公开(公告)号：US12083230B2

公开(公告)日：2024-09-10

申请号：US17191341

申请日：2021-03-03

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： Nikolas T Weissmueller ,  Robert K Prud'Homme

IPC: A61K9/51 ,  B82Y5/00 ,  C08L89/00 ,  C09D189/00

CPC classification number: A61K9/5169 ,  B82Y5/00 ,  C08L89/00 ,  C09D189/00

Abstract: In one aspect, methods of preparing composite nanoparticle compositions are described herein. For example, in some embodiments, a method comprises providing a zein solution stream, an organic fluid stream including at least one additive and at least one buffer fluid stream. The zein solution stream, organic fluid stream and buffer fluid stream are delivered to a chamber for mixing at one or more rates sufficient to flash precipitate composite nanoparticles including the additive encapsulated by a shell comprising the zein.

公开(公告)号：US20240281577A1

公开(公告)日：2024-08-22

申请号：US18170735

申请日：2023-02-17

Applicant: Adobe Inc. ,  The Trustees of Princeton University

Inventor： Connelly Stuart Barnes ,  Yuting Yang ,  Adam Finkelstein ,  Andrew Bensley Adams

IPC: G06F30/27 ,  G06N3/084

CPC classification number: G06F30/27 ,  G06N3/084

Abstract: Discontinuity modeling techniques of computing functions of a program are described. In one example, a program has a computing function that includes a discontinuity. An input is received by the data modeling system that identifies an axis. A plurality of samples is then generated by the data modeling system along the axis based on an output of the program. The samples are then used as a basis by the data modeling system to generate a data model that models the discontinuity. The data model includes, in one example, one or more gradients and models the discontinuity using a 1D box kernel.

公开(公告)号：US20240271168A1

公开(公告)日：2024-08-15

申请号：US18443118

申请日：2024-02-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： Yasuo YOSHIKUNI ,  Zong-Yen WU ,  Ping-Hung HSIEH ,  Sudharsan DWARAKNATH ,  Zengyi SHAO ,  Wan SUN ,  Joshua D. RABINOWITZ ,  Yihui SHEN

IPC: C12P7/44 ,  C12N9/10

CPC classification number: C12P7/44 ,  C12N9/1029 ,  C12Y203/01182

Abstract: The present invention provides for a genetically modified yeast host cell comprising a heterologous citramalate synthase, or multiple copies of a citramalate synthase, and knocked out or reduced in expression, or under conditional expression, for an endogenous or native pyruvate decarboxylase (PDC) gene; a method for constructing the genetically modified yeast host cell, and a method for producing citramalate using the genetically modified yeast host cell.

公开(公告)号：US20240268402A1

公开(公告)日：2024-08-15

申请号：US18442060

申请日：2024-02-14

Applicant: The Trustees of Princeton University

Inventor： Justin E. Silpe ,  Bonnie L. Bassler

IPC: A23C3/08 ,  A23C9/20

CPC classification number: A23C3/08 ,  A23C9/206

Abstract: Described herein, are compositions and methods for preserving human milk, preventing rancidity of human milk, extending shelf life of human milk, and maintaining the nutritional properties of human milk. Specifically, the present disclosure provides, among other things, devices for storing preserved human milk and methods and compositions for preserving the same.

公开(公告)号：US20240268013A1

公开(公告)日：2024-08-08

申请号：US18636858

申请日：2024-04-16

Applicant: The Trustees of Princeton University

Inventor： Fatima Arezu Ebrahimi

IPC: H05H1/54 ,  H01F6/06

CPC classification number: H05H1/54 ,  H01F6/06

Abstract: According to various embodiments, a system for using magnetic reconnection to accelerate plasma is disclosed. The system includes a pair of electrodes including two concentric rings separated by an electrode gap and held at different electrostatic potential by applying a voltage to generate an inter-electrode electric field. The system further includes a plurality of magnetic coils configured to produce magnetic field lines that connect the pair of electrodes. The system additionally includes a gas injector configured to inject gas into the electrode gap, the injected gas being partially ionized by the inter-electrode electric field to generate a poloidal current that flows along open magnetic field lines across the electrode gap. A total Lorentz force causes oppositely directed magnetic field lines to be expanded around a region of the gas injector to further create an azimuthal current in the form of an axially elongated current sheet that is unstable such that the axially elongated current sheet reconnects and breaks into plasmoids.

公开(公告)号：US12049878B2

公开(公告)日：2024-07-30

申请号：US17896651

申请日：2022-08-26

Applicant: The Trustees of Princeton University

Inventor： Jacob Simmonds ,  Yevgeny Raitses

IPC: F03H1/00

CPC classification number: F03H1/0068

Abstract: Disclosed is a miniaturized plasma propulsion device with minimized surface area of the thruster walls exposed to the plasma and, as a result, reduced plasma-surface interactions including a set of segmented electrodes to facilitate the following improvements compared to relevant existing technologies: 1) control of the plasma flow including focusing of the plasma plume 2) increase of the thrust 2) reduction of inefficiencies associated with the electron cross field current, and 3) mitigation of low frequency oscillations. The electrodes affect all these actions when a DC or modulated voltage is applied to one or all of them with the same or different amplitudes, with the same or different frequencies or phases which are all optimized to realize the best performance through changes in the acceleration and/or ionization regions. In addition, the applied voltage to the main electrodes may also be modulated.

公开(公告)号：US12038489B2

公开(公告)日：2024-07-16

申请号：US17920202

申请日：2021-04-21

Applicant: The Trustees of Princeton University

Inventor： Alexei Goun ,  Herschel Rabitz

IPC: G01R33/44 ,  G01R33/34 ,  G01R33/36

CPC classification number: G01R33/441 ,  G01R33/34015 ,  G01R33/3607

Abstract: Systems and methods are described, and one method includes illuminating a target-of-interest (TI) with an RF energy configured to effect, over a time duration extending from a first time to a second time, an increase in a temperature of the TI. At a first detection time within the time duration, a first temperature NQR signal spectrum of the TI is detected, and a corresponding first temperature NQR spectrum data set is generates. At a second detection time, subsequent to the first detection time, a second temperature NQR signal spectrum of the TI is detected and corresponding second temperature NQR spectrum data set is output. Based at least in part on the first temperature NQR spectral dataset and the second temperature NQR spectral dataset, the TI is classified between including the SI and not including the SI.

公开(公告)号：US20240208815A1

公开(公告)日：2024-06-27

申请号：US18405407

申请日：2024-01-05

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： John T. Groves ,  Roy Xiao

IPC: C01B11/02 ,  A61L2/18 ,  B01J31/18 ,  B01J31/22 ,  B01J31/26 ,  C02F1/76 ,  C02F103/02 ,  C07F15/02 ,  D21C9/14

CPC classification number: C01B11/024 ,  A61L2/18 ,  B01J31/2295 ,  B01J31/26 ,  C07F15/025 ,  D21C9/14 ,  B01J31/1815 ,  B01J31/183 ,  B01J2531/025 ,  B01J2531/842 ,  C02F1/76 ,  C02F2103/023 ,  C02F2303/04

Abstract: Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO2− to at least one of an iron porphyrin catalyst or an iron porphyrazine catalyst are described.

公开(公告)号：US12009111B2

公开(公告)日：2024-06-11

申请号：US18119981

申请日：2023-03-10

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： David Gates

IPC: G21B1/05 ,  H01F6/06

CPC classification number: G21B1/055 ,  H01F6/06

Abstract: Disclosed herein is a stellarator comprising two sets of coils, namely a set of encircling coils which encircle the plasma axis, and a set of shaping coils which do not encircle any other coil or the plasma. In some embodiments, the encircling coils include a structural element to maintain their shape under magnetic forces. In some embodiments, the shaping coils are mounted onto one or more structural elements which, together with the shaping coils, constitute a field shaping unit. Also disclosed is a controller which may modify the electrical current flowing in one or more subsets of the coils in order to achieve target plasma parameters. Also disclosed is a method of designing a set of shaping coils by discretizing a surface dipole or current potential distribution.

公开(公告)号：US12007890B2

公开(公告)日：2024-06-11

申请号：US18139785

申请日：2023-04-26

Applicant: The Trustees of Princeton University

Inventor： Naveen Verma ,  Hossein Valavi ,  Hongyang Jia

IPC: G06F12/06 ,  G06F12/02 ,  G06F17/16 ,  G06N3/065 ,  G11C11/4074 ,  G11C11/4094 ,  G11C11/4097 ,  G11C11/419 ,  H03K19/20

CPC classification number: G06F12/0607 ,  G06F12/0207 ,  G06F17/16 ,  G06N3/065 ,  G11C11/4074 ,  G11C11/4094 ,  G11C11/4097 ,  G11C11/419 ,  H03K19/20 ,  G06F2212/454

Abstract: Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for providing programmable or pre-programmed in-memory computing operations.