公开(公告)号：US5707998A

公开(公告)日：1998-01-13

申请号：US525739

申请日：1995-09-25

Applicant: Yasutaka Takase ,  Nobuhisa Watanabe ,  Hideyuki Adachi ,  Kohtaro Kodama ,  Hiroki Ishihara ,  Takao Saeki ,  Shigeru Souda

Inventor： Yasutaka Takase ,  Nobuhisa Watanabe ,  Hideyuki Adachi ,  Kohtaro Kodama ,  Hiroki Ishihara ,  Takao Saeki ,  Shigeru Souda

IPC: C07D405/12 ,  C07D405/14 ,  C07D521/00 ,  C07D403/00 ,  A61K31/505 ,  C07D239/94 ,  C07D403/02

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D405/12 ,  C07D405/14

Abstract: The present invention relates to a nitrogen-containing heterocyclic compound exhibiting an inhibitory activity against cGMP-PDE. The compound represented by the formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1 represents a group represented by the formula: --NR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 each represent hydrogen, lower alkyl or the like) or the like; R.sup.2 represents a group represented by the formula: ##STR2## (wherein R.sup.8 represents a carboxyl group which may be protected, or the like) or the like; and R.sup.3 represents a group represented by the formula: ##STR3## (wherein R.sup.6 and R.sup.7 each represent hydrogen, lower alkyl or the like) or the like.

Abstract translation: PCT No.PCT / JP94 / 00446 Sec。 371 1995年9月25日第 102（e）1995年9月25日PCT PCT 1994年3月18日PCT公布。 公开号WO94 / 22855 日期：1994年10月13日本发明涉及对cGMP-PDE具有抑制活性的含氮杂环化合物。 由式（I）表示的化合物或其药学上可接受的盐：其中R1表示由式-NR4R5表示的基团（其中R4和R5各自表示氢，低级烷基等）或 类似; R2表示由下式表示的基团：其中R8表示可被保护的羧基等）等。 并且R 3表示由下式表示的基团：其中R 6和R 7各自表示氢，低级烷基等）等。

公开(公告)号：US5679304A

公开(公告)日：1997-10-21

申请号：US382156

申请日：1995-02-01

Applicant: Nobuhisa Watanabe ,  Mikihiro Kuramitsu

Inventor： Nobuhisa Watanabe ,  Mikihiro Kuramitsu

IPC: B29C45/26 ,  B29C45/14 ,  B29K105/20 ,  B29L31/34 ,  B29L31/36 ,  H01H13/705 ,  H01H1/10

CPC classification number: B29C45/14754 ,  B29C45/14 ,  H01H13/705 ,  B29L2031/466 ,  H01H2221/004 ,  H01H2221/016 ,  H01H2229/044

Abstract: A method of manufacturing a panel button includes providing a molding die including a transferable molding die defining a cavity, a core molding die having a runner, a sprue and a gate and a stationary molding die having a sprue. A hollow space is provided in a bottom of the cavity wherein a push button is formed. A projecting portion is inserted into the cavity and is formed on the underside of the core molding die. Two hollow coaxial spaces are connected to each other, one to form a boss, the other to form an elastic arm. A plastic sheet is introduced into the cavity and is sandwiched between the transferable molding die and the core molding die. The plastic sheet has an unbonding portion at a position where the push button is to be formed. A molten resin material is injected into the cavity through the runner, sprue and gate. The thus formed panel button includes the push button on the plastic sheet.

Abstract translation: 一种制造面板按钮的方法包括提供一种成型模具，该模具包括限定空腔的可转移模制模具，具有流道的芯模具模具，浇口和浇口以及具有浇口的固定模具。 在空腔的底部设置有中空空间，其中形成按钮。 突出部分插入空腔中并形成在芯模塑模具的下侧。 两个空心同轴空间彼此连接，一个形成凸台，另一个形成弹性臂。 将塑料片引入空腔中并夹在可转移成型模具和芯成型模具之间。 塑料片在要形成按钮的位置处具有无粘结部分。 熔融树脂材料通过浇道，浇道和浇口注入腔体。 由此形成的面板按钮包括塑料片上的按钮。

公开(公告)号：US5462958A

公开(公告)日：1995-10-31

申请号：US182061

申请日：1994-05-19

Applicant: Kenji Hayashi ,  Nobuhisa Watanabe ,  Koichi Nose ,  Hiroshi Tanaka ,  Issei Ohtsuka ,  Motoji Kokushi ,  Hironobu Hiyoshi ,  Hiroko Kobayashi ,  Toshie Yamada ,  Toru Horie

Inventor： Kenji Hayashi ,  Nobuhisa Watanabe ,  Koichi Nose ,  Hiroshi Tanaka ,  Issei Ohtsuka ,  Motoji Kokushi ,  Hironobu Hiyoshi ,  Hiroko Kobayashi ,  Toshie Yamada ,  Toru Horie

IPC: C07C275/34 ,  C07D233/54 ,  C07D233/60 ,  C07D233/64 ,  A61K31/415 ,  A61K31/195

CPC classification number: C07D233/64 ,  C07C275/34

Abstract: The present invention provides a novel benzene derivative useful as a preventive and medically treating medicine for arteriosclerosis, and a cholesterol O-acyl transferase inhibitor comprising the benzene derivative as an active ingredient.The benzene derivative according to the present invention is represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a carboxyl group which may be protected or a group represented by the formula: ##STR2## wherein R.sup.5 represents a lower alkyl group or a hydroxyalkyl group and R.sup.6 represents a hydrogen atom or a hydroxyl group; R.sup.2 represents a hydrogen atom, a lower alkyl group or the like; R.sup.3 and R.sup.4 each represent a hydrogen atom or a hydroxyl group; and p is an integer of 1 to 6.

Abstract translation: PCT No.PCT / JP93 / 00961 Sec。 371日期1994年5月19日 102（e）日期1994年5月19日PCT提交1993年7月12日PCT公布。 出版物WO94 / 02452 日本1993年3月2日。本发明提供了可用作预防和医学治疗动脉硬化药物的苯衍生物，以及含有苯衍生物作为活性成分的胆固醇O-酰基转移酶抑制剂。 根据本发明的苯衍生物由以下通式（I）表示：其中R 1表示可被保护的羧基或由下式表示的基团：其中R5表示 低级烷基或羟烷基，R6表示氢原子或羟基; R2表示氢原子，低级烷基等; R3和R4各自表示氢原子或羟基; p为1〜6的整数。

公开(公告)号：US4580586A

公开(公告)日：1986-04-08

申请号：US560402

申请日：1983-12-12

Applicant: Chihiro Kitoh ,  Masayuki Suzumori ,  Takashi Sugiyama ,  Nobuhisa Watanabe

Inventor： Chihiro Kitoh ,  Masayuki Suzumori ,  Takashi Sugiyama ,  Nobuhisa Watanabe

IPC: A45D33/00 ,  A45D33/20 ,  A45D33/22 ,  A45D40/22 ,  B65D45/18

CPC classification number: A45D33/20 ,  A45D40/22

Abstract: A vanity case comprises a main container having a receptacle and a cover, and a tray for detachably holding the main container therein. The receptacle has a space in which a pair of sliding pieces are disposed for an engagement with a projection of the cover. The sliding pieces are connected together in such manner that the inner ends approach each other to hold the projection therebetween when the outer ends are located away from each other and projected beyond the side walls of the receptacle by an elastic means. A means is provided for maintaining the cover in the closed position and upon rearward movement of the main container with respect to the tray, for releasing the closed position of the cover.

Abstract translation: 梳妆盒包括具有容器和盖的主容器和用于将主容器可拆卸地保持在其中的托盘。 插座具有一个空间，在该空间中设置一对滑动件以与盖的突起接合。 滑动件以这样的方式连接在一起，使得当外端彼此远离并通过弹性装置突出超过容器的侧壁时，内端彼此接近以将突出部保持在其间。 提供一种用于将盖保持在关闭位置和主容器相对于托盘向后运动的装置，用于释放盖的关闭位置。

公开(公告)号：US4392503A

公开(公告)日：1983-07-12

申请号：US375953

申请日：1982-05-06

Applicant: Nobuhisa Watanabe

Inventor： Nobuhisa Watanabe

IPC: A45C13/10 ,  A45D40/22 ,  A45D33/00

CPC classification number: A45C13/1084 ,  A45D40/22 ,  Y10S292/38

Abstract: A vanity case is provided in which an unlatch member is housed in a rectangular recess formed in either one of a receptacle member and a cover member and has its one end formed as a free end extending upwardly while the other end retained in the recess. The free end is arranged to lie closely adjacent to a marginal portion of the other member in a closed position of the cover and also arranged to move inwardly to apply such force as to separate the cover from the receptacle, thereby releasing the engagement of the latching members when the unlatch member is pushed inwardly.

Abstract translation: 提供了一种梳妆盒，其中一个开口部件被容纳在形成在容器部件和盖部件中的任一个中的矩形凹部中，并且其一端形成为向上延伸的自由端，而另一端保持在凹部中。 自由端设置成在盖的关闭位置紧邻另一个构件的边缘部分，并且还设置成向内移动以施加这样的力，以将盖与插座分离，由此释放闩锁 当解锁成员被向内推时，成员。

公开(公告)号：US08476301B2

公开(公告)日：2013-07-02

申请号：US13609716

申请日：2012-09-11

Applicant: Ichiro Yoshida ,  Tadashi Okabe ,  Yasunobu Matsumoto ,  Nobuhisa Watanabe ,  Yoshiaki Ohashi ,  Yuji Onizawa ,  Hitoshi Harada

Inventor： Ichiro Yoshida ,  Tadashi Okabe ,  Yasunobu Matsumoto ,  Nobuhisa Watanabe ,  Yoshiaki Ohashi ,  Yuji Onizawa ,  Hitoshi Harada

IPC: A61K31/445 ,  C07D401/12

CPC classification number: A61K31/4025 ,  A61K31/454 ,  C07D401/12 ,  C07D403/12

Abstract: A compound represented by formula (1) or a pharmaceutically acceptable salt thereof has an inhibitory effect in the fractalkine-CX3CR1 pathway: wherein R represents a C1-6 alkyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group A, a C3-8 cycloalkyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group A, or a C3-8 cycloalkenyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group A, X represents a C1-6 alkyl group, Y and Z are the same or different from each other and each represents a halogen atom or a C1-6 alkyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group B, n represents 0 or 1, Substituent Group A consists of halogen atoms, and Substituent Group B consists of halogen atoms.

Abstract translation: 由式（1）表示的化合物或其药学上可接受的盐具有抑制作用：其中R表示未取代的或具有1至3个选自取代基组A的取代基的C 1-6烷基，C3- 8个未取代的或具有1〜3个选自取代基组A的取代基的环烷基，或未取代或具有1-3个选自取代基组A的取代基的C 3-8环烯基，X表示C 1-6烷基，Y和Z是 相同或不同，各自表示卤素原子或未取代或具有1〜3个选自取代基组B的取代基的C 1-6烷基，n表示0或1，取代基组A由卤素原子和取代基组B 由卤素原子组成。

公开(公告)号：US08124780B2

公开(公告)日：2012-02-28

申请号：US12189590

申请日：2008-08-11

Applicant: Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

Inventor： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

IPC: C07D401/12

CPC classification number: C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

Abstract: A novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases is provided, which has an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

Abstract translation: 提供了可用作酸性相关疾病的治疗或预防剂的新型化合物，其对胃酸分泌具有优异的抑制作用，保持对胃酸分泌的抑制作用的优异效果，从而保持胃内pH高 长时间，具有更多的安全性和适当的物理化学稳定性。 提供一种化合物，其中R 1和R 3可以相同或不同，各自表示氢原子或C 1 -C 6烷基; R2代表（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9-三氧杂螺[5.5]十一烷-3 - 甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R4，R5，R6和R7表示氢原子，卤素原子，C1-C6烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; W1表示单键，亚甲基或亚乙基，它们的盐或它们的溶剂合物。

公开(公告)号：US07781452B2

公开(公告)日：2010-08-24

申请号：US11385786

申请日：2006-03-22

Applicant: Shuhei Miyazawa ,  Hitoshi Harada ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Kotaro Kodama ,  Junichi Nagakawa ,  Kiyoshi Oketani ,  Nobuhisa Watanabe

Inventor： Shuhei Miyazawa ,  Hitoshi Harada ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Kotaro Kodama ,  Junichi Nagakawa ,  Kiyoshi Oketani ,  Nobuhisa Watanabe

IPC: A61K31/444 ,  C07D471/02

CPC classification number: A61K31/444 ,  C07D471/04

Abstract: A compound represented by the following general formula (1), or a salt or hydrate thereof:[Formula 1] wherein R1 represents a C1-C6 alkyl group or C2-C6 alkynyl group which may be substituted, or a phenyl group which may be substituted, R2 represents a hydrogen atom or a C1-C6 alkyl group, R3 represents methyl or ethyl group, R4 represents a C1-C6 alkyl group, R5 represents a hydrogen atom, provided that a compound wherein R1 is a C1-C6 alkyl group unsubstituted or substituted with a halogen atom and R2 is a hydrogen atom is excluded.

Abstract translation: 由下述通式（1）表示的化合物或其盐或水合物：[式1]其中R 1表示可以被取代的C 1 -C 6烷基或C 2 -C 6炔基，或可以是 取代基，R 2表示氢原子或C 1 -C 6烷基，R 3表示甲基或乙基，R 4表示C 1 -C 6烷基，R 5表示氢原子，条件是其中R 1为C 1 -C 6烷基 未被取代或被卤素原子取代且R 2为氢原子。

公开(公告)号：US20090288462A1

公开(公告)日：2009-11-26

申请号：US12440776

申请日：2007-09-25

Applicant: Tomotaka Nishimoto ,  Yasuhiro Okada ,  Chihiro Jgarashi ,  Takanori Yoshitake ,  Nobuhisa Watanabe

Inventor： Tomotaka Nishimoto ,  Yasuhiro Okada ,  Chihiro Jgarashi ,  Takanori Yoshitake ,  Nobuhisa Watanabe

IPC: B21C51/00

CPC classification number: H05K3/323 ,  H05K3/3494 ,  H05K3/361 ,  H05K2201/10151 ,  H05K2201/10204 ,  H05K2203/0195 ,  H05K2203/163

Abstract: To provide a component crimping apparatus control method which enables a measuring tool to directly measure a temperature of a part pressed by a pressing head.The component crimping apparatus control method is applied to a component crimping apparatus which crimps a component onto a plate-shaped work, and causes a measuring tool shaped identically as the work to measure a temperature or a pressure of a pressed part in a pressing process of pressing a component onto the work using a heated pressing head. The method includes acquiring information indicating whether or not the measuring tool is held in the component crimping apparatus, and, in the case where the information indicating that the measuring tool is held is acquired, positioning the measuring tool identically as the work, and executing the pressing process on the component to be attached to the measuring tool after the positioning.

Abstract translation: 提供一种能够使测量工具直接测量由按压头按压的部位的温度的部件压接装置控制方法。 将部件压接装置控制方法应用于将部件压接在板状工件上的部件压接装置，并且使得形成为相同形状的测量工具作为工件，以在压制过程中测量压制部件的温度或压力 使用加热的压头将部件压在工件上。 该方法包括获取指示测量工具是否保持在部件压接装置中的信息，并且在获取表示测量工具的信息被获取的情况下，将测量工具相同地定位为工件，并且执行 定位后要附着在测量工具上的部件按压过程。

公开(公告)号：US07349091B2

公开(公告)日：2008-03-25

申请号：US11143630

申请日：2005-06-03

Applicant: Hideo Wada ,  Nobuhisa Watanabe ,  Takayuki Taminaga ,  Hajime Kashida

Inventor： Hideo Wada ,  Nobuhisa Watanabe ,  Takayuki Taminaga ,  Hajime Kashida

IPC: G01J4/00

CPC classification number: G03B17/18

Abstract: The optical object discriminating device includes a light projecting part which applies light, which is emitted from a semiconductor light emitting element, to a measuring object which is an object to be measured, and a light receiving part which receives reflected light reflected by the measuring object. Between the light receiving part and the measuring object is placed a polarization-state selector part which permits polarized light of a specified polarization direction to pass therethrough. A signal processing part processes a signal outputted by the light receiving part, and measures intensity of light of the polarization direction permitted by the polarization-state selector part to pass therethrough.

Abstract translation: 光学物体识别装置包括将从半导体发光元件发射的光施加到作为被测量物体的测量对象的光投射部分和接收被测量对象反射的反射光的光接收部分 。 在光接收部和测量对象之间设置允许偏振方向的偏振光通过的偏振状态选择部。 信号处理部分处理由光接收部分输出的信号，并且测量由偏振态选择器部分允许的偏振方向的光通过其中的光强度。