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公开(公告)号：US11650405B2
公开(公告)日：2023-05-16
申请号：US17098058
申请日：2020-11-13
Applicant: SCOPIO LABS LTD.
Inventor： Ben Leshem , Eran Small , Erez Na'aman , Ittai Madar
CPC classification number: G02B21/006 , G02B21/06 , G02B21/34 , G02B21/367
Abstract: A microscope for computational microscopic layer separation may include an imaging device that includes a lens and an image sensor, an illumination system for illuminating a sample, and an actuator to adjust an axial position of a focal plane with respect to the sample. The microscope may also include a processor operatively coupled to the imaging device and the illumination system. The processor may be configured to measure, using the image sensor and the illumination system, optical aberrations of the imaging device at the axial position, and determine whether to adjust the focal plane with respect to the sample in response to the one or more optical aberrations. Various other systems and methods are also disclosed.
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公开(公告)号：US20230005281A1
公开(公告)日：2023-01-05
申请号：US17931271
申请日：2022-09-12
Applicant: SCOPIO LABS LTD.
Inventor： Ben LESHEM , Eran SMALL , Itai HAYUT , Erez NA'AMAN , Eyal BEN-BASSAT
Abstract: A microscope for adaptive sensing may comprise an illumination assembly, an image capture device configured to collect light from a sample illuminated by the assembly, and a processor. The processor may be configured to execute instructions which cause the microscope to capture, using the image capture device, an initial image set of the sample, identify, in response to the initial image set, an attribute of the sample, determine, in response to identifying the attribute, a three-dimensional (3D) process for sensing the sample, and generate, using the determined 3D process, an output image set comprising more than one focal plane. Various other methods, systems, and computer-readable media are also disclosed.
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公开(公告)号：US20200302144A1
公开(公告)日：2020-09-24
申请号：US16851830
申请日：2020-04-17
Applicant: SCOPIO LABS LTD.
Inventor： Ben LESHEM , Eran SMALL , Itai HAYUT , Erez NA'AMAN , Eyal BEN-BASSAT
Abstract: A microscope for adaptive sensing may comprise an illumination assembly, an image capture device configured to collect light from a sample illuminated by the assembly, and a processor. The processor may be configured to execute instructions which cause the microscope to capture, using the image capture device, an initial image set of the sample, identify, in response to the initial image set, an attribute of the sample, determine, in response to identifying the attribute, a three-dimensional (3D) process for sensing the sample, and generate, using the determined 3D process, an output image set comprising more than one focal plane. Various other methods, systems, and computer-readable media are also disclosed.
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14.发明申请公开(公告)号：US20190235224A1
公开(公告)日：2019-08-01
申请号：US15775389
申请日：2016-11-10
Applicant: Scopio Labs Ltd.
Inventor： Eran SMALL , Ben LESHEM , Ittay MADAR , Erez NAAMAN , Itai HAYUT
CPC classification number: G02B21/367 , G02B7/09 , G02B7/36 , G02B21/02 , G02B21/06 , G02B21/245 , G02B21/36 , G06K9/00134 , G06K9/00147 , H04N5/2253 , H04N5/2254 , H04N5/2256
Abstract: Systems and methods are disclosed for constructing an image of a sample using a plurality of images acquired under multiple illumination conditions. In one implementation, a microscope may include an image capture device, an illumination assembly, and a controller. The controller may cause the illumination assembly to illuminate the sample at a series of different illumination conditions. The controller may further acquire from image capture device a plurality of images of the sample, wherein the plurality of images includes at least one image for each illumination condition. The controller may also determine, from the at least one image, image data of the sample for each illumination condition. The controller may further generate, from the determined image data for each illumination condition and in a non-iterative process, a reconstructed image of the sample. The reconstructed image may have a second image resolution higher than the first image resolution.
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公开(公告)号：US20240160000A1
公开(公告)日：2024-05-16
申请号：US18559473
申请日：2022-05-26
Applicant: SCOPIO LABS LTD.
Inventor： Ben LESHEM , Erez NA'AMAN , Eran SMALL , Ben SARUSI
Abstract: A microscope system may be integrated with a coverslipping device. A method of preparing a microscope slide for imaging a sample on the microscope slide may include placing a transparent flowable material on the sample while the slide is supported with one or more linkages coupled to a processor, covering the sample with a coverslip, and placing the microscope slide on a microscope stage with the one or more linkages coupled to the slide and the processor. Various other systems and methods are provided.
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Patent Agency Ranking
16.发明公开公开(公告)号：US20230384205A1
公开(公告)日：2023-11-30
申请号：US18248566
申请日：2021-11-09
Applicant: SCOPIO LABS LTD.
Inventor： Shahar KARNY , Ben LESHEM , Erez NA'AMAN , Eran SMALL , Itai HAYUT
CPC classification number: G01N15/1434 , G06T7/0012 , G06T3/4053 , G06V20/698 , G06V20/693 , G02B21/008 , G01N2015/008
Abstract: A microscope system for full field morphology analysis may include an optical scanning apparatus to scan the sample with an effective numerical aperture of at least 0.8, and a processor coupled to the scanning apparatus. The processor may be configured to: scan the sample with the optical scanning apparatus to produce a plurality of images of the sample, the plurality of images comprising at least 500 blood cells, analyze the plurality of images to determine at least 10 morphology parameters for each of the at least 500 blood cells, and output the at least 10 morphology parameters. The microscope system may include a display for presenting data. Various other systems and methods are provided.
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公开(公告)号：US11409095B2
公开(公告)日：2022-08-09
申请号：US16875721
申请日：2020-05-15
Applicant: SCOPIO LABS LTD.
Inventor： Ittai Madar , Eran Small , Itai Hayut , Erez Na'aman
Abstract: A microscope including an illumination assembly, an image capture device and a processor can be configured to selectively identify regions of a sample including artifacts or empty space. By selectively identifying regions of the sample that have artifacts or empty space, the amount of time to generate an image of the sample and resources used to generate the image can be decreased substantially while providing high resolution for appropriate regions of the computational image. The processor can be configured to change the imaging process in response to regions of the sample that includes artifacts or empty space. The imaging process may include a higher resolution process to output higher resolution portions of the computational image for sample regions including valid sample material, and a lower resolution process to output lower resolution portions of the computational image for sample regions including valid sample material.
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公开(公告)号：US20210149169A1
公开(公告)日：2021-05-20
申请号：US17098058
申请日：2020-11-13
Applicant: SCOPIO LABS LTD.
Inventor： Ben LESHEM , Eran SMALL , Erez NA'AMAN , Ittai MADAR
Abstract: A microscope for computational microscopic layer separation may include an imaging device that includes a lens and an image sensor, an illumination system for illuminating a sample, and an actuator to adjust an axial position of a focal plane with respect to the sample. The microscope may also include a processor operatively coupled to the imaging device and the illumination system. The processor may be configured to measure, using the image sensor and the illumination system, optical aberrations of the imaging device at the axial position, and determine whether to adjust the focal plane with respect to the sample in response to the one or more optical aberrations. Various other systems and methods are also disclosed.
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公开(公告)号：US20200278362A1
公开(公告)日：2020-09-03
申请号：US16875665
申请日：2020-05-15
Applicant: SCOPIO LABS LTD.
Inventor： Itai HAYUT , Erez NA'AMAN , Eran SMALL
Abstract: A microscope system may comprise a plurality of microscope modules, a cassette for holding a plurality of slides, a slide loader configured to move the plurality of slides between the cassette and the plurality of microscope modules, and a processor coupled to the slide loader. The processor may be configured with instructions which, when executed, cause the slide loader to move a slide into or from a selected microscope module among the plurality of microscope modules. Various other methods, systems, and computer-readable media are also disclosed.
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公开(公告)号：US20180348500A1
公开(公告)日：2018-12-06
申请号：US15774881
申请日：2016-11-10
Applicant: SCOPIO LABS LTD.
Inventor： Erez NAAMAN, III , Michael Shimon ILUZ , Itai HAYUT
CPC classification number: G02B21/367 , G06F19/00 , G06K9/00134 , G06K9/2081 , G06T3/4053 , G16H10/40
Abstract: Microscopes and methods for processing images of a sample are disclosed. In one implementation, a microscope includes an illumination assembly configured to illuminate the sample under two or more different illumination conditions. The microscope further includes at least one image capture device configured to capture image information associated with the sample and at least one controller. The at least one controller is programmed to receive, from the at least one image capture device, a plurality of images associated with the sample. At least a first portion of the plurality of images is associated with a first region of the sample, and a second portion of the plurality of images is associated with a second region of the sample. The at least one controller is further programmed to initiate a first computation process to generate a high resolution image of the first region by combining image information selected from the first portion of the plurality of images; receive, after initiating the first computation process and before completing the first computation process, a request associated with prioritizing a second computation process for generating a high resolution image of the second region; and initiate, after receiving the request, the second computation process to generate the high resolution image of the second region by combining image information selected from the second portion of the plurality of images.
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