公开(公告)号：US12123856B2

公开(公告)日：2024-10-22

申请号：US17659772

申请日：2022-04-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andreas Leinenbach ,  Aart Pieter van Doorn

IPC: G01N30/02 ,  G01N30/36

CPC classification number: G01N30/36 ,  G01N2030/027

Abstract: A liquid chromatographic (LC) system is herein disclosed, the LC system comprising at least one fluidic stream comprising at least one HPLC column, a downstream valve connected to the at least one fluidic stream and connectable to a detector via a valve-to-detector conduit, wherein the at least one fluidic stream is connectable to the valve-to-detector conduit via the downstream valve, and where the LC system further comprises a downstream pump fluidically connected to the downstream valve and connectable to the at least one fluidic stream via the downstream valve in order to backflush and thereby clean the at least one HPLC column. A respective automated LC method is herein also disclosed.

公开(公告)号：US20240337598A1

公开(公告)日：2024-10-10

申请号：US18620273

申请日：2024-03-28

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Wenzel Salzmann

IPC: G01N21/359 ,  G01N21/33 ,  G01N21/3577

CPC classification number: G01N21/359 ,  G01N21/33 ,  G01N21/3577 ,  G01N2201/0627 ,  G01N2201/0635 ,  G01N2201/0638

Abstract: A light source (112) for generating illumination light for illuminating at least one sample is disclosed. The light source (112) comprises



at least one array of light emitters (114), wherein each of the light emitters (114) is configured for emitting at least one light beam along a light beam path, wherein the light beam has a predefined wavelength range, and
at least one reflective optical grating (116) configured for overlaying the light beam paths, at least one transfer element (118);

wherein the transfer element (118) is arranged between the array of light emitters (114) and the optical grating (116) such that the transfer element (118) directs the emitted light beams onto the optical grating (116) and provides the light beams reflected from the optical grating (116) and impinging on the transfer element (118) into at least one measurement channel (120), wherein the measurement channel (120) is configured for receiving at least one sample.

公开(公告)号：US12085573B2

公开(公告)日：2024-09-10

申请号：US14576944

申请日：2014-12-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Hund ,  Maria Schoedl

IPC: G01N33/68 ,  G16H50/30 ,  G16H50/70

CPC classification number: G01N33/689 ,  G16H50/30 ,  G16H50/70 ,  G01N2333/475 ,  G01N2333/515 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2800/368

Abstract: The present invention concerns the field of diagnostic assays for prenatal diagnosis of preeclampsia. In particular, it relates to a method for diagnosing whether a pregnant subject is not at risk for preeclampsia within a short window of time comprising a) determining the amount of at least one angiogenesis biomarker selected from the group consisting of sFlt-1, Endoglin and PlGF in a sample of said subject, and b) comparing the amount with a reference, whereby a subject being not at risk for developing preeclampsia within a short period of time is diagnosed if the amount is identical or decreased compared to the reference in the cases of sFlt-1 and Endoglin and identical or increased in the case of PlGF, wherein said reference allows for making the diagnosis with a negative predictive value of at least about 98%. Further contemplates are devices and kits for carrying out said method.

公开(公告)号：US20240248098A1

公开(公告)日：2024-07-25

申请号：US18558098

申请日：2022-04-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Felix Gruenewald ,  Victor Johann Raul Jeger ,  Martin Klammer ,  Philipp Schuetz ,  Maria von Holtey ,  Stephen Weber ,  Heike Wegmeyer ,  Ursula-Henrike Wienhues-Thelen

IPC: G01N33/68 ,  G16H50/20

CPC classification number: G01N33/6893 ,  G16H50/20 ,  G01N2800/26 ,  G01N2800/50

Abstract: The present invention concerns the field of diagnostics. Specifically. it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject. said first biomarker being NGAL. determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: HBP (Heparin-binding protein). Aspartate aminotransferase. Bilirubin. Alanine aminotransferase. ESM-1 and a BNP-type peptide. comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers. and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being NGAL and a second biomarker selected from the group consisting of: HBP (Heparin-binding protein). Aspartate aminotransferase. Bilirubin. Alanine aminotransferase. ESM-1 and a BNP-type peptide. or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection. Moreover. the invention further relates to a computer-implemented method for assessing a subject with suspected infection and a device and a kit for assessing a subject with suspected infection.

公开(公告)号：US20240242826A1

公开(公告)日：2024-07-18

申请号：US18562880

申请日：2022-05-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Matthias Frenzel ,  Javier Martinez Fernandez ,  Ramona Seel

IPC: G16H40/40

CPC classification number: G16H40/40

Abstract: A computer-implemented method of automatic registration of a device in a laboratory system comprising:



transmitting from the to be registered device specific information to a managing unit (“unit”) via a first interface;
the unit requesting a solution specific configuration from a remote infrastructure via a second interface, receiving the solution specific configuration from the remote infrastructure via the second interface, and transmitting the solution specific configuration to the device to be registered via the first interface, the solution specific configuration being based on the device specific information and configuration information about the laboratory system; and
transmitting a request from the unit comprising updated solution specific configuration to the laboratory devices, the updated solution specific configuration comprising information about the device to be registered and changes due to addition of said device, wherein the laboratory configuration step comprising providing the updated solution specific configuration to the remote infrastructure.

公开(公告)号：US20240242794A1

公开(公告)日：2024-07-18

申请号：US18560126

申请日：2022-04-28

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Josep Fernandez

IPC: G16H10/40 ,  G01N35/00 ,  G01N35/04

CPC classification number: G16H10/40 ,  G01N35/00871 ,  G01N35/04 ,  G01N2035/0091

Abstract: A method for operating a laboratory automation system, comprising, a transport system, a plurality of transfer devices; a portable device; and a plurality of data communication modules. The method comprises: receiving device information for the devices in the portable device, the device information being indicative a device identification; receiving a first user input in the portable device, the user input being indicative of a selection of a first device from the plurality of devices; in response to receiving the first user input, pairing the first device with the transport system for data communication in operation of the first device for at least one of sample pre-analytics and sample analysis; and providing first pairing information in the portable device, the first paring information being indicative of the first device and the distribution system being paired successfully. Further, a laboratory automation system and a laboratory in-vitro diagnostics system are provided.

公开(公告)号：US20240230675A1

公开(公告)日：2024-07-11

申请号：US18558144

申请日：2022-04-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Felix Gruenewald ,  Victor Johann Raul Jeger ,  Martin Klammer ,  Philipp Schuetz ,  Maria von Holtey ,  Stephen Weber ,  Heike Wegmeyer ,  Ursula-Henrike Wienhues-Thelen

IPC: G01N33/68 ,  C12Q1/37 ,  C12Q1/48 ,  C12Q1/52 ,  G01N33/70 ,  G01N33/72 ,  G16H50/30

CPC classification number: G01N33/6893 ,  C12Q1/37 ,  C12Q1/485 ,  C12Q1/52 ,  G01N33/70 ,  G01N33/728 ,  G16H50/30 ,  G01N2333/71 ,  G01N2333/8139 ,  G01N2333/91188 ,  G01N2333/9121 ,  G01N2800/26 ,  G01N2800/50

Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being sFlt1, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: Cystatin C, IGFBP7, a cardiac Troponin, Creatinine, STREM1, PCT and Bilirubin, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being sFltl and a second biomarker selected from the group consisting of: Cystatin C, IGFBP7, a cardiac Troponin, Creatinine, sTREM1, PCT and Bilirubin, or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection. Moreover, the invention further relates to a computer-implemented method for assessing a subject with suspected infection and a device and a kit for assessing a subject with suspected infection.

公开(公告)号：US20240221957A1

公开(公告)日：2024-07-04

申请号：US18556849

申请日：2022-04-21

Applicant: Koichi Ito ,  Roche Diagnostics Operations, Inc.

Inventor： Hiroshi Yoshimura

IPC: G16H50/30 ,  G01N33/68 ,  G01N33/70 ,  G01N33/78 ,  G01N33/92 ,  G16H50/20

CPC classification number: G16H50/30 ,  G01N33/6827 ,  G01N33/70 ,  G01N33/78 ,  G01N33/92 ,  G16H50/20

Abstract: An information processing device includes a first determination unit that inputs information related to total protein (TP), cholinesterase (ChE), total cholesterol (TC), creatinine (CREA), and creatine phosphokinase (CPK) to a first learning-completed model based on information related to a blood examination of a subject and outputs information related to whether thyroid stimulation hormone (TSH) of the subject is in a range for which medical treatment is needed.

公开(公告)号：US12021752B2

公开(公告)日：2024-06-25

申请号：US17360539

申请日：2021-06-28

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stephen Martin ,  Alexandra Paun ,  Jakub Winiarz

IPC: H04L47/24 ,  H04L43/062 ,  G16H10/40

CPC classification number: H04L47/24 ,  H04L43/062 ,  G16H10/40

Abstract: A computer implemented method and associated apparatus, networked system, computer readable medium, and computer program element are presented. The computer-implemented method generates a message filter configuration based on a message priority indication received from a first analyzer network. The first analyzer network comprises at least one analytical device configured to generate a message. The method comprises receiving, at a data processing agent, a message priority indication indicating a priority assigned to the message in the first analyzer network, providing, at the data processing agent, at least one message filter configuration based on the message priority indication of the message, and communicating the message filter configuration, or a portion thereof, to a second analyzer network comprising a second analytical device.

公开(公告)号：US12017216B2

公开(公告)日：2024-06-25

申请号：US17141786

申请日：2021-01-05

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andreas Drechsler ,  Darko Klinec ,  Michael Koehler ,  Alexander Jakob ,  Michael Zeder

IPC: B01L3/00 ,  G01F23/284 ,  G01F23/292 ,  G01F23/80 ,  G01N23/20 ,  G01N23/20091 ,  G01N35/00 ,  G01N21/3577 ,  G01N21/3581

CPC classification number: B01L3/502715 ,  G01F23/284 ,  G01F23/292 ,  G01F23/804 ,  G01N23/20091 ,  G01N35/00732 ,  B01L2300/1861 ,  G01N21/3577 ,  G01N21/3581

Abstract: A method to process a laboratory carrier in a laboratory system based on a feature of a test liquid in the laboratory carrier is presented. The laboratory system comprises the laboratory carrier comprising the test liquid, a terahertz wave source, a terahertz detector, a laboratory carrier processing device, and a control unit. Using terahertz technology and data analysis, the feature of the test liquid in the laboratory carrier can be determined. In addition, the control unit controls the laboratory carrier processing device based on the determined feature of the test liquid.