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    LAPAROSCOPIC ACCESS PORT AND PORT SLEEVE ARRANGEMENT
    11.
    发明申请
    LAPAROSCOPIC ACCESS PORT AND PORT SLEEVE ARRANGEMENT 审中-公开

    公开(公告)号：US20120165611A1

    公开(公告)日：2012-06-28

    申请号：US13322652

    申请日：2010-05-27

    Applicant: Neil Warren ,  Andrea Potter ,  Robin Crossley ,  Jeremy Gardner ,  Ian Dera

    Inventor： Neil Warren ,  Andrea Potter ,  Robin Crossley ,  Jeremy Gardner ,  Ian Dera

    IPC: A61B1/32

    CPC classification number: A61B17/3421 ,  A61B17/3423 ,  A61B2017/3443

    Abstract: Disclosed are embodiments of a laparoscopic access port having a head (portion 450) for use generally externally of a patient and for providing a seal around a laparoscopic tool (not shown)when said tool is inserted into the head via a (bore 408); and a sleeve portion (410) connected to the head and for accommodating the tool, the sleeve (410) extending along an axis and being adapted for inserting generally into the body of a patient in the direction of the axis;said access port being adjustable in overall length X in the direction of the axis, the sleeve portion comprising a shank (411) attached or attachable to the head (450) and a flanged piece (413) moveable relative to the shank by means of a mechanism for causing the overall length X of the port to adjust, the mechanism being operable externally of the patient at or adjacent the head, for example by means of rotation of an element of a lower head part (440), or by sliding motion of the shank (411) and flanged piece (413).

    Abstract translation: 公开了一种腹腔镜进入口的实施例，其具有通常用于患者外部的头部（部分450），并且当所述工具经由（孔408）插入头部时，围绕腹腔镜工具（未示出）提供密封; 以及连接到所述头部并用于容纳所述工具的套筒部分（410），所述套筒（410）沿着轴线延伸并且适于沿所述轴线的方向大致插入患者体内;所述进入口可调节 整个长度X在轴线方向上，套筒部分包括一个连接到头部（450）上的或可附接到头部（450）的柄部（411），以及一个法兰片（413），可通过一种机构使其相对于柄移动， 所述端口的长度X可以调整，所述机构可以例如通过下头部件（440）的元件的旋转，或者通过所述柄部（411）的滑动运动在所述头部处或邻近所述患者的外部操作， 和凸缘件（413）。

    Process for the preparation of enantiomerically-enriched cyclopropylalanine derivates
    13.
    发明授权
    Process for the preparation of enantiomerically-enriched cyclopropylalanine derivates 失效

    公开(公告)号：US06635784B2

    公开(公告)日：2003-10-21

    申请号：US09957549

    申请日：2001-09-20

    Applicant: Sheryl Davis Debenham ,  Neil Warren Boaz

    Inventor： Sheryl Davis Debenham ,  Neil Warren Boaz

    IPC: C07C6974

    CPC classification number: C07D263/42 ,  C07B2200/07 ,  C07C231/10 ,  C07C231/18 ,  C07C233/47 ,  C07C233/86 ,  C07C269/00 ,  C07C269/06 ,  C07C271/22 ,  C07F9/4006 ,  C07C233/84 ,  C07C233/87

    Abstract: Disclosed are processes for the preparation of enantiomerically-enriched cyclopropylalanine derivatives by the hydrogenation of certain enamides in the presence of a catalyst comprising a transition metal and a substantially enantiomerically-pure bis-phosphine catalyst and certain novel enamide ester compounds which are intermediates in the processes. The processes include novel 2-step and 3-step processes for the preparation of enantiomerically-enriched cyclopropylalanine derivatives. The two-step process comprises the steps of reacting cyclopropanecarboxaldehyde with a substituted phosphorylglycine to afford an enamide ester which then is hydrogenated in the presence of a catalyst comprising a transition metal and a substantially enantiomerically-pure bis-phosphine catalyst. The three-step process comprises the steps of forming an azlactone from an N-acylglycine and cyclopropanecarboxaldehyde, converting the azlactone to the aforesaid enamide which then is hydrogenated in the presence of a catalyst comprising a transition metal and a substantially enantiomerically-pure bis-phosphine catalyst.

    Carbonate derivatives as skin care
    15.
    发明授权
    Carbonate derivatives as skin care 有权
    碳酸盐衍生物作为护肤品

    公开(公告)号：US08613940B2

    公开(公告)日：2013-12-24

    申请号：US12975562

    申请日：2010-12-22

    Applicant: Neil Warren Boaz

    Inventor： Neil Warren Boaz

    IPC: A61K31/265 ,  A61K6/02 ,  C07C69/96

    CPC classification number: A61K8/37 ,  A61K2800/522 ,  A61Q19/02 ,  A61Q19/08 ,  C07C68/02 ,  C07C69/96

    Abstract: Carbonates of anti-aging ingredients, in particular anti-oxidants and skin illuminating phenol ingredients, have been prepared as derivatives of these ingredients with enhanced physical properties. It has been demonstrated that these carbonates will hydrolyze under enzymatic catalysis to release the parent ingredient. In contrast, esters of the phenolic groups in many cases do not hydrolyze under the same conditions.

    Abstract translation: 已经制备了抗衰老成分的碳酸盐，特别是抗氧化剂和皮肤照射酚成分，作为具有增强的物理性质的这些成分的衍生物。 已经证明这些碳酸酯将在酶催化下水解以释放母体成分。 相反，在许多情况下酚基的酯在相同的条件下不会水解。

    Hydroxyalkanoic acid and hydroxyalkanoice acid oligomer esters of retinol
    16.
    发明授权
    Hydroxyalkanoic acid and hydroxyalkanoice acid oligomer esters of retinol 有权
    视黄醇的羟基链烷酸和羟基链烷酸酸低聚物酯

    公开(公告)号：US08329938B2

    公开(公告)日：2012-12-11

    申请号：US13031375

    申请日：2011-02-21

    Applicant: Neil Warren Boaz

    Inventor： Neil Warren Boaz

    IPC: C07C69/66 ,  C07C69/74 ,  C07C69/34 ,  A61K8/02

    CPC classification number: C07C403/12 ,  A61K8/85 ,  A61Q19/00 ,  C07C2601/16 ,  C12P7/62 ,  C12P23/00

    Abstract: Retinyl hydroxyesters and retinyl oligo-hydroxyesters were prepared using a chemoenzymatic process from retinol and short chain esters of hydroxycarboxylic acids or short chain esters of hydroxycarboxylic acids. The presence of the hydroxyl group on the acid can result in a mixture of esters from various oligomers of the hydroxycarboxylic acid. The retinyl ester products are readily enzymatically hydrolyzed in vitro, which indicates that application to the skin should result in release of the anti-aging ingredient retinol (without the inherent instability and irritation) along with the acid, which, if chosen appropriately, should also have desirable biological effects. This combination should be effective as an anti-aging skin care ingredient.

    Abstract translation: 使用视黄醇和羟基羧酸的短链酯或羟基羧酸的短链酯的化学酶法制备视黄基羟基酯和视黄酯低聚羟基酯。 酸上的羟基的存在可以产生来自羟基羧酸的各种低聚物的酯的混合物。 视黄酯产物在体外容易地酶水解，这表明施用于皮肤应该导致抗老化成分视黄醇的释放（没有固有的不稳定性和刺激性）以及酸，如果适当选择，也应当 具有理想的生物效应。 该组合应作为抗衰老护肤成分有效。

    Reduction And Removal Of Particles
    17.
    发明申请
    Reduction And Removal Of Particles 有权
    减少和去除颗粒

    公开(公告)号：US20120067212A1

    公开(公告)日：2012-03-22

    申请号：US13291728

    申请日：2011-11-08

    Applicant: Neil Warren ,  Robin Crossley ,  Steven Brown ,  Andrew Cheer

    Inventor： Neil Warren ,  Robin Crossley ,  Steven Brown ,  Andrew Cheer

    IPC: B03C3/38

    CPC classification number: A61N1/20 ,  A61B17/320068 ,  A61B18/00 ,  A61B18/02 ,  A61B18/1445 ,  A61B18/20 ,  A61B2018/00083 ,  A61B2018/00601 ,  A61B2018/1497 ,  A61B2218/008 ,  B03C3/383 ,  B03C3/41 ,  B03C2201/10 ,  B03C2201/26

    Abstract: Disclosed is apparatus 100 for the reduction or removal of smoke particles suspended in a local atmosphere A and resulting from a surgical procedure, the apparatus including or comprising two electrodes 140 and 150 each in electrical communication with or being electrically connectable to opposite poles of a source of high voltage dc electricity. A first of the electrodes 140 may be electrically connectable to a patient P. and a second 150 may be positionable within or adjacent a patient such that the two electrodes, when in communication with opposite poles of said high voltage, ionise said particles in use, for attracting said particles toward the patient or toward the second of the electrodes.

    Abstract translation: 公开了用于减少或去除悬浮在局部气氛A中并由外科手术产生的烟雾颗粒的装置100，该装置包括或包括两个电极140和150，两个电极140和150各自与源极的相反极电连通或可电连接 的高压直流电。 电极140中的第一个可以可电连接到患者P.并且第二个150可以位于患者体内或与病人相邻的位置，使得两个电极在与所述高电压的相反极通信时使所使用的所述粒子离子化， 用于将所述颗粒吸引到患者或朝向第二电极。

    SURGICAL MANIPULATOR
    19.
    发明申请
    SURGICAL MANIPULATOR 审中-公开
    外科手术

    公开(公告)号：US20110230706A1

    公开(公告)日：2011-09-22

    申请号：US13062370

    申请日：2009-09-04

    Applicant: Neil Warren

    Inventor： Neil Warren

    IPC: A61B17/00

    CPC classification number: A61B17/00234 ,  A61B2017/308 ,  A61B2017/3488

    Abstract: Surgical Manipulator A surgical manipulator (10) is disclosed which employs a suction cup (30) to hold body parts (50) whilst the manipulator is moved to manipulate the body part (50). Suction at the cup (30) is provided by means of a central passage (16) running through an extension (20) and through a handle part (14) to a vacuum connector (12). The suction at the cup (30) can be adjusted by a slider (15) which adjustably opens the passage (16) to atmosphere. Needles (58) and the like can be introduced into the passage (16) and thereby into the body part (50). For laparoscopic surgery the manipulator can be introduced into a laparoscopic port (52) by collapsing the suction cup (30) within an introducer sleeve (22 FIG. 3). The introducer sleeve (22) can act as a suction device when the cup (30) is collapsed within it. The needle (58) can be replaced by a diathermy electrode (60 FIG. 6) and irrigation is possible using an additional supply tube (121 FIG. 4).

    Abstract translation: 外科手术器公开了一种手术操纵器（10），其在操纵器被移动以操纵身体部分（50）的同时使用吸盘（30）来保持身体部分（50）。 在杯（30）处的抽吸通过穿过延伸部（20）并通过把手部分（14）到达真空连接器（12）的中心通道（16）来提供。 可以通过可调节地将通道（16）打开到大气中的滑块（15）来调节杯子（30）处的吸力。 针（58）等可以被引入到通道（16）中，从而进入主体部分（50）。 对于腹腔镜手术，通过将吸盘（30）在引导器套筒（图3））中折叠，可以将操纵器引入腹腔镜口（52）。 当杯（30）在其内折叠时，导引套筒（22）可用作抽吸装置。 针（58）可以由透热电极（图6的60）代替，并且可以使用额外的供给管（图4）来进行冲洗。

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