity, reduction potential, dissolved gases, specific ions, and microbiological count. The apparatus comprises an integrated sample testing device used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The apparatus also comprises an instrument having a photon detection assembly for use with the sample testing device. The instrument can also comprise one or more sensing probes and a communication port to facilitate data collection, transfer and analysis.

    Abstract translation: 通过测量其多个参数，包括从含有ATP，ADP，碱性磷酸酶或其它参数如pH，温度的反应样品发射的光来评价产品，成分，环境或过程的样品的质量的方法和装置， 电导率，还原电位，溶解气体，特定离子和微生物计数。 该装置包括用于收集样品，混合试剂，使样品反应并将其收集在测量室中的集成样品测试装置。 该装置还包括具有用于样品测试装置的光子检测组件的仪器。 仪器还可以包括一个或多个感测探头和通信端口，以便于数据收集，传输和分析。

    Encoding and decoding reactions for determining target molecules
    12.
    发明申请
    Encoding and decoding reactions for determining target molecules 失效
    用于确定靶分子的编码和解码反应

    公开(公告)号：US20050260640A1

    公开(公告)日：2005-11-24

    申请号：US11090830

    申请日：2005-03-24

    Applicant: Mark Andersen ,  Kenneth Livak ,  Adam Broomer ,  Caifu Chen

    Inventor： Mark Andersen ,  Kenneth Livak ,  Adam Broomer ,  Caifu Chen

    IPC: C12Q1/68

    CPC classification number: C12Q1/6869 ,  C12Q1/6851 ,  C12Q2525/191 ,  C12Q2525/185 ,  C12Q2521/501 ,  C12Q2525/155 ,  C12Q2521/313 ,  C12Q2537/143 ,  C12Q2525/161

    Abstract: The present invention is directed to methods, reagents, and kits for detecting the presence or absence of (or quantifying) target polynucleotide sequences and proteins in at least one sample using encoding and decoding reactions. When a particular target polynucleotide is present in a sample for example, a reaction product is formed in the encoding reaction that includes addressable primer portions. At least one labeling probe and at least one address primer can be employed in the decoding amplification reaction thereby providing a detectable signal value depending upon whether a sequence is present or absent. In some embodiments, the encoding comprises a ligation reaction with linker probes, and single nucleotide polymorphisms (SNPs) are analyzed.

    Abstract translation: 本发明涉及用于使用编码和解码反应检测至少一个样品中靶多核苷酸序列和蛋白质的存在或不存在（或定量）的方法，试剂和试剂盒。 当特定靶多核苷酸例如存在于样品中时，在包含可寻址引物部分的编码反应中形成反应产物。 可以在解码扩增反应中使用至少一个标记探针和至少一个地址引物，从而根据序列是否存在提供可检测的信号值。 在一些实施方案中，编码包含与接头探针的连接反应，并分析单核苷酸多态性（SNP）。

    Multi-mode combination alarm and locking apparatus for bicycles, motorcycles and the like
    13.
    发明授权
    Multi-mode combination alarm and locking apparatus for bicycles, motorcycles and the like 失效
    用于自行车，摩托车等的多模组合报警和锁定装置

    公开(公告)号：US5408212A

    公开(公告)日：1995-04-18

    申请号：US946844

    申请日：1992-09-18

    Applicant: Chip E. R. Meyers ,  Frederick W. Schmidt ,  Mark Andersen

    Inventor： Chip E. R. Meyers ,  Frederick W. Schmidt ,  Mark Andersen

    IPC: B62H5/20 ,  B62J3/00 ,  E05B45/00 ,  E05B67/00 ,  E05B67/06 ,  E05B67/38

    CPC classification number: E05B73/0011 ,  B62H5/20 ,  B62J3/00 ,  E05B45/005 ,  E05B2067/386 ,  E05B67/063 ,  Y10T70/454 ,  Y10T70/5872

    Abstract: The present invention is a multi-mode combination alarm and locking apparatus for bicycles, motorcycles and the like. The case of the combination alarm and locking apparatus can be attached to a bicycle or the like by a hollow bracket which can detachably mounted to a tubular section of the bicycle frame. In the preferred embodiment the combination alarm and locking apparatus includes a U-bolt lock. In an alternative embodiment the combination alarm and locking apparatus can be used in conjunction with a U-bolt lock. The combination alarm and locking apparatus also has a cable lock which has an elongated flexible cable with a conductive core and is retained by a retractable spool. The spool is releasibly engaged with a releasible rachet mechanism which controls the retraction of the spool. The combination alarm and locking apparatus further provides a multi-mode alarm protection to the bicycle, including the motion detection, the battery compartment door tampering detection and the cable lock continuity detection, all operable with a single key.

    Abstract translation: 本发明是用于自行车，摩托车等的多模式组合报警和锁定装置。 组合报警和锁定装置的情况可以通过可拆卸地安装到自行车车架的管状部分的中空支架附接到自行车等。 在优选实施例中，组合报警和锁定装置包括U型螺栓锁。 在替代实施例中，组合报警和锁定装置可以与U型螺栓锁结合使用。 组合报警和锁定装置还具有电缆锁，其具有带导电芯的细长柔性电缆并且由可缩回线轴保持。 阀芯与可控制的止回阀机构可释放地接合，该机构控制阀芯的回缩。 组合报警和锁定装置还对自行车提供多模式警报保护，包括运动检测，电池盒门篡改检测和电缆锁连续性检测，均可用单个键操作。

    Methods, compositions, and kits for forming labeled polynucleotides
    17.
    发明申请
    Methods, compositions, and kits for forming labeled polynucleotides 审中-公开
    用于形成标记多核苷酸的方法，组合物和试剂盒

    公开(公告)号：US20060166235A1

    公开(公告)日：2006-07-27

    申请号：US11303765

    申请日：2005-12-15

    Applicant: Lori Hennessy ,  Mark Andersen

    Inventor： Lori Hennessy ,  Mark Andersen

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: C12Q1/6876 ,  C12P19/34 ,  C12Q1/6806 ,  C12Q2565/102 ,  C12Q2537/162 ,  C12Q2521/501

    Abstract: The present teachings provide novel methods, compositions, and kits for forming multi-labeled polynucleotides. In some embodiments of the present teachings, multiplexed amplification reactions are performed with a plurality of primer pairs, wherein one primer in a given primer pair comprises a distinct label. Additional labeling of the resulting amplicons can be accomplished by using at least one bridge oligonucleotide to ligate a labeled tag oligonucleotide to each labeled extension product, thereby forming a plurality of multi-labeled polynucleotides. Detection of labels such as florophores and mobility modifiers in the plurality of multi-labeled polynucleotides can identify a sample. Such sample identification can be performed using a mobility dependent analysis technique such as capillary electrophoresis, and can applicable in the field of forensics.

    Abstract translation: 本教导提供用于形成多标记多核苷酸的新方法，组合物和试剂盒。 在本教导的一些实施方案中，多个扩增反应用多个引物对进行，其中给定引物对中的一个引物包含不同的标记。 通过使用至少一个桥寡核苷酸将标记的标签寡核苷酸连接到每个标记的延伸产物，从而形成多个多标记多核苷酸，可以完成所得扩增子的附加标记。 在多个多标记多核苷酸中检测标记如花青素和移动性修饰剂可以鉴定样品。 可以使用诸如毛细管电泳的迁移率依赖性分析技术来进行这种样品鉴定，并且可以应用于取证领域。

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