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    COMPOSITIONS AND METHODS FOR TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS
    11.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS 审中-公开
    用于治疗眼病和疾病的组合物和方法

    公开(公告)号：US20090197967A1

    公开(公告)日：2009-08-06

    申请号：US12162476

    申请日：2007-01-26

    申请人： Ryo Kubota ,  Ahmad Fawzi ,  Ian L. Scott ,  Vladimir A. Kuksa

    发明人： Ryo Kubota ,  Ahmad Fawzi ,  Ian L. Scott ,  Vladimir A. Kuksa

    IPC分类号： A61K31/135 ,  A61K31/13

    CPC分类号： A61K31/137

    摘要： Provided herein are compositions and methods for treating ophthalmic diseases and disorders. Compositions comprising retinylamine derivative compounds provided herein are useful for treating and preventing ophthalmic diseases and disorders, including diabetic retinopathy diabetic maculopathy, diabetic macular edema, retinal ischemia, ischemia-reperfusion related retinal injury, and metabolic optic neuropathy.

    摘要翻译： 本文提供了用于治疗眼科疾病和病症的组合物和方法。 包含本文提供的视黄醇衍生物化合物的组合物可用于治疗和预防眼科疾病和病症，包括糖尿病性视网膜病，糖尿病性黄斑变性，糖尿病性黄斑水肿，视网膜缺血，缺血再灌注相关的视网膜损伤和代谢性视神经病变。

    SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SAME
    12.
    发明申请
    SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SAME 有权
    半导体器件及其制造方法

    公开(公告)号：US20080296729A1

    公开(公告)日：2008-12-04

    申请号：US12130096

    申请日：2008-05-30

    申请人： Ryo KUBOTA ,  Nobutaka Nagai ,  Satoshi Kura

    发明人： Ryo KUBOTA ,  Nobutaka Nagai ,  Satoshi Kura

    IPC分类号： H01L29/92 ,  H01L21/02

    CPC分类号： H01L28/91

    摘要： A semiconductor device is manufactured by forming a hole as being extended through a first insulating film and an insulating interlayer stacked over a semiconductor substrate, allowing side-etching of the inner wall of the hole to proceed specifically in a portion of the insulating interlayer, to thereby form a structure having the first insulating film projected out from the edge towards the center of the hole; forming a lower electrode film as being extended over the top surface, side face and back surface of the first insulating film, and over the inner wall and bottom surface of the hole; filling a protective film in the hole; removing the lower electrode film specifically in portions fallen on the top surface and side face of the first insulating film; removing the protective film; and forming a cylindrical capacitor in the hole.

    摘要翻译： 半导体器件通过在第一绝缘膜和覆盖在半导体衬底上的绝缘夹层延伸形成孔，通过对绝缘中间层的一部分特定的孔的内壁进行侧蚀， 从而形成具有从边缘向孔的中心突出的第一绝缘膜的结构; 在所述第一绝缘膜的上表面，侧面和背面延伸并在所述孔的内壁和底面上方形成下电极膜; 在孔中填充保护膜; 在第一绝缘膜的顶表面和侧面上分别去掉下电极膜; 去除保护膜; 并在孔中形成圆柱形电容器。

    Methods and systems for extended in vitro culture of neuronal cells
    13.
    发明申请
    Methods and systems for extended in vitro culture of neuronal cells 审中-公开
    延长体外培养神经元细胞的方法和系统

    公开(公告)号：US20080175826A1

    公开(公告)日：2008-07-24

    申请号：US11985856

    申请日：2007-11-16

    申请人： Ryo Kubota ,  Thomas A. Reh ,  Andrew J. Fischer

    发明人： Ryo Kubota ,  Thomas A. Reh ,  Andrew J. Fischer

    IPC分类号： A61K35/12 ,  C12N5/06 ,  A61P27/02 ,  C12Q1/02

    CPC分类号： C12N5/0621 ,  C12N5/062 ,  C12N2502/08 ,  C12N2503/02

    摘要： A cell culture system related to extended in vitro culture of mature neuronal cells and methods for preparing the cell culture system are provided. In a preferred embodiment the invention provides a cell culture system comprising a mixture of mature neuronal retinal cells and cells isolated from a ciliary body. Methods for identifying bioactive agents that alter neurodegeneration of neuronal retinal cells are also provided.

    摘要翻译： 提供了与成熟神经元细胞的延长的体外培养相关的细胞培养系统和用于制备细胞培养系统的方法。 在优选的实施方案中，本发明提供了包含成熟神经元视网膜细胞和从睫状体分离的细胞的混合物的细胞培养系统。 还提供了用于鉴定改变神经元视网膜细胞神经变性的生物活性剂的方法。

    Extended Primary Retinal Cell Culture and Stress Models, and Methods of Use
    14.
    发明申请
    Extended Primary Retinal Cell Culture and Stress Models, and Methods of Use 审中-公开
    扩展的主要视网膜细胞培养和应激模型和使用方法

    公开(公告)号：US20080003634A1

    公开(公告)日：2008-01-03

    申请号：US11758480

    申请日：2007-06-05

    申请人： Ryo Kubota

    发明人： Ryo Kubota

    IPC分类号： C12N5/06 ,  C12Q1/02

    CPC分类号： C12N5/062 ,  C12N2503/02 ,  G01N33/5005 ,  G01N33/5014

    摘要： A cell culture system related to extended in vitro culture of mature retinal cells and methods for preparing the cell culture system are provided. Also provided is a retinal cell culture stress model related to extended in vitro culture of mature retinal cells in the presence of a stressor and methods for using the cell culture stress model. The invention provides a cell culture system comprising a long-term culture of mature retinal cells, without requiring addition of other types of non-retinal cells such as purified glia, or cells isolated from ciliary bodies within the eye, and the addition of a stressor such as light, A2E, cigarette smoke condensate, glutamate, or hydrostatic pressure. Methods for identifying bioactive agents that alter viability, neurodegeneration, or survival of retinal cells using the retinal cell culture stress system are also provided.

    摘要翻译： 提供了与成熟视网膜细胞的延长体外培养相关的细胞培养系统和用于制备细胞培养系统的方法。 还提供了一种视网膜细胞培养应激模型，其涉及在应激源存在下成熟视网膜细胞的延长体外培养和使用细胞培养应激模型的方法。 本发明提供一种包含成熟视网膜细胞的长期培养物的细胞培养系统，而不需要添加其它类型的非视网膜细胞，例如纯化的神经胶质细胞，或从眼睛内的睫状体分离的细胞，以及加入应激源 如光，A2E，香烟烟雾凝结物，谷氨酸或静水压力。 还提供了用于鉴定使用视网膜细胞培养应激系统改变视网膜细胞的存活力，神经变性或存活的生物活性剂的方法。

    Methods and systems for extended in vitro culture of neuronal cells
    15.
    发明授权
    Methods and systems for extended in vitro culture of neuronal cells 失效
    延长体外培养神经元细胞的方法和系统

    公开(公告)号：US07312025B2

    公开(公告)日：2007-12-25

    申请号：US10618076

    申请日：2003-07-11

    申请人： Ryo Kubota ,  Thomas A Reh ,  Andrew J Fischer

    发明人： Ryo Kubota ,  Thomas A Reh ,  Andrew J Fischer

    IPC分类号： C12N5/06 ,  C12Q1/00 ,  C12Q1/02

    CPC分类号： C12N5/0621 ,  C12N5/062 ,  C12N2502/08 ,  C12N2503/02

    摘要： A cell culture system related to extended in vitro culture of mature neuronal cells and methods for preparing the cell culture system are provided. In a preferred embodiment the invention provides a cell culture system comprising a mixture of mature neuronal retinal cells and cells isolated from a ciliary body. Methods for identifying bioactive agents that alter neurodegeneration of neuronal retinal cells are also provided.

    摘要翻译： 提供了与成熟神经元细胞的延长的体外培养相关的细胞培养系统和用于制备细胞培养系统的方法。 在优选的实施方案中，本发明提供了包含成熟神经元视网膜细胞和从睫状体分离的细胞的混合物的细胞培养系统。 还提供了用于鉴定改变神经元视网膜细胞的神经变性的生物活性剂的方法。

    Compositions and methods for diagnosing and treating retinal diseases
    16.
    发明申请
    Compositions and methods for diagnosing and treating retinal diseases 审中-公开
    用于诊断和治疗视网膜疾病的组合物和方法

    公开(公告)号：US20060252107A1

    公开(公告)日：2006-11-09

    申请号：US11361027

    申请日：2006-02-22

    申请人： Ryo Kubota ,  Krzysztof Palczewski ,  Anna Gall

    发明人： Ryo Kubota ,  Krzysztof Palczewski ,  Anna Gall

    IPC分类号： G01N33/53 ,  C07K16/18 ,  C07K14/47 ,  C07D213/55 ,  C07D213/20 ,  C12N5/06

    CPC分类号： A61K39/0007 ,  A61K2039/6031 ,  C07D213/20 ,  C07D213/38 ,  C07D213/50 ,  C07D213/56 ,  C07K16/44

    摘要： The present invention relates generally to the preparation and use of retinoid N-retinylidene-N-retinyl-ethanolamine (A2E) conjugated to a carrier polypeptide and to the preparation and use of antibodies that bind specifically to A2E. The invention relates to the use of A2E conjugates as immunogens or vaccines and to the use of A2E specific antibodies for treatment of ophthalmic diseases. Provided herein are methods for enhancing retinal neuronal cell survival, including photoreceptor cell survival, using antibodies that specifically bind to A2E or by inducing an immune response using an A2E immunoconjugate. Enhancing survival of photoreceptor cells or decreasing accumulation of A2E in the eye using the A2E immunoconjugates or A2E specific antibodies is useful for treatment of ophthalmic diseases such as macular degeneration.

    摘要翻译： 本发明一般涉及与载体多肽缀合的类视黄醇N-亚视黄基-N-视黄醇 - 乙醇胺（A2E）的制备和用途，以及制备和使用与A2E特异性结合的抗体。 本发明涉及使用A2E缀合物作为免疫原或疫苗，以及使用A2E特异性抗体治疗眼科疾病。 本文提供了使用特异性结合A2E的抗体或通过使用A2E免疫缀合物诱导免疫应答来增强视网膜神经元细胞存活的方法，包括感光细胞存活。 使用A2E免疫缀合物或A2E特异性抗体提高感光细胞的存活或减少A2E在眼中的积累，可用于治疗眼部疾病如黄斑变性。

    Semiconductor device and method of manufacturing the same
    17.
    发明授权
    Semiconductor device and method of manufacturing the same 有权
    半导体装置及其制造方法

    公开(公告)号：US08748282B2

    公开(公告)日：2014-06-10

    申请号：US13169626

    申请日：2011-06-27

    申请人： Ryo Kubota ,  Nobutaka Nagai ,  Satoshi Kura

    发明人： Ryo Kubota ,  Nobutaka Nagai ,  Satoshi Kura

    IPC分类号： H01L29/72

    CPC分类号： H01L28/91

    摘要： A semiconductor device is manufactured by forming a hole as being extended through a first insulating film and an insulating interlayer stacked over a semiconductor substrate, allowing side-etching of the inner wall of the hole to proceed specifically in a portion of the insulating interlayer, to thereby form a structure having the first insulating film projected out from the edge towards the center of the hole; forming a lower electrode film as being extended over the top surface, side face and back surface of the first insulating film, and over the inner wall and bottom surface of the hole; filling a protective film in the hole; removing the lower electrode film specifically in portions fallen on the top surface and side face of the first insulating film; removing the protective film; and forming a cylindrical capacitor in the hole.

    摘要翻译： 半导体器件通过在第一绝缘膜和覆盖在半导体衬底上的绝缘夹层延伸形成孔，通过对绝缘中间层的一部分特定的孔的内壁进行侧蚀， 从而形成具有从边缘向孔的中心突出的第一绝缘膜的结构; 在所述第一绝缘膜的上表面，侧面和背面延伸并在所述孔的内壁和底面上方形成下电极膜; 在孔中填充保护膜; 在第一绝缘膜的顶表面和侧面上分别去掉下电极膜; 去除保护膜; 并在孔中形成圆柱形电容器。

    Semiconductor device and method of manufacturing the same
    20.
    发明授权
    Semiconductor device and method of manufacturing the same 有权
    半导体装置及其制造方法

    公开(公告)号：US07985997B2

    公开(公告)日：2011-07-26

    申请号：US12130096

    申请日：2008-05-30

    申请人： Ryo Kubota ,  Nobutaka Nagai ,  Satoshi Kura

    发明人： Ryo Kubota ,  Nobutaka Nagai ,  Satoshi Kura

    IPC分类号： H01L29/72

    CPC分类号： H01L28/91

    摘要： A semiconductor device is manufactured by forming a hole as being extended through a first insulating film and an insulating interlayer stacked over a semiconductor substrate, allowing side-etching of the inner wall of the hole to proceed specifically in a portion of the insulating interlayer, to thereby form a structure having the first insulating film projected out from the edge towards the center of the hole; forming a lower electrode film as being extended over the top surface, side face and back surface of the first insulating film, and over the inner wall and bottom surface of the hole; filling a protective film in the hole; removing the lower electrode film specifically in portions fallen on the top surface and side face of the first insulating film; removing the protective film; and forming a cylindrical capacitor in the hole.

    摘要翻译： 半导体器件通过在第一绝缘膜和覆盖在半导体衬底上的绝缘夹层延伸形成孔，通过对绝缘中间层的一部分特定的孔的内壁进行侧蚀， 从而形成具有从边缘向孔的中心突出的第一绝缘膜的结构; 在所述第一绝缘膜的上表面，侧面和背面延伸并在所述孔的内壁和底面上方形成下电极膜; 在孔中填充保护膜; 在第一绝缘膜的顶表面和侧面上分别去掉下电极膜; 去除保护膜; 并在孔中形成圆柱形电容器。