公开(公告)号：US20120091334A1

公开(公告)日：2012-04-19

申请号：US13340176

申请日：2011-12-29

申请人： Mircea Guna

发明人： Mircea Guna

IPC分类号： B01D59/44

CPC分类号： H01J49/4265 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/061 ,  H01J49/26

摘要： A method for operating tandem ion traps is provided, involving a) accumulating ions in the first ion trap at a first time; b) transmitting a first plurality of ions out of the first ion trap and into the second ion trap at a second time, the first plurality of ions having masses within a first mass range; c) retaining a second plurality of ions in the first ion trap at the second time, the second plurality of ions having masses within a second mass range different from the first mass range; d) transmitting the first plurality of ions out of the second ion trap at a third time; and, e) transmitting the second plurality of ions out of the first ion trap and into the second ion trap at the third time.

摘要翻译： 提供了一种用于操作串联离子阱的方法，包括：a）在第一时间将第一离子阱中的离子累积; b）在第二时间将第一多个离子从第一离子阱中传输到第二离子阱中，第一多个离子具有在第一质量范围内的质量; c）在第二时间将第二多个离子保留在第一离子阱中，第二多个离子具有在与第一质量范围不同的第二质量范围内的质量; d）第三次将第一多个离子从第二离子阱中传出; 以及e）在第三时间将第二多个离子从第一离子阱中传出并进入第二离子阱。

公开(公告)号：US20080078927A1

公开(公告)日：2008-04-03

申请号：US11839081

申请日：2007-08-15

申请人： Mircea Guna

发明人： Mircea Guna

IPC分类号： H01J49/26

CPC分类号： H01J49/4225 ,  H01J49/0063 ,  H01J49/4285

摘要： A method of operating a mass spectrometer having an elongated rod set and a set of auxiliary electrodes is provided, the rod set having an entrance end and an exit end and a longitudinal axis. The method comprises a) admitting ions into the entrance end of the rod set; b) trapping at least some of the ions in the rod set by producing a barrier field at an exit member adjacent to the exit end of the rod set and by producing an RF field between the rods of the rod set; and, c) providing an auxiliary AC excitement voltage to the set of auxiliary electrodes to energize a first group of ions of a selected mass to charge.

摘要翻译： 提供一种操作具有细长杆组和一组辅助电极的质谱仪的方法，该杆组具有入口端和出射端以及纵向轴线。 该方法包括：a）将离子引入棒组的入口端; b）通过在与所述杆组的出口端相邻的出口构件处产生阻挡场并且通过在所述杆组的杆之间产生RF场来捕获杆组中的至少一些离子; 以及c）向所述一组辅助电极提供辅助AC兴奋电压，以激励所选质量的第一组离子进行充电。

公开(公告)号：US07259371B2

公开(公告)日：2007-08-21

申请号：US11315788

申请日：2005-12-22

申请人： Bruce A. Collings ,  Thomas R. Covey ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre V. Loboda ,  Bradley B. Schneider ,  Bruce A. Thomson

发明人： Bruce A. Collings ,  Thomas R. Covey ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre V. Loboda ,  Bradley B. Schneider ,  Bruce A. Thomson

IPC分类号： H01J49/00

CPC分类号： H01J49/067 ,  H01J49/063

摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.

摘要翻译： 在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。 入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。 一旦形成，具有预定横截面以至基本上径向限制超音速自由射流膨胀的至少一个离子导向器可以将离子聚焦以透过真空室。 这有效地改善离子源和质量分析器之间的离子传递。

公开(公告)号：US20060169891A1

公开(公告)日：2006-08-03

申请号：US11315788

申请日：2005-12-22

申请人： Bruce Collings ,  Thomas Covey ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bradley Schneider ,  Bruce Thomson

发明人： Bruce Collings ,  Thomas Covey ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bradley Schneider ,  Bruce Thomson

IPC分类号： B01D59/44

CPC分类号： H01J49/067 ,  H01J49/063

摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.

摘要翻译： 在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。 入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。 一旦形成，具有预定横截面以至基本上径向限制超音速自由射流膨胀的至少一个离子导向器可以将离子聚焦以透过真空室。 这有效地改善离子源和质量分析器之间的离子传递。

公开(公告)号：US20060151692A1

公开(公告)日：2006-07-13

申请号：US11032376

申请日：2005-01-10

申请人： Bruce Collings ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bruce Thomson

发明人： Bruce Collings ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bruce Thomson

IPC分类号： B01D59/44

CPC分类号： H01J49/04 ,  H01J49/062

摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.

摘要翻译： 在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。 入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。 一旦形成，具有预定横截面以基本上径向限制超音速自由射流膨胀的离子导向器可将离子聚焦以透过真空室。 这有效地改善离子源和质量分析器之间的离子传递。

公开(公告)号：US20130240724A1

公开(公告)日：2013-09-19

申请号：US13818570

申请日：2011-08-25

申请人： Mircea Guna

发明人： Mircea Guna

IPC分类号： H01J49/42

CPC分类号： H01J49/4285 ,  H01J49/422 ,  H01J49/4225

摘要： A system and method involving processing ions in a linear ion trap are provided, involving a two-dimensional asymmetric substantially quadrupole field having a hexapole and octopole component.

摘要翻译： 提供了涉及在线性离子阱中处理离子的系统和方法，涉及具有六极和八极分量的二维不对称基本四极场。

公开(公告)号：US08766170B2

公开(公告)日：2014-07-01

申请号：US12480160

申请日：2009-06-08

申请人： Mircea Guna ,  Frank Londry

发明人： Mircea Guna ,  Frank Londry

IPC分类号： H01J49/42 ,  B01D59/44

CPC分类号： H01J49/4265 ,  H01J49/0031 ,  H01J49/004

摘要： A method for operating tandem ion traps is provided, involving a) accumulating ions in the first ion trap at a first time; b) transmitting a first plurality of ions out of the first ion trap and into the second ion trap at a second time, the first plurality of ions having masses within a first mass range; c) retaining a second plurality of ions in the first ion trap at the second time, the second plurality of ions having masses within a second mass range different from the first mass range; d) transmitting the first plurality of ions out of the second ion trap at a third time; and, e) transmitting the second plurality of ions out of the first ion trap and into the second ion trap at the third time.

公开(公告)号：US20140131569A1

公开(公告)日：2014-05-15

申请号：US14131972

申请日：2012-07-11

申请人： Mircea Guna

发明人： Mircea Guna

IPC分类号： H01J49/04

CPC分类号： H01J49/4265 ,  H01J49/004 ,  H01J49/422 ,  H01J49/427

摘要： A method for operating a mass spectrometer having an ion trap over a plurality of selected mass-to-charge ranges constituting an overall mass-to-charge range is disclosed. For each of the plurality of selected mass-to-charge ranges the method comprises filling the ion trap with fragmented ions of the selected mass-to-charge ranges, cooling the fragmented ions trapped in the ion trap for a first cooling period, applying an RF voltage and a resolving direct current voltage to the ion trap for eliminating any remaining fragmented ions outside the selected ion mass-to-charge range and retaining ions within the selected ion mass-to-charge range, cooling the retained ions in the ion trap for a second cooling period, and scanning the retained ions out of the ion trap and detecting the ions released therefrom.

摘要翻译： 公开了一种在构成整体质量 - 电荷范围的多个选定的质量 - 电荷范围内操作具有离子阱的质谱仪的方法。 对于多个选择的质量 - 电荷范围中的每一个，该方法包括用选择的质量 - 电荷范围的碎片离子填充离子阱，冷却在第一冷却期间捕集在离子阱中的碎裂离子， RF电压和分离到离子阱的直流电压，用于消除选定的离子质量 - 电荷范围之外的任何剩余的分散离子，并将离子保持在所选择的离子质量 - 电荷范围内，冷却离子阱中的保留离子 在第二冷却期间，并将残留的离子从离子阱中扫描出来并检测从其释放的离子。

公开(公告)号：US08237109B2

公开(公告)日：2012-08-07

申请号：US12359621

申请日：2009-01-26

申请人： Mircea Guna ,  Bruce Collings

发明人： Mircea Guna ,  Bruce Collings

IPC分类号： B01D59/44 ,  H01J49/00

CPC分类号： H01J49/005 ,  H01J49/063 ,  H01J49/4225

摘要： Methods for fragmenting ions retained in an ion trap are described. In various embodiments, a non-steady-state pressure of a neutral collision gas of less than about 5×10−4 Torr and an excitation amplitude of less than about 500 mV (peak to ground) is used to fragment ions with greater than about 80% fragmentation efficiency. In various embodiments, duration of ion excitation is greater than about 25 ms.

摘要翻译： 描述了保留在离子阱中的分离离子的方法。 在各种实施方案中，使用小于约5×10-4乇的中性碰撞气体的非稳定状态压力和小于约500mV（峰对地）的激发振幅来分离大于约 80％的碎片效率。 在各种实施例中，离子激发的持续时间大于约25ms。

公开(公告)号：US20120168619A1

公开(公告)日：2012-07-05

申请号：US13416352

申请日：2012-03-09

申请人： Mircea Guna

发明人： Mircea Guna

IPC分类号： H01J49/26

CPC分类号： H01J49/4225 ,  H01J49/427

摘要： A two-dimensional substantially quadrupole field is provided. The field comprises a quadrupole harmonic of amplitude A2 and an octopole harmonic of amplitude A4, wherein A4 is greater than 0.01% of A2, A4 is less than 5% of A2, and, for any other higher order harmonic with amplitude An present in the field, n being any integer greater than 2 except 4, A4 is greater than ten times An.

摘要翻译： 提供二维基本四极场。 该场包括幅度为A2的四极谐波和幅度A4的八极谐波，其中A4大于A2的0.01％，A4小于A2的5％，并且对于任何其它具有振幅的高次谐波，存在于 场，n除了4以外大于2的任何整数，A4大于An的十倍。