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公开(公告)号：US20190282804A1
公开(公告)日：2019-09-19
申请号：US16363681
申请日：2019-03-25
Applicant: Oculeve, Inc.
Inventor： Douglas Michael Ackermann , James Donald Loudin
IPC: A61N1/05 , H02J7/00 , A61N1/36 , A61H21/00 , A61H23/02 , A61N1/378 , A61F7/12 , A61N1/04 , A61H1/00 , A61N7/00 , A61H9/00
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
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公开(公告)号：US10252048B2
公开(公告)日：2019-04-09
申请号：US15438577
申请日：2017-02-21
Applicant: Oculeve, Inc.
Inventor： James Donald Loudin , Daniel N. Hamilton , Manfred Franke , Douglas Michael Ackermann
Abstract: Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue.
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公开(公告)号：US20180064941A1
公开(公告)日：2018-03-08
申请号：US15802340
申请日：2017-11-02
Inventor： Douglas Michael ACKERMANN , James Donald LOUDIN , Janusz KUZMA , Daniel PALANKER , Scott Franklin WETENKAMP
CPC classification number: A61N1/36046 , A61N1/36057 , A61N1/3606 , A61N1/37205 , A61N1/37211 , A61N1/3756
Abstract: Described here are stimulation systems and methods for stimulating one or more anatomical targets in a patient for treatment conditions such as dry eye. The stimulation system may include a controller and a microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a signal received from the controller and apply the signal via one or more electrodes to an anatomical target. In some variations, the microstimulator may include a passive generation circuit configured to generate a pulse based on a signal received from the controller.
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公开(公告)号：US20170368359A1
公开(公告)日：2017-12-28
申请号：US15699905
申请日：2017-09-08
Applicant: Oculeve, Inc.
Inventor： James Donald LOUDIN , Manfred FRANKE , Daniel N. HAMILTON , Anand DORAISWAMY , Douglas Michael ACKERMANN
CPC classification number: A61N1/3787 , A61N1/36046 , A61N1/3606 , A61N1/36121 , A61N1/3756 , B29D11/00038 , B29D11/00826
Abstract: Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.
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公开(公告)号：US20170354536A1
公开(公告)日：2017-12-14
申请号：US15649364
申请日：2017-07-13
Applicant: Oculeve, Inc.
Inventor： Janusz KUZMA , Douglas Michael ACKERMANN , Christopher William STIVERS
Abstract: Systems, devices, and methods for delivering an implant to the orbit. In some instances, the systems may include a delivery device having a tongue member and a handle. The delivery device may further include an ejector configured to deliver an implant from the tongue member. The delivery device may also include a piercing member configured to create an opening in tissue. The systems may further include a piercing member for creating an opening in tissue. In some instances, the piercing member may have a first blade member rotatably connected to a second blade member.
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Patent Agency Ranking
公开(公告)号：US09770583B2
公开(公告)日：2017-09-26
申请号：US14630471
申请日：2015-02-24
Applicant: Oculeve, Inc.
Inventor： Amitava Gupta , Marie Dvorak Christ , F. Richard Christ
IPC: A61N1/04 , A61N1/05 , A61K9/00 , C08J3/075 , H01B1/12 , C08F220/54 , C08F230/08 , A61N1/36
CPC classification number: A61N1/0546 , A61N1/0456 , A61N1/0496 , A61N1/36014 , C08F220/54 , C08F230/08 , H01B1/125 , Y10T29/49826 , Y10T29/49885 , C08F226/10 , C08F220/20 , C08F2222/1013 , C08F2230/085
Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.
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公开(公告)号：US09764150B2
公开(公告)日：2017-09-19
申请号：US14920847
申请日：2015-10-22
Applicant: Oculeve, Inc.
Inventor： James Donald Loudin , Manfred Franke , Daniel N. Hamilton , Anand Doraiswamy , Douglas Michael Ackermann
CPC classification number: A61N1/3787 , A61N1/36046 , A61N1/36121 , B29D11/00038 , B29D11/00826
Abstract: Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.
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公开(公告)号：US09440065B2
公开(公告)日：2016-09-13
申请号：US14313937
申请日：2014-06-24
Applicant: Oculeve, Inc.
Inventor： Douglas Michael Ackermann , James Donald Loudin , John Wardle , Jarren Armond Baldwin , Daniel N. Hamilton , Janusz Kuzma , Christopher William Stivers , Manfred Franke
IPC: A61N1/05 , A61N1/36 , A61H1/00 , A61F7/12 , A61N1/378 , A61H9/00 , A61H21/00 , A61H23/02 , H02J7/00 , A61M31/00 , A61N7/00
CPC classification number: A61N1/0546 , A61F7/12 , A61H1/00 , A61H9/0071 , A61H21/00 , A61H23/02 , A61H23/0218 , A61H23/0245 , A61H23/0263 , A61H2201/0153 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/025 , A61H2201/10 , A61H2201/165 , A61H2201/5002 , A61H2201/5005 , A61H2201/5015 , A61H2201/5035 , A61H2201/5038 , A61H2201/5043 , A61H2205/023 , A61H2205/024 , A61M31/00 , A61N1/0456 , A61N1/36014 , A61N1/36046 , A61N1/36071 , A61N1/36132 , A61N1/36146 , A61N1/3615 , A61N1/36171 , A61N1/36175 , A61N1/3787 , A61N7/00 , A61N2007/0043 , H02J7/0044
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
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公开(公告)号：US20140277429A1
公开(公告)日：2014-09-18
申请号：US14207072
申请日：2014-03-12
Applicant: Oculeve, Inc.
Inventor： Janusz KUZMA , Douglas Michael ACKERMANN , Christopher William STIVERS
IPC: A61F2/14
CPC classification number: A61F9/007 , A61F2/14 , A61F2/141 , A61F2/148 , A61F2/1662 , A61F9/0017 , A61M31/007 , A61M2210/0612
Abstract: Described here are systems, devices, and methods for delivering an implant to the orbit. In some instances, the systems may comprise a delivery device having a tongue member and a handle. The delivery device may further include an ejector configured to deliver an implant from the tongue member. The delivery device may also include a piercing member configured to create an opening in tissue. The systems may further comprise a piercing member for creating an opening in tissue. In some instances, the piercing member may have a first blade member rotatably connected to a second blade member.
Abstract translation: 这里描述的是用于将植入物递送到轨道的系统，装置和方法。 在一些情况下，系统可以包括具有舌部件和手柄的输送装置。 输送装置还可以包括被配置为从舌部件输送植入物的喷射器。 输送装置还可以包括构造成在组织中产生开口的刺穿构件。 该系统还可以包括用于在组织中形成开口的刺穿构件。 在一些情况下，穿刺构件可以具有可旋转地连接到第二叶片构件的第一叶片构件。
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