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公开(公告)号：US20180240059A1
公开(公告)日：2018-08-23
申请号：US15550574
申请日：2016-01-22
Applicant: Shibuya Corporation
Inventor： Shiaru MURANAKA , Kenji YONEDA , Hiroshi UTSUMI
IPC: G06Q10/06 , G06Q50/04 , G05B19/418
Abstract: A schedule management system 1 having isolators 3 (production facilities) and a main control device 4 for managing a production schedules of all the isolators 3. The production process of each isolator constituting the production schedule has a plurality of sub-processes, the production status being determined in the sub-process.The main control device 4 adds a new separating operation to the passage process and performs an update when the main control device 4 obtains a determination result that the separation of cells in a separation state confirmation operation (sub-process) in the passage process is insufficient while a passage process for cells A is being carried out in the isolators.The main control device 4 alters the start time of a culture medium exchange process for other cells B different from the updated passage operation, and updates the production schedule.
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公开(公告)号：US20180203327A1
公开(公告)日：2018-07-19
申请号：US15868164
申请日：2018-01-11
Applicant: SHIBUYA CORPORATION
Inventor： Toshiaki NAKA , Motoi SASAKI , Akito TSUCHIYA
CPC classification number: G02F1/39 , G02F1/3501 , G02F2001/3503 , G02F2203/055 , G02F2203/13
Abstract: A pumping beam L1 enters from a pumping beam projector 3 into one end surface 2a of a nonlinear crystal 2, the pumping beam L1 and idler wave L2 are generated from another end surface 2b of the nonlinear crystal 2. The pumping beam L1 emitted from the other end surface 2b of the nonlinear crystal 2 is reflected and re-enters as a pumping beam L′ into the other end surface 2b and the idler wave L2 generated from the other end surface 2b of the nonlinear crystal is reflected by the reflection optical system 6 and re-enters as a seed beam L2′ into the other end surface 2b. The idler wave L2 enters as the seed beam L2′ together with the pumping beam L1′ into the nonlinear crystal and thus a terahertz wave with a large output and including a plurality of wavelengths can be generated.
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公开(公告)号：US09897893B2
公开(公告)日：2018-02-20
申请号：US15411086
申请日：2017-01-20
Applicant: SHIBUYA CORPORATION
Inventor： Kodo Kawase , Toshiaki Naka , Motoi Sasaki , Akito Tsuchiya
CPC classification number: G02F1/3501 , G02F1/3532 , G02F1/39 , G02F2001/3503 , G02F2001/3507 , G02F2001/392 , G02F2201/302 , G02F2203/13 , H01S3/0092 , H01S2302/02
Abstract: In a terahertz wave generation apparatus including a first non-linear optical crystal 3 on which first laser L1 and second laser L2 from laser generation means 2 are incident to generate terahertz wave TH1, the laser generation means includes a second non-linear optical crystal 7 on which laser having the same wavelength as that of the second laser is incident to generate idler light L1 including a plurality of wavelengths, and makes the idler light L1 generated from the second non-linear optical crystal incident on the first non-linear optical crystal as the first laser L1, to generate terahertz wave including a plurality of wavelengths from the first non-linear optical crystal 3, and wavelength selection means including a transmission section which transmits an idler light having the specific wavelength in the idler light including the plurality of wavelengths can be provided, as needed. Thus, terahertz wave having a high output power and including a plurality of wavelengths can be obtained, and the wavelength selection means easily obtains a required terahertz wave having the specific wavelength.
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公开(公告)号：US09878062B2
公开(公告)日：2018-01-30
申请号：US15112248
申请日：2015-01-07
Applicant: SHIBUYA CORPORATION
Inventor： Masaharu Shomura , Takuya Funazuka
CPC classification number: A61L2/20 , C12M37/00 , C12M41/40 , F24F3/161 , F24F2003/1614 , F24F2003/1628
Abstract: A decontamination operation chamber is partitioned into a first operation chamber and a second operation chamber. A connecting portion that connects the first operation chamber and the second operation chamber can be closed. The pressure of the first operation chamber and the second operation chamber is adjusted by a pressure-adjusting mechanism. When the connecting portion is opened and the first operation chamber and the second operation chamber are connected, an inlet portion for the first operation chamber and an outlet portion for the second operation chamber are closed and air flow is generated from the second operation chamber to the first operation chamber by the pressure-adjusting mechanism. When carrying an object into an aseptic manipulation chamber, the object is housed in the first operation chamber and a first decontamination operation is performed, then the object is transferred to the second operation chamber and a second decontamination operation is performed.
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公开(公告)号：US20170246211A1
公开(公告)日：2017-08-31
申请号：US15512390
申请日：2015-08-19
Applicant: SHIBUYA CORPORATION , YAMAGUCHI UNIVERSITY
Inventor： Isao SAKAIDA , Shuji TERAI , Taro TAKAMI , Koichi FUJISAWA , Naoki YAMAMOTO , Kenji YONEDA
IPC: A61K35/28 , C12Q1/48 , C12N5/0775 , G01N33/50
Abstract: The present invention relates to a method for evaluating the activity level of mesenchymal stem cells, and a method for culturing mesenchymal stem cells using the evaluation method in the field of culturing mesenchymal stem cells for regenerative medicine, and further, a method for producing a therapeutic agent for liver dysfunction and a therapeutic agent for liver dysfunction. This method for evaluating mesenchymal stem cell activity according to the present invention comprises an assay step for assaying the amount of adenylate kinase 4 (AK4) in the mesenchymal stem cells; and a determination step for determining the activity level of the mesenchymal stem cells from the assayed amount of adenylate kinase 4.In this method, the activity level of mesenchymal stem cells can be evaluated from the assayed amount of AK4, for instance, if the mitochondrial activity level of mesenchymal stem cells is high, the mesenchymal stem cells can be evaluated as ideal for use as a therapeutic agent, while if mitochondrial activity of the mesenchymal stem cells is low and aging does not proceed, the mesenchymal stem cells can be evaluated as suitable for subculture.
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Patent Agency Ranking
公开(公告)号：US20170219911A1
公开(公告)日：2017-08-03
申请号：US15411086
申请日：2017-01-20
Applicant: SHIBUYA CORPORATION
Inventor： Kodo KAWASE , Toshiaki NAKA , Motoi SASAKI , Akito TSUCHIYA
CPC classification number: G02F1/3501 , G02F1/3532 , G02F1/39 , G02F2001/3503 , G02F2001/3507 , G02F2001/392 , G02F2201/302 , G02F2203/13 , H01S3/0092 , H01S2302/02
Abstract: In a terahertz wave generation apparatus including a first non-linear optical crystal 3 on which first laser L1 and second laser L2 from laser generation means 2 are incident to generate terahertz wave TH1, the laser generation means includes a second non-linear optical crystal 7 on which laser having the same wavelength as that of the second laser is incident to generate idler light L1 including a plurality of wavelengths, and makes the idler light L1 generated from the second non-linear optical crystal incident on the first non-linear optical crystal as the first laser L1, to generate terahertz wave including a plurality of wavelengths from the first non-linear optical crystal 3, and wavelength selection means including a transmission section which transmits an idler light having the specific wavelength in the idler light including the plurality of wavelengths can be provided, as needed. Thus, terahertz wave having a high output power and including a plurality of wavelengths can be obtained, and the wavelength selection means easily obtains a required terahertz wave having the specific wavelength.
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公开(公告)号：US20170130189A1
公开(公告)日：2017-05-11
申请号：US15322643
申请日：2015-06-12
Applicant: SHIBUYA CORPORATION
Inventor： Masahiro SAKAMOTO , Noriaki NISHIMURA
Abstract: An automatic culturing device configured such that, in a work chamber 2a maintained in a sterile state, first and second robots 6 and 7 are arranged so that the movable ranges thereof partially overlap each other, and such that liquid supply means 10 which supplies liquids, containing a culture medium and liquid medicine, to containers held by the robots, and temporary placement sections (handing-over table 42, centrifuge tube holder 43, and heated room 44), each of which hands over the containers between the first and second robots, are provided in the movable ranges of the first and second robots, which ranges overlap each other.The first robot takes out the containers housed in housing means (rotary stocker 8), and the second robot holds and transports the containers handed over from the first robot via the temporary placement section.The cultivating operation can be efficiently performed.
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18.发明申请公开(公告)号：US20160123800A1
公开(公告)日：2016-05-05
申请号：US14926967
申请日：2015-10-29
Applicant: SHIBUYA CORPORATION
Inventor： Daisuke Watanabe
IPC: G01J1/42 , G06K9/62 , G06K9/46 , G01N33/483 , G06T7/00
CPC classification number: G01J1/42 , G01N33/4833 , G06K9/00127 , G06T7/0016 , G06T7/194 , G06T2207/10056 , G06T2207/30024
Abstract: The present invention relates to a cell peeling recognizing device and a cell peeling recognizing method.When a moving part (robot 6) moves culture vessel 5, imaging device 14 images an interior of culture vessel 5 a plurality of times as the cells move inside the culture vessel due to the moment of inertia, and recognizing part 10a recognizes the peeled state of cells C by comparing various sets of the captured imaging data. The peeled state of cells in the culture vessel can be determined with high precision.
Abstract translation: 细胞剥离识别装置及细胞剥离识别方法技术领域本发明涉及细胞剥离识别装置和细胞剥离识别方法。 当移动部件（机器人6）移动培养容器5时，成像装置14由于转动惯量而随着细胞在培养容器内移动而多次扫描培养容器5的内部，并且识别部分10a识别剥离状态 通过比较各组捕获的成像数据的单元格C。 可以高精度地测定培养容器中的细胞的剥离状态。
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公开(公告)号：US12109517B2
公开(公告)日：2024-10-08
申请号：US17196327
申请日：2021-03-09
Applicant: SHIBUYA CORPORATION
Inventor： Toshiaki Naka , Shigeki Koishi , Akira Hatanaka
CPC classification number: B01D29/56 , B01D29/62 , B01D61/145 , B01D2201/085 , B01D2201/088 , B01D2311/2649 , B01D2311/2692
Abstract: A liquid containing exosomes is filtered through a first filter that has a hole diameter that passes the exosomes and blocks cells, and is then stored in a first storage unit (rough filtration step). Next, pressure is applied to the inside of the first storage unit to pump the liquid to a pre-filtration chamber in a second filter that blocks the exosomes so that water in the liquid is filtered out into a post-filtration chamber. The exosome-containing liquid that was not filtered out is returned to the first storage unit, thereby increasing the exosome concentration in the liquid for extraction (concentration step). The exosome-containing concentrate in the first storage unit is then filtered through a third filter having a hole diameter that passes the exosomes and blocks bacteria, and is sent to a recovery unit (sterilization filtration step).
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公开(公告)号：US11939208B2
公开(公告)日：2024-03-26
申请号：US17352804
申请日：2021-06-21
Applicant: SHIBUYA CORPORATION
Inventor： Noriaki Nishimura
CPC classification number: B67D7/42 , B67D7/0283 , G01N35/1011 , G01N35/1065
Abstract: A liquid is efficiently suctioned and discharged from and to a container formed by a plurality of aligned storing portions for storing the liquid, using a plurality of nozzles. Provided is a liquid suction/discharge device including a container support device for supporting a culture container formed by a plurality of aligned storing portions, and a nozzle support device for supporting a plurality of nozzles in a state in which distal ends of the nozzles are directed downward. The nozzle support device includes a nozzle support member that swingably supports the plurality of nozzles using prescribed parts as support points, and the liquid suction/discharge device further includes a nozzle inclination device for causing each of the nozzles to be inclined with respect to the nozzle support member.
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